Standout Papers
Citation Impact
Citing Papers
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
2012 Standout
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
2013 StandoutScience
Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota
2012 StandoutScience
A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair
2013
PARP inhibitors: Synthetic lethality in the clinic
2017 StandoutScience
Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer
2013
Mouse Embryonic Stem Cells, but Not Somatic Cells, Predominantly Use Homologous Recombination to Repair Double-Strand DNA Breaks
2010
Classical and Alternative End-Joining Pathways for Repair of Lymphocyte-Specific and General DNA Double-Strand Breaks
2012
Long Patch Base Excision Repair Proceeds via Coordinated Stimulation of the Multienzyme DNA Repair Complex
2009 StandoutNobel
Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)
2015
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
DNA Ends Alter the Molecular Composition and Localization of Ku Multicomponent Complexes
2012
The DNA-damage response in human biology and disease
2009 StandoutNature
Base-excision repair of oxidative DNA damage
2007 StandoutNature
Critical DNA damage recognition functions of XPC‐hHR23B and XPA‐RPA in nucleotide excision repair
2003
Replication Protein A Confers Structure-specific Endonuclease Activities to the XPF-ERCC1 and XPG Subunits of Human DNA Repair Excision Nuclease
1996 StandoutNobel
The role of DNA dependent protein kinase in synapsis of DNA ends
2003
Spontaneous tumor development in bone marrow-rescued DNA-PKcs3A/3A mice due to dysfunction of telomere leading strand deprotection
2015
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
2012
DNA-PKcs and ATM co-regulate DNA double-strand break repair
2009
Long-patch base excision repair of apurinic/apyrimidinic site DNA is decreased in mouse embryonic fibroblast cell lines treated with plumbagin: involvement of cyclin-dependent kinase inhibitor p21Waf-1/Cip-1
2002
Replication Protein A phosphorylation and the cellular response to DNA damage
2004
In Vitro Chemiluminescence Assay to Measure Excision Repair in Cell Extracts
2003
Chemotherapy-related secondary leukemias: A role for DNA repair by error-prone non-homologous end joining in topoisomerase II — Induced chromosomal rearrangements
2006
Order of Assembly of Human DNA Repair Excision Nuclease
1999 StandoutNobel
Damage recognition in nucleotide excision repair of DNA
2000
Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells
2015
Using Yeast to Understand Drugs that Target Topoisomerasesa
1996
In vitro eukaryotic DNA excision repair assays: An overview
1995
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks
2009 StandoutNobel
Reaction Mechanism of Human DNA Repair Excision Nuclease
1996 StandoutNobel
DNA damage recognition during nucleotide excision repair in mammalian cells
1999
Regulation of DNA double-strand break repair pathway choice
2007
DNA repair deficiency as a therapeutic target in cancer
2008
Roles of base excision repair subpathways in correcting oxidized abasic sites in DNA
2006
Xeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein
2002
Role of Artemis in DSB repair and guarding chromosomal stability following exposure to ionizing radiation at different stages of cell cycle
2006
Open complex formation around a lesion during nucleotide excision repair provides a structure for cleavage by human XPG protein
1997
Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient
1999
The diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art
2012
Multiple functions of MRN in end-joining pathways during isotype class switching
2009
Differential human nucleotide excision repair of paired and mispaired cisplatin-DNA adducts
1997
Impairment of Proliferating Cell Nuclear Antigen-dependent Apurinic/Apyrimidinic Site Repair on Linear DNA
1998
MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings
2008
Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones
2007
Analysis of Incision Sites Produced by Human Cell Extracts and Purified Proteins during Nucleotide Excision Repair of a 1,3-Intrastrand d(GpTpG)-Cisplatin Adduct
1996
DNA Polymerase β and Flap Endonuclease 1 Enzymatic Specificities Sustain DNA Synthesis for Long Patch Base Excision Repair
2004
Search-and-replace genome editing without double-strand breaks or donor DNA
2019 StandoutNature
PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
2006
DNA Repair: Enzymatic Mechanisms and Relevance to Drug Response
1996
Poly(ADP-ribose): novel functions for an old molecule
2006 Standout
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
IgH class switching and translocations use a robust non-classical end-joining pathway
2007 Nature
A multistep damage recognition mechanism for global genomic nucleotide excision repair
2001
Assay for Nucleotide Excision Repair Protein Activity Using Fractionated Cell Extracts and UV-Damaged Plasmid DNA
2003
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation
2010
The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase and increases its DNA substrate utilisation efficiency: implications for DNA repair
2004
DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
2014
DDB Accumulates at DNA Damage Sites Immediately after UV Irradiation and Directly Stimulates Nucleotide Excision Repair
2002 StandoutNobel
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Therapeutic potential of PARP inhibitors for metastatic breast cancer
2011
Targeting DNA topoisomerase II in cancer chemotherapy
2009 Standout
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells
2004
The Hallmarks of Aging
2013 Standout
Exploring complex networks
2001 StandoutNature
Single-strand break repair and genetic disease
2008
Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?
