Citation Impact
Citing Papers
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Declining signal dependence of N rf2‐ M af S ‐regulated gene expression correlates with aging phenotypes
2013
Interaction of hHR23 with S5a
1999
Functional analysis of the proteasome regulatory particle
1999
Ubiquitin-binding domains
2005
Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin–proteasome degradation
2001
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
2002 Standout
Structural Requirements for Cannabinoid Receptor Probes
2005
The Ubiquitin Proteasome System in Neurodegenerative Diseases
2003 StandoutNobel
Determinants of Nuclear and Cytoplasmic Ubiquitin-mediated Degradation of MyoD
2003 StandoutNobel
Regulation of V2 Vasopressin Receptor Degradation by Agonist-promoted Ubiquitination
2003 StandoutNobel
Getting in and out of the proteasome
2000
Ubiquitin-Proteasome-mediated Degradation of Id1 Is Modulated by MyoD
2004 StandoutNobel
Ubiquitin in chains
2000
Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1α
2007 StandoutNobel
Regulation and Functions of the ER-Associated Nrf1 Transcription Factor
2022 StandoutNobel
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Solution structure of Vps27 UIM-ubiquitin complex important for endosomal sorting and receptor downregulation
2003
5-Lipoxygenase inhibitors with histamine H 1 receptor antagonist activity
2004
Structure and function of the radical enzyme ribonucleotide reductase
2001
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
Studies on the role of NonA in mRNA biogenesis
2006
Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism
2016 Standout
A Genomic and Functional Inventory of Deubiquitinating Enzymes
2005 Standout
Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection
2006 StandoutNobel
Ubiquitination of β-Arrestin Links Seven-transmembrane Receptor Endocytosis and ERK Activation
2007 StandoutNobel
Carboxylic Acid (Bio)Isosteres in Drug Design
2013
Structure of Atg5·Atg16, a Complex Essential for Autophagy
2006 StandoutNobel
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
2002 StandoutNature
Ectopic Expression of Nonliganded Retinoic Acid Receptor β Abrogates AP-1 Activity by Selective Degradation of c-Jun in Cervical Carcinoma Cells
2004 StandoutNobel
Glycyl radical enzymes: a conservative structural basis for radicals
1999
Role of ubiquitin- and Ubl-binding proteins in cell signaling
2007
Protein degradation and protection against misfolded or damaged proteins
2003 StandoutNature
Processing of p105 Is Inhibited by Docking of p50 Active Subunits to the Ankyrin Repeat Domain, and Inhibition Is Alleviated by Signaling via the Carboxyl-terminal Phosphorylation/ Ubiquitin-Ligase Binding Domain
2001 StandoutNobel
Antigen processing by the proteasome
2001
Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation
2003
Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome
1998
Mechanisms and functions of Nrf2 signaling in Drosophila
2015
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
2018 StandoutNobel
A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins
2002 Nature
Imaging Dynamic Redox Changes in Mammalian Cells with Green Fluorescent Protein Indicators
2004 StandoutNobel
Attenuation of diet‐induced atherosclerosis in rabbits with a highly selective 15‐lipoxygenase inhibitor lacking significant antioxidant properties
1997
The Ubiquitin-Interacting Motifs Target the Endocytic Adaptor Protein Epsin for Ubiquitination
2002
Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis
2002
The Tumor Suppressor Protein p16 and the Human Papillomavirus Oncoprotein-58 E7 Are Naturally Occurring Lysine-less Proteins That Are Degraded by the Ubiquitin System
2004 StandoutNobel
The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity
2013
A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems
2001
Atherosclerosis
2001 Standout
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
A Subcomplex of the Proteasome Regulatory Particle Required for Ubiquitin-Conjugate Degradation and Related to the COP9-Signalosome and eIF3
1998
A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy
2016
Transcription Factor Nrf1 Is Topologically Repartitioned across Membranes to Enable Target Gene Transactivation through Its Acidic Glucose-Responsive Domains
2014
Ligand‐Independent Degradation of Epidermal Growth Factor Receptor Involves Receptor Ubiquitylation and Hgs, an Adaptor Whose Ubiquitin‐Interacting Motif Targets Ubiquitylation by Nedd4
2002
A Ubiquitin-interacting Motif (UIM) Is Essential for Eps15 and Eps15R Ubiquitination
2002
The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein Stress
2003 Standout
Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin‐like domain
2003
Iron-Catalyzed Reactions in Organic Synthesis
2004 Standout
Radical Initiation in the Class I Ribonucleotide Reductase: Long-Range Proton-Coupled Electron Transfer?
2003
Quantum Chemical Studies of Radical-Containing Enzymes
2003
Multiubiquitin Chain Binding Subunit MCB1 (RPN10) of the 26S Proteasome Is Essential for Developmental Progression in Physcomitrella patens
1999
Regio- and Stereochemically Controlled Formation of Hydroxamic Acid Containinganti- orsyn-1,4-Cycloalkenols from Acylnitroso-Derived Diels−Alder Adducts
2001
Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase-independent inhibition by aspirin.
1996 StandoutNobel
Mechanisms of platelet-activating factor-induced lipid body formation: requisite roles for 5-lipoxygenase and de novo protein synthesis in the compartmentalization of neutrophil lipids.
