Citation Impact
Citing Papers
Multiplex Genome Engineering Using CRISPR/Cas Systems
2013 StandoutScience
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
2015 StandoutNobel
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Cyclization of short DNA fragments and bending fluctuations of the double helix
2005
Alteration of enzyme specificity by computational loop remodeling and design
2009 StandoutNobel
Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases
2007
Coevolution of a Homing Endonuclease and Its Host Target Sequence
2007
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
2008 StandoutNature
Assessment of the optimization of affinity and specificity at protein–DNA interfaces
2009 StandoutNobel
Structural transitions and elasticity from torque measurements on DNA
2003 Nature
Inference of Macromolecular Assemblies from Crystalline State
2007 Standout
Discriminating between homodimeric and monomeric proteins in the crystalline state
2000
Computational Enzyme Design
2013 StandoutNobel
The Crystal Structure of the Gene Targeting Homing Endonuclease I-SceI Reveals the Origins of its Target Site Specificity
2003
Cancer Cell Metabolism: Warburg and Beyond
2008 Standout
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
Flexible DNA Target Site Recognition by Divergent Homing Endonuclease Isoschizomers I-CreI and I-MsoI
2003
Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor
2003
Crystal structures of I-SceI complexed to nicked DNA substrates: snapshots of intermediates along the DNA cleavage reaction pathway
2008
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
2014 StandoutNature
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites.
2001
Self-assembly of DNA into nanoscale three-dimensional shapes
2009 StandoutNature
Degeneration of a homing endonuclease and its target sequence in a wild yeast strain
2001
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
Invasion of a multitude of genetic niches by mobile endonuclease genes
2000
DNA Recognition and Cleavage by the LAGLIDADG Homing Endonuclease I-Cre I
1998
The Structure of I-CeuI Homing Endonuclease: Evolving Asymmetric DNA Recognition from a Symmetric Protein Scaffold
2006
Crystal Structure of an Archaeal Intein-encoded Homing Endonuclease PI-PfuI
2000
From Monomeric to Homodimeric Endonucleases and Back: Engineering Novel Specificity of LAGLIDADG Enzymes
2006
Bending modes of DNA directly addressed by cryo-electron microscopy of DNA minicircles
2009 StandoutNobel
Homing endonucleases: keeping the house in order
1997
Evolutionary dynamics of introns and homing endonuclease ORFs in a region of the large subunit of the mitochondrial rRNA in Glomus species (arbuscular mycorrhizal fungi, Glomeromycota)
2010
Blinded by the Light: The Growing Complexity of p53
2009 Standout
Comprehensive computational design of mCreI homing endonuclease cleavage specificity for genome engineering
2011 StandoutNobel
Homing endonuclease structure and function
2005
Massively parallel determination and modeling of endonuclease substrate specificity
2014 StandoutNobel
DNA Binding and Cleavage by the HNH Homing Endonuclease I-HmuI
2004
Meganucleases and DNA Double-Strand Break-Induced Recombination: Perspectives for Gene Therapy
2007
A novel endonuclease mechanism directly visualized for I-PpoI.
