Standout Papers
Citation Impact
Citing Papers
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
2006
Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer
2005 StandoutNobel
Loss of IGF2 Imprinting: A Potential Marker of Colorectal Cancer Risk
2003 Science
General Transcription Factor Binding at CpG Islands in Normal Cells Correlates with Resistance to De novo DNA Methylation in Cancer Cells
2010
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
2004 StandoutScience
The Melanoma-Upregulated Long Noncoding RNA SPRY4-IT1 Modulates Apoptosis and Invasion
2011
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
2010 StandoutScience
Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput sequencing
2010
Direct conversion of fibroblasts to functional neurons by defined factors
2010 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences
2009
Fluorescent In Situ Hybridization of DNA Probes in the Interphase and Metaphase Stages of the Cell Cycle
2012
The lncRNA MIR31HG regulates p16INK4A expression to modulate senescence
2015
An integrated encyclopedia of DNA elements in the human genome
2012 StandoutNature
NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs
2007
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming
2009
Increased methylation variation in epigenetic domains across cancer types
2011
Functions of DNA methylation: islands, start sites, gene bodies and beyond
2012 Standout
Mutations of mitotic checkpoint genes in human cancers
1998 Nature
Essential role of mouse telomerase in highly proliferative organs
1998 StandoutNatureNobel
Epigenetic regulation of theINK4b-ARF-INK4alocus
2010
The Genetic Signatures of Noncoding RNAs
2009
Circular RNAs are a large class of animal RNAs with regulatory potency
2013 StandoutNature
CpG islands and the regulation of transcription
2011 Standout
Elevation of Highly Up-regulated in Liver Cancer (HULC) by Hepatitis B Virus X Protein Promotes Hepatoma Cell Proliferation via Down-regulating p18
2012
The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2–3
2001
The history of cancer epigenetics
2004 Standout
SIRT3 Regulates Mitochondrial Protein Acetylation and Intermediary Metabolism
2011
The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs
2013
The rise of regulatory RNA
2014
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Epigenetics in human disease and prospects for epigenetic therapy
2004 StandoutNature
The role of long non-coding RNAs in genome formatting and expression
2015
Charting a dynamic DNA methylation landscape of the human genome
2013 Nature
A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells
2013
A polymorphism in the chromosome 9p21 ANRIL locus is associated to Philadelphia positive acute lymphoblastic leukemia
2011
Long Noncoding RNAs: Emerging Stars in Gene Regulation, Epigenetics and Human Disease
2014
9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response
2011 Nature
Developmental programming of CpG island methylation profiles in the human genome
2009
The emerging role of lncRNAs in cancer
2015 Standout
Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains
2011
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
Genetic instabilities in human cancers
1998 StandoutNature
The power and the promise of DNA methylation markers
2003
Cisplatin and paclitaxel target significant long noncoding RNAs in laryngeal squamous cell carcinoma
2014
Long Noncoding RNAs in Cancer Pathways
2016 Standout
NAD+ as a Signaling Molecule Modulating Metabolism
2011
Long non-coding RNAs: A new frontier in the study of human diseases
2013
Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells
2004
Chromosome arm 16q in Wilms tumors: Unbalanced chromosomal translocations, loss of heterozygosity, and assessment of the CTCF gene
2002
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
DNA methylation and genomic imprinting: insights from cancer into epigenetic mechanisms
2002
Bidirectional Transcription Directs Both Transcriptional Gene Activation and Suppression in Human Cells
2008
Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue
2004
Sirtuins, Aging, and Metabolism
2011
Changes in H2A.Z occupancy and DNA methylation during B-cell lymphomagenesis
2010
Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans
2011
The multilayered complexity of ceRNA crosstalk and competition
2014 StandoutNature
The Inherent Processivity of the Human de Novo Methyltransferase 3A (DNMT3A) Is Enhanced by DNMT3L
2010
Long non-coding RNAs as regulators of the endocrine system
2015
BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration
2012
Hypomethylation and hypermethylation of DNA in Wilms tumors
2002
Long Noncoding RNAs in Cancer: From Function to Translation
2015
Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis
2005
Insulin and insulin-like growth factor signalling in neoplasia
2008 Standout
A Differentially Methylated Imprinting Control Region within the Kcnq1 Locus Harbors a Methylation-sensitive Chromatin Insulator
2002
DNA hypomethylation and human diseases
2006
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells
2009
Uncoupling Antisense-Mediated Silencing and DNA Methylation in the Imprinted Gnas Cluster
2011
The Mammalian Epigenome
2007 Standout
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers
1996
Targeting long non-coding RNA to therapeutically upregulate gene expression
2013
Noncoding RNA in development
2008
Large non-coding RNAs: missing links in cancer?
