Citation Impact
Citing Papers
Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites
2009 StandoutScience
Sleep Drives Metabolite Clearance from the Adult Brain
2013 StandoutScience
Promoter Choice Determines Splice Site Selection in Protocadherin α and γ Pre-mRNA Splicing
2002 StandoutNobel
Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins
2017
Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease
2019
Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice
2015
A decade of modeling Alzheimer's disease in transgenic mice
2006
ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion
2017 Nobel
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
ApoE4 Accelerates Early Seeding of Amyloid Pathology
2017
ApoE Promotes the Proteolytic Degradation of Aβ
2008
Untangling Genetic Risk for Alzheimer’s Disease
2017
The Ubiquitin Proteasome System in Neurodegenerative Diseases
2003 StandoutNobel
Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis
2014
Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
1991 StandoutNature
Necroptosis and its role in inflammation
2015 StandoutNature
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Preparing Synthetic Aβ in Different Aggregation States
2010
Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes
2012
COUP transcription factor is a member of the steroid receptor superfamily
1989 Nature
apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain
2008
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
1997 StandoutNature
CYP2E1 Degradation by in Vitro Reconstituted Systems: Role of the Molecular Chaperone hsp90
2000
Two genes encode distinct glutamate decarboxylases
1991 Standout
Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight
2018
Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch
1998
Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins
1994 StandoutNobel
The Human Androgen Receptor: Complementary Deoxyribonucleic Acid Cloning, Sequence Analysis and Gene Expression in Prostate
1988
The origin of pattern and polarity in the Drosophila embryo
1992 StandoutNobel
High-resolution mapping of a minor histocompatibility antigen gene on mouse chromosome 2
1993
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
1990 StandoutNature
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
Impact of genetic engineering on the understanding of spermatogenesis
2001
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector
2018
Structural and functional features of central nervous system lymphatic vessels
2015 StandoutNature
Haploinsufficiency of Human APOE Reduces Amyloid Deposition in a Mouse Model of Amyloid-β Amyloidosis
2011
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
The nuclear receptor superfamily: The second decade
1995 Standout
A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm
1993 StandoutNobel
Biochemistry of Amyloid -Protein and Amyloid Deposits in Alzheimer Disease
2012
Protein folding in the cell
1992 StandoutNature
Drainage of Cells and Soluble Antigen from the CNS to Regional Lymph Nodes
2013
The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily
1990 StandoutNobel
Delimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse.
1993 StandoutNobel
NMR analysis of a 900K GroEL–GroES complex
2002 StandoutNatureNobel
Reducing Human Apolipoprotein E Levels Attenuates Age-Dependent Aβ Accumulation in Mutant Human Amyloid Precursor Protein Transgenic Mice
2012
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology
2017
A multi-modal parcellation of human cerebral cortex
2016 StandoutNature
Genetics of primary progressive multiple sclerosis
2014
APOε4 is associated with enhanced in vivo innate immune responses in human subjects
2014
Abdominal segmentation of the Drosophila embryo requires a hormone receptor-like protein encoded by the gap gene knirps
1988 Nature
The Role of Apolipoprotein E in Alzheimer's Disease
2009
A Frameshift Mutation Destabilizes Androgen Receptor Messenger RNA in theTfmMouse
1991
The Rat Androgen Receptor: Primary Structure, Autoregulation of its Messenger Ribonucleic Acid, and Immunocytochemical Localization of the Receptor Protein
1988
Two amino acids within the knuckle of the first zinc finger specify DNA response element activation by the glucocorticoid receptor
1989
Expression of active hormone and DNA-binding domains of the chicken progesterone receptor in E. coli.
1989
ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical NeuronsIn Vivo
2009
Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence
2016
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
2012 Nature
Postmortem Delay Has Minimal Effect on Brain RNA Integrity
2007
Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
1991 StandoutNature
Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration
2013
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
The role of microglia in amyloid clearance from the AD brain
2010
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
2017 Standout
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
Gene regulation by steroid hormones
1989 Standout
Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease
2016
Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1
2007
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.
1993 StandoutNobel
Structure and polymorphism of the mouse prion protein gene.
1994 StandoutNobel
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology
2020 StandoutNobel
Development of Monocytes, Macrophages, and Dendritic Cells
2010 StandoutScience
Apolipoprotein E is essential for amyloid deposition in theAPPV717Ftransgenic mouse model of Alzheimer's disease
1999
Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice.
1994 StandoutNobel
Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells
2009
AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease
2018
Determinants of target gene specificity for steroid/thyroid hormone receptors
1989
Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis
2012
Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis
1995 StandoutScience
MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice
2018
Transcriptional neoteny in the human brain
2009 StandoutNobel
Transport Pathways for Clearance of Human Alzheimer's Amyloid β-Peptide and Apolipoproteins E and J in the Mouse Central Nervous System
2006
Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance
2011
Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain
2013
A Century of Alzheimer's Disease
2006 StandoutScience
Expression of Human Apolipoprotein E3 or E4 in the Brains ofApoe−/−Mice: Isoform-Specific Effects on Neurodegeneration
1999
Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant.