2015
Chapter 2 DNA-PK
2008
Mammalian DNA nucleotide excision repair reconstituted with purified protein components
1995
Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining
2015
Establishment of a Microplate‐Formatted Cell‐Based Immunoassay for Rapid Analysis of Nucleotide Excision Repair Ability in Human Primary Cells
2012
DNA-protein cross-linking by trans-[PtCl2(E-iminoether)2]. A concept for activation of the trans geometry in platinum antitumor complexes
2003
Mechanisms of resistance to cisplatin
2001
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
2009
Unraveling the Complexities of DNA-Dependent Protein Kinase Autophosphorylation
2014
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination
2009
DNA?protein crosslinks: their induction, repair, and biological consequences
2005
Magnesium in Man: Implications for Health and Disease
2014 Standout
Molecular Interaction Map of the Mammalian Cell Cycle Control and DNA Repair Systems
1999 Nobel
Quality Control by DNA Repair
1999 StandoutScienceNobel
TATA Binding Protein Discriminates between Different Lesions on DNA, Resulting in a Transcription Decrease
1998
THE GENETIC DEFECT IN ATAXIA-TELANGIECTASIA
1997
XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes
2011
Loss of DNA–protein crosslinks from formaldehyde-exposed cells occurs through spontaneous hydrolysis and an active repair process linked to proteosome function
2000
Human XPA and RPA DNA repair proteins participate in specific recognition of triplex-induced helical distortions
2002
Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53
1998 StandoutScience
Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
2003
cis -Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects
2008 StandoutNobel
Highly specific and sensitive method for measuring nucleotide excision repair kinetics of ultraviolet photoproducts in human cells
2013 StandoutNobel
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 StandoutNobel
New synthetic substrates of mammalian nucleotide excision repair system
2013
Assembly, subunit composition, and footprint of human DNA repair excision nuclease
1998 StandoutNobel
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Cancer Genome Landscapes
2013 StandoutScience
ATR-Dependent Phosphorylation of DNA-Dependent Protein Kinase Catalytic Subunit in Response to UV-Induced Replication Stress
2006
Simultaneous precise editing of multiple genes in human cells
2019 StandoutNobel
Loss of DNA–protein crosslinks from formaldehyde-exposed cells occurs through spontaneous hydrolysis and an active repair process linked to proteosome function
2000
Significance analysis of microarrays applied to the ionizing radiation response
2001 Standout
Flap Endonuclease 1: A Central Component of DNA Metabolism
2004
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
2017 StandoutNobel
Nuclear to Cytoplasmic Translocation of Heterogeneous Nuclear Ribonucleoprotein U Enhances TLR-Induced Proinflammatory Cytokine Production by Stabilizing mRNAs in Macrophages
2012
hMutSβ Is Required for the Recognition and Uncoupling of Psoralen Interstrand Cross-Links In Vitro
2002
Initiation of DNA Interstrand Cross-Link Repair in Humans: the Nucleotide Excision Repair System Makes Dual Incisions 5′ to the Cross-linked Base and Removes a 22- to 28-Nucleotide-long Damage-Free Strand
1997 StandoutNobel
Human DNA Repair Genes
2001 StandoutScienceNobel
Direct Cellular Responses to Platinum-Induced DNA Damage
2007
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
DNA-Induced Dimerization of Poly(ADP-ribose) Polymerase-1 Triggers Its Activation
2005
Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage
1998 StandoutScience
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
2010 StandoutNobel
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1
2004 StandoutNobel
Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide
2011 StandoutScience
Removal of oxygen free-radical-induced 5′,8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cells
2000 StandoutNobel
A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia
2004
Repair of DNA–polypeptide crosslinks by human excision nuclease
2006 StandoutNobel
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
Repair of Intermediate Structures Produced at DNA Interstrand Cross-Links in Saccharomyces cerevisiae
2000
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
2016 StandoutNobel
Liquid phase condensation in cell physiology and disease
2017 StandoutScience
Works of Patrick Calsou being referenced
A cisplatin-resistant murine leukemia cell line exhibits increased topoisomerase II activity.
