Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem–like Cells in an Akt/Foxo3a/TRAIL–Dependent Manner
2015
Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate
2015
Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia
2014
EglN2 associates with the NRF 1‐ PGC 1α complex and controls mitochondrial function in breast cancer
2015 StandoutNobel
Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype
2016 StandoutNobel
The emerging landscape of novel 4-1BB (CD137) agonistic drugs for cancer immunotherapy
2023
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
Cancer–stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis
2012 StandoutNobel
The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks
2017 StandoutNobel
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma
2014
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
2011
Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer
2016 StandoutNobel
Role of Dopamine Receptors in the Anticancer Activity of ONC201
2017
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
MYC on the Path to Cancer
2012 Standout
A view on drug resistance in cancer
2019 StandoutNature
Targeting cellular metabolism to improve cancer therapeutics
2013
Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells
2016
The biology and management of non-small cell lung cancer
2018 StandoutNature
Glutamine and cancer: cell biology, physiology, and clinical opportunities
2013
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
Understanding the tumor immune microenvironment (TIME) for effective therapy
2018 Standout
The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4
2013
Links between metabolism and cancer
2012
Cancer stem cells revisited
2017 Standout
Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport
2014
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
2015 StandoutNobel
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)–mediated induction of the long noncoding RNA NICI
2019 StandoutNobel
Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
2017 StandoutNobel
Hypoxia and the extracellular matrix: drivers of tumour metastasis
2014 StandoutNobel
Colorectal cancer
2019 Standout
Impact of MYC in regulation of tumor cell metabolism
2014
From Krebs to clinic: glutamine metabolism to cancer therapy
2016 Standout
Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents
2015
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer
2013 StandoutNobel
Immunotherapy in colorectal cancer: rationale, challenges and potential
2019
Targeting apoptosis in cancer therapy
2020 Standout
Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA
2017
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment
2018
CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth
2013
Development of immuno-oncology drugs — from CTLA4 to PD1 to the next generations
2016
Common pitfalls in preclinical cancer target validation
2017 StandoutNobel
Regulation and Function of the PD-L1 Checkpoint
2018 Standout
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Allo-network drugs: harnessing allostery in cellular networks
2011
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
2021
Strategies and challenges for the next generation of antibody–drug conjugates
2017 Standout
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection
2009
Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion
2014
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Ferroptosis: mechanisms, biology and role in disease
2021 Standout
The PI3K Pathway in Human Disease
2017 Standout
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
New developments for antibody-drug conjugate-based therapeutic approaches
2016
VEGF in Signaling and Disease: Beyond Discovery and Development
2019 Standout
Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors
2018 StandoutNobel
Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox
2016 StandoutNobel
ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases
2016
Immunotherapy for Colorectal Cancer
2017
Metabolic control of cell death
2014 Science
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic
2020
Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion
2014 StandoutNobel
Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues
2019
CRISPR-enhanced engineering of therapy-sensitive cancer cells for self-targeting of primary and metastatic tumors
2018
Spermidine in health and disease
2018 StandoutScience
The CDK4/6 inhibitor palbociclib synergizes with irinotecan to promote colorectal cancer cell death under hypoxia
2017
Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation
2017 StandoutNobel
Chimeric Antigen Receptor Therapy
2018 Standout
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch
2016
Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2
2015
Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway
2015 StandoutNobel
A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation
2016 StandoutNobel
Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach
2015
Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration
2018 StandoutNobel
Advances in Copper Complexes as Anticancer Agents
2013 Standout
First clinical experience with DRD2/3 antagonist ONC201 in H3 K27M–mutant pediatric diffuse intrinsic pontine glioma: a case report
2019
KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment
2016
De-Risking Immunotherapy: Report of a Consensus Workshop of the Cancer Immunotherapy Consortium of the Cancer Research Institute
2016 StandoutNobel
Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules
2019 StandoutNobel
Works of Patrick A. Mayes being referenced
Overcoming Hypoxia-Induced Apoptotic Resistance through Combinatorial Inhibition of GSK-3β and CDK1
2011
The BRAF and MEK Inhibitors Dabrafenib and Trametinib: Effects on Immune Function and in Combination with Immunomodulatory Antibodies Targeting PD-1, PD-L1, and CTLA-4
2015
Combinatorial Regulation of Neuroblastoma Tumor Progression by N-Myc and Hypoxia Inducible Factor HIF-1α
2010
Serial Transcriptome Analysis and Cross-Species Integration Identifies Centromere-Associated Protein E as a Novel Neuroblastoma Target
2010
Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway
2015
Modulation of TRAIL-induced tumor cell apoptosis in a hypoxic environment
2005
What are caspases 3 and 7 doing upstream of the mitochondria?
2006
The promise and challenges of immune agonist antibody development in cancer
2018
ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation
2012
Novel anti–B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma
2014
Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects
2013
Off-Target Lapatinib Activity Sensitizes Colon Cancer Cells Through TRAIL Death Receptor Up-Regulation
2011