Patrick J. Nygren

De novo design of modular and tunable protein biosensors

Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution

Signalling scaffolds and local organization of cellular behaviour

Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities

Rapid online buffer exchange for screening of proteins, protein complexes and cell lysates by native mass spectrometry

Fluorescence nanoscopy in cell biology

AKT/PKB Signaling: Navigating the Network

De novo design of tyrosine and serine kinase-driven protein switches

O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity

Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution

Glycoproteomics

Mechanisms of Insulin Action and Insulin Resistance

Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks

Quantitative proteomics identifies altered O‐GlcNAcylation of structural, synaptic and memory‐associated proteins in Alzheimer's disease

Reconfigurable asymmetric protein assemblies through implicit negative design

The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin

MetaUniDec: High-Throughput Deconvolution of Native Mass Spectra

Local protein kinase A action proceeds through intact holoenzymes

Protein Kinase A Opposes the Phosphorylation-dependent Recruitment of Glycogen Synthase Kinase 3β to A-kinase Anchoring Protein 220

Anchored phosphatases modulate glucose homeostasis

Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex