Citation Impact
Citing Papers
Clinical Practice Guidelines for the Management Candidiasis: 2009 Update by the Infectious Diseases Society of America
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Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America
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Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem
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Alteration of enzyme specificity by computational loop remodeling and design
2009 StandoutNobel
A Point Mutation in the 14α-Sterol Demethylase Gene cyp51A Contributes to Itraconazole Resistance in Aspergillus fumigatus
2003
Bacterial gene amplification: implications for the evolution of antibiotic resistance
2009
Wild-type MIC distributions, epidemiological cutoff values and species-specific clinical breakpoints for fluconazole and Candida: Time for harmonization of CLSI and EUCAST broth microdilution methods
2010
New Beauvericins, Potentiators of Antifungal Miconazole Activity, Produced by Beauveria sp. FKI-1366: I. Taxonomy, Fermentation, Isolation and Biological Properties
2004 StandoutNobel
Combination and Sequential Antifungal Therapy for Invasive Aspergillosis: Review of Published In Vitro and In Vivo Interactions and 6281 Clinical Cases from 1966 to 2001
2003
Antifungal Agents in the 1990s
1997
Candidacidal Activity of Salivary Histatins
1998
Emerging azole antifungals
2005
Antifungal Drug Resistance in Aspergillus
2000
Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions
2000
Vulvovaginal candidosis
2007 Standout
Nosocomial Candidiasis: Emerging Species, Reservoirs, and Modes of Transmission
1996
Itraconazole
1989
Characterization of Saccharomyces cerevisiae CYP61, Sterol Δ22-Desaturase, and Inhibition by Azole Antifungal Agents
1997
AP1-mediated Multidrug Resistance in Saccharomyces cerevisiae Requires FLR1 Encoding a Transporter of the Major Facilitator Superfamily
1997
Preparation of human metabolites of propranolol using laboratory‐evolved bacterial cytochromes P450
2005 StandoutNobel
CLINICAL RELEVANCE OF ANTIFUNGAL RESISTANCE
1997
Systemically Administered Antifungal Agents
1992
History and new insights into host defense against vaginal candidiasis
2004
Cushing's syndrome
2015 Standout
Defensins: antimicrobial peptides of innate immunity
2003 Standout
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future
2017 Standout
Paralog Re-Emergence: A Novel, Historically Contingent Mechanism in the Evolution of Antimicrobial Resistance
2014
Plant Sterol 14α-Demethylase Affinity for Azole Fungicides
2001
Salivary Histatin 5 Induces Non-lytic Release of ATP fromCandida albicans Leading to Cell Death
1999
Cytochrome P450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2)
2003 StandoutNobel
Itraconazole: an effective oral antifungal for onychomycosis
2001
Recent developments in pradimicin-benanomicin and triazole antibiotics
1997
Substrate recognition sites in 14α-sterol demethylase from comparative analysis of amino acid sequences and X-ray structure of Mycobacterium tuberculosis CYP51
2001
The Amino Acid Residues Affecting the Activity and Azole Susceptibility of Rat CYP51 (Sterol 14-Demethylase P450)
2001
Fluconazole
1990
Antibiotic resistance and its cost: is it possible to reverse resistance?
2010 Standout
Evolution of Antifungal Susceptibility amongCandidaSpecies Isolates Recovered from Human Immunodeficiency Virus–Infected Women Receiving Fluconazole Prophylaxis
2001
Designing antimicrobial peptides: form follows function
2011 Standout
Emerging fungal resistance
2004
Targeting the Adaptability of Heterogeneous Aneuploids
2015
Chemotherapy for Leishmaniasis: Biochemical Mechanisms, Clinical Efficacy, and Future Strategies
1988
Echinocandin antifungal drugs
2003 Standout
Chemoinformatics and Library Design
2010
Citridones, New Potentiators of Antifungal Miconazole Activity, Produced by Penicillium sp. FKI-1938
2005 StandoutNobel
Itraconazole: pharmacology, clinical experience and future development
1996
Citrinamides, New Potentiators of Antifungal Miconazole Activity, Produced by Penicillium sp. FKI-1938
2008 StandoutNobel
Clinical Pharmacology of Systemic Antifungal Agents: A Comprehensive Review of Agents in Clinical Use, Current Investigational Compounds, and Putative Targets for Antifungal Drug Development
1998
The Future of Antifungal Therapy
1996
Endocrine and Antitumoral Effects of R76713 in Rats
1990
Inhibition of Angiogenesis by the Antifungal Drug Itraconazole
2007
In vitro activity of a new echinocandin, LY303366, and comparison with fluconazole, flucytosine and amphotericin B against Candida species† †This study was presented, in part, at the 37th ICAAC in Toronto, Canada, 28th September – 1st October 1997.