2010
Natural RNA circles function as efficient microRNA sponges
2013 StandoutNature
SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
2010
Association of H19 Promoter Methylation with the Expression of H19 and IGF-II Genes in Adrenocortical Tumors
2002
Cancer epigenetics reaches mainstream oncology
2011
Long noncoding RNAs and prostate carcinogenesis: the missing ‘linc’?
2014
Genetic instability in colorectal cancers
1997 StandoutNature
Dynamics of DNA Methylation in Recent Human and Great Ape Evolution
2013
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts
2009
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
1996 Nature
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
The Behaviour of 5-Hydroxymethylcytosine in Bisulfite Sequencing
2010
Non-coding RNAs in human disease
2011 Standout
Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling
2010
The Reality of Pervasive Transcription
2011
The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer
2002
Junk DNA and the long non-coding RNA twist in cancer genetics
2015
Functions and Mechanisms of Long Noncoding RNAs in Ovarian Cancer
2015
Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a
2010
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
Differential DNA Methylation Correlates with Differential Expression of Angiogenic Factors in Human Heart Failure
2010
The present and future role of microfluidics in biomedical research
2014 StandoutNature
Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1
2008
Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation
2010
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation
2008
Long noncoding RNAs during normal and malignant hematopoiesis
2014
Charting histone modifications and the functional organization of mammalian genomes
2010
Epigenetic modifications as therapeutic targets
2010
Microarray Analysis and Organization of Circadian Gene Expression in Drosophila
2001 StandoutNobel
Progress and challenges in translating the biology of atherosclerosis
2011 StandoutNature
Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress
2010
Characterization of HULC, a Novel Gene With Striking Up-Regulation in Hepatocellular Carcinoma, as Noncoding RNA
2006
Genetic and epigenetic stability of human pluripotent stem cells
2012
Epigenetic modifications and human disease
2010 Standout
Aberrant Epigenetic Landscape in Cancer: How Cellular Identity Goes Awry
2010
Functions and mechanisms of long noncoding RNAs in lung cancer
2016
The Hallmarks of Aging
2013 Standout
A decade of exploring the cancer epigenome — biological and translational implications
2011 Standout
DNA-binding factors shape the mouse methylome at distal regulatory regions
2011 Nature
A human imprinting centre demonstrates conserved acquisition but diverged maintenance of imprinting in a mouse model for Angelman syndrome imprinting defects
2005
Androgen‐responsive long noncoding RNA CTBP1‐AS promotes prostate cancer
2013
Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression
2010
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
2010 StandoutNature
Human DNA methylomes at base resolution show widespread epigenomic differences
2009 StandoutNature
Orphan CpG Islands Identify Numerous Conserved Promoters in the Mammalian Genome
2010
Targeting long non-coding RNAs in cancers: Progress and prospects
2013
Long noncoding RNAs: functional surprises from the RNA world
2009 Standout
SIRT1 Regulates HIV Transcription via Tat Deacetylation
2005
miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA
2011
Long non-coding RNAs: insights into functions
2009 Standout
A Comprehensive Analysis of Allelic Methylation Status of CpG Islands on Human Chromosome 21q
2004
Comprehensive methylome map of lineage commitment from haematopoietic progenitors
2010 Nature
DNA Methylation Profiling of the Human Major Histocompatibility Complex: A Pilot Study for the Human Epigenome Project
2004
The Polycomb complex PRC2 and its mark in life
2011 StandoutNature
Epigenetic Alterations of H19 and LIT1 Distinguish Patients with Beckwith-Wiedemann Syndrome with Cancer and Birth Defects
