Citation Impact
Citing Papers
Human cerebral organoids recapitulate gene expression programs of fetal neocortex development
2015 StandoutNobel
K-ras and Wnt Signaling Synergize to Accelerate Prostate Tumorigenesis in the Mouse
2008
A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth
2013
Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis
2013
Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target
2008 Science
miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway
2014
Genome-wide gain-of-function screen identifies novel regulators of pluripotency
2010
Ki67 Index, HER2 Status, and Prognosis of Patients With Luminal B Breast Cancer
2009 Standout
Postnatal Deletion of Fat Storage-inducing Transmembrane Protein 2 (FIT2/FITM2) Causes Lethal Enteropathy
2015
Immunohistochemistry versus Microsatellite Instability Testing For Screening Colorectal Cancer Patients at Risk For Hereditary Nonpolyposis Colorectal Cancer Syndrome
2008
Hallmarks of Cancer: The Next Generation
2011 Standout
G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway
2009 StandoutNobel
Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma
2004 Standout
Deficient mismatch repair system in patients with sporadic advanced colorectal cancer
2009
The Intestinal Crypt, A Prototype Stem Cell Compartment
2013
The molecular hallmarks of epigenetic control
2016 Standout
Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications
2006
Signals from the lysosome: a control centre for cellular clearance and energy metabolism
2013 Standout
Frequency of Hereditary Non-Polyposis Colorectal Cancer among Unselected Patients with Colorectal Cancer in Germany
2006
HNPCC versus sporadic microsatellite-unstable colon cancers follow different routes toward loss of HLA class I expression
2007
Can we safely target the WNT pathway?
2014
Microsatellite Instability in Colorectal Cancer
2010 Standout
Inflammation and Cancer: Triggers, Mechanisms, and Consequences
2019 Standout
A Two-Step Model for Colon Adenoma Initiation and Progression Caused by APC Loss
2009
Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease−Associated Colorectal Cancers
2016
Genetic Dissection of Differential Signaling Threshold Requirements for the Wnt/β-Catenin Pathway In Vivo
2010
Forces in Tissue Morphogenesis and Patterning
2013 Standout
Dysregulation of Wnt/β-Catenin Signaling in Gastrointestinal Cancers
2011
Wnt Signaling in Cancer
2012
β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
2010
Nanomedicine and drug delivery strategies for treatment of inflammatory bowel disease
2015
Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer
2015
Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis
2008 Standout
Abl Regulates Planar Polarized Junctional Dynamics through β-Catenin Tyrosine Phosphorylation
2012
Wnt signaling in cancer
2016 Standout
Transforming Growth Factor-β Signaling in Immunity and Cancer
2019 Standout
WNT signalling pathways as therapeutic targets in cancer
2012 Standout
Highly penetrant hereditary cancer syndromes
2004
Single-cell messenger RNA sequencing reveals rare intestinal cell types
2015 Nature
Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments
2016
Podocalyxin variants and risk of prostate cancer and tumor aggressiveness
2006
Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways
2009 StandoutNobel
Hereditary ovarian carcinoma: Heterogeneity, molecular genetics, pathology, and management
2009
Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer
2016 Standout
Effects of extracellular matrix viscoelasticity on cellular behaviour
2020 StandoutNature
Cancer stem cells revisited
2017 Standout
Inherited Cancer Syndromes in Children and Young Adults
2010
Restriction of intestinal stem cell expansion and the regenerative response by YAP
2012 Nature
Role of transforming growth factor-β superfamily signaling pathways in human disease
2008
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
2015 Standout
Lynch Syndrome Patients with Limited Family History Identified in a Laboratory Setting: A Descriptive Study
2015 Standout
EGAPP supplementary evidence review: DNA testing strategies aimed at reducing morbidity and mortality from Lynch syndrome
2009
Interplay between metabolic identities in the intestinal crypt supports stem cell function
2017 Nature
Inflammation and Colon Cancer
2010 Standout
Intestinal label-retaining cells are secretory precursors expressing Lgr5
2013 Nature
Cancer in inflammatory bowel disease
2012
Wnt/β-catenin signaling in cancer stemness and malignant behavior
2007
The DNA Damage Response: Making It Safe to Play with Knives
2010 Standout
Dynamics and functions of lipid droplets
2018 Standout
Annual report to the nation on the status of cancer, 1975‐2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates
2009 Standout
Microfluidic organs-on-chips
2014 Standout
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways
2017 StandoutNobel
Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters
2016
Identification and characterization of genomic rearrangements ofMSH2 andMLH1 in Lynch syndrome (HNPCC) by novel techniques
2003
The essence of senescence: Figure 1.
