Citation Impact
Citing Papers
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
2015 StandoutNatureNobel
Risk Associations of Glycemic Burden and Obesity With Liver Cancer—A 10‐Year Analysis of 15,280 Patients With Type 2 Diabetes
2022
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
Targeting Hepatitis B Virus With CRISPR/Cas9
2014
β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
2009 StandoutNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
The Spring α-Helix Coordinates Multiple Modes of HCV (Hepatitis C Virus) NS3 Helicase Action
2016 StandoutNobel
Digital PCR to assess gene-editing frequencies (GEF-dPCR) mediated by designer nucleases
2016
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Inflammation and cancer
2002 StandoutNature
A guide to genome engineering with programmable nucleases
2014 Standout
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
Nanotechnology for therapy and imaging of liver diseases
2011
Control of cccDNA function in hepatitis B virus infection
2009
Redox-triggered intracellular dePEGylation based on diselenide-linked polycations for DNA delivery
2013
mRNA-based therapeutics — developing a new class of drugs
2014 StandoutNobel
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
Bacterial CRISPR/Cas DNA endonucleases: A revolutionary technology that could dramatically impact viral research and treatment
2015
Expanding the Biologist’s Toolkit with CRISPR-Cas9
2015 StandoutNobel
Current prospects for RNA interference-based therapies
2011
Superoxide generation from Kupffer cells contributes to hepatocarcinogenesis: studies on NADPH oxidase knockout mice
2004
The landscape of mRNA nanomedicine
2022
Zinc-finger Nucleases as a Novel Therapeutic Strategy for Targeting Hepatitis B Virus DNAs
2010
Hepatitis B Virus Replication Is Regulated by the Acetylation Status of Hepatitis B Virus cccDNA-Bound H3 and H4 Histones
2006
Harnessing the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated Cas9 system to disrupt the hepatitis B virus
2015
AAV-Mediated Delivery of Zinc Finger Nucleases Targeting Hepatitis B Virus Inhibits Active Replication
2014
Lipid-based vectors for siRNA delivery
2012
Synthetic Biology Platform for Sensing and Integrating Endogenous Transcriptional Inputs in Mammalian Cells
2016
Targeting hepatitis B virus cccDNA by CRISPR/Cas9 nuclease efficiently inhibits viral replication
2015
The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo
2014
DNA cleavage enzymes for treatment of persistent viral infections: Recent advances and the pathway forward
2014
Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinoma
2007
Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection
2006 StandoutNobel
Survival and apoptosis: a dysregulated balance in liver cancer
2007
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
RNA interference against viruses: strike and counterstrike
2007
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
2007 Standout
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
2021 StandoutNobel
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
2010 StandoutNature
Therapeutic genome editing: prospects and challenges
2015
Prospects for a vaccine against the hepatitis C virus
2005 StandoutNatureNobel
Nuclear factor-κB in cancer development and progression
2006 StandoutNature
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
2007 StandoutNature
Structure–activity relationships study of 6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl) quinolin-2(1H)-one derivatives as novel non-nucleoside anti-hepatitis B virus agents
2010
Mechanisms of HBV-induced hepatocellular carcinoma
2016
Directed evolution of the surface chemistry of the reporter enzyme β-glucuronidase
1999
Search-and-replace genome editing without double-strand breaks or donor DNA
2019 StandoutNature
The natural history of cervical HPV infection: unresolved issues
2006
Hydrodynamic Gene Delivery: Its Principles and Applications
2007
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
2015 StandoutNobel
The carboxy‐terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia‐inducible factor‐1α
2004
Inhibition of HBV Expression in HBV Transgenic Mice Using AAV-Delivered CRISPR-SaCas9
2018
An Accurate, Clinically Feasible Multi-Gene Expression Assay for Predicting Metastasis in Uveal Melanoma
2010
Recovery, Persistence, and Sequelae in Hepatitis C Virus Infection: A Perspective on Long-Term Outcome
2000
Oncogenic DNA viruses
2001 StandoutNobel
TP53 and liver carcinogenesis
2003
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Infections as a major preventable cause of human cancer
2000
Targeting the Achilles heel of the hepatitis B virus: a review of current treatments against covalently closed circular DNA
2015 StandoutNobel
Leptin and the regulation of body weight in mammals
1998 StandoutNature
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Erk Associates with and Primes GSK-3β for Its Inactivation Resulting in Upregulation of β-Catenin
2005
Recent synthetic transport systems
2011
Dual-targeting and pH/redox-responsive multi-layered nanocomplexes for smart co-delivery of doxorubicin and siRNA
2015
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
2009 StandoutNobel
Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas
2010 StandoutScience
