Citation Impact
Citing Papers
Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo
2005
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
2007 Standout
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma
2013 StandoutNobel
Functional analysis of mutant and wild-type Drosophila origin recognition complex
2001
A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals
2008 StandoutNobel
CD73-Deficient Mice Are Resistant to Carcinogenesis
2012
Transposition-Driven Genomic Heterogeneity in the Drosophila Brain
2013 StandoutScienceNobel
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors
2020 StandoutScienceNobel
Hypoxia-inducible factor-1 alpha–dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
2012
Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production
2011
Caspase‐11 activates a canonical NLRP3 inflammasome by promoting K + efflux
2015
A2A Adenosine Receptor May Allow Expansion of T Cells Lacking Effector Functions in Extracellular Adenosine-Rich Microenvironments
2009
Differentiation Stage-Specific Requirement in Hypoxia-Inducible Factor-1α–Regulated Glycolytic Pathway during Murine B Cell Development in Bone Marrow
2009 StandoutNobel
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
2011 StandoutNobel
Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2
2015
Construction of novel repeat proteins with rigid and predictable structures using a shared helix method
2017
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
A Novel Antagonist of the Immune Checkpoint Protein Adenosine A2a Receptor Restores Tumor-Infiltrating Lymphocyte Activity in the Context of the Tumor Microenvironment
2017
A2B adenosine receptor dampens hypoxia-induced vascular leak
2007
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Subsets of Human Origin Recognition Complex (ORC) Subunits Are Expressed in Non-proliferating Cells and Associate with Non-ORC Proteins
2000
Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease
2012
The ‘danger’ sensors that STOP the immune response: the A2 adenosine receptors?
2005
Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation
2013
Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues
2007
Combination cancer immunotherapy and new immunomodulatory targets
2015
Extracellular adenosine triphosphate and adenosine in cancer
2010
Chemotherapy induces ATP release from tumor cells
2009
Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer
2015
Structure of the Type VI Secretion System Contractile Sheath
2015 StandoutNobel
A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice
2008
Hypoxia and Inflammation
2011 Standout
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
2014 StandoutNobel
Activation and regulation of the inflammasomes
2013 Standout
Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection
2014
Hypoxia Inducible Factor (HIF)-1 Coordinates Induction of Toll-Like Receptors TLR2 and TLR6 during Hypoxia
2007
Synaptic Protein Synthesis Associated with Memory Is Regulated by the RISC Pathway in Drosophila
2006
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection
2015
Short- and Long-Term Memory in Drosophila Require cAMP Signaling in Distinct Neuron Types
2009
T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response
2009
Purinergic regulation of the immune system
2016
Regulation of hypoxia adaptation: an overlooked virulence attribute of pathogenic fungi?
2010
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
2014 StandoutNature
Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma
2017
CD73: a potent suppressor of antitumor immune responses
2012
Replication from oriP of Epstein-Barr Virus Requires Human ORC and Is Inhibited by Geminin
2001
Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
2014 Standout
Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation
2010
Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo
2014
Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase
2008
A pathogenic picornavirus acquires an envelope by hijacking cellular membranes
2013 Nature
Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity
2011
Novel asymmetrically engineered antibody Fc variant with superior FcγR binding affinity and specificity compared with afucosylated Fc variant
2013
Targeting the hypoxia-adenosinergic signaling pathway to improve the adoptive immunotherapy of cancer
2013
Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia
2009
The PYRIN domain–only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses
2014
The Hydroxylase Inhibitor Dimethyloxallyl Glycine Attenuates Endotoxic Shock Via Alternative Activation of Macrophages and IL-10 Production by B1 Cells
2011
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
The Human Origin Recognition Complex Protein 1 Dissociates from Chromatin during S Phase in HeLa Cells
2001
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Inflammasomes: mechanism of assembly, regulation and signalling
2016 Standout
Drosophila ORC specifically binds to ACE3, an origin of DNA replication control element
1999
Multiple Mechanisms Regulate Subcellular Localization of Human CDC6
2001
Regulation of immune cells by local-tissue oxygen tension: HIF1α and adenosine receptors
2005
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
2016 StandoutNature
Cancer immunotherapy comes of age
2011 StandoutNature
Adenosine, an endogenous distress signal, modulates tissue damage and repair
2007
Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage
2001 Nature
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Association of Human Origin Recognition Complex 1 with Chromatin DNA and Nuclease-resistant Nuclear Structures
2000
Caffeine promotes anti-tumor immune response during tumor initiation: Involvement of the adenosine A2A receptor
2015
Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
2013
The Hallmarks of Aging
2013 Standout
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Interdependence of hypoxic and innate immune responses
2009
Hypoxia inducible factor (HIF) function in innate immunity and infection
2007
Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure)
2016
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Architecture of the Human Origin Recognition Complex
2001
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Inflammasomes: mechanism of action, role in disease, and therapeutics
2015 Standout
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
Assembly of the Human Origin Recognition Complex
2001
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
