Standout Papers
Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes
2020 StandoutNobel
MYC Drives Pten/Trp53 -Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2
2015
Phthalimide conjugation as a strategy for in vivo target protein degradation
2015 Science
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Acute B lymphoblastic leukaemia‐propagating cells are present at high frequency in diverse lymphoblast populations
2012
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
2019 StandoutNobel
Non-Cell-Autonomous Tumor Suppression by p53
2013
Targeting JAK kinase in solid tumors: emerging opportunities and challenges
2015
RNAi screening comes of age: improved techniques and complementary approaches
2014
Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining
2014 StandoutNobel
A view on drug resistance in cancer
2019 StandoutNature
Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification
2016
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty
2012 Standout
Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
2017
Targeting Epigenetic Readers in Cancer
2012
Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps
2014
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Cancer Epigenetics: From Mechanism to Therapy
2012 Standout
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
2014 Standout
The Human Transcription Factors
2018 Standout
Regulatory Enhancer–Core-Promoter Communication via Transcription Factors and Cofactors
2016
Indolocarbazole natural products: occurrence, biosynthesis, and biological activity
2006
An Optimized microRNA Backbone for Effective Single-Copy RNAi
2013
Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect
2016 Standout
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Relapsed childhood acute lymphoblastic leukaemia
2013
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
2015 StandoutNobel
Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch
2016 StandoutNobel
Metazoan MicroRNAs
2018 Standout
Targeting the IL-6/JAK/STAT3 signalling axis in cancer
2018 Standout
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
2020 StandoutNobel
Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition
2013
Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy
2015
Tumour heterogeneity and cancer cell plasticity
2013 StandoutNature
TET enzymes, TDG and the dynamics of DNA demethylation
2013 StandoutNature
Molecular genetics in acute myeloid leukemia
2010
Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
2015
CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer
2015
EMT: 2016
2016 Standout
Leukemic mutations in the methylation‐associated genes DNMT3A and IDH2 are rare events in pediatric AML: A report from the Children's Oncology Group
2011
BET domain co-regulators in obesity, inflammation and cancer
2012
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
2013 Standout
The promise of Janus kinase inhibitors in the treatment of hematological malignancies
2016
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
TGF-β Tumor Suppression through a Lethal EMT
2016
Clonal evolution in cancer
2012 StandoutNature
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
2012
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
2016 StandoutNobel
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
2014 Standout
The PI3K Pathway in Human Disease
2017 Standout
A decade of exploring the cancer epigenome — biological and translational implications
2011 Standout
T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
2014 Standout
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance
2014
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Microenvironmental regulation of tumor progression and metastasis
2013 Standout
MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
2014
Phospho Switch Triggers Brd4 Chromatin Binding and Activator Recruitment for Gene-Specific Targeting
2013
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance
2011
Transcription control by the ENL YEATS domain in acute leukaemia
2017 Nature
An Argonaute phosphorylation cycle promotes microRNA-mediated silencing
2017 Nature
CRISPR/Cas9-Mediated Genome Editing of Epigenetic Factors for Cancer Therapy
2015
Acute Myeloid Leukemia
2015 Standout
A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes
2014 Science
Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma
2014
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Where do we stand in the treatment of relapsed acute lymphoblastic leukemia?
2012
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis
2010
SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis
2018 Science
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia
2012
Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids
2012 Standout
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis
2013
Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia
2013
Epigenetic plasticity: A central regulator of epithelial-to-mesenchymal transition in cancer
2014
Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34− fraction
2010
Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers
2014
Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1)
2010
Molecular Genetics of Acute Lymphoblastic Leukemia
2005
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines
2021 StandoutNobel
Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration
2018 StandoutNobel
Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia
2021 StandoutNobel
Genetics and biology of pancreatic ductal adenocarcinoma
2016
AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features
2009
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia
2016 Standout
The evolving role of FLT3 inhibitors in acute myeloid leukemia: quizartinib and beyond
2014
Xenografts of highly resistant leukemia recapitulate the clonal composition of the leukemogenic compartment
2011
Where do we stand in the treatment of relapsed acute lymphoblastic leukemia?
2012
Anti-CD22–chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
2012
Breastfeeding and Childhood Leukemia Incidence
2015
Works of Patrick A. Brown being referenced
High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias
2010
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
2011 StandoutNature
NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia
2008
Combinations of the FLT3 inhibitor CEP-701 and chemotherapy synergistically kill infant and childhood MLL-rearranged ALL cells in a sequence-dependent manner
2006
NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease
2013
FLT3/ITD Mutation Signaling Includes Suppression of SHP-1
2004
FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression
2004
Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting
2010
A phase 1 dosing study of ruxolitinib in children with relapsed or refractory solid tumors, leukemias, or myeloproliferative neoplasms: A Children's Oncology Group phase 1 consortium study (ADVL1011)
2015
Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways
2006
Treatment of infant leukemias: challenge and promise
2013
Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia
2012
IMC-EB10, an Anti-FLT3 Monoclonal Antibody, Prolongs Survival and Reduces Nonobese Diabetic/Severe Combined Immunodeficient Engraftment of Some Acute Lymphoblastic Leukemia Cell Lines and Primary Leukemic Samples
2006
Novel agents for the treatment of childhood acute leukemia
2015
The incidence and clinical significance of nucleophosmin mutations in childhood AML
2007
Next-Generation NAMPT Inhibitors Identified by Sequential High-Throughput Phenotypic Chemical and Functional Genomic Screens
2013