Citation Impact
Citing Papers
Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.
1988
Supramolecular Structure of the Salmonella typhimurium Type III Protein Secretion System
1998 Science
Complete Replication of Hepatitis C Virus in Cell Culture
2005 StandoutScienceNobel
Atomic Structure of Human Adenovirus by Cryo-EM Reveals Interactions Among Protein Networks
2010 Science
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
2015 StandoutNatureNobel
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
Hepatitis B Virus Activates Deoxynucleotide Synthesis in Nondividing Hepatocytes by Targeting the R2 Gene
2009
Expression of the SV40 promoter in fission yeast: Identification and characterization of an AP-1-like factor
1988 StandoutNobel
Retinoblastoma protein switches the E2F site from positive to negative element
1992 Nature
EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins
1996 StandoutNobel
The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch
1989 StandoutNatureNobel
Atomic model of the type III secretion system needle
2012 StandoutNatureNobel
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex
2001 StandoutNobel
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
A Human Gene Encoding a Putative Basic Helix–Loop–Helix Phosphoprotein Whose mRNA Increases Rapidly in Cycloheximide-Treated Blood Mononuclear Cells
1994
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation
1990 StandoutNatureNobel
The E2F transcription factor is a cellular target for the RB protein
1991 Standout
p53/E1b58kDa Complex Regulates Adenovirus Replication
1997
The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein
1991 StandoutNobel
Prospects for a vaccine against the hepatitis C virus
2005 StandoutNatureNobel
DNA-binding activity of the adenovirus-induced E4F transcription factor is regulated by phosphorylation.
1989
Structural Clues to Prion Replication
1994 StandoutScienceNobel
DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control
1994
The adenovirus type 5 E1B-55K oncoprotein is a highly active shuttle protein and shuttling is independent of E4orf6, p53 and Mdm2
2000
Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
1991 StandoutNobel
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
1996 StandoutNobel
Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein
1998
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A
1991
Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display Differential Efficiency and Cell Tropism after Delivery to Different Regions of the Central Nervous System
2004
Translational activation of the lck proto-oncogene
1988 StandoutNatureNobel
CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation
1998 StandoutNobel
The embryonal carcinoma stem cell Ela-like activity involves a differentiation-regulated transcription factor
1990
Transcriptional repression by YY1, a human GLI-Krüippel-related protein, and relief of repression by adenovirus E1A protein
1991
Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation
1990 StandoutNatureNobel
Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes.
1991
Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence
1997
Use of Adeno-Associated Virus as a General Transduction Vector for Mammalian Cells
1992
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: A novel mechanism for E1A trans-activation
1990
Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 Å resolution
1992 StandoutNobel
Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein
1995 StandoutNobel
Cyclin A and the retinoblastoma gene product complex with a common transcription factor
1991 StandoutNatureNobel
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F
1991
An Arginine-Faced Amphipathic Alpha Helix Is Required for Adenovirus Type 5 E4orf6 Protein Function
1999
Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses.
1987
Sequences of the 5′ portion of the humanc-sisgene: characterization of the transcriptional promoter and regulation of expression of the protein product by 5' untranslated mRNA sequences
1987
Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity
2013 StandoutScienceNobel
A synthetic HIS4 regulatory element confers general amino acid control on the cytochrome c gene (CYC1) of yeast.
1985
An Adenovirus Type 5 (Ad5) Amplicon-Based Packaging Cell Line for Production of High-Capacity Helper-Independent ΔE1-E2-E3-E4 Ad5 Vectors
2005
Characterization of a Cofactor That Regulates Dimerization of a Mammalian Homeodomain Protein
1991 Science
Genetic analysis of the adenovirus E4 6/7 trans activator: interaction with E2F and induction of a stable DNA-protein complex are critical for activity
1991
The Nuclear Export Signal within the E4orf6 Protein of Adenovirus Type 5 Supports Virus Replication and Cytoplasmic Accumulation of Viral mRNA
2000
Activation of the E2F transcription factor in adenovirus-infected cells involves E1A-dependent stimulation of DNA-binding activity and induction of cooperative binding mediated by an E4 gene product
1990
Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.
1987
Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells
1996
Adenovirus Late Gene Expression Does Not Require a Rev-Like Nuclear RNA Export Pathway
2000
Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides
1985
An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F.