2001
Mechanisms of Antimicrobial Peptide Action and Resistance
2003 Standout
Oral Azole Drugs as Systemic Antifungal Therapy
1994
Hit finding: towards ‘smarter’ approaches
2009
Lead compounds discovered from libraries
2001
Cyclodextrin-based pharmaceutics: past, present and future
2004 Standout
Functional Genomics Approaches for the Identification and Validation of Antifungal Drug Targets
2002
Terconazole Cream for Non-Candida albicans Fungal Vaginitis: Results of a Retrospective Analysis
2000
Antifungals: mechanism of action and resistance, established and novel drugs
1998
In vitro and in vivo evaluation of antifungal agents
1989
Antifungal agents: An overview. Part II
1994
Are azole fungicides losing ground against Septoria wheat disease? Resistance mechanisms in Mycosphaerella graminicola
2008
Itraconazole
1996
Molecular mechanisms of azole resistance in fungi
2006
An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1
2008
Microbial multidrug resistance
1997
Efficacy of ketoconazole against Leishmania braziliensis panamensis cutaneous leishmaniasis
1990
Cytochromes P450, Drugs, and Diseases
2003
Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences
2002
Itraconazole Prophylaxis for Fungal Infections in Patients with Advanced Human Immunodeficiency Virus Infection: Randomized, Placebo‐Controlled, Double‐Blind Study
1999
Immunity to fungal infections
2011 Standout
Itraconazole cyclodextrin solution
1997
Molecular diversity of sterol 14α‐demethylase substrates in plants, fungi and humans
1998
Characterization of Ecdysteroid 26-Hydroxylase: An Enzyme Involved in Molting Hormone Inactivation
2000
P450 inhibitors of use in medical treatment: Focus on mechanisms of action
1995
Comparison of Caspofungin and Amphotericin B for Invasive Candidiasis
2002 Standout
Leishmaniasis
1999 Standout
Biological effects of essential oils – A review
2007 Standout
Antifungal agents: mechanisms of action
2003 Standout
Differential expression of ATP-binding cassette and/or major facilitator superfamily class efflux pumps contributes to voriconazole resistance in Aspergillus flavus
2013
Antifungal drug resistance
1995
Fluconazole tolerance in clinical isolates of Cryptococcus neoformans
1997
Histoplasmosis: a Clinical and Laboratory Update
2007
Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14 alpha-demethylase and aromatase.
2002 Standout
Fungal infections: a growing threat.
1996
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Substitutions at Methionine 220 in the 14α-Sterol Demethylase (Cyp51A) of Aspergillus fumigatus Are Responsible for Resistance In Vitro to Azole Antifungal Drugs
2004
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Tissue-Specific Inducible Expression of Antimicrobial Peptide Genes in Drosophila Surface Epithelia
2000 StandoutNobel
Identification of Farnesoid X Receptor β as a Novel Mammalian Nuclear Receptor Sensing Lanosterol
2003 StandoutNobel
Antifungal agents: chemotherapeutic targets and immunologic strategies
1996
Crystal structure of cytochrome P450 14α-sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors
2001
Antitumor Antibiotics: Bleomycin, Enediynes, and Mitomycin
2005 Standout
Mechanism of Fluconazole Resistance in Candida krusei
1998
In vitro studies of activities of the antifungal triazoles SCH56592 and itraconazole against Candida albicans, Cryptococcus neoformans, and other pathogenic yeasts
1997
Ketoconazole and Other Imidazole Derivatives as Inhibitors of Steroidogenesis
1986
Antifungal susceptibility testing
1993
Nuclear Receptors and Lipid Physiology: Opening the X-Files
2001 StandoutScience
In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus
2004
Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance
1999 Standout
Itraconazole resistance in Aspergillus fumigatus
1997
Conazoles
2010
Structure and Total Synthesis of Fungal Calpinactam, A New Antimycobacterial Agent
2009 StandoutNobel
Current and Emerging Azole Antifungal Agents
1999 Standout
Targeted Short-Term Fluconazole Prophylaxis Among Very Low Birth Weight and Extremely Low Birth Weight Infants
2006
Molecular Evolution of Antifungal Drug Resistance
2017
The lipid composition and permeability to azole of an azole- and polyene-resistant mutant ofCandida albicans
1987
Itraconazole
2000
Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors
1996
Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters
1995
Mycotoxins
2003 Standout
In vitro activities of voriconazole (UK-109,496) against fluconazole-susceptible and -resistant Candida albicans isolates from oral cavities of patients with human immunodeficiency virus infection
1997