1994
DNA repair activity in protein extracts of fresh human malignant lymphoid cells.
1996
DNA-dependent Protein Kinase and XRCC4-DNA Ligase IV Mobilization in the Cell in Response to DNA Double Strand Breaks
2004
DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal
2014
UV Induction of Excision Repair Enzymes Detected in Protein Extracts from Schizosaccharomyces pombe
1994
Alternative end-joining pathway(s): Bricolage at DNA breaks
2014
DNA excision‐repair synthesis is enhanced in a murine leukemia L1210 cell line resistant to cisplatin
1993
Modification of deoxyribose-phosphate residues by extracts of ataxia telangiectasia cells
1990 StandoutNobel
Role of DNA repair in the mechanisms of cell resistance to alkylating agents and cisplatin
1993
Double Strand Breaks in DNA Inhibit Nucleotide Excision Repair in Vitro
1996
A Chemiluminescent Microplate Assay to Detect DNA Damage Induced by Genotoxic Treatments
1995
Measurement of Damage-Specific DNA Incision by Nucleotide Excision Repair in Vitro
1994
Involvement of Poly(ADP-ribose) Polymerase-1 and XRCC1/DNA Ligase III in an Alternative Route for DNA Double-strand Breaks Rejoining
2004
Repair synthesis by human cell extracts in cisplatin damaged DNA is preferentially determined by minor adducts
1992
UV sensitivity and impaired nucleotide excision repair in DNA-dependent protein kinase mutant cells
1998
Involvement of Polynucleotide Kinase in a Poly(ADP-ribose) Polymerase-1-dependent DNA Double-strand Breaks Rejoining Pathway
2005
Cross-Resistance to Ionizing Radiation in a Murine Leukemic Cell Line Resistant tocis-Dichlorodiammineplatinum(II): Role of Ku Autoantigen
1999
Rapid Quantification of DNA Repair Synthesis in Cell Extracts
1993
The activity of the DNA-dependent protein kinase (DNA-PK) complex is determinant in the cellular response to nitrogen mustards
2000
Effect of double-strand break DNA sequence on the PARP-1 NHEJ pathway
2007
Ku Entry into DNA Inhibits Inward DNA Transactions in Vitro
2000
Interplay between Ku, Artemis, and the DNA-dependent Protein Kinase Catalytic Subunit at DNA Ends
2006
Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks
2011
Properties of damage-dependent DNA incision by nucleotide excision repair in human cell-free extracts
1994
Cell nonhomologous end joining capacity controls SAF-A phosphorylation by DNA-PK in response to DNA double-strand breaks inducers
2009
DNA damage excision repair in microplate wells with chemiluminescence detection: Development and perspectives
1999
The DNA-dependent Protein Kinase Catalytic Activity Regulates DNA End Processing by Means of Ku Entry into DNA
1999
The DNA repair complex DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy
2006
Deficient nucleotide excision repair activity in protein extracts from normal human lymphocytes
1995
Coordinated Assembly of Ku and p460 Subunits of the DNA-dependent Protein Kinase on DNA Ends is Necessary for XRCC4–ligase IV Recruitment
2003
TRF2/RAP1 and DNA–PK mediate a double protection against joining at telomeric ends
2010
Interactions of the transcription/DNA repair factor TFIIH and XP repair proteins with DNA lesions in a cell-free repair assay
1998
Long‐patch DNA repair synthesis during base excision repair in mammalian cells
2003
A noncatalytic function of the ligation complex during nonhomologous end joining
2013
Nucleotide excision repair DNA synthesis by excess DNA polymerase β: a potential source of genetic instability in cancer cells
2000
Preferential Repair Incision of Cross-Links versus Monoadducts in Psoralen-Damaged Plasmid DNA by Human Cell-Free Extracts
1996
Long-term XPC Silencing Reduces DNA Double-Strand Break Repair
2007
DNA Replication but Not Nucleotide Excision Repair Is Required for UVC-Induced Replication Protein A Phosphorylation in Mammalian Cells
2000
A DNA double-strand break defective fibroblast cell line (180BR) derived from a radiosensitive patient represents a new mutant phenotype.
1997