Citation Impact
Citing Papers
Enantioselective palladium-catalysed conjugate addition of arylsiloxanes
2007 StandoutNobel
The influence of drug-like concepts on decision-making in medicinal chemistry
2007 Standout
Fragment-based lead discovery
2004
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Modular click chemistry libraries for functional screens using a diazotizing reagent
2019 StandoutNatureNobel
The influence of lipophilicity in drug discovery and design
2012
The application of in silico drug-likeness predictions in pharmaceutical research
2015
Probing the links between in vitro potency, ADMET and physicochemical parameters
2011
Drug-like properties: guiding principles for design – or chemical prejudice?
2004
Lead- and drug-like compounds: the rule-of-five revolution
2004 Standout
ESKAPEing the labyrinth of antibacterial discovery
2015
How many drug targets are there?
2006 Standout
Prospects for productivity
2004
Probing the β2 Adrenoceptor Binding Site with Catechol Reveals Differences in Binding and Activation by Agonists and Partial Agonists
2005 StandoutNobel
Physicochemical Profiling (Solubility, Permeability and Charge State)
2001
Quantifying the chemical beauty of drugs
2012
ChEMBL: a large-scale bioactivity database for drug discovery
2011 Standout
Using the Golden Triangle to optimize clearance and oral absorption
2009
Drug research: myths, hype and reality
2003
Environmental fate and toxicity of ionic liquids: A review
2009
The Science of Antibiotic Discovery
2020 Standout
A quantitative assessment of hERG liability as a function of lipophilicity
2006
Synthetic mimics of mammalian cell surface receptors: prosthetic molecules that augment living cells
2005
How to improve R&D productivity: the pharmaceutical industry's grand challenge
2010 Standout
Synthetic peroxides as antimalarials
2004
Structure-based drug screening for G-protein-coupled receptors
2012 StandoutNobel
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
The impact of natural products upon modern drug discovery
2008
Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions
2013
The evolution of synthetic oral drug properties
2005
The graphical representation of ADME-related molecule properties for medicinal chemists
2010
Global mapping of pharmacological space
2006
Microfluidic organs-on-chips
2014 Standout
Evaluation of a Liver Microfluidic Biochip to Predict In Vivo Clearances of Seven Drugs in Rats
2013
Modulation of Ocular Surface Glycocalyx Barrier Function by a Galectin-3 N-terminal Deletion Mutant and Membrane-Anchored Synthetic Glycopolymers
2013 StandoutNobel
New G-protein-coupled receptor crystal structures: insights and limitations
2008 StandoutNobel
KEGG for representation and analysis of molecular networks involving diseases and drugs
2009 Standout
Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies
2007
Chemical predictive modelling to improve compound quality
2013
Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors
2012
The rise of fragment-based drug discovery
2009
The ChEMBL database in 2017
2016 Standout
Relating protein pharmacology by ligand chemistry
2007 Standout
The role of drug metabolizing enzymes in clearance
2014
Controllable Donor–Acceptor Neutral [2]Rotaxanes
2004 StandoutNobel
High-throughput drug discovery: What can we expect from HTS?
2005
Prediction of drug-membrane interactions by IAM–HPLC: effects of different phospholipid stationary phases on the partition of bases
2004
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 Standout
The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?