Terconazole cream for non-Candida albicans fungal vaginitis: Results of a retrospective analysis
2000
Advances in leishmaniasis
2005 Standout
LY303366 Exhibits Rapid and Potent Fungicidal Activity in Flow Cytometric Assays of Yeast Viability
1999
Clinical, Cellular, and Molecular Factors That Contribute to Antifungal Drug Resistance
1998
Posaconazole: A Next-Generation Triazole Antifungal
2007
Mechanism and regulation of swelling-activated inositol efflux in brain glial cells
1993
Correlation between rhodamine 123 accumulation and azole sensitivity in Candida species: possible role for drug efflux in drug resistance
1996
Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America
2016 Standout
Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America
2015 Standout
Tandem Repeat of a Transcriptional Enhancer Upstream of the Sterol 14α-Demethylase Gene ( CYP51 ) in Penicillium digitatum
2000
Sterol composition of Cryptococcus neoformans in the presence and absence of fluconazole
1994
Genetic Basis for Differential Activities of Fluconazole and Voriconazole against Candida krusei
2003
Candida glabrata : Review of Epidemiology, Pathogenesis, and Clinical Disease with Comparison to C. albicans
1999
Worldwide emergence of resistance to antifungal drugs challenges human health and food security
2018 StandoutScience
Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance
2001 Standout
Characterization of Mechanisms of Fluconazole Resistance in a Candida albicans Isolate from a Japanese Patient with Chronic Mucocutaneous Candidiasis
2004
Characterization of echinocandin-resistant mutants of Candida albicans: genetic, biochemical, and virulence studies
1996
Protein−Surfactant Film Voltammetry of Wild-Type and Mutant Cytochrome P450 BM3
2005 StandoutNobel
The Inflammasomes: Guardians of the Body
2009 Standout
Synergistic Antifungal Activities of Bafilomycin A 1 , Fluconazole, and the Pneumocandin MK-0991/Caspofungin Acetate (L-743,873) with Calcineurin Inhibitors FK506 and L-685,818 against Cryptococcus neoformans
2000
In vitro and in vivo antifungal activities of ER-30346, a novel oral triazole with a broad antifungal spectrum
1996
Aspergillus fumigatusand Aspergillosis
1999 Standout
Combination therapy of murine invasive candidiasis with fluconazole and amphotericin B
1995
High-Frequency, In Vitro Reversible Switching of Candida lusitaniae Clinical Isolates from Amphotericin B Susceptibility to Resistance
1999
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Critical Annotations to the Use of Azole Antifungals for Plant Protection
2001
Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America
2008 Standout
Relationships between Respiration and Susceptibility to Azole Antifungals in Candida glabrata
2003
Total Synthesis of Citridone A
2011 StandoutNobel
Efficacy of ER-30346, a novel oral triazole antifungal agent, in experimental models of aspergillosis, candidiasis, and cryptococcosis
1996
Burn Wound Infections
2006 Standout
In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes
2009
Efficacy of FK463, a (1,3)-β- d -Glucan Synthase Inhibitor, in Disseminated Azole-Resistant Candida albicans Infection in Mice
2000
Human Salivary Histatins: Promising Anti-Fungal Therapeutic Agents
1998
Use of amphotericin B with azole antifungal drugs: what are we doing?
1995
Resistance of Candida species to fluconazole
1995
Interaction of azole antifungal agents with cytochrome P-45014DM purified from Saccharomyces cerevisiae microsomes
1987
Fungicidal mechanism of action of D0870 against Cryptococcus neoformans under acidic conditions
1997
Pharmacology of Itraconazole
2001
Characteristics of the heterologously expressed human lanosterol 14α-demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human andCandida albicans CYP51 with azole antifungal agents
1999
Natural Defenses against Candida Colonization Breakdown in the Oral Cavities of the Elderly
1999
Functional Significance of Cell Volume Regulatory Mechanisms
1998 Standout
Deletion of the Candida glabrata ERG3 and ERG11 genes: effect on cell viability, cell growth, sterol composition, and antifungal susceptibility
1995
Comparative effects of the azole-based fungicide flusilazole on yeast and mammalian lanosterol 14 alpha-methyl demethylase
1989
Increased Sensitivity of Mannanemia Detection Tests by Joint Detection of α- and β-Linked Oligomannosides during Experimental and Human Systemic Candidiasis
2004
Antifungal Susceptibility Testing: Practical Aspects and Current Challenges
2001
Mechanism of Amphotericin B Resistance in Leishmania donovani Promastigotes
1998
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
2004 Standout
