Standout Papers
Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Human Toll-Like Receptors Mediate Cellular Activation by Mycobacterium tuberculosis
1999
Transcriptional regulation of memory B cell differentiation
2020
Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity
1990
The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain
1989
Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation
1990
Roles of the ankyrin repeats and C-terminal region of the mouse Notch1 intracellular region
1998 StandoutNobel
Control of type-D GABAergic neuron differentiation by C. elegans UNC-30 homeodomain protein
1994 StandoutNatureNobel
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
New type of POU domain in germ line-specific protein Oct-4
1990 Nature
Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit
1997 StandoutNobel
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Transcriptional activation by the Antennapedia and fushi tarazu proteins in cultured Drosophila cells
1989
extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1
1993 StandoutNobel
The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry
2012
Protein-tyrosine Phosphatase Inhibitors Block Tumor Necrosis Factor-dependent Activation of the Nuclear Transcription Factor NF-kB
1995
A purified Drosophila homeodomain protein represses transcription in vitro
1989
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase
1999 StandoutNobel
Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules
1994
Microglia and Wnt Pathways: Prospects for Inflammation in Alzheimer’s Disease
2020
Quality Control of Membraneless Organelles
2018
A mediator required for activation of RNA polymerase II transcription in vitro
1991 StandoutNatureNobel
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
2001
Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates
2019 Standout
A human lymphoid- specific transcription factor that activates immunoglobulin genes is a homoeobox protein
1988 Nature
Ectopic Expression of Nonliganded Retinoic Acid Receptor β Abrogates AP-1 Activity by Selective Degradation of c-Jun in Cervical Carcinoma Cells
2004 StandoutNobel
Activin signalling and response to a morphogen gradient
1994 StandoutNatureNobel
Selective autophagy mediated by autophagic adapter proteins
2011 Standout
MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1
1997 Nature
Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor
1990
CD36 is a sensor of diacylglycerides
2005 StandoutNatureNobel
Caenorhabditis elegans has scores of homoeobox-containing genes
1989 StandoutNatureNobel
Transcriptional activation and repression by Ultrabithorax proteins in cultured Drosophila cells
1989
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
1988 Nature
Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation
1988
Autophagy in Human Health and Disease
2013 Standout
The structure and function of the homeodomain
1989 Standout
The gradient morphogen bicoid is a concentration-dependent transcriptional activator
1989
Targets of homeotic gene control in Drosophila
1990 Nature
In vitro binding to the leucine tRNA gene identifies a novel yeast homeobox gene
1993
Ubiquitin Modulates Liquid-Liquid Phase Separation of UBQLN2 via Disruption of Multivalent Interactions
2018
Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements
1990 Nature
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
2001 StandoutNatureNobel
Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4
2013
Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox geneHox-#150;1.6
1992 StandoutNatureNobel
Dynamics and mechanism of repair of ultraviolet-induced (6–4) photoproduct by photolyase
2010 StandoutNatureNobel
Induction across germ layers in Drosophila mediated by a genetic cascade
1990
A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells
1990
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
1995 StandoutNobel
The Drosophila gene torso encodes a putative receptor tyrosine kinase
1989 StandoutNatureNobel
Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice
1992 StandoutNatureNobel
Inhibition of NF-κB by Sodium Salicylate and Aspirin
1994 StandoutScience
Functional dissection of ultrabithorax proteins in D. melanogaster
1990
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response
2004
Regulation of transcription and cell identity by POU domain proteins
1991 StandoutNobel
Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen
1989 StandoutNatureNobel
The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1—Pit-1 interactions
1990
Ikaros in immune receptor signaling, lymphocyte differentiation, and function
2010
Expression of a large family of POU-domain regulatory genes in mammalian brain development
1989 Nature
A new photoreactivating enzyme that specifically repairs ultraviolet light-induced (6-4)photoproducts
1993 Nature
Germinal center B and follicular helper T cells: siblings, cousins or just good friends?
2011
Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer
1998 StandoutNobel
DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9
1989
A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo
1990 Nature
What determines the specificity of action of Drosophila homeodomain proteins?
1990
The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16
1989 Nature
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors.
1990
A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain
1988
Conversion of HPV 18 positive non-tumorigenic HeLa-fibroblast hybrids to invasive growth involves loss of TNF-α mediated repression of viral transcription and modification of the AP-1 transcription complex
1999 StandoutNobel
The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein Stress
2003 Standout
Stimulation of transcription by an Ultrabithorax protein in vitro.
1990
Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy
2012
Identification of a growth suppression domain within the retinoblastoma gene product.
1992 StandoutNobel
Sequence analysis of the cis-regulatory regions of the bithorax complex of Drosophila.
1995 StandoutNobel
Stress granules as crucibles of ALS pathogenesis
2013
Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B–cell differentiation
2013
CD28 Mediates a Potent Costimulatory Signal for Rapid Degradation of IκBβ Which Is Associated with Accelerated Activation of Various NF-κB/Rel Heterodimers
1996
The DNA binding specificity of the bipartite POU domain and its subdomains.
1992
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.
1996 Standout
Correct developmental expression of a cloned alcohol dehydrogenase gene transduced into the drosophila germ line
1983
Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells
1995 StandoutScienceNobel
Extinction of the HPV18 upstream regulatory region in cervical carcinoma cells after fusion with non-tumorigenic human keratinocytes under non-selective conditions.
1991 StandoutNobel
Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-II
1990 StandoutNatureNobel
Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation.
