Standout Papers
- High-Resolution Modeling of Transmembrane Helical Protein Structures from Distant Homologues (2014)
- Prediction of membrane protein structures with complex topologies using limited constraints (2009)
- Ultrahigh resolution drug design I: Details of interactions in human aldose reductase–inhibitor complex at 0.66 Å (2004)
- The Structure of a Receptor with Two Associating Transmembrane Domains on the Cell Surface: Integrin αIIbβ3 (2009)
- Introduction of a polar core into the de novo designed protein
T op7 (2016) - Toward high-resolution prediction and design of transmembrane helical protein structures (2007)
Citation Impact
Citing Papers
Halogen bonds in biological molecules
2004 Standout
Protein interaction networks revealed by proteome coevolution
2019 StandoutScienceNobel
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
Comprehensive computational design of ordered peptide macrocycles
2017 StandoutScienceNobel
Exploiting conformational dynamics to modulate the function of designed proteins
2023 StandoutNobel
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
Protein structure determination using metagenome sequence data
2017 StandoutScienceNobel
Hallucinating symmetric protein assemblies
2022 StandoutScienceNobel
NMR Structure Determination for Larger Proteins Using Backbone-Only Data
2010 StandoutScienceNobel
Accurate computational design of multipass transmembrane proteins
2018 StandoutScienceNobel
Accurate de novo structure prediction of large transmembrane protein domains using fragment-assembly and correlated mutation analysis
2012
Sculpting conducting nanopore size and shape through de novo protein design
2024 StandoutScienceNobel
Conformational equilibria and intrinsic affinities define integrin activation
2017
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
De novo protein design—From new structures to programmable functions
2024
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
Computation and Functional Studies Provide a Model for the Structure of the Zinc Transporter hZIP4
2015 StandoutNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Modulation of Integrin Activation by an Entropic Spring in the β-Knee
2010 StandoutNobel
Halogen bonding in halocarbon–protein complexes: a structural survey
2011
Integrin Structure, Activation, and Interactions
2011
Improved molecular replacement by density- and energy-guided protein structure optimization
2011 StandoutNatureNobel
Models of Voltage-Dependent Conformational Changes in NaChBac Channels
2008
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
An Integrated Framework Advancing Membrane Protein Modeling and Design
2015
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
2016 StandoutNatureNobel
The structure of an integrin/talin complex reveals the basis of inside‐out signal transduction
2009
Talins and kindlins: partners in integrin-mediated adhesion
2013
Structural mechanism of integrin inactivation by filamin
2015
Halogen bonding: an electrostatically-driven highly directional noncovalent interaction
2010 Standout
Dynamics of the Kv1.2 Voltage-Gated K+ Channel in a Membrane Environment
2007
Coarse grained model for exploring voltage dependent ion channels
2011 StandoutNobel
Modelling the catalytic reaction in human aldose reductase
1999
Joint X-ray and neutron refinement withphenix.refine
2010
Piezo proteins are pore-forming subunits of mechanically activated channels
2012 StandoutNatureNobel
Large-Scale Movement within the Voltage-Sensor Paddle of a Potassium Channel—Support for a Helical-Screw Motion
2008
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Abiotic reduction of ketones with silanes catalysed by carbonic anhydrase through an enzymatic zinc hydride
2021
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
2017 StandoutNatureNobel
Nonbonding interactions of organic halogens in biological systems: implications for drug discovery and biomolecular design
2010
An Anion Binding Site in Human Aldose Reductase: Mechanistic Implications for the Binding of Citrate, Cacodylate, and Glucose 6-Phosphate
1994
A Brief History of De Novo Protein Design: Minimal, Rational, and Computational
2021
Constructing ion channels from water-soluble α-helical barrels
2021
Regulation of integrin affinity on cell surfaces
2011
Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology
2010
Halogen bonding (X‐bonding): A biological perspective
2012
Structural and energetic basis of folded-protein transport by the FimD usher
2013 StandoutNatureNobel
The coming of age of de novo protein design
2016 StandoutNatureNobel
Extent of Voltage Sensor Movement during Gating of Shaker K+ Channels
2008
Halogen Bonding in Supramolecular Chemistry
2008
Predicting protein structures with a multiplayer online game
2010 StandoutNatureNobel
Sensing voltage across lipid membranes
2008 Nature
High-resolution crystallography and drug design
2005
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Structure of human aldose reductase holoenzyme in complex with Statil: An approach to structure‐based inhibitor design of the enzyme
2002
Programmable synthetic receptors: the next-generation of cell and gene therapies
2024
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Protein binding specificity versus promiscuity
2010
Improved protein structure prediction using potentials from deep learning
2020 StandoutNatureNobel
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies
2020
A synthetic homing endonuclease-based gene drive system in the human malaria mosquito
2011 StandoutNatureNobel
The Membrane- and Soluble-Protein Helix-Helix Interactome: Similar Geometry via Different Interactions
2015
Aldose reductase: model for a new paradigm of enzymic perfection in detoxification catalysts
1992
Programmable design of orthogonal protein heterodimers
2018 StandoutNatureNobel
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Cryo-EM structure of a type IV secretion system
2022 StandoutNatureNobel
Protein Structure Prediction and Design in a Biologically Realistic Implicit Membrane
2020
Calculation of the Gating Charge for the Kv1.2 Voltage-Activated Potassium Channel
2010
Three-Dimensional Structures of Membrane Proteins from Genomic Sequencing
2012
The Backrub Motion: How Protein Backbone Shrugs When a Sidechain Dances
2006
Regulation of Integrin Activation
2011
Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration
2017 StandoutNobel
Intact αIIbβ3 Integrin Is Extended after Activation as Measured by Solution X-ray Scattering and Electron Microscopy
2011
Mapping the receptor site for α-scorpion toxins on a Na + channel voltage sensor
2011
Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation
2008
Integrin extension enables ultrasensitive regulation by cytoskeletal force
2017
In vitro selection and characterization of RNA aptamers binding thyroxine hormone
2007
Increasing the affinity of selective bZIP‐binding peptides through surface residue redesign
2014
Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
2013 StandoutScienceNobel
One contact for every twelve residues allows robust and accurate topology‐level protein structure modeling
2013 StandoutNobel
Probing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110.
