Citation Impact
Citing Papers
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination
2003 StandoutNobel
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch
2004 StandoutScienceNobel
MSH2–MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes
2005
AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts
2002 StandoutScienceNobel
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
Discovery of Activation‐Induced Cytidine Deaminase, the Engraver of Antibody Memory
2007 StandoutNobel
Evolution of the Immunoglobulin Heavy Chain Class Switch Recombination Mechanism
2007
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice
2017
Linking class-switch recombination with somatic hypermutation
2001 StandoutNobel
Tumour escape from immune surveillance through dendritic cell inactivation
2002
The role of CD28 and cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) in regulatory T‐cell biology
2006
Inflammation and cancer
2002 StandoutNature
Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System
2013
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK
2007
Death by TNF: a road to inflammation
2022
Cryo-EM Structure of the DNA-Dependent Protein Kinase Catalytic Subunit at Subnanometer Resolution Reveals α Helices and Insight into DNA Binding
2008
XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining
2006
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
2004
B Cell Development Leads Off with a Base Hit
2004
New insights into nNOS regulation of vascular homeostasis
2005 StandoutNobel
Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4
2007
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
2001 StandoutNature
Separate domains of AID are required for somatic hypermutation and class-switch recombination
2004 StandoutNobel
Nonoverlapping Functions of DNA Polymerases Mu, Lambda, and Terminal Deoxynucleotidyltransferase during Immunoglobulin V(D)J Recombination In Vivo
2006
The AID enzyme induces class switch recombination in fibroblasts
2002 StandoutNatureNobel
Nucleases of the Metallo-β-lactamase Family and Their Role in DNA and RNA Metabolism
2007
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
A DNA-PKcs mutation in a radiosensitive T–B– SCID patient inhibits Artemis activation and nonhomologous end-joining
2008
Transcription-coupled mutagenesis by the DNA deaminase AID.
2004
The generation of antibody diversity through somatic hypermutation and class switch recombination
2004
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
The mechanisms of immune diversification and their disorders
2003
Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence
2007
Interleukin‐10 does not affect phagocytosis of particulate antigen by bonemarrow‐derived dendritic cells but does impair antigen presentation
2000
Type 1/Type 2 Immunity in Infectious Diseases
2001
A coming-of-age story: activation-induced cytidine deaminase turns 10
2009
Role of genomic instability and p53 in AID-induced c-myc–Igh translocations
2006 Nature
Taking dendritic cells into medicine
2007 StandoutNatureNobel
The role of activation-induced cytidine deaminase in antibody diversification, immunodeficiency, and B-cell malignancies
2004
Lymphocyte-Specific Compensation for XLF/Cernunnos End-Joining Functions in V(D)J Recombination
2008
CD4+ T Cell Clones Producing both Interferon-γ and Interleukin-10 Predominate in Bronchoalveolar Lavages of Active Pulmonary Tuberculosis Patients
1999
Requirement of Non-canonical Activity of Uracil DNA Glycosylase for Class Switch Recombination
2006 StandoutNobel
XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps
2007
Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ
2007
Chemokines in cancer
2002
Somatic hypermutation at A·T pairs: polymerase error versus dUTP incorporation
2005
γH2AX and cancer
2008
DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
2014
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics
2001
APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation
2008
Impaired response to interferon-α/β and lethal viral disease in human STAT1 deficiency
2003
Aid
2004 StandoutNobel
A Biochemically Defined System for Coding Joint Formation in V(D)J Recombination
2008
Mechanism and Control of V(D)J Recombination versus Class Switch Recombination: Similarities and Differences
2005
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
An evolutionarily conserved target motif for immunoglobulin class-switch recombination
2004
C-Terminal Deletion of AID Uncouples Class Switch Recombination from Somatic Hypermutation and Gene Conversion
2003
DNA‐PK autophosphorylation facilitates Artemis endonuclease activity
2006
Activation-induced Cytidine Deaminase Deaminates 5-Methylcytosine in DNA and Is Expressed in Pluripotent Tissues
2004
Activation-induced deaminase: controversies and open questions
2004
Cancer-related inflammation
2008 StandoutNature
T-cell-antigen recognition and the immunological synapse
2003
Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism
2003
The Mechanism of Human Nonhomologous DNA End Joining
2007
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
Chapter 2 DNA-PK
2008
Inflammation, inflammatory cells and angiogenesis: decisions and indecisions
2007
Mismatch Recognition and Uracil Excision Provide Complementary Paths to Both Ig Switching and the A/T-Focused Phase of Somatic Mutation
2004
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
2001 StandoutNatureNobel
Absence of IgD-CD27(+) memory B cell population in X-linked hyper-IgM syndrome.
1998
Crystal Structure of Human XLF: A Twist in Nonhomologous DNA End-Joining
2007
Negative regulation of activation-induced cytidine deaminase in B cells
2006 StandoutNobel
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
2009
Demystifying the development of dendritic cell subtypes, a little
2008
Mechanisms of double-strand break repair in somatic mammalian cells
2009
HOW CELLS RESPOND TO INTERFERONS
1998 Standout
A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs
2001 StandoutNobel
DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8 + T cells in a spectrum of human MHC I haplotypes
2007 StandoutNobel
Dependence of antibody gene diversification on uracil excision
2007
Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro
2012 StandoutNobel
Comment on "Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch"
2004 Science
Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination
2007
Fine-Structure Analysis of Activation-Induced Deaminase Accessibility to Class Switch Region R-Loops
2005
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Molecular mechanism for generation of antibody memory
2008 StandoutNobel
Increased Antimycobacterial Immunity in Interleukin-10-Deficient Mice
1999
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
IFN-γ enables cross-presentation of exogenous protein antigen in human Langerhans cells by potentiating maturation
2004
Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40
2000 StandoutNobel
Differentiation of T Regulatory Cells by Immature Dendritic Cells
2001
Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells
2004 StandoutNobel
Regulatory Activity of Autocrine IL-10 on Dendritic Cell Functions
2001
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
2010 Standout
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency
2014
Interleukin-10 and the Interleukin-10 Receptor
2001 Standout
Double-Strand Break End Resection and Repair Pathway Choice
2011
Molecular Mechanisms of Antibody Somatic Hypermutation
2007
Molecular Mechanisms RegulatinG Th1 Immune Responses
2003
Dendritic cells cross-present HIV antigens from live as well as apoptotic infected CD4 + T lymphocytes
2004
The role of Foxp3 and Tbet co-expressing Treg cells in lung carcinoma
2018
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants
2008 StandoutNobel
Recombinogenic Phenotype of Human Activation-Induced Cytosine Deaminase
2004
Antigen Presentation and T Cell Stimulation by Dendritic Cells
2002
Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice
1998
Variable deletion and duplication at recombination junction ends: Implication for staggered double-strand cleavage in class-switch recombination
2001 StandoutNobel
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
2010 StandoutNobel
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
2004 StandoutNobel
TGF-β1 Reciprocally Controls Chemotaxis of Human Peripheral Blood Monocyte-Derived Dendritic Cells Via Chemokine Receptors
2000
Endogenously Expressed nef Uncouples Cytokine and Chemokine Production from Membrane Phenotypic Maturation in Dendritic Cells
2002 StandoutNobel
Antibody to Langerin/CD207 localizes large numbers of CD8α + dendritic cells to the marginal zone of mouse spleen
2009 StandoutNobel
Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends
2007
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
2004 StandoutNobel
THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling
1997
The microbial mimic poly IC induces durable and protective CD4+T cell immunity together with a dendritic cell targeted vaccine
2008 StandoutNobel
De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination
2004 StandoutNobel
Inducible DNA breaks in Ig S regions are dependent on AID and UNG
2005
AID to overcome the limitations of genomic information
2005 StandoutNobel
Works of Patrick Revy being referenced
TGF-β1 Prevents the Noncognate Maturation of Human Dendritic Langerhans Cells
1999
RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair
2016
Hyper‐immunoglobulin M syndromes caused by intrinsic B‐lymphocyte defects
2005
The Repair of DNA Damages/Modifications During the Maturation of the Immune System: Lessons from Human Primary Immunodeficiency Disorders and Animal Models
2005
Functional antigen-independent synapses formed between T cells and dendritic cells
2001
Hyper-IgM syndrome type 4 with a B lymphocyte–intrinsic selective deficiency in Ig class-switch recombination
2003
Cernunnos Interacts with the XRCC4·DNA-ligase IV Complex and Is Homologous to the Yeast Nonhomologous End-joining Factor Nej1
2006
Human Models of Inherited Immunoglobulin Class Switch Recombination and Somatic Hypermutation Defects (Hyper-IgM Syndromes)
2004
XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome
2006 Nature
V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining
2007
Interferon-γ –Receptor Deficiency in an Infant with Fatal Bacille Calmette–Guérin Infection
1996
Cernunnos, a Novel Nonhomologous End-Joining Factor, Is Mutated in Human Immunodeficiency with Microcephaly
2006
Delineation of the Xrcc4-interacting Region in the Globular Head Domain of Cernunnos/XLF
2010
Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination
2003
T cell adhesion lowers the threshold for antigen detection
2003
Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection.
1998
Normal CD40-mediated activation of monocytes and dendritic cells from patients with hyper-IgM syndrome due to a CD40 pathway defect in B cells
1998
Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis
2012
The Block in Immunoglobulin Class Switch Recombination Caused by Activation-Induced Cytidine Deaminase Deficiency Occurs Prior to the Generation of DNA Double Strand Breaks in Switch μ Region
2003
Retinoids Regulate Survival and Antigen Presentation by Immature Dendritic Cells
2003
Abnormal CD40-mediated activation pathway in B lymphocytes from patients with hyper-IgM syndrome and normal CD40 ligand expression.
1997
Structural characterization of filaments formed by human Xrcc4–Cernunnos/XLF complex involved in nonhomologous DNA end-joining
2011
Cernunnos Deficiency Reduces Thymocyte Life Span and Alters the T Cell Repertoire in Mice and Humans
2012
TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells.
1999