1990
The Adenovirus Type 5 E1B-55K Oncoprotein Actively Shuttles in Virus-Infected Cells, Whereas Transport of E4orf6 Is Mediated by a CRM1-Independent Mechanism
2001
Human Adeno-Associated Virus Type 5 Is Only Distantly Related to Other Known Primate Helper-Dependent Parvoviruses
1999 StandoutNobel
The adenovirus E1B 55 kd protein influences mRNA transport via an intranuclear effect on RNA metabolism.
1989
Two Distinct Activities Contribute to the Oncogenic Potential of the Adenovirus Type 5 E4orf6 Protein
2000
Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C
1995 StandoutScienceNobel
Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport.
1985
Inducible binding of a factor to the c-fos enhancer
1986
Adenoviral control regions activated by E1A and the cAMP response element bind to the same factor.
1988
Transcriptional activation of cloned human β-globin genes by viral immediate-early gene products
1983
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Oncogenic potential of the adenovirus E4orf6 protein.
1996
An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.
1994
Role of E2F transcription factor in E1A-mediated trans activation of cellular genes
1991
A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway.
1990
TheC. elegansvitellogenin genes: short sequence repeats in the promoter regions and homology to the vertebrate genes
1985
An adenovirus early region 4 gene product is required for induction of the infection-specific form of cellular E2F activity.
1989
Adenovirus EIIA early promoter: transcriptional control elements and induction by the viral pre-early EIA gene, which appears to be sequence independent.
1985
The human β-interferon gene enhancer is under negative control
1986
Replication of ONYX-015, a Potential Anticancer Adenovirus, Is Independent of p53 Status in Tumor Cells
1998 StandoutNobel
Analysis of the proliferating cell nuclear antigen promoter and its response to adenovirus early region 1.
1990
Co-transcribed 3′ host sequences augment expression of integrated hepatitis B virus DNA.
1985
The adenovirus E4 17-kilodalton protein complexes with the cellular transcription factor E2F, altering its DNA-binding properties and stimulating E1A-independent accumulation of E2 mRNA
1990
A Functional Complex of Adenovirus Proteins E1B-55kDa and E4orf6 Is Necessary To Modulate the Expression Level of p53 but Not Its Transcriptional Activity
2000
Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells
1997
Antibodies specific for the carboxy- and amino-terminal regions of simian virus 40 large tumor antigen.
1980
Multicomponent differentiation-regulated transcription factors in F9 embryonal carcinoma stem cells.
1991
Enhancer I Predominance in Hepatitis B Virus Gene Expression
2004
A Drosophila CREB/CREM Homolog Encodes Multiple Isoforms, Including a Cyclic AMP-Dependent Protein Kinase-Responsive Transcriptional Activator and Antagonist
1995
Adenovirus E1B Proteins Are Required for Accumulation of Late Viral mRNA and for Effects on Cellular mRNA Translation and Transport
1985
Real-Time Sensing and Discrimination of Single Chemicals Using the Channel of Phi29 DNA Packaging Nanomotor
2012
Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection
1987
42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter
1987 StandoutNobel
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA
1985 StandoutNobel
A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus
1985
Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff
1985
Viruses in Human Cancers
1991 StandoutScienceNobel
Association of adenovirus early-region 1A proteins with cellular polypeptides.
1986
Characterization of the major mRNAs from adenovirus 2 early region 4 by cDNA cloning and sequencing
1984 StandoutNobel
Analysis of Synthesis, Stability, Phosphorylation, and Interacting Polypeptides of the 34-Kilodalton Product of Open Reading Frame 6 of the Early Region 4 Protein of Human Adenovirus Type 5
1999
The product of the avian erythroblastosis virus erbB locus is a glycoprotein
1983 StandoutNobel
In vitro mutagenesis of a putative DNA binding domain of SV40 large-T
1984
Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.
1993
Analysis of xbx genes in C. elegans
2005 StandoutNobel
A simplified system for generating recombinant adenoviruses
1998 Standout
Cooperative Interactions Between the Caenorhabditis elegans Homeoproteins UNC-86 and MEC-3
1993 StandoutScienceNobel
Cognate DNA Binding Specificity Retained After Leucine Zipper Exchange Between GCN4 and C/EBP
1989 StandoutScienceNobel
Identification of Three Functions of the Adenovirus E4orf6 Protein That Mediate p53 Degradation by the E4orf6-E1B55K Complex
2001
A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4.