1999
In vitro analysis of the relationship between endonuclease and maturase activities in the bi‐functional group I intron‐encoded protein, I‐AniI
2003
Rational Engineering of Enzyme Allosteric Regulation through Sequence Evolution Analysis
2012
A novel electrochemical detection method for aptamer biosensors
2005
Crystal structure of the thermostable archaeal intron-encoded endonuclease I- Dmo I 1 1Edited by I. A. Wilson
1999
Isolation and Characterization of New Homing Endonuclease Specificities at Individual Target Site Positions
2004
Design, Activity, and Structure of a Highly Specific Artificial Endonuclease
2002 StandoutNobel
I- Ppo I and I- Cre I homing site sequence degeneracy determined by random mutagenesis and sequential in vitro enrichment 1 1Edited by G. Smith
1998
Computational redesign of endonuclease DNA binding and cleavage specificity
2006 StandoutNatureNobel
Statistical modeling and analysis of the LAGLIDADG family of site- specific endonucleases and identification of an intein that encodes a site-specific endonuclease of the HNH family
1997
Homing endonucleases: structural and functional insight into the catalysts of intron/intein mobility
2001
Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth
2011
A synthetic homing endonuclease-based gene drive system in the human malaria mosquito
2011 StandoutNatureNobel
A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells
2003
Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
2013 Standout
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
Pyruvate kinase: Function, regulation and role in cancer
2015
Evolution from DNA to RNA recognition by the bI3 LAGLIDADG maturase
2005
Mutations altering the cleavage specificity of a homing endonuclease
2002
The monomeric homing endonuclease PI-SceI has two catalytic centres for cleavage of the two strands of its DNA substrate
1999
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases
2012 StandoutNobel
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs
2010 StandoutNobel
Meganucleases and Other Tools for Targeted Genome Engineering: Perspectives and Challenges for Gene Therapy
2011
Pyruvate kinase M2 is a phosphotyrosine-binding protein
2008 Nature
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Heritable targeted mutagenesis in maize using a designed endonuclease
2009
Analysis of the LAGLIDADG interface of the monomeric homing endonuclease I-DmoI
2004
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Mining Endonuclease Cleavage Determinants in Genomic Sequence Data
2011 StandoutNobel
Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation
2013 StandoutNobel
Exploitation of binding energy for catalysis and design
2009 StandoutNatureNobel
Organic Photocatalysts for the Oxidation of Pollutants and Model Compounds
2011
Functional Nucleic Acid Sensors
2009 Standout
Organic Photoredox Catalysis
2016 Standout
Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
2011 Standout
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Discriminating between homodimeric and monomeric proteins in the crystalline state
2000
Reprogramming homing endonuclease specificity through computational design and directed evolution
2013 StandoutNobel
Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus
2014 StandoutNobel
Structural Basis for Tumor Pyruvate Kinase M2 Allosteric Regulation and Catalysis,
2005
Macromolecular Modeling with Rosetta
2008 StandoutNobel
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 StandoutNobel
Progress in Modeling of Protein Structures and Interactions
2005 StandoutScienceNobel
A longitudinal study on the mental health of general population during the COVID-19 epidemic in China
2020 Standout
The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism
2010
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Graphitic Carbon Nitride (g-C3N4)-Based Photocatalysts for Artificial Photosynthesis and Environmental Remediation: Are We a Step Closer To Achieving Sustainability?
2016 Standout
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Fluorescent Dyes and Their Supramolecular Host/Guest Complexes with Macrocycles in Aqueous Solution
2011
Na+ more strongly inhibits DNA compaction by spermidine (3+) than K+
2006
Metal–Organic Frameworks and Self-Assembled Supramolecular Coordination Complexes: Comparing and Contrasting the Design, Synthesis, and Functionality of Metal–Organic Materials
2012 Standout
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Genetic Analysis of the Chlamydomonas reinhadtii I-CreI Mobile Intron Homing System in Escherichia coli
1997
Sequence-Dependent Effects in the Cyclization of Short DNA
2006
Computational design of a red fluorophore ligase for site-specific protein labeling in living cells
2014 StandoutNobel
A simple physical model for binding energy hot spots in protein–protein complexes
2002 StandoutNobel
Works of Patrick J. Heath being referenced
The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate
1998
Effect of Bending Strain on the Torsion Elastic Constant of DNA
1996
Crystallization and preliminary x-ray studies of I-CreI: a group I intron-encoded endonuclease fromC. reinhardtii
1997
Effects of Na+and Mg2+on the Structures of Supercoiled DNAs: Comparison of Simulations with Experiments
1996
The structure of I-Crel, a Group I intron-encoded homing endonuclease
1997
Fluorescence and Photobleaching Studies of Methylene Blue Binding to DNA
1994
Examining the Dimensionality, Reliability, and Invariance of the Depression, Anxiety, and Stress Scale–21 (DASS-21) Across Eight Countries
2020