Standout Papers
Citation Impact
Citing Papers
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
2009 StandoutScience
Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity
2013 StandoutScience
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
2009 StandoutScience
Trained immunity: A program of innate immune memory in health and disease
2016 StandoutScience
Copper-free click chemistry in living animals
2010 StandoutNobel
Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer
2013
Structure-Function Relationships in Flavoenzyme-dependent Amine Oxidations
2002
Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury
2015
Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1
2004 Standout
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Polyamine delivery as a tool to modulate stem cell differentiation in skeletal tissue engineering
2013
Cancer Chemoprevention and Nutri-Epigenetics: State of the Art and Future Challenges
2012
Mammalian polyamine metabolism and function
2009
Structure of the Histone Acetyltransferase Hat1
1998 StandoutNobel
Role of Estrogen Receptor Gene Demethylation and DNA Methyltransferase·DNA Adduct Formation in 5-Aza-2′deoxycytidine-induced Cytotoxicity In Human Breast Cancer Cells
1997
Nitric oxide induced by polyamines involves antioxidant systems against chilling stress in tomato (Lycopersicon esculentum Mill.) seedling
2016
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Retinoic acid receptors: From molecular mechanisms to cancer therapy
2014
Spermidine levels are implicated in heavy metal tolerance in a spermidine synthase overexpressing transgenic European pear by exerting antioxidant activities
2009
Covalent Binding of the Nitroso Metabolite of Sulfamethoxazole Is Important in Induction of Drug-Specific T-Cell Responses in Vivo
2008
Decreased Ornithine Decarboxylase Activity in the Kidneys of Dahl Salt-Sensitive Rats.
2002
Spermine pretreatment confers dehydration tolerance of citrus in vitro plants via modulation of antioxidative capacity and stomatal response
2010
eIF4E – from translation to transformation
2004
Modulation of learning and memory by natural polyamines
2016
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Increased Polyamine Intake Inhibits Age-Associated Alteration in Global DNA Methylation and 1,2-Dimethylhydrazine-Induced Tumorigenesis
2013
Modulation of cellular function by polyamines
2009
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease
2008
Microbes, Microbiota, and Colon Cancer
2014
The gut microbiota, bacterial metabolites and colorectal cancer
2014 Standout
Epigenetic regulation of normal and malignant hematopoiesis
2007
Spermidine/Spermine-N1-Acetyltransferase 2 Is an Essential Component of the Ubiquitin Ligase Complex That Regulates Hypoxia-inducible Factor 1α
2007 StandoutNobel
Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions
2011
Hallmarks of aging: An expanding universe
2023 Standout
Cancer Epigenetics: From Mechanism to Therapy
2012 Standout
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
2014 StandoutNature
Role of caspases in the regulation of apoptotic pancreatic islet beta‐cells death
2004
A new mechanism of antibiotic resistance in Enterobacteriaceae induced by a structural modification of the major porin
2001
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
The biochemistry of apoptosis
2000 StandoutNature
Role of the Microbiota in Immunity and Inflammation
2014 Standout
Functional Role of G9a Histone Methyltransferase in Cancer
2015
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Role of sulfur chirality in the chemical processes of biology
2005
Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction of autophagy
2016
Polyamines in renal failure
2006
Polyamines: Natural and engineered abiotic and biotic stress tolerance in plants
2011
The epigenetics of epithelial-mesenchymal plasticity in cancer
2013
Gene Silencing in Cancer in Association with Promoter Hypermethylation
2003 Standout
The Photoprotective Role of Spermidine in Tomato Seedlings under Salinity-Alkalinity Stress
2014
2002
Palladium‐Catalyzed Selective Anti‐Markovnikov Oxidation of Allylic Esters
2013 StandoutNobel
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
2016 Standout
Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling
2007
Palladium‐Catalyzed anti‐Markovnikov Oxidation of Terminal Alkenes
2014 StandoutNobel
The Epigenetic Memory of Monocytes and Macrophages as a Novel Drug Target in Atherosclerosis
2015
EMT: 2016
2016 Standout
Apoptosis without caspases: an inefficient molecular guillotine?
1999
Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders
2013 Standout
The quest to slow ageing through drug discovery
2020
A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth
2013
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms
2013 Standout
Caloric restriction mimetics: towards a molecular definition
2014
Polyamines and cancer: old molecules, new understanding
2004
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Change in lipoperoxidation but not in scavenging enzymes activity during polyamine embryoprotection in rat embryo cultured in hyperglycemic media
2012
lincRNAs act in the circuitry controlling pluripotency and differentiation
2011 StandoutNature
A marker for Stevens–Johnson syndrome
2004 StandoutNature
A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects
2012
Epigenetic Regulation of EMT: The Snail Story
2014
Spermidine/Spermine N1-Acetyltransferase-1 Binds to Hypoxia-inducible Factor-1α (HIF-1α) and RACK1 and Promotes Ubiquitination and Degradation of HIF-1α
2007 StandoutNobel
Protective Role of Spermidine in Colitis and Colon Carcinogenesis
2021
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase
2018 StandoutNobel
Activation of H2O2 by Chiral Confined Brønsted Acids: A Highly Enantioselective Catalytic Sulfoxidation
2012 StandoutNobel
Iron Oxide Nanoparticles for Sustained Delivery of Anticancer Agents
2005
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Structure and critical residues at the active site of spermidine/spermine-N1-acetyltransferase
1996
Acute Myeloid Leukemia
2015 Standout
Molecular Basis of Bacterial Outer Membrane Permeability Revisited
2003 Standout
Interactions Between the Microbiota and the Immune System
2012 StandoutScience
Magnetic Iron Oxide Nanoparticles: Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications
2008 Standout
Transport, metabolism and elimination mechanisms of anti-HIV agents
1999
Spermidine Alleviates Severity of Murine Experimental Autoimmune Encephalomyelitis
2011
Semisynthetic Flavone-Derived Antimicrobials with Therapeutic Potential against Methicillin-Resistant Staphylococcus aureus (MRSA)
2017
Structures of wild-type and mutant human spermidine/spermine N 1 -acetyltransferase, a potential therapeutic drug target
2006
Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia
2013
Structure and function of pore-forming beta-barrels from bacteria.
2002
Spermidine Ameliorates Neurodegeneration in a Mouse Model of Normal Tension Glaucoma
2015
Spermidine in health and disease
2018 StandoutScience
Enantioselective Synthesis of Tetraponerines by Pd- and Ru-Catalyzed Domino Reactions
2000
Mitochondrial Dysfunction and Type 2 Diabetes
2005 StandoutScience
PD-1 deficiency reveals various tissue-specific autoimmunity by H-2band dose-dependent requirement of H-2g7for diabetes in NOD mice
2008 StandoutNobel
Cadaverine Inhibition of Porin Plays a Role in Cell Survival at Acidic pH
2002
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Spermidine alleviates oxidative stress in silk glands of Bombyx mori
2016
Identification of a New Endogenous Metabolite and the Characterization of Its Protein Interactions through an Immobilization Approach
2008 StandoutNobel
Host-Gut Microbiota Metabolic Interactions
2012 StandoutScience
The ecology of the microbiome: Networks, competition, and stability
2015 StandoutScience
Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration
2018 StandoutNobel
Cancer and the microbiota
2015 Science
Vibrio cholerae OmpU and OmpT Porins Are Differentially Affected by Bile
2002
Metal–Organic Frameworks in Biomedicine
2011 Standout
Oral administration of polyamines ameliorates liver ischemia/reperfusion injury and promotes liver regeneration in rats
2016
Cytotoxic effects of cigarette smoke extract on an alveolar type II cell-derived cell line
2001
Toxicity of Polyamines and Their Metabolic Products
2013
Aldehyde Selective Wacker Oxidations of Phthalimide Protected Allylic Amines: A New Catalytic Route to β3-Amino Acids
2009 StandoutNobel
Cutaneous Drug Reactions
2001
Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline
2018
Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism
2004
Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity.
2001
Cancer Epigenetics: Modifications, Screening, and Therapy
2007
The role of spermidine/spermineN1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells
2007
Works of Patrick M. Woster being referenced
Novel Oligoamine Analogues Inhibit Lysine-Specific Demethylase 1 and Induce Reexpression of Epigenetically Silenced Genes
2009
Induction of programmed cell death in human breast cancer cells by an unsymmetrically alkylated polyamine analogue.