2010 Standout
Remodelling the extracellular matrix in development and disease
2014 Standout
Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes MSH2, MLH1, MSH6, and PMS2 responsible for hereditary nonpolyposis colorectal cancer (HNPCC)
2005
Ink4a/Arf and Oncogene-Induced Senescence Prevent Tumor Progression during Alternative Colorectal Tumorigenesis
2010
Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression
2009
Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study
2017 Standout
Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer
2009
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
Intestinal epithelial cells: regulators of barrier function and immune homeostasis
2014 Standout
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
2010
Review article: the Lynch syndrome (hereditary nonpolyposis colorectal cancer)*
2007
Genomic Profiling of MicroRNAs and Messenger RNAs Reveals Hormonal Regulation in MicroRNA Expression in Human Endometrium1
2009
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
2015 StandoutNature
Technology Insight: identification of biomarkers with tissue microarray technology
2004
Cisplatin in cancer therapy: Molecular mechanisms of action
2014 Standout
Sensors and regulators of intracellular pH
2009 Standout
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
2009 Standout
Knocking down barriers: advances in siRNA delivery
2009 Standout
β-Catenin Is Required for the Tumorigenic Behavior of Triple-Negative Breast Cancer Cells
2015
Notch: Architect, Landscaper, and Guardian of the Intestine
2011 Standout
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
2017 Standout
Loss of the chloride channel ClC‐7 leads to lysosomal storage disease and neurodegeneration
2005
Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications
2009
Receptor subtype discrimination using extensive shape complementary designed interfaces
2019 StandoutNobel
Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
2008 Nature
Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice
2008
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
TGF-β signaling alterations and susceptibility to colorectal cancer
2007
A Founder Mutation of the <EMPH TYPE="ITAL">MSH2</EMPH> Gene and Hereditary Nonpolyposis Colorectal Cancer in the United States
2004
Modeling Development and Disease with Organoids
2016 Standout
DLS and zeta potential – What they are and what they are not?
2016 Standout
Fusobacterium nucleatum — symbiont, opportunist and oncobacterium
2018 Standout
Immunogenic cell death and DAMPs in cancer therapy
2012 Standout
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
2013 Standout
Use of Microsatellite Instability and Immunohistochemistry Testing for the Identification of Individuals at Risk for Lynch Syndrome
2005
Signaling Receptors for TGF-β Family Members
2016
Genetic reconstitution of tumorigenesis in primary intestinal cells
2013
The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY
2017 Standout
Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts
2014
Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium
2008
Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling
2011
KIT (CD117)-Positive Breast Cancers Are Infrequent and Lack KIT Gene Mutations
2004
Organogenesis in a dish: Modeling development and disease using organoid technologies
2014 StandoutScience
The MicroRNA Spectrum in 12 Body Fluids
2010 Standout
Feasibility of Screening for Lynch Syndrome Among Patients With Colorectal Cancer
2008
Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications
2013 Science
Wnt signalling in development and disease
2008
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
Targeting LGR5 + cells with an antibody-drug conjugate for the treatment of colon cancer
2015
Bioorthogonal Labeling of Human Prostate Cancer Tissue Slice Cultures for Glycoproteomics
2017 StandoutNobel
Immunohistochemical Test for MLH1 and MSH2 Expression Predicts Clinical Outcome in Stage II and III Colorectal Cancer Patients
2006
Works of Patrick Franken being referenced
Progesterone Inhibition of Wnt/β-Catenin Signaling in Normal Endometrium and Endometrial Cancer
2009
Smad4 haploinsufficiency: a matter of dosage
2008
β-Catenin signaling dosage dictates tissue-specific tumor predisposition in Apc-driven cancer
2012
Wnt pathway-related gene expression during malignant progression in ulcerative colitis
2007
Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer
2016
Cross-Species Comparison of Human and Mouse Intestinal Polyps Reveals Conserved Mechanisms in Adenomatous Polyposis Coli (APC)-Driven Tumorigenesis
2008
Tumour–stroma interactions in colorectal cancer: converging on β-catenin activation and cancer stemness
2008
APC and Oncogenic KRAS Are Synergistic in Enhancing Wnt Signaling in Intestinal Tumor Formation and Progression
2006
First-trimester diagnosis of late-infantile neuronal ceroid lipofuscinosis (LINCL) by tripeptidyl peptidase I assay and CLN2 mutation analysis
2001
Paneth Cells in Intestinal Homeostasis and Tissue Injury
2012
Conventional and Tissue Microarray Immunohistochemical Expression Analysis of Mismatch Repair in Hereditary Colorectal Tumors
2003
β -catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis
2011
Generation of a tightly regulated doxycycline‐inducible model for studying mouse intestinal biology
2008
A 10‐Mb paracentric inversion of chromosome arm 2p inactivates MSH2 and is responsible for hereditary nonpolyposis colorectal cancer in a North‐American kindred
2002
A Targeted Constitutive Mutation in the Apc Tumor Suppressor Gene Underlies Mammary But Not Intestinal Tumorigenesis
2009
TGFBR1☆6A May Contribute to Hereditary Colorectal Cancer
2005