Isolation and characterization of fluconazole- and amphotericin B-resistant Candida albicans from blood of two patients with leukemia
1997
Hidden Killers: Human Fungal Infections
2012 Standout
Multilaboratory Study of Epidemiological Cutoff Values for Detection of Resistance in Eight Candida Species to Fluconazole, Posaconazole, and Voriconazole
2014
A new triazole, voriconazole (UK-109,496), blocks sterol biosynthesis in Candida albicans and Candida krusei
1997
Rapid Acquisition of Stable Azole Resistance by Candida glabrata Isolates Obtained before the Clinical Introduction of Fluconazole
2005
Multiple Patterns of Resistance to Fluconazole in Candida glabrata Isolates from a Patient with Oropharyngeal Candidiasis Receiving Head and Neck Radiation
2003
Efficacy of LY303366 against Amphotericin B-Susceptible and -Resistant Aspergillus fumigatus in a Murine Model of Invasive Aspergillosis
1998
A New Aspergillus fumigatus Resistance Mechanism Conferring In Vitro Cross-Resistance to Azole Antifungals Involves a Combination of cyp51A Alterations
2007
Mechanisms of Azole Resistance in Clinical Isolates of Candida glabrata Collected during a Hospital Survey of Antifungal Resistance
2005
Mechanisms of Azole Resistance in a Clinical Isolate of Candida tropicalis
2005
Works of Patrick Marichal being referenced
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1995
Data reduction and representation in drug discovery
2006
Novel antifungals based on 4-substituted imidazole: A combinatorial chemistry approach to lead discovery and optimization
2000
Anti-CandidaDrugs — The Biochemical Basis for Their Activity
1987
Novel antifungals based on 4-substituted imidazole: solid-phase synthesis of substituted aryl sulfonamides towards optimization of in vitro activity
2000
Synergic effects of tactolimus and azole antifungal agents against azole-resistant Candida albican strains
1998
Mode of Action Studies: Basis for the Search of New Antifungal Drugs
1988
Saperconazole: A selective inhibitor of the cytochrome P‐450‐dependent ergosterol synthesis in Candida albicans, Aspergillus fumigatus and Trichophyton mentagrophytes
1990
Rhodamine 6G efflux for the detection of CDR1-overexpressing azole-resistant Candidaalbicans strains
1999
Mechanisms and clinical impact of antifungal drug resistance
1994
Molecular mechanisms of drug resistance in fungi
1994
Mode of action of anti-Candida drugs: Focus on terconazole and other ergosterol biosynthesis inhibitors
1991
Origin of differences in susceptibility of Candida krusei to azole antifungal agents
1995
Biochemical Approaches to Selective Antifungal Activity. Focus on Azole Antifungals
1989
The Novel Azole R126638 Is a Selective Inhibitor of Ergosterol Synthesis in Candida albicans , Trichophyton spp., and Microsporum canis
2004
Hypothesis on the molecular basis of the antifungal activity of N-substituted imidazoles and triazoles
1983
Culture Media for the Study of the Effects of Azole Derivatives on Germ Tube Formation and Hyphal Growth of C. albicans/Nährböden zur Untersuchung der Wirkungen von Azolderivaten auf die Keimschlauchbildung und das Hyphenwachstum bei C. albicans
1986
Molecular biological characterization of an azole-resistant Candida glabrata isolate
1997
Cytochrome p‐450: Target for itraconazole
1986
Effects of ketoconazole and itraconazole on growth and sterol synthesis in Pityrosporum ovale
1986
Characterization of an azole-resistant Candida glabrata isolate
1992
The interaction of miconazole and ketoconazole with lipids
1982
Interaction of azole derivatives with cytochrome P‐450 isozymes in yeast, fungi, plants and mammalian cells
1987
The action of itraconazole and ketoconazole on growth and sterol synthesis inAspergillus fumigatusandAspergillus niger
1985
Mutation in cytochrome P-450-dependent 14α-demethylase results in decreased affinity for azole antifungals
1990
Biochemical basis for the activity and selectivity of oral antifungal drugs.
1990
Molecular basis for the antimycotic and antibacterial activity of N‐substituted imidazoles and triazoles: The inhibition of isoprenoid biosynthesis
1984
Contribution of mutations in the cytochrome P450 14α-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans
1999
Hypothesis on the mechanism of resistance to fluconazole in Histoplasma capsulatum
1997
Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans
1993
Synthesis and in Vitro and in Vivo Structure−Activity Relationships of Novel Antifungal Triazoles for Dermatology
2005
REALISIS: A Medicinal Chemistry-Oriented Reagent Selection, Library Design, and Profiling Platform
2004
The action of itraconazole and ketoconazole on growth and sterol synthesis in Aspergillus fumigatus and Aspergillus niger.
1985