Design of multifunctional non-viral gene vectors to overcome physiological barriers: Dilemmas and strategies
2011
Hepatocellular carcinoma
2022 Standout
Genome-editing Technologies for Gene and Cell Therapy
2016
Oxime Linkage: A Robust Tool for the Design of pH-Sensitive Polymeric Drug Carriers
2011
The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity
2022 StandoutNobel
Genome Engineering with Targetable Nucleases
2014
PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization
2018
Hepatocellular Carcinoma
2019 Standout
Obese gene expression at in vivo levels by fat pads derived from s.c. implanted 3T3-F442A preadipocytes
1997
Inhibition of hepatitis B virus by the CRISPR/Cas9 system via targeting the conserved regions of the viral genome
2015
Targeted and Equally Distributed Delivery of mRNA to Organs with Pentaerythritol-Based One-Component Ionizable Amphiphilic Janus Dendrimers
2023 StandoutNobel
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
2016 Standout
Multi-State Regulation of the Dihydrogen Phosphate Binding Affinity to a Light- and Heat-Responsive Bis-Urea Receptor
2014 StandoutNobel
Nanotechnology for Multimodal Synergistic Cancer Therapy
2017 Standout
Inhibition of Adipogenesis by Wnt Signaling
2000 StandoutScience
Targeted delivery of siRNA against hepatitis B virus by preS1 peptide molecular ligand
2013
Seed Sequence-Matched Controls Reveal Limitations of Small Interfering RNA Knockdown in Functional and Structural Studies of Hepatitis C Virus NS5A-MOBKL1B Interaction
2014 StandoutNobel
Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus
2014 StandoutNobel
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Supramolecular Helical Systems: Helical Assemblies of Small Molecules, Foldamers, and Polymers with Chiral Amplification and Their Functions
2016 Standout
Unique antiviral mechanism discovered in anti-hepatitis B virus research with a natural product analogue
2007
Lipids and Lipid Derivatives for RNA Delivery
2021
Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers
2021 StandoutNobel
Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function
2009
RNA Interference-Mediated Silencing of the Respiratory Syncytial Virus Nucleocapsid Defines a Potent Antiviral Strategy
2009
RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase
2013 StandoutNobel
Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device
2021 StandoutNobel
Magnetic Nanoparticles: Design and Characterization, Toxicity and Biocompatibility, Pharmaceutical and Biomedical Applications
2012 Standout
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
2017 StandoutNobel
Targeted DNA Mutagenesis for the Cure of Chronic Viral Infections
2012
De novo design of protein logic gates
2020 StandoutScienceNobel
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Works of Patrick Arbuthnot being referenced
ssAAVs containing cassettes encoding SaCas9 and guides targeting hepatitis B virus inactivate replication of the virus in cultured cells
2017
A Cellular Gene Up–Regulated by Hepatitis B Virus-Encoded X Antigen Promotes Hepatocellular Growth and Survival
2001
In vivo bioimaging with tissue-specific transcription factor activated luciferase reporters
2015
Progress in the use of RNA interference as a therapy for chronic hepatitis B virus infection
2010
Effective Inhibition of HBV Replication in Vivo by Anti-HBx Short Hairpin RNAs
2005
DODAG; a versatile new cationic lipid that mediates efficient delivery of pDNA and siRNA
2009
Rapid purification of recombinant Taq DNA polymerase by freezing and high temperature thawing of bacterial expression cultures
1995
The role of long non-coding RNAs in hepatitis B virus-related hepatocellular carcinoma
2015
Exploiting the RNA interference pathway to counter hepatitis B virus replication
2005
Efficient silencing of gene expression with modular trimeric Pol II expression cassettes comprising microRNA shuttles
2009
Downregulation of E-cadherin by hepatitis B virus X antigen in hepatocellullar carcinoma
2005
Inactivation of Hepatitis B Virus Replication in Cultured Cells and In Vivo with Engineered Transcription Activator-Like Effector Nucleases
2013
Putative role of hepatitis B virus X protein in hepatocarcinogenesis: Effects on apoptosis, DNA repair, mitogen‐activated protein kinase and JAK/STAT pathways
2000
Specific Inhibition of HBV Replication In Vitro and In Vivo With Expressed Long Hairpin RNA
2007
The translation initiation factor, hu-Sui1 may be a target of hepatitis B X antigen in hepatocarcinogenesis
1999
Self-amplifying RNA vaccines for infectious diseases
2020
Progress With Developing Use of Gene Editing To Cure Chronic Infection With Hepatitis B Virus
2016
Regulatory elements of hepatitis B virus transcription
2002
Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of β-catenin
2006
Efficient Inhibition of Hepatitis B Virus Replication In Vivo , Using Polyethylene Glycol-Modified Adenovirus Vectors
2008
Controlling HBV Replication in Vivo by Intravenous Administration of Triggered PEGylated siRNA-Nanoparticles
2009
Hepatitis B virus and hepatocellular carcinoma
2001
HEPATITIS B VIRUS AND HEPATOCELLULAR CARCINOMA
1979
Hepatoma cell-specific expression of a retrovirally transferred gene is achieved by α-fetoprotein but not insulinlike growth factor II regulatory sequences
1995
Hepatitis B virus and hepatocellular carcinoma.
2001