Standout Papers
- OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation (2014)
- Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance (2013)
- Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts (2009)
- Roles of individual prolyl‐4‐hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice (2012)
- Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α (2008)
- Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α) (2011)
- Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism (2010)
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Hypoxia induces rapid changes to histone methylation and reprograms chromatin
2019 Science
Regulation of the Histone Demethylase JMJD1A by Hypoxia-Inducible Factor 1α Enhances Hypoxic Gene Expression and Tumor Growth
2009
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
Metabolic Associations of Reduced Proliferation and Oxidative Stress in Advanced Breast Cancer
2012
Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival
2014 StandoutNobel
Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases
2011 StandoutNobel
Fumarate induces redox-dependent senescence by modifying glutathione metabolism
2015
Cancer–stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis
2012 StandoutNobel
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
2011 StandoutNobel
A Mitochondrial Switch Promotes Tumor Metastasis
2014
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
2005 StandoutNobel
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism
2015
Hallmarks of Cancer: The Next Generation
2011 Standout
Structural and Mechanistic Studies on the Inhibition of the Hypoxia-inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates
2006
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma.
2009 StandoutNobel
Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors
2010 StandoutNobel
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma
2014
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
2010 Standout
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
2011
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer
2016 StandoutNobel
Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects
2014
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
2016 StandoutNobel
Alterations of metabolic genes and metabolites in cancer
2012
Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells
2015 StandoutNobel
Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts
2013
Reductive carboxylation supports growth in tumour cells with defective mitochondria
2011 Nature
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
2016 StandoutNobel
Control of Cyclin D1 and Breast Tumorigenesis by the EglN2 Prolyl Hydroxylase
2009 StandoutNobel
The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF
2008
HIF-1: upstream and downstream of cancer metabolism
2009 StandoutNobel
Identification of non-coding genetic variants in samples from hypoxemic respiratory disease patients that affect the transcriptional response to hypoxia
2016
Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases
2010
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia
2017 StandoutNobel
Revisiting the TCA cycle: signaling to tumor formation
2011
Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells
2009
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
2008 Standout
Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Epigenetic Regulation of the Hypoxic Response via Hypoxia-Inducible Factor and Histone Modifying Enzymes
2011
NRF2 and cancer: the good, the bad and the importance of context
2012
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma
2011
Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer
2006
Transcriptional regulation by hypoxia inducible factors
2013
HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond
2015
Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning
2010 StandoutNobel
Hypoxic Induction of the Regulator of G-Protein Signalling 4 Gene Is Mediated by the Hypoxia-Inducible Factor Pathway
2012
Hypoxia causes epigenetic gene regulation in macrophages by attenuating Jumonji histone demethylase activity
2010
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)–mediated induction of the long noncoding RNA NICI
2019 StandoutNobel
Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction
2010
Mitochondria, Oxidants, and Aging
2005 Standout
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
2005 Standout
The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling
2013
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer
2013 StandoutNobel
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia
2013
Hypoxia-induced Expression of Carbonic Anhydrase 9 Is Dependent on the Unfolded Protein Response
2009
Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia
2014
Cooperativity of Stress-Responsive Transcription Factors in Core Hypoxia-Inducible Factor Binding Regions
2012
Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression
2012 StandoutNobel
Genome-wide analysis revealsNRP1as a direct HIF1α-E2F7 target in the regulation of motorneuron guidancein vivo
2015
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
Hypoxia‐inducible factor 1 mediates increased expression of NADPH oxidase‐2 in response to intermittent hypoxia
2011 StandoutNobel
Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer
2015 StandoutNobel
Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling
2010 StandoutNobel
VHL, the story of a tumour suppressor gene
2014
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer
2012
Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia
2009
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER
2014
Metabolic dysregulation in monogenic disorders and cancer — finding method in madness
2015
Mitochondrial TCA cycle metabolites control physiology and disease
2020 Standout
Chromatin as an oxygen sensor and active player in the hypoxia response
2011
Reading, writing and erasing mRNA methylation
2019 Standout
Glucose Utilization via Glycogen Phosphorylase Sustains Proliferation and Prevents Premature Senescence in Cancer Cells
2012
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Regulation of Metabolism by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Mitochondria and cancer
2012 Standout
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Heterogeneity of tumor-induced gene expression changes in the human metabolic network
2013
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
2009 StandoutNobel
Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer
2016
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Oxygen homeostasis
2009 StandoutNobel
The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts
2012
The hypoxia‐inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens
2010 StandoutNobel
Clues from cell metabolism
2010 StandoutNatureNobel
Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase
2012
Fundamentals of cancer metabolism
2016 Standout
Epigenetic Regulation by Histone Demethylases in Hypoxia
2015
Chromatin and oxygen sensing in the context of JmjC histone demethylases
2014
Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
2014 Standout
Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes
2017
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Epigenetics: New Questions on the Response to Hypoxia
2011
Adult hematopoietic stem cells lacking Hif-1α self-renew normally
2016 StandoutNobel
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Metabolic reprogramming and cancer progression
2020 StandoutScience
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy
2014 StandoutNobel
Genome-wide identification and annotation of HIF-1α binding sites in two cell lines using massively parallel sequencing
2010
Isocitrate Dehydrogenase Mutations Are Rare in Pheochromocytomas and Paragangliomas
2009
Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis
2009
Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway
2015 StandoutNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Dynamic Change of Chromatin Conformation in Response to Hypoxia Enhances the Expression of GLUT3 (SLC2A3) by Cooperative Interaction of Hypoxia-Inducible Factor 1 and KDM3A
2012
Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO)
2013
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Multiple Factors Affecting Cellular Redox Status and Energy Metabolism Modulate Hypoxia-Inducible Factor Prolyl Hydroxylase Activity In Vivo and In Vitro
2006
Works of Patrick J. Pollard being referenced
Expression of HIF-1α, HIF-2α (EPAS1), and Their Target Genes in Paraganglioma and Pheochromocytoma with VHL and SDH Mutations
2006
The TCA cycle and tumorigenesis
2003
Inborn and acquired metabolic defects in cancer
2011
Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency
2013
Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
2009 StandoutNobel
Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance
2013 StandoutNobel
Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism
2010 StandoutNobel
Oncometabolites: linking altered metabolism with cancer
2013
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
2011 Nature
Roles of individual prolyl‐4‐hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice
2012 StandoutNobel
Targeted Inactivation of Fh1 Causes Proliferative Renal Cyst Development and Activation of the Hypoxia Pathway
2007
Distinct expression profile in fumarate-hydratase-deficient uterine fibroids
2005
SDH mutations in cancer
2011
Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α)
2011 StandoutNobel
Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome
2004
The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase
2003
Adult Leydig Cell Tumors of the Testis Caused by Germline Fumarate Hydratase Mutations
2006
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α
2008 StandoutNobel
OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation
2014 StandoutNobel
The Succinated Proteome of FH-Mutant Tumours
2014