2009
PUF proteins: repression, activation and mRNA localization
2010
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Oxygen homeostasis
2009 StandoutNobel
The Genetics of Symptom-Based Phenotypes: Toward a Molecular Classification of Schizophrenia
2008
Immunogenic cell death and DAMPs in cancer therapy
2012 Standout
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
2017 StandoutNature
Adenosine: An Old Drug Newly Discovered
2009
Down-regulation of MicroRNA-31 in CD4+ T Cells Contributes to Immunosuppression in Human Sepsis by Promoting TH2 Skewing
2016
A specific subdomain in φ29 DNA polymerase confers both processivity and strand-displacement capacity
2005 StandoutNobel
Orc mutants arrest in metaphase with abnormally condensed chromosomes
2001
Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3 high regulatory T cells in humans
2015 StandoutNobel
Nanoscale distribution of mitochondrial import receptor Tom20 is adjusted to cellular conditions and exhibits an inner-cellular gradient
2011 StandoutNobel
Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein–Barr virus
2001
Physiological Control of Immune Response and Inflammatory Tissue Damage by Hypoxia -Inducible Factors and Adenosine A2AReceptors
2004 Nobel
Fc receptors in antibody‐dependent enhancement of viral infections
2015
HIF-1α Overexpression and Experimental Murine Atherosclerosis
2009
Requirements for T Lymphocyte Migration in Explanted Lymph Nodes
2007
Cutting Edge: Hypoxia-Inducible Factor 1α and Its Activation-Inducible Short Isoform I.1 Negatively Regulate Functions of CD4+ and CD8+ T Lymphocytes
2006
Adenosine A2a receptor-mediated, normoxic induction of HIF-1 through PKC and PI-3K-dependent pathways in macrophages
2007
Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function
2014
Immunological mechanisms of the antitumor effects of supplemental oxygenation
2015
Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies
2013
Adenosine A2B Receptor Blockade Slows Growth of Bladder and Breast Tumors
2011
Signaling through the A2B Adenosine Receptor Dampens Endotoxin-Induced Acute Lung Injury
2010
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins
2011 StandoutNobel
IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV
2013 Science
Innate Immune Recognition of Cancer
2015
Sweeping antibody as a novel therapeutic antibody modality capable of eliminating soluble antigens from circulation
2016
Hypoxia-Inducible Factor–Dependent Repression of Equilibrative Nucleoside Transporter 2 Attenuates Mucosal Inflammation During Intestinal Hypoxia
2008
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes
2022 StandoutScienceNobel
Inflammasomes and Metabolic Disease
2013
Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis
2010
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Blockade of A 2A receptors potently suppresses the metastasis of CD73 + tumors
2013
Modular repeat protein sculpting using rigid helical junctions
2020 StandoutNobel
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Unique potential of 4-1BB agonist antibody to promote durable regression of HPV + tumors when combined with an E6/E7 peptide vaccine
2015 StandoutNobel
Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice
2015
Adenosinergic Regulation of the Expansion and Immunosuppressive Activity of CD11b+Gr1+ Cells
2011
Regulation of Chromosome Replication
2000
Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis
2013
The NAIP –NLRC 4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus
2015
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Recognition of Bacteria by Inflammasomes
2012
A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment
2016
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
DNA Replication in Eukaryotic Cells
2002 Standout
Nitric oxide prevents axonal degeneration by inducing HIF-1–dependent expression of erythropoietin
2011 StandoutNobel
Antimetastatic Effects of Blocking PD-1 and the Adenosine A2A Receptor
2014
Targeting Cancer-Derived Adenosine:New Therapeutic Approaches
2014
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
2015 StandoutNobel
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS‐induced PMN trafficking into the lungs
2008
CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer
2013
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody
2018 StandoutNobel
Works of Patrick Smith being referenced
A2A adenosine receptor protects tumors from antitumor T cells
2006
Design of an expression system to enhance MBP-mediated crystallization
2017
Structure of the Absent in Melanoma 2 (AIM2) Pyrin Domain Provides Insights into the Mechanisms of AIM2 Autoinhibition and Inflammasome Assembly
2013
Gene dose effect reveals no Gs-coupled A2A adenosine receptor reserve in murine T-lymphocytes: studies of cells from A2A-receptor-gene-deficient mice
2001
Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor
2012
Oxygenation Inhibits the Physiological Tissue-Protecting Mechanism and Thereby Exacerbates Acute Inflammatory Lung Injury
2005
Analysis of A2a receptor-deficient mice reveals no significant compensatory increases in the expression of A2b, A1, and A3 adenosine receptors in lymphoid organs
2003
Targeted Deletion of HIF-1α Gene in T Cells Prevents their Inhibition in Hypoxic Inflamed Tissues and Improves Septic Mice Survival
2007
The Phe105 Loop of Alix Bro1 Domain Plays a Key Role in HIV-1 Release
2011
Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling
2001
The staufen/pumilio Pathway Is Involved in Drosophila Long-Term Memory
2003
Study of A2A adenosine receptor gene deficient mice reveals that adenosine analogue CGS 21680 possesses no A2A receptor‐unrelated lymphotoxicity
2000
latheo Encodes a Subunit of the Origin Recognition Complex and Disrupts Neuronal Proliferation and Adult Olfactory Memory When Mutant
1999
Inhibitory Fcγ Receptor Is Required for the Maintenance of Tolerance through Distinct Mechanisms
2014
Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling
2001
FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo
2010
Mouse model recapitulating human Fcγ receptor structural and functional diversity
2012
Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase‐1
2013
Gene dose effect reveals no Gs-coupled A2A adenosine receptor reserve in murine T-lymphocytes: studies of cells from A2A-receptor-gene-deficient mice
2001
A2A receptor dependent and A2A receptor independent effects of extracellular adenosine on murine thymocytes in conditions of adenosine deaminase deficiency
2000