Standout Papers
Citation Impact
Citing Papers
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Comprehensive computational design of ordered peptide macrocycles
2017 StandoutScienceNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2
1996
Fatty Acid Substrate Specificities of Human Prostaglandin-endoperoxide H Synthase-1 and −2
1995
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
1995 StandoutNobel
Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system
1994
Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation
1999 StandoutNatureNobel
NMR structure of the mouse prion protein domain PrP(121–231)
1996 StandoutNatureNobel
A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and −2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors
1996
Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2
1995
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Detergents for the stabilization and crystallization of membrane proteins
2007
A Computationally Designed Water-Soluble Variant of a G-Protein-Coupled Receptor: The Human Mu Opioid Receptor
2013
Crystal structure and mechanism of a calcium-gated potassium channel
2002 StandoutNatureNobel
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
New approaches to high-throughput phasing
2002
Redesigning an integral membrane K+ channel into a soluble protein
2005
Crystallizing membrane proteins using lipidic mesophases
2009
Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution
2001 StandoutNatureNobel
Reactions of Prostaglandin Endoperoxide Synthase and Its Compound I with Hydroperoxides
1996
Simple screening method for improving membrane protein thermostability
2011
A short history ofSHELX
2007 Standout
A lipid’s eye view of membrane protein crystallization in mesophases
2000
Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2
1999
Structure and function of an irreversible agonist-β2 adrenoceptor complex
2011 StandoutNatureNobel
The role of dynamics in allosteric regulation
2003
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization
2018 StandoutNatureNobel
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
Structure and Function of the Membrane Anchor Domain of Hepatitis C Virus Nonstructural Protein 5A
2004
An Amino-terminal Amphipathic α-Helix Mediates Membrane Association of the Hepatitis C Virus Nonstructural Protein 5A
2002
UCSF Chimera—A visualization system for exploratory research and analysis
2004 Standout
High-resolution structure prediction and the crystallographic phase problem
2007 StandoutNatureNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Searching protein structure databases has come of age
1994
Glycotripod Amphiphiles for Solubilization and Stabilization of a Membrane‐Protein Superassembly: Importance of Branching in the Hydrophilic Portion
2008
Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease
1990
A hydrogen-atom abstraction model for the function of YZ in photosynthetic oxygen evolution
1995
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
2011 StandoutNatureNobel
Fv fragment-mediated crystallization of the membrane protein bacterial cytochrome c oxidase
1995 Nobel
How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 å resolution
1996
Comparison of Peroxidase Reaction Mechanisms of Prostaglandin H Synthase-1 Containing Heme and Mangano Protoporphyrin IX
1997
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Prostaglandin endoperoxide synthases-1 and -2
1995
De novo design of a fluorescence-activating β-barrel
2018 StandoutNatureNobel
Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2
1996 Standout
Advances in direct methods for protein crystallography
1999
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
The exploration of macrocycles for drug discovery — an underexploited structural class
2008
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
1995 StandoutNobel
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
1996 StandoutNature
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
2005 StandoutNatureNobel
Orientation‐specific signalling by thrombopoietin receptor dimers
2011
Structural Characterization of Arachidonyl Radicals Formed by Prostaglandin H Synthase-2 and Prostaglandin H Synthase-1 Reconstituted with Mangano Protoporphyrin IX
1998
Helix capping
1998
Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin
2001 Standout
Structure and dynamics of the M3 muscarinic acetylcholine receptor
2012 StandoutNatureNobel
Spectroscopic Evidence for Reaction of Prostaglandin H Synthase-1 Tyrosyl Radical with Arachidonic Acid
1995
Role of Val509 in Time-dependent Inhibition of Human Prostaglandin H Synthase-2 Cyclooxygenase Activity by Isoform-selective Agents
1996
Involvement of Arginine 120, Glutamate 524, and Tyrosine 355 in the Binding of Arachidonate and 2-Phenylpropionic Acid Inhibitors to the Cyclooxygenase Active Site of Ovine Prostaglandin Endoperoxide H Synthase-1
1996
Membrane protein crystallization
2003
Accurate prediction of the stability and activity effects of site-directed mutagenesis on a protein core
1991 StandoutNatureNobel
Nucleases: diversity of structure, function and mechanism
2010
COX-2 inhibitors
1999 Standout
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Principles determining the structure of β-sheet barrels in proteins II. The observed structures
1994
Colossal cages in zeolitic imidazolate frameworks as selective carbon dioxide reservoirs
2008 StandoutNatureNobel
Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-[125I]iodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site
1996
Copper amine oxidase: a novel use for a tyrosine
1995
Comparison of branched-chain and tightly coupled reaction mechanisms for prostaglandin H synthase
1995
Arginine 120 of Prostaglandin G/H Synthase-1 Is Required for the Inhibition by Nonsteroidal Anti-inflammatory Drugs Containing a Carboxylic Acid Moiety
1995
Die Vancomycin-Antibiotica und der Kampf gegen resistente Bakterien
1999
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Enzyme Mechanisms for Polycyclic Triterpene Formation
2000 Nobel
Chemical Glycobiology
2001 StandoutScienceNobel
MEMBRANE PROTEIN FOLDING AND STABILITY: Physical Principles
1999
The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum.