2002
DNA methylation and human disease
2005 Standout
A Novel CpG Island Set Identifies Tissue-Specific Methylation at Developmental Gene Loci
2008
A long nuclear‐retained non‐coding RNA regulates synaptogenesis by modulating gene expression
2010
Non-coding RNAs and new opportunities for the private sector
2009
The evolution of gene expression levels in mammalian organs
2011 StandoutNatureNobel
Dynamic changes in the human methylome during differentiation
2010
CpG islands – ‘A rough guide’
2009
LncRNA: A link between RNA and cancer
2014
Chromatin structure and the inheritance of epigenetic information
2010
Long Noncoding RNA, Polycomb, and the Ghosts Haunting INK4b-ARF-INK4a Expression
2011
RNA–protein analysis using a conditional CRISPR nuclease
2013 StandoutNobel
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
2003
MYC regulates the non-coding transcriptome
2014
Long Noncoding RNA and Cancer: A New Paradigm
2017 Standout
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
1999
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
2012
Deracemization of α-Aryl Hydrocoumarins via Catalytic Asymmetric Protonation of Ketene Dithioacetals
2012 StandoutNobel
Capillary Based Patterning of Cellular Communities in Laterally Open Channels
2010
Cancer Cell Cycles
1996 StandoutScience
Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan
2014 StandoutScienceNobel
Use of H19 Gene Regulatory Sequences in DNA-Based Therapy for Pancreatic Cancer
2010
Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
1998 StandoutScience
Mammalian Sirtuins: Biological Insights and Disease Relevance
2010 Standout
Development of targeted therapy for a broad spectrum of cancers (pancreatic cancer, ovarian cancer, glioblastoma and HCC) mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences.
2012
BSmooth: from whole genome bisulfite sequencing reads to differentially methylated regions
2012
Large Intervening Non-Coding RNA HOTAIR is Associated with Hepatocellular Carcinoma Progression
2011
Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation
2007
An Antisense RNA Regulates the Bidirectional Silencing Property of the Kcnq1 Imprinting Control Region
2004
Cancer Genome Landscapes
2013 StandoutScience
The Eukaryotic Genome as an RNA Machine
2008 Science
Long Intergenic Noncoding RNAs: New Links in Cancer Progression
2011
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2
2006
Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression
2005
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma.
2003
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Long noncoding RNAs in prostate cancer: mechanisms and applications
2014
H19-Promoter-Targeted Therapy Combined with Gemcitabine in the Treatment of Pancreatic Cancer
2012
Epigenetic reprogramming in mammalian nuclear transfer
2003
Works of Patrick Onyango being referenced
Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk
2007
SIRT3, a human SIR2 homologue, is an NAD- dependent deacetylase localized to mitochondria
2002
Molecular Cloning and Expression Analysis of Five Novel Genes in Chromosome 1p36
1998
Genomics and cancer
2002
A Genome-Wide Screen for Normally Methylated Human CpG Islands That Can Identify Novel Imprinted Genes
2002
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
2008 Nature
Sequence and Comparative Analysis of the Mouse 1-Megabase Region Orthologous to the Human 11p15 Imprinted Domain
2000
Large-scale isolation of human 1p36-specific P1 clones and their use for fluorescence in situ hybridization
1994
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
2009 Standout
Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2.
2002
Monoallelic expression and methylation of imprinted genes in human and mouse embryonic germ cell lineages
2002
A nucleolar protein, H19 opposite tumor suppressor ( HOTS ), is a tumor growth inhibitor encoded by a human imprinted H19 antisense transcript
2011
Loss of imprinting of insulin-like growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site.
2001