Citation Impact
Citing Papers
Defects in the Neuroendocrine Axis Contribute to Global Development Delay in a Drosophila Model of NGLY1 Deficiency
2018
Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility
2021 StandoutNobel
Ubiquitin-binding domains
2006
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution
2010
The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression
2015
Roles of NRF3 in the Hallmarks of Cancer: Proteasomal Inactivation of Tumor Suppressors
2020
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
DDI2 Is a Ubiquitin-Directed Endoprotease Responsible for Cleavage of Transcription Factor NRF1
2020
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes
2011 Standout
lincRNAs: Genomics, Evolution, and Mechanisms
2013 Standout
The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold
2016
Proteasomal Degradation Is Transcriptionally Controlled by TCF11 via an ERAD-Dependent Feedback Loop
2010
RNAi Screening Implicates a SKN-1–Dependent Transcriptional Response in Stress Resistance and Longevity Deriving from Translation Inhibition
2010
The Ubiquitin Proteasome System in Neurodegenerative Diseases
2003 StandoutNobel
No Effects of Gluten in Patients With Self-Reported Non-Celiac Gluten Sensitivity After Dietary Reduction of Fermentable, Poorly Absorbed, Short-Chain Carbohydrates
2013
Regulation of V2 Vasopressin Receptor Degradation by Agonist-promoted Ubiquitination
2003 StandoutNobel
Getting in and out of the proteasome
2000
Ubiquitin in chains
2000
Regulation and Functions of the ER-Associated Nrf1 Transcription Factor
2022 StandoutNobel
A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome
2001
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase
2003 StandoutNobel
Investigating the importance of proteasome-interaction for Rad23 function
2002
Distinct Functional Surface Regions on Ubiquitin
2001
Proteasome-Mediated Processing of Nrf1 Is Essential for Coordinate Induction of All Proteasome Subunits and p97
2014
Nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) is regulated by O-GlcNAc transferase
2017
Integration of the Unfolded Protein and Oxidative Stress Responses through SKN-1/Nrf
2013
The Human Intestinal Microbiome in Health and Disease
2016 Standout
Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma
2009 Standout
E2/E3-mediated Assembly of Lysine 29-linked Polyubiquitin Chains
1999
Functional Classification and Experimental Dissection of Long Noncoding RNAs
2018 Standout
The Prevalence of Celiac Disease in the United States
2012
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism
2016 Standout
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
2002 StandoutNature
Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance
2021
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
2011 StandoutNatureNobel
Ectopic Expression of Nonliganded Retinoic Acid Receptor β Abrogates AP-1 Activity by Selective Degradation of c-Jun in Cervical Carcinoma Cells
2004 StandoutNobel
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Beneficial modulation of the gut microbiota
2014
Protein degradation and protection against misfolded or damaged proteins
2003 StandoutNature
Processing of p105 Is Inhibited by Docking of p50 Active Subunits to the Ankyrin Repeat Domain, and Inhibition Is Alleviated by Signaling via the Carboxyl-terminal Phosphorylation/ Ubiquitin-Ligase Binding Domain
2001 StandoutNobel
Noncanonical MMS2-Encoded Ubiquitin-Conjugating Enzyme Functions in Assembly of Novel Polyubiquitin Chains for DNA Repair
1999
Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome
1998
Mechanisms and functions of Nrf2 signaling in Drosophila
2015
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
2001 StandoutNature
SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans
2015
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
2018 StandoutNobel
Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system
2012
Scalable molecular dynamics with NAMD
2005 Standout
An Architectural Role for a Nuclear Noncoding RNA: NEAT1 RNA Is Essential for the Structure of Paraspeckles
2009
The Logic of the 26S Proteasome
2017
Transcription factor Nrf1 is negatively regulated by its O‐GlcNAcylation status
2015
Regulation of proteasome assembly and activity in health and disease
2018
The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones
2014 Standout
Recognition of the polyubiquitin proteolytic signal
2000
Specific SKN-1/Nrf Stress Responses to Perturbations in Translation Elongation and Proteasome Activity
2011
Proteasome Activators
2011
The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases
2014
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
2000 StandoutNature
Structural basis for the specificity of ubiquitin C-terminal hydrolases
1999
Structural Basis for the Specificity and Catalysis of Human Atg4B Responsible for Mammalian Autophagy
2005 StandoutNobel
Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain
2000 Standout
The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity
2013
Differential and overlapping targets of the transcriptional regulators NRF1, NRF2, and NRF3 in human cells
2019
Long Noncoding RNAs: Cellular Address Codes in Development and Disease
2013 Standout
Coordinated regulation of protein synthesis and degradation by mTORC1
2014 Nature
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
The mechanical stability of ubiquitin is linkage dependent
2003