2009
Medicinal chemical properties of successful central nervous system drugs
2005
Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery
2020 StandoutNobel
Iron‐Catalyzed C(sp2)H and C(sp3)H Methylations of Amides and Anilides
2015
Fragment-based lead discovery: leads by design
2005
Antibacterial drug discovery in the resistance era
2016 StandoutNature
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
3d Transition Metals for C–H Activation
2018 Standout
Fluorine in medicinal chemistry
2007 Standout
Room-Temperature Ionic Liquids: Solvents for Synthesis and Catalysis. 2
2011 Standout
pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures
2015 Standout
The Influence of Target Family and Functional Activity on the Physicochemical Properties of Pre-Clinical Compounds
2006
Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals
2014 Standout
Azole-Based Energetic Salts
2011 Standout
Characteristic Physical Properties and Structural Fragments of Marketed Oral Drugs
2003
Docking of Macrocycles: Comparing Rigid and Flexible Docking in Glide
2017
In Situ Click Chemistry: Enzyme Inhibitors Made to Their Own Specifications
2004 StandoutNobel
Influence of Molecular Flexibility and Polar Surface Area Metrics on Oral Bioavailability in the Rat
2004
Enantioselective synthesis of the individual stereoisomers of a brassinolide mimetic
2004
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
Extraction and Analysis of Chemical Modification Patterns in Drug Development
2009
The Many Roles for Fluorine in Medicinal Chemistry
2008 Standout
Dependence of Molecular Properties on Proteomic Family for Marketed Oral Drugs
2006
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry
2007 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Design, Synthesis, and Structure–Activity and Structure–Pharmacokinetic Relationship Studies of Novel [6,6,5] Tricyclic Fused Oxazolidinones Leading to the Discovery of a Potent, Selective, and Orally Bioavailable FXa Inhibitor
2014
Time-Related Differences in the Physical Property Profiles of Oral Drugs
2004
Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy
2014
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Finding the sweet spot: the role of nature and nurture in medicinal chemistry
2012
Formation of a New Ia3d Cubic Meso-Structured Silica via Triblock Copolymer-Assisted Synthesis
2003
Formation Mechanism of Anionic Surfactant-Templated Mesoporous Silica
2006
On the Controllable Soft-Templating Approach to Mesoporous Silicates
2007 Standout
Computational Prediction of Oral Drug Absorption Based on Absorption Rate Constants in Humans
2006
Generation of a Set of Simple, Interpretable ADMET Rules of Thumb
2008
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Organic Carbonates as Solvents in Synthesis and Catalysis
2010 Standout
ETCM: an encyclopaedia of traditional Chinese medicine
2018 Standout
Price-Focused Analysis of Commercially Available Building Blocks for Combinatorial Library Synthesis
2015
In silico prediction of multiple-category classification model for cytochrome P450 inhibitors and non-inhibitors using machine-learning method
2017
Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
2020 StandoutNobel
Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
2009 Standout
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties
2021 Standout
Discovery of Daclatasvir, a Pan-Genotypic Hepatitis C Virus NS5A Replication Complex Inhibitor with Potent Clinical Effect
2014
An architectonic macrolide library based on a C2-symmetric macrodiolide toward pharmaceutical compositions
2015 StandoutNobel
Asymmetric 1,4-addition of aryltrialkoxysilanes to α,β-unsaturated esters and amides catalyzed by a chiral rhodium complex
2006
PubChem in 2021: new data content and improved web interfaces
2020 Standout
An Empirical Process for the Design of High-Throughput Screening Deck Filters
2006
Enzyme-Mediated Preparation of Optically Active 1,2-Diols Bearing a Long Chain: Enantioselective Hydrolysis of Cyclic Carbonates
2000
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds
2014
Noncovalent Cell Surface Engineering: Incorporation of Bioactive Synthetic Glycopolymers into Cellular Membranes
2008 StandoutNobel
A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool
2016
Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety
2011
Benzylamines via Iron-Catalyzed Direct Amination of Benzyl Alcohols
2015 StandoutNobel
7 Supramolecular chemistry
2003
Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues
2011 StandoutNobel
Works of Patrick Barton being referenced
THE BINDING OF DRUGS TO HEPATOCYTES AND ITS RELATIONSHIP TO PHYSICOCHEMICAL PROPERTIES
2004
Drug-Phospholipid Interactions. 2. Predicting the Sites of Drug Distribution Using n-Octanol/Water and Membrane/Water Distribution Coefficients
1997
Transmembrane Signalling
2002
The Effect of lonic Strength on Liposome–Buffer and 1-Octanol–Buffer Distribution Coefficients
1998
Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092
2012
The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties
2002
A Comparison of Physiochemical Property Profiles of Development and Marketed Oral Drugs
2003
QSAR and the Rational Design of Long-Acting Dual D2-Receptor/β2-Adrenoceptor Agonists
2003
Structure–activity relationships in the esterase-catalysed hydrolysis and transesterification of esters and lactones
1994
A Rapid Computational Filter for Cytochrome P450 1A2 Inhibition Potential of Compound Libraries
2005
The resolution of racemic 1,2-diols by the esterase catalysed hydrolysis of the corresponding cyclic carbonate
1992