1996
The Regulatory Particle of the Saccharomyces cerevisiae Proteasome
1998
The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis
1999 Standout
Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time
2017
Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity
2016
Drug screens of NGLY1 Deficiency worm and fly models reveal catecholamine, NRF2 and anti-inflammatory pathway activation as potential clinical approaches
2019
Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation
1983 StandoutScienceNobel
Disabling the Protease DDI2 Attenuates the Transcriptional Activity of NRF1 and Potentiates Proteasome Inhibitor Cytotoxicity
2020
Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity
2019 StandoutNobel
Signals for Sorting of Transmembrane Proteins to Endosomes and Lysosomes
2003 Standout
Leukotriene D: a slow reacting substance from rat basophilic leukemia cells.
1980 StandoutNobel
Current methods for the synthesis of 2-substituted azoles
2004
Transcriptome and functional analysis in a Drosophila model of NGLY1 deficiency provides insight into therapeutic approaches
2018
Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.
1981 StandoutNobel
p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition
2014
Identification and Characterization of a Drosophila Proteasome Regulatory Network
2005
Ataxin-3 Interactions with Rad23 and Valosin-Containing Protein and Its Associations with Ubiquitin Chains and the Proteasome Are Consistent with a Role in Ubiquitin-Mediated Proteolysis
2003
Leukotriene C: a slow-reacting substance from murine mastocytoma cells.
1979 StandoutNobel
Slow Reacting Substance of Anaphylaxis
1969
Deubiquitinating function of ataxin-3: Insights from the solution structure of the Josephin domain
2005
Leukotrienes are potent constrictors of human bronchi
1980 StandoutNatureNobel
Proteasomal Ubiquitin Receptor RPN-10 Controls Sex Determination inCaenorhabditis elegans
2006
Involvement of lipoxygenase in lysophosphatidic acid-stimulated hydrogen peroxide release in human HaCaT keratinocytes
2000
Quantum Chemical Studies of Radical-Containing Enzymes
2003
Activation of C−H Bonds by Metal Complexes
1997 Standout
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Analysis of a Gene Encoding Rpn10 of the Fission Yeast Proteasome Reveals That the Polyubiquitin-binding Site of This Subunit Is Essential When Rpn12/Mts3 Activity Is Compromised
2000
Divergent Evolution of Enzymatic Function: Mechanistically Diverse Superfamilies and Functionally Distinct Suprafamilies
2001
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
DNA Double-Strand Breaks
2002 StandoutNobel
Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
2004 StandoutScience
The Microbial Engines That Drive Earth's Biogeochemical Cycles
2008 StandoutScience
MESA ISOCHRONES AND STELLAR TRACKS (MIST). I. SOLAR-SCALED MODELS
2016 Standout
Deracemizing α‐Branched Carboxylic Acids by Catalytic Asymmetric Protonation of Bis‐Silyl Ketene Acetals with Water or Methanol
2019 StandoutNobel
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
The Chemical Composition of the Sun
2009 Standout
Rhodium-Catalyzed C−C Bond Formation via Heteroatom-Directed C−H Bond Activation
2009 Standout
Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress
2013
Reduction of the active-site iron by potent inhibitors of lipoxygenases
1991
Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes
2002
Proton-Coupled Electron Transfer
2012 Standout
Hydroxymethylfurfural, A Versatile Platform Chemical Made from Renewable Resources
2013 Standout
Proteasome dysfunction inDrosophilasignals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging
2013
Mutation of the E6-AP Ubiquitin Ligase Reduces Nuclear Inclusion Frequency While Accelerating Polyglutamine-Induced Pathology in SCA1 Mice
1999 StandoutNobel
Works of Patrick Young being referenced
Bacteriophage T4 Anaerobic Ribonucleotide Reductase Contains a Stable Glycyl Radical at Position 580
1996
Orally active hydroxamic acid inhibitors of leukotriene biosynthesis
1988
In vivo characterization of hydroxamic acid inhibitors of 5-lipoxygenase
1987
Structure-activity analysis of a class of orally active hydroxamic acid inhibitors of leukotriene biosynthesis
1988
Characterization of Two Polyubiquitin Binding Sites in the 26 S Protease Subunit 5a
1998
5-lipoxygenase inhibitory activity of zileuton.
1990
Use of RNA Interference and Complementation To Study the Function of the Drosophila and Human 26S Proteasome Subunit S13
2003
5-Lipoxygenase Inhibitors: Synthesis and Structure−Activity Relationships of a Series of 1-Aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones
1996
Observational Tests and Predictive Stellar Evolution. II. Nonstandard Models
2005
Cannabinoids. Synthesis and central nervous system activity of 8-substituted 10-hydroxy-5,5-dimethyl-5H-[1]benzopyrano[4,3-c]pyridine and derivatives
1977
Basic Leucine Zipper Protein Cnc-C Is a Substrate and Transcriptional Regulator of the Drosophila 26S Proteasome
2010
Pharmacologic properties of N-p-chloro-benzhydryl-N′-methyl homopiperazine dihydrochloride (homochlorcyclizine; SA-97), a serotonin antagonist
1960
New azacannabinoids highly active in the central nervous system
1983