1994
Structure and Function of a Squalene Cyclase
1997 Science
Tandem Facial Amphiphiles for Membrane Protein Stabilization
2010 StandoutNobel
A Self-Complexing [2]Catenane
2000 StandoutNobel
Heme Enzyme Structure and Function
2014
The design and implementation ofSnBversion 2.0
1999
NAMD2: Greater Scalability for Parallel Molecular Dynamics
1999 Standout
Diversifying Vancomycin via Chemoenzymatic Strategies
2005
Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase
1995
Trapping a transition state in a computationally designed protein bottle
2015 StandoutScienceNobel
Detergents as Tools in Membrane Biochemistry
2001
Trapping and Stabilization of Integral Membrane Proteins by Hydrophobically Grafted Glucose-Based Telomers
2009
The Halogen Bond
2016 Standout
The Kinetic Factors That Determine the Affinity and Selectivity for Slow Binding Inhibition of Human Prostaglandin H Synthase 1 and 2 by Indomethacin and Flurbiprofen
1996
Molecular recognition
1991
Protein Radicals in Enzyme Catalysis
1998 Standout
Activation of olefins via asymmetric Brønsted acid catalysis
2018 StandoutScienceNobel
A Trivalent System from Vancomycin· d -Ala- d -Ala with Higher Affinity Than Avidin·Biotin
1998 Science
Heme-Containing Oxygenases
1996 Standout
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Structural diversity of calmodulin binding to its target sites
2013
X-ray Crystal Structure of Teicoplanin A2-2 Bound to a Catalytic Peptide Sequence via the Carrier Protein Strategy
2014
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Works of Patrick J. Loll being referenced
Structural Basis for Calmodulin as a Dynamic Calcium Sensor
2012
Static light scattering studies of OmpF porin: Implications for integral membrane protein crystallization
2000
Assessing the role of detergent–detergent interactions in membrane protein crystallization
2001
The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1
1994 StandoutNature
X-ray crystal structures of staphylococcal nuclease complexed with the competitive inhibitor cobalt(II) and nucleotide
1995
The crystal structure of the ternary complex of staphylococcal nuclease, Ca2+ and the inhibitor pdTp, refined at 1.65 Å
1989
Membrane protein structural biology: the high throughput challenge
2003
Structure of the complex between teicoplanin and a bacterial cell-wall peptide: use of a carrier-protein approach
2013
The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase
1995
Compatibility of detergents with the microbatch-under-oil crystallization method
2003
Identification of the transmembrane dimer interface of the bovine papillomavirus E5 protein
2001
Beyond the detergent effect: a binding site for sodium dodecyl sulfate (SDS) in mammalian apoferritin
2012
A ligand-mediated dimerization mode for vancomycin
1998
De novostructure determination of vancomycin aglycon using the anomalous scattering of chlorine
2001
Calibration of Size-Exclusion Chromatography: Use of a Double Gaussian Distribution Function to Describe Pore Sizes
1995
Structural basis for high‐affinity volatile anesthetic binding in a natural 4‐helix bundle protein
2005
A Carrier Protein Strategy Yields the Structure of Dalbavancin
2012
Crystallization and preliminary X-ray analysis of a quadruple mutant of staphylococcal nuclease.
1988
Vancomycin Binding to Low-Affinity Ligands: Delineating a Minimum Set of Interactions Necessary for High-Affinity Binding
1999
The Role of Sugar Residues in Molecular Recognition by Vancomycin
2001
Strategies for crystallizing membrane proteins
1996
Synthesis and Use of Iodinated Nonsteroidal Antiinflammatory Drug Analogs as Crystallographic Probes of the Prostaglandin H2 Synthase Cyclooxygenase Active Site,
1996
Simultaneous Recognition of a Carboxylate-Containing Ligand and an Intramolecular Surrogate Ligand in the Crystal Structure of an Asymmetric Vancomycin Dimer
1997
Configurational Entropy and Cooperativity between Ligand Binding and Dimerization in Glycopeptide Antibiotics
2003
Prostaglandin H synthase
1994