1993 StandoutNobel
High Level Expression in Escherichia coli of the DNA-binding Domain of the Glucocorticoid Receptor in a Functional Form Utilizing Domainspecific Cleavage of a Fusion Protein
1989
Stromal regulation of epithelial function
1991
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions
2013
Solution NMR Techniques for Large Molecular and Supramolecular Structures
2002 StandoutNobel
A single base deletion in the Tfm androgen receptor gene creates a short-lived messenger RNA that directs internal translation initiation.
1991
ApoE facilitates the microglial response to amyloid plaque pathology
2018
Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein
2002 StandoutScience
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Alzheimer’s Disease: The Challenge of the Second Century
2011
Localization of the 90-kDa heat shock protein-binding site within the hormone-binding domain of the glucocorticoid receptor by peptide competition
1991
A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit.
1989
Type 1 Neurofibromatosis Gene: Identification of a Large Transcript Disrupted in Three NF1 Patients
1990 StandoutScience
Growth Factors and Cancer
1991 StandoutScience
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
1989 StandoutScience
Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease
2006
G 1 Events and Regulation of Cell Proliferation
1989 StandoutScience
Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.
1996
STRUCTURE AND FUNCTION IN GroEL-MEDIATED PROTEIN FOLDING
1998
Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity.
1989
Distinct patterns of brain activity in young carriers of the APOE -ε4 allele
2009
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Characterization and expression of a cDNA encoding the human androgen receptor.
1989
Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase
1995 StandoutScience
Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.
1999
Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice
2002 StandoutNobel
LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
2006 Standout
Cleft palate in mice with a targeted mutation in the γ-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67
1997 StandoutNobel
Works of Patrick M. Sullivan being referenced
Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice
2014
Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models
2015
ApoE isoform-dependent changes in hippocampal synaptic function
2009
A simple, efficient tool for assessment of mice after unilateral cortex injury
2007
APOE Genotype and an ApoE-mimetic Peptide Modify the Systemic and Central Nervous System Inflammatory Response
2003
Overexpression of Androgen-Binding Protein/Sex Hormone-Binding Globulin in Male Transgenic Mice: Tissue Distribution and Phenotypic Disorders1
1997
Reduced levels of human apoE4 protein in an animal model of cognitive impairment
2009
Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice
2014
Human Apolipoprotein E4 Targeted Replacement Mice Show Increased Prevalence of Intracerebral Hemorrhage Associated with Vascular Amyloid Deposition
2008
Human Apolipoprotein E4 Worsens Acute Axonal Pathology but Not Amyloid-β Immunoreactivity After Traumatic Brain Injury in 3×TG-AD Mice
2013
Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models
2016
Human Apolipoprotein E2, E3, and E4 Isoform-Specific Transgenic Mice: Human-like Pattern of GlialandNeuronal Immunoreactivity in Central Nervous System Not Observed in Wild-Type Mice
1996
Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks
2008
Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele
2012
Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis
2017
ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-β1–42
2004
Marked regional differences of brain human apolipoprotein e expression in targeted replacement mice
2004
ApoE isoform affects LTP in human targeted replacement mice
2004
Blockade of nicotinic acetylcholine receptors suppresses hippocampal long‐term potentiation in wild‐type but not ApoE4 targeted replacement mice
2005
Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice
2001
Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology
2005
Aβ42 neurotoxicity in primary co-cultures: Effect of apoE isoform and Aβ conformation
2006
Blocking the Interaction between Apolipoprotein E and Aβ Reduces Intraneuronal Accumulation of Aβ and Inhibits Synaptic Degeneration
2013
HumanAPOEIsoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice
2009
Mortalin is regulated by APOE in hippocampus of AD patients and by human APOE in TR mice
2006
Human Apolipoprotein E4 Alters the Amyloid-β 40:42 Ratio and Promotes the Formation of Cerebral Amyloid Angiopathy in an Amyloid Precursor Protein Transgenic Model
2005
The Low Density Lipoprotein Receptor Regulates the Level of CentralNervous System Human and Murine Apolipoprotein E but Does Not Modify AmyloidPlaque Pathology in PDAPPMice
2005
Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis
1997
Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice
2012
Characterization and expression of the complementary DNA encoding rat histidine decarboxylase.
1990
Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by trans splicing.
1991
Cloning of Human Androgen Receptor Complementary DNA and Localization to the X Chromosome
1988 Science
Apolipoprotein E allele-dependent pathogenesis: A model for age-related retinal degeneration
2005
Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior
2004
Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-β
2005
APOE Genotype Affects Outcome in a Murine Model of Sepsis: Implications for a New Treatment Strategy
2009