Liver-specific deletion of Ngly1 causes abnormal nuclear morphology and lipid metabolism under food stress
2019
Molecular Architecture and Assembly of the Eukaryotic Proteasome
2013
A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy
2016
Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway
2016
Transcription Factor Nrf1 Is Topologically Repartitioned across Membranes to Enable Target Gene Transactivation through Its Acidic Glucose-Responsive Domains
2014
The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein Stress
2003 Standout
Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin‐like domain
2003
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction
2016
Coping with Protein Quality Control Failure
2017
Irritable Bowel Syndrome
2015 Standout
Aggresomes: A Cellular Response to Misfolded Proteins
1998 Standout
Defining the Functional Targets of Cap‘n’collar Transcription Factors NRF1, NRF2, and NRF3
2020
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
Multiubiquitin Chain Binding Subunit MCB1 (RPN10) of the 26S Proteasome Is Essential for Developmental Progression in Physcomitrella patens
1999
The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis
1999 Standout
Rad23 Promotes the Targeting of Proteolytic Substrates to the Proteasome
2002
Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity
2016
Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss in Patients With Morbid Obesity
2018 Standout
Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration
2011
Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity
2017 StandoutNobel
Disabling the Protease DDI2 Attenuates the Transcriptional Activity of NRF1 and Potentiates Proteasome Inhibitor Cytotoxicity
2020
Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach
2012
Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence
2015
Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity
2019 StandoutNobel
Structure and Function of the 26S Proteasome
2018
British Guideline on the Management of Asthma
2008
Transcriptome and functional analysis in a Drosophila model of NGLY1 deficiency provides insight into therapeutic approaches
2018
Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1
2016 StandoutNobel
Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits
2015
p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition
2014
A Controlled Trial of Gluten-Free Diet in Patients With Irritable Bowel Syndrome-Diarrhea: Effects on Bowel Frequency and Intestinal Function
2013
Proteasomes in the archaea: from structure to function
2000
Loss of peptide: N -glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase
2021
O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1
2018
Subunit order of eukaryotic TRiC/CCT chaperonin by cross-linking, mass spectrometry, and combinatorial homology modeling
2012 StandoutNobel
Interfacial Enzymology: The Secreted Phospholipase A2-Paradigm
2001
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Ddi1 is a ubiquitin-dependent protease
2020
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1
2018
Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes
2009
Loss of N-Glycanase 1 Alters Transcriptional and Translational Regulation in K562 Cell Lines
2020
Scanning the human proteome for calmodulin-binding proteins
2005 StandoutNobel
Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy
2015 StandoutNobel
Colorectal cancer screening for average‐risk adults: 2018 guideline update from the American Cancer Society
2018
Nuclear factor‐erythroid 2‐related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice
2013
Basic Leucine Zipper Protein Cnc-C Is a Substrate and Transcriptional Regulator of the Drosophila 26S Proteasome
2010
Impairment of the Ubiquitin-Proteasome System by Protein Aggregation
2001 StandoutScience
Discovery of an NRF 1‐specific inducer from a large‐scale chemical library using a direct NRF 1‐protein monitoring system
2015
Engineering of Kuma030: A Gliadin Peptidase That Rapidly Degrades Immunogenic Gliadin Peptides in Gastric Conditions
2015 StandoutNobel
Proteasome dysfunction inDrosophilasignals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging
2013
Works of Patrick Young being referenced
A Conserved Unfoldase Activity for the p97 AAA-ATPase in Proteasomal Degradation
2009
Are doctors still failing to assess and treat asthma attacks? An audit of the management of acute attacks in a Health District
1999
Structure of S5a Bound to Monoubiquitin Provides a Model for Polyubiquitin Recognition
2005
Colonoscopy for Colorectal Cancer Screening
2013
Studies on the role of NonA in mRNA biogenesis
2006
Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells
2010
Association Between Length of Barrett's Esophagus and Risk of High-grade Dysplasia or Adenocarcinoma in Patients Without Dysplasia
2013
The Prevalence of Celiac Disease Among Patients With Nonconstipated Irritable Bowel Syndrome Is Similar to Controls
2011
Identification and Characterization of a DrosophilaNuclear Proteasome Regulator
2001
The Hydrophobic Effect Contributes to Polyubiquitin Chain Recognition
1998
Characterization of a REG/PA28 Proteasome Activator Homolog in Dictyostelium discoideum Indicates that the Ubiquitin- and ATP-Independent REGγ Proteasome Is an Ancient Nuclear Protease
2009
Probiotics for the Treatment of Inflammatory Bowel Disease
2012
Identification and Characterization of a Drosophila Proteasome Regulatory Network
2005