1994 StandoutNobel
Tumor necrosis factor and lymphotoxin. Qualitative and quantitative differences in the mediation of early and late cellular response.
1994
Murine Developmental Control Genes
1990 Science
The purification of a human mismatch-binding protein and identification of its associated ATPase and helicase activities.
1992
The Oct-2 protein binds cooperatively to adjacent octamer sites.
1989
NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss.
1993
Homeobox genes in normal hematopoiesis and leukemia
1992
Repression of the IgH Enhancer in Teratocarcinoma Cells Associated with a Novel Octamer Factor
1989 ScienceNobel
Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins.
1994 StandoutNobel
A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo.
1993
The oct-1 homeo domain contacts only part of the octamer sequence and full oct-1 DNA-binding activity requires the POU-specific domain.
1990
Cloning and characterization of PSF, a novel pre-mRNA splicing factor.
1993
Homoeo boxes, POU proteins and the limits to promiscuity
1988 Nature
Disturbance of Tumor Necrosis Factor Alpha-Mediated Beta Interferon Signaling in Cervical Carcinoma Cells
2002 StandoutNobel
Alymphoplasia (aly)-Type Nuclear Factor κB–Inducing Kinase (Nik) Causes Defects in Secondary Lymphoid Tissue Chemokine Receptor Signaling and Homing of Peritoneal Cells to the Gut-Associated Lymphatic Tissue System
2000 StandoutNobel
Homeotic gene expression in the visceral mesoderm of Drosophila embryos.
1989
Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways
1996
Interactions of the Oct-1 POU subdomains with specific DNA sequences and with the HSV alpha-trans-activator protein.
1990
How do different transcription factors binding the same DNA sequence sort out their jobs?
1989
Viruses in Human Cancers
1991 StandoutScienceNobel
A New Lens for RNA Localization: Liquid-Liquid Phase Separation
2018
Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1
1987 Science
Regulation of Inducible and Tissue-Specific Gene Expression
1987 Science
Transcription Factor IRF4 Regulates Germinal Center Cell Formation through a B Cell–Intrinsic Mechanism
2014
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
1989 StandoutScience
Genes Activated in the Presence of an Immunoglobulin Enhancer or Promoter Are Negatively Regulated by a T-Lymphoma Cell Line
1988
Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity.
1990 StandoutNobel
The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway
1999 Standout
B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice
2021 StandoutNobel
Expression and Activity of the POU Transcription Factor SCIP
1990 Science
The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains.
1988 Nobel
The DNA binding domain (POU domain) of transcription factor oct-1 suffices for stimulation of DNA replication.
1990
Defective T Cell Differentiation in the Absence of Jnk1
1998 Science
The Mating of a Fly
1994 StandoutScienceNobel
High-affinity binding sites for the Deformed protein are required for the function of an autoregulatory enhancer of the Deformed gene.
1991
POU-domain transcription factors: pou-er-ful developmental regulators.
1991
Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.
1990
Genes activated in the presence of an immunoglobulin enhancer or promoter are negatively regulated by a T-lymphoma cell line.
1988
Expression of Abdominal-B homeoproteins in Drosophila embryos
1990
Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells
1995
Testing gene function early in the B cell lineage in mb1-cre mice
2006
The cell type-specific octamer transcription factor OTF-2 has two domains required for the activation of transcription.
1990
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
A single amino acid can determine the DNA binding specificity of homeodomain proteins
1989
The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.
1988
Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3.
1995
Works of Patrick Matthias being referenced
Influenza A virus uses the aggresome processing machinery for host cell entry
2014 Science
Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner
2018
Acetylation of intrinsically disordered regions regulates phase separation
2018
B cell development and immunoglobulin gene transcription in the absence of Oct-2 and OBF-1
2001
Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells
1989 Standout
Transcriptional control of B cell development and function
2003
Silencing and Nuclear Repositioning of the λ5 Gene Locus at the Pre-B Cell Stage Requires Aiolos and OBF-1
2008
Eukaryotic expression vectors for the analysis of mutant proteins
1989
Extinction of an immunoglobulin κ promoter in cell hybrids is mediated by the octamer motif and correlates with suppression of Oct-2 expression
1990
Transcriptional networks in developing and mature B cells
2005
The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response
2007
Drosophila homoeotic genes encode transcriptional activators similar to mammalian OTF-2
1988 Nature
OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins
1995
The Transcriptional Regulation of Germinal Center Formation
2018
HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo
2003
A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells
1988 Nature
B-cell-specif ic coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation
1996 Nature
HDAC6–p97/VCP controlled polyubiquitin chain turnover
2006
The Ets factor Spi-B is a direct critical target of the coactivator OBF-1
2006
Expression of a chicken lysozyme recombinant gene is regulated by progesterone and dexamethasone after microinjection into oviduct cells
1982
Lack of the Transcriptional Coactivator OBF-1 Prevents the Development of Systemic Lupus Erythematosus-Like Phenotypes in Aiolos Mutant Mice
2003
Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA).
1988
Cell type-specificity elements of the immunoglobulin heavy chain gene enhancer.
1987
Transient expression of the chicken lysozyme gene after transfer into human cells.
1982
Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells.
1990
Octamer transcription factors bind to two different sequence motifs of the immunoglobulin heavy chain promoter.
1989
Differential requirement for OBF-1 during antibody-secreting cell differentiation
2005
Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally
2008
Interplay between histone deacetylases and autophagy ‐ from cancer therapy to neurodegeneration
2011