1993
Diiodoacetylene: compact, strong ditopic halogen bond donor
2012
De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity
2016 StandoutScienceNobel
Gating charge interactions with the S1 segment during activation of a Na + channel voltage sensor
2011
High thermodynamic stability of parametrically designed helical bundles
2014 StandoutScienceNobel
Robust and accurate prediction of residue–residue interactions across protein interfaces using evolutionary information
2014 StandoutNobel
Catalytic mechanism of aldose reductase studied by the combined potentials of quantum mechanics and molecular mechanics
1998
Realistic simulation of the activation of voltage-gated ion channels
2012 StandoutNobel
Study of the Halogen Bonding between Pyridine and Perfluoroalkyl Iodide in Solution Phase Using the Combination of FTIR and19F NMR
2013
Macromolecular Modeling with Rosetta
2008 StandoutNobel
Electrostatic complementarity in an aldose reductase complex from ultra-high-resolution crystallography and first-principles calculations
2003
Sequential formation of ion pairs during activation of a sodium channel voltage sensor
2009
Design of self-assembling transmembrane helical bundles to elucidate principles required for membrane protein folding and ion transport
2017
Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement
2010
Recent Developments in the Methods and Applications of the Bond Valence Model
2009 Standout
The Halogen Bond
2016 Standout
The Rosetta All-Atom Energy Function for Macromolecular Modeling and Design
2017 StandoutNobel
Computer Simulation Studies of the Catalytic Mechanism of Human Aldose Reductase
2000 StandoutNobel
Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin
2011 StandoutScienceNobel
Engineering functional materials by halogen bonding
2006
Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin
2016
Molecular Template for a Voltage Sensor in a Novel K+ Channel. III. Functional Reconstitution of a Sensorless Pore Module from a Prokaryotic Kv Channel
2008
Validation of de novo designed water‐soluble and transmembrane β‐barrels by in silico folding and melting
2024
Energetics of Halogen Bonding of Group 10 Metal Fluoride Complexes
2011
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Structural basis for gating charge movement in the voltage sensor of a sodium channel
2011 StandoutNobel
Works of Patrick Barth being referenced
Computational design of dynamic receptor—peptide signaling complexes applied to chemotaxis
2023
Evolutionary-guided de novo structure prediction of self-associated transmembrane helical proteins with near-atomic accuracy
2015
Novel NADPH-binding domain revealed by the crystal structure of aldose reductase
1992 Nature
High-Resolution Modeling of Transmembrane Helical Protein Structures from Distant Homologues
2014 StandoutNobel
A ‘specificity’ pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil
1997
Reprogramming cellular functions with engineered membrane proteins
2017
Closing In on the Resting State of the Shaker K+ Channel
2007
Aldose and aldehyde reductases: Correlation of molecular modeling and mass spectrometric studies on the binding of inhibitors to the active site
2000
Production of crystals of human aldose reductase with very high resolution diffraction
1999
The Structure of a Receptor with Two Associating Transmembrane Domains on the Cell Surface: Integrin αIIbβ3
2009 StandoutNobel
The structure of human aldose reductase bound to the inhibitor IDD384
2000
Computational design of G Protein-Coupled Receptor allosteric signal transductions
2019
Computationally designed GPCR quaternary structures bias signaling pathway activation
2022
Computational design of ligand-binding membrane receptors with high selectivity
2017
Enhancing Structure Prediction and Design of Soluble and Membrane Proteins with Explicit Solvent-Protein Interactions
2017
Toward high-resolution computational design of the structure and function of helical membrane proteins
2016
A topological and conformational stability alphabet for multipass membrane proteins
2016
Ultrahigh resolution drug design I: Details of interactions in human aldose reductase–inhibitor complex at 0.66 Å
2004 Standout
Toward high-resolution prediction and design of transmembrane helical protein structures
2007 StandoutNobel
Targeting Metastable Coiled-Coil Domains by Computational Design
2008
Computational design of orthogonal membrane receptor-effector switches for rewiring signaling pathways
2018
Binding of aldose reductase inhibitors: correlation of crystallographic and mass spectrometric studies
1999
Prediction of membrane protein structures with complex topologies using limited constraints
2009 StandoutNobel
Aldose Reductase from Pig Lens
1995
Naturally evolved G protein-coupled receptors adopt metastable conformations
2012