Citation Impact
Citing Papers
Activation of the p62‐Keap1‐NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
2015 Standout
Oxidative Stress
2017 Standout
Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells
2014 Science
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
2014 Standout
Loss of C9 ORF 72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death
2016
Transcriptional Regulation by Nrf2
2017 Standout
Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy
2015
The multifaceted role of Nrf2 in mitochondrial function
2016
dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region
2022 StandoutNobel
KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
2017
Ferroptosis: molecular mechanisms and health implications
2020 Standout
Head and neck squamous cell carcinoma
2020 Standout
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
2015
Ferroptosis: Death by Lipid Peroxidation
2015 Standout
Glutathione peroxidases
2012 Standout
R loops: new modulators of genome dynamics and function
2015
Reduced formation of depurinating estrogen-DNA adducts by sulforaphane or KEAP1 disruption in human mammary epithelial MCF-10A cells
2013
Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor
2011
Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability
2014
Targeting Ferroptosis to Iron Out Cancer
2019 Standout
Identification of aldo-keto reductases as NRF2-target marker genes in human cells
2013
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
2022 Standout
NRF2 and the Hallmarks of Cancer
2018
Targeting oxidative stress in disease: promise and limitations of antioxidant therapy
2021 Standout
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
2015
Isotope-targeted glycoproteomics (IsoTaG): a mass-independent platform for intact N- and O-glycopeptide discovery and analysis
2015 StandoutNobel
C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles
2016
Cancer stem cells revisited
2017 Standout
Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder
2020
Non-coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNA
2015
Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing
2015
High-resolution AFM structure of DNA G-wires in aqueous solution
2018
Decoding ALS: from genes to mechanism
2016 StandoutNature
Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates
2019 Standout
From Krebs to clinic: glutamine metabolism to cancer therapy
2016 Standout
The Effects of Sequence Variation on Genome-wide NRF2 Binding—New Target Genes and Regulatory SNPs
2016
SuFExable polymers with helical structures derived from thionyl tetrafluoride
2021 StandoutNobel
Rapid online buffer exchange for screening of proteins, protein complexes and cell lysates by native mass spectrometry
2020 StandoutNobel
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Regulation of Ferroptotic Cancer Cell Death by GPX4
2014 Standout
Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration
2018
Widespread Translational Remodeling during Human Neuronal Differentiation
2017 StandoutNobel
NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
2019 Standout
Intrinsically disordered proteins in cellular signalling and regulation
2014 Standout
Oxidative Stress in Cancer
2020 Standout
R-Loops as Cellular Regulators and Genomic Threats
2019
Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS
2014
G-quadruplex structures mark human regulatory chromatin
2016
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
2014 Standout
Ferroptosis: process and function
2016 Standout
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
2022 Standout
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
2015 Standout
Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death
2014
Targeting ferroptosis as a vulnerability in cancer
2022 Standout
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
2019 Standout
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
2019 StandoutNature
Ferroptosis: mechanisms, biology and role in disease
2021 Standout
Mitochondrial free fatty acid β-oxidation supports oxidative phosphorylation and proliferation in cancer cells
2015
The Role of Dipeptide Repeats in C9ORF72-Related ALS-FTD
2017
Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers
2016
The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells
2012
PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2
2016 StandoutNobel
Nrf2 activation improves experimental rheumatoid arthritis
2023 StandoutNobel
The Roles of NRF2 in Modulating Cellular Iron Homeostasis
2017
NRF2 and Hypoxia-Inducible Factors: Key Players in the Redox Control of Systemic Iron Homeostasis
2020
Inhibition of the NRF2/KEAP1 Axis: A Promising Therapeutic Strategy to Alter Redox Balance of Cancer Cells
2021
Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities
2018
Modulating NRF2 in Disease: Timing Is Everything
2018
Nrf2, the Master Regulator of Anti-Oxidative Responses
2017
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
2016 Standout
Protein Analysis by Shotgun/Bottom-up Proteomics
2013
Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease
2016
Mitochondrial Proteomics Approach Reveals Voltage-Dependent Anion Channel 1 (VDAC1) as a Potential Biomarker of Gastric Cancer
2015
Gene targets of sulforaphane in head and neck squamous cell carcinoma
2019
Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane
2017
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
2018 Standout
Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function
2016
Mechanisms of Diabetic Complications
2013 Standout
Clinical significance of T cell metabolic reprogramming in cancer
2016
The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
2020
Bioorthogonal Labeling of Human Prostate Cancer Tissue Slice Cultures for Glycoproteomics
2017 StandoutNobel
Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal
2014 Standout
Combination therapy strategies for improving PD‐1 blockade efficacy: a new era in cancer immunotherapy
2017 StandoutNobel
2016
GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function
2015
CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks
2020 StandoutNobel
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
2015
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
2016 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
Works of Patrick G. Shaw being referenced
Screening for therapeutic targets of vorinostat by SILAC‐based proteomic analysis in human breast cancer cells
2010
Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles
2011
Inhibition of histone deacetylase suppresses EGF signaling pathways by destabilizing EGFR mRNA in ER-negative human breast cancer cells
2008
Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells
2011
Integrated Proteomic and Metabolic Analysis of Breast Cancer Progression
2013
C9orf72 nucleotide repeat structures initiate molecular cascades of disease
2014 Nature