Standout Papers
Citation Impact
Citing Papers
Emergence of spatial structure in the tumor microenvironment due to the Warburg effect
2013
T cell metabolism drives immunity
2015
Normalization of CD4 + T cell metabolism reverses lupus
2015
Targeted cell killing by reconstituted caspases
2007 StandoutNobel
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
2010 StandoutNobel
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
Notch signalling controls pancreatic cell differentiation
1999 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism
2024 StandoutNobel
PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity
2020
Emerging Role for Members of the Bcl-2 Family in Mitochondrial Morphogenesis
2009
The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo
2015
From molecular to modular cell biology
1999 StandoutNatureNobel
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Regulation and function of mTOR signalling in T cell fate decisions
2012
MYC on the Path to Cancer
2012 Standout
A guide to immunometabolism for immunologists
2016 Standout
A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome
2001
Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase
2003 StandoutNobel
The biology and management of non-small cell lung cancer
2018 StandoutNature
Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch
2013
Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis
2010
Cancer Cell Metabolism: Warburg and Beyond
2008 Standout
Expression of Ndi1p, an alternative NADH:ubiquinone oxidoreductase, increases mitochondrial membrane potential in a C. elegans model of mitochondrial disease
2007
Apoptosis: controlled demolition at the cellular level
2007 Standout
Autophagy fights disease through cellular self-digestion
2008 StandoutNature
Caspase activation and apoptosis in response to proteasome inhibitors
2005
The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection
2014
Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis
2016
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
2014
Role of autophagy in cancer
2007 Standout
Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells
2009
Proliferating cell nuclear antigen: More than a clamp for DNA polymerases
1997
Chemical modulators of autophagy as biological probes and potential therapeutics
2010
From Krebs to clinic: glutamine metabolism to cancer therapy
2016 Standout
Metabolism of inflammation limited by AMPK and pseudo-starvation
2013 Nature
IKK/NF- B signaling: balancing life and death - a new approach to cancer therapy
2005 Standout
ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death
2010
Famine versus feast: understanding the metabolism of tumors in vivo
2015
Insight into the heterogeneity of breast cancer through next-generation sequencing
2011
Caspase- and mitochondrial dysfunction-dependent mechanisms of lysosomal leakage and cathepsin B activation in DNA damage-induced apoptosis
2005
UV Irradiation Triggers Ubiquitin-Dependent Degradation of p21WAF1 to Promote DNA Repair
2003
Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization
2010
Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation
2010
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
2015 Standout
Targeting T Cell Immunometabolism for Cancer Immunotherapy; Understanding the Impact of the Tumor Microenvironment
2014
Cytochrome c is released in a single step during apoptosis
2005 StandoutNobel
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
The Cdk and PCNA domains on p21Cip1both function to inhibit G1/S progression during hyperoxia
2004
Mitochondria in the Regulation of Innate and Adaptive Immunity
2015
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
Autophagy and Aging
2011 Standout
Proteasomal Turnover of p21Cip1 Does Not Require p21Cip1 Ubiquitination
2000
Modulation of intracellular ROS levels by TIGAR controls autophagy
2009
Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways
2005
Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
2013 Standout
Self-eating and self-killing: crosstalk between autophagy and apoptosis
2007 Standout
Translational activation of the lck proto-oncogene
1988 StandoutNatureNobel
Mitochondria as multifaceted regulators of cell death
2019 Standout
The Hallmarks of Aging
2013 Standout
MYC-induced reprogramming of glutamine catabolism supports optimal virus replication
2015
Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling
2013
T cell metabolic fitness in antitumor immunity
2015
Latent KSHV Infected Endothelial Cells Are Glutamine Addicted and Require Glutaminolysis for Survival
2015
Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development
2014
Autophagy in immunity and inflammation
2011 StandoutNature
Mitochondria and cell death: outer membrane permeabilization and beyond
2010 Standout
Targeting T cell metabolism for therapy
2015
Molecular regulation of effector and memory T cell differentiation
2014
Computational design of a synthetic PD-1 agonist
2021 StandoutNobel
Serotonin modulates a specific potassium current in the sensory neurons that show presynaptic facilitation in Aplysia.
1982 StandoutNobel
Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC
2012
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
The Pathophysiology of Mitochondrial Cell Death
2004 StandoutScience
Cell Communication, Calcium Ion, and Cyclic Adenosine Monophosphate
1970 Science
PAROTIN: A SALIVARY GLAND HORMONE
1960
A specific subdomain in φ29 DNA polymerase confers both processivity and strand-displacement capacity
2005 StandoutNobel
Identification of a Cyclin-cdk2 Recognition Motif Present in Substrates and p21-Like Cyclin-Dependent Kinase Inhibitors
1996 StandoutNobel
Measuring Bioenergetics in T Cells Using a Seahorse Extracellular Flux Analyzer
2016
Mitochondria and the Autophagy–Inflammation–Cell Death Axis in Organismal Aging
2011 Science
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists
1999 StandoutNobel
Developmental biology of the pancreas
1995
Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
2015
Mitochondrial Fission, Fusion, and Stress
2012 StandoutScience
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Autophagy During Cardiac Stress: Joys and Frustrations of Autophagy
2010
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
2004 StandoutNobel
A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells.
1996
CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors
1997 Standout
Membrane flow and interconversions among endomembranes
1979
Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal
1962 StandoutNobel
Genetically targeted cell disruption in Caenorhabditis elegans
1997 StandoutNobel
Intracellular Aspects of the Process of Protein Synthesis
1975 StandoutScienceNobel
Fueling Immunity: Insights into Metabolism and Lymphocyte Function
2013 Science
mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function
2014
Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene
1987
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1
2004 StandoutNobel
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Compartmentalized assembly of oligosaccharides on exported glycoproteins in yeast
1981 StandoutNobel
Infection of primary cells by adeno-associated virus type 2 results in a modulation of cell cycle-regulating proteins
1997 StandoutNobel
Works of Patrick Fitzgerald being referenced
Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration
2006
The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
2011 Standout
Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway
1999
Homogeneity and heterogeneity in pancreas cancer: presence of predominant and minor morphological types and implications
1986
Disruption of Mitochondrial Function during Apoptosis Is Mediated by Caspase Cleavage of the p75 Subunit of Complex I of the Electron Transport Chain
2004
Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway
1999
GAPDH and Autophagy Preserve Survival after Apoptotic Cytochrome c Release in the Absence of Caspase Activation
2007
Role for Cyclin A-dependent Kinase in DNA Replication in Human S Phase Cell Extracts
1996
LOCALIZATION OF RADIOACTIVITY AFTER ADMINISTRATION OF LABELED PROLACTIN PREPARATIONS TO THE FEMALE RAT
1951
Pancreatic acinar cell regeneration. IV. Regeneration after resection.
1968
Pancreatic acinar cell regeneration.
1968
CHANGES IN PANCREATIC ACINAR CELLS DURING PROTEIN DEPRIVATION
1962
Pancreatic Acinar Cell Regeneration
1966 Nature
The comparative ultrastructure of the pancreatic islet of Langerhans
1966
Pancreas acinar cell differentiation. I. Morphologic and enzymatic comparisons of embryonic rat pancreas anlage grown in organ culture.
1969
p21 contains independent binding sites for cyclin and cdk2: both sites are required to inhibit cdk2 kinase activity.
1996