1993
The product of the retroviral transforming gene v-myb is a truncated version of the protein encoded by the cellular oncogene c-myb
1983 StandoutNobel
Functional domains of adenovirus type 5 E1a proteins
1987
The Adenovirus E1B-55K Transforming Polypeptide Modulates Transport or Cytoplasmic Stabilization of Viral and Host Cell mRNAs
1986
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
Blockage by Adenovirus E4orf6 of Transcriptional Activation by the p53 Tumor Suppressor
1996 Science
Polyoma virus DNA replication requires an enhancer
1984 Nature
Analyses of Single-Amino-Acid Substitution Mutants of Adenovirus Type 5 E1B-55K Protein
2001
Sequence analysis in the E1 region of adenovirus type 4 DNA
1986
Control of rDNA replication in Tetrahymena involves a cis-acting upstream repeat of a promoter element
1986 StandoutNobel
Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion
1984
Differences in human α- and β-globin gene expression in mouse erythroleukemia cells: The role of intragenic sequences
1984 StandoutNobel
Regulation of p53-dependent apoptosis, transcriptional repression, and cell transformation by phosphorylation of the 55-kilodalton E1B protein of human adenovirus type 5
1997
Adenovirus E4-dependent activation of the early E2 promoter is insufficient to promote the early-to-late-phase transition
1991
Persistent and Transient Replication of Full-Length Hepatitis C Virus Genomes in Cell Culture
2002
Works of Patrick Hearing being referenced
Control of adenovirus packaging
2005
EivF, a factor required for transcription of the adenovirus EIV promoter, binds to an element involved in EIa-dependent activation and cAMP induction.
1988
Interaction of EF-C/RFX-1 with the Inverted Repeat of Viral Enhancer Regions Is Required for Transactivation
1995
Adenovirus-Facilitated Nuclear Translocation of Adeno-Associated Virus Type 2
2002
The adenovirus type 5 E1A enhancer contains two functionally distinct domains: One is specific for E1A and the other modulates all early units in cis
1986
Cellular Components Interact with Adenovirus Type 5 Minimal DNA Packaging Domains
1998
Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection
1989
The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor, E2F, through a direct complex.
1989
The Adenovirus E4-6/7 Protein Transactivates the E2 Promoter by Inducing Dimerization of a Heteromeric E2F Complex
1994
Bipartite structure and functional independence of adenovirus type 5 packaging elements
1997
Identification of a repeated sequence element required for efficient encapsidation of the adenovirus type 5 chromosome
1987
Nuclear factor EF-1A binds to the adenovirus E1A core enhancer element and to other transcriptional control regions.
1989
Independent cyclic AMP and E1A induction of adenovirus early region 4 expression
1989
Functional interaction of nuclear factors EF-C, HNF-4, and RXR alpha with hepatitis B virus enhancer I
1993
Sequence-Independent Autoregulation of the Adenovirus Type 5 E1A Transcription Unit
1985
Distinct Roles of the Adenovirus E4 ORF3 Protein in Viral DNA Replication and Inhibition of Genome Concatenation
2003
Cellular proteins associated with simian virus 40 early gene products in newly infected cells
1979
Analysis of adenovirus early region 4-encoded polypeptides synthesized in productively infected cells
1987
cis and trans requirements for the selective packaging of adenovirus type 5 DNA
1992
Interaction of a nuclear factor with the polyomavirus enhancer region.
1986
Adenovirus early region 1B 58,000-dalton tumor antigen is physically associated with an early region 4 25,000-dalton protein in productively infected cells
1984
The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element
1983
RFX1 is identical to enhancer factor C and functions as a transactivator of the hepatitis B virus enhancer.
1993
RFX1 is Identical to Enhancer Factor C and Functions as a Transactivator of the Hepatitis B Virus Enhancer
1993
Cellular transcription factor binds to adenovirus early region promoters and to a cyclic AMP response element
1988
Functional analysis of the nucleotide sequence surrounding the cap site for adenovirus type 5 region E1A messenger RNAs
1983
Adenovirus type 5 packaging domain is composed of a repeated element that is functionally redundant
1990
Identification and characterization of an immunologically conserved adenovirus early region 11,000 Mr protein and its association with the nuclear matrix
1982
The adenovirus E4-6/7 protein transactivates the E2 promoter by inducing dimerization of a heteromeric E2F complex.
1994