1995
Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling
2020
Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase
1996
Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide
2007
Molecular basis for the polyamine-OmpF porin interactions: inhibitor and mutant studies 1 1Edited by G. von Heijne
2000
Alternative Spermidine Biosynthetic Route Is Critical for Growth of Campylobacter jejuni and Is the Dominant Polyamine Pathway in Human Gut Microbiota
2011
Polyamines and cancer: implications for chemotherapy and chemoprevention
2013
Design of small molecule epigenetic modulators
2013
Properties of purified recombinant human polyamine oxidase, PAOh1/SMO
2003
Synthesis and evaluation of unsymmetrically substituted polyamine analogs as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential antitumor agents
1993
Structural Specificity of Polyamines and Polyamine Analogues in the Protection of DNA from Strand Breaks Induced by Reactive Oxygen Species
1998
Clinical aspects of cell death in breast cancer: the polyamine pathway as a new target for treatment.
1999
Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells
1989
Spermine Oxidase SMO(PAOh1), Not N1-Acetylpolyamine Oxidase PAO, Is the Primary Source of Cytotoxic H2O2 in Polyamine Analogue-treated Human Breast Cancer Cell Lines
2005
Irreversible inhibition of human S-adenosylmethionine decarboxylase by the pure diastereomeric forms of S-(5′-deoxy-5′-adenosyl)-1-ammonio-4-methylsulfonio-2-cyclopentene (AdoMac)
1995
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
2012
Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis
2007
Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells
2003
A Role for Bioactivation and Covalent Binding within Epidermal Keratinocytes in Sulfonamide-Induced Cutaneous Drug Reactions
2000
S-(5'-Deoxy-5'-adenosyl)-1-aminoxy-4-(methylsulfonio)-2-cyclopentene (AdoMao): An Irreversible Inhibitor of S-Adenosylmethionine Decarboxylase with Potent in Vitro Antitrypanosomal Activity
1995
Preparation of the pure diastereomeric forms of S- (5′-deoxy-5′-adenosyl)-1-ammonio-4-methylsulfonio-2- cyclopentene and their evaluation as irreversible inhibitors of S-adenosylmethionine decarboxylase from Escherichia coli
1993
Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity
2005
Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes
2007
Polyamine analogue induction of programmed cell death in human lung tumor cells.
1996
Recent Advances in the Development of Polyamine Analogues as Antitumor Agents
2009
Metabolism of an Alkyl Polyamine Analog by a Polyamine Oxidase from the Microsporidian Encephalitozoon cuniculi
2009
Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure.
2001
Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice.
1996
Targeting polyamine metabolism for cancer therapy and prevention
2016
Polyamine analogues targeting epigenetic gene regulation
2009
Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents: Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins
2019
Polyamine catabolism contributes to enterotoxigenicBacteroides fragilis-induced colon tumorigenesis
2011
Synthesis of protected allylic amines via palladium(0)-catalyzed amination of allylic acetates
1998
Combination of standard cytotoxic agents with polyamine analogues in the treatment of breast cancer cell lines.
2001
The role of polyamine catabolism in polyamine analogue-induced programmed cell death
1997
Is Hydroxylamine-Induced Cytotoxicity a Valid Marker for Hypersensitivity Reactions to Sulfamethoxazole in Human Immunodeficiency Virus-Infected Individuals?
1999
The role of polyamine catabolism in anti-tumour drug response
2003
Terminally Alkylated Polyamine Analogues as Chemotherapeutic Agents
2000
Antibacterial Diamines Targeting Bacterial Membranes
2016
Unsymmetrically substituted polyamine analogue induces caspase-independent programmed cell death in Bcl-2-overexpressing cells.
1998
Detoxification of the polyamine analogue N1-ethyl-N11-[(cycloheptyl)methy]-4,8-diazaundecane (CHENSpm) by polyamine oxidase.
2002
The natural polyamine spermine functions directly as a free radical scavenger
1998 Standout
Induction of human spermine oxidase SMO(PAOh1) is regulated at the levels of new mRNA synthesis, mRNA stabilization and newly synthesized protein
2005