Standout Papers
Citation Impact
Citing Papers
Membrane-tethered mucin-like polypeptides sterically inhibit binding and slow fusion kinetics of influenza A virus
2020 StandoutNobel
Maturation-Dependent HIV-1 Surface Protein Redistribution Revealed by Fluorescence Nanoscopy
2012 StandoutScienceNobel
Functional specialization of β-arrestin interactions revealed by proteomic analysis
2007 StandoutNobel
Drosophila Deltex mediates Suppressor of Hairless-independent and late-endosomal activation of Notch signaling
2004
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
Down-regulation of Delta by proteolytic processing
2002
Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor
2001 StandoutNobel
SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway
2002
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Notch and Presenilin Regulate Cellular Expansion and Cytokine Secretion but Cannot Instruct Th1/Th2 Fate Acquisition
2008
Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes
2002
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Deregulated NOTCH Signaling in Acute T-Cell Lymphoblastic Leukemia/Lymphoma: New Insights, Questions, and Opportunities
2005
Influenza Virus Partially Counteracts Restriction Imposed by Tetherin/BST-2
2012
Mechanisms and Functional Implications of Adult Neurogenesis
2008 Standout
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2
2000
The Notch Ligands, Jagged and Delta, Are Sequentially Processed by α-Secretase and Presenilin/γ-Secretase and Release Signaling Fragments
2003
The Notch Ligands, Delta1 and Jagged2, Are Substrates for Presenilin-dependent “γ-Secretase” Cleavage
2003
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
Mucosal physical and chemical innate barriers: Lessons from microbial evasion strategies
2015
Adult neurogenesis and functional plasticity in neuronal circuits
2006
Signaling at neuro/immune synapses
2012
TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity
2002 Standout
The C-terminal PDZ-Ligand of JAGGED1 Is Essential for Cellular Transformation
2003
Regulated Intramembrane Proteolysis
2000
Kuz and TACE can activate Notch independent of ligand
2008
Tumor necrosis factor-α converting enzyme
2002
Fringe is a glycosyltransferase that modifies Notch
2000 Nature
Mammalian Numb Proteins Promote Notch1 Receptor Ubiquitination and Degradation of the Notch1 Intracellular Domain
2003
Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila
2005 StandoutNobel
Notch Signaling: A Dance of Proteins Changing Partners
2000
A common enzyme connects Notch signaling and Alzheimer's disease
2000
HIV-1-resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene
1998 StandoutNobel
Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE
2005
Dengue: a continuing global threat
2010 Standout
Integrating new neurons into the adult olfactory bulb: joining the network, life–death decisions, and the effects of sensory experience
2005
Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1
2000
HIV-1 Genome Nuclear Import Is Mediated by a Central DNA Flap
2000 StandoutNobel
Interaction of Retroviral Reverse Transcriptase with Template–Primer Duplexes during Replication
1997
HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase
1995
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
Notch signalling: a simple pathway becomes complex
2006 Standout
Structural basis for autoinhibition of Notch
2007
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
2023 StandoutNobel
Icy: an open bioimage informatics platform for extended reproducible research
2012
Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3
2008
Requirements for Presenilin-Dependent Cleavage of Notch and Other Transmembrane Proteins
2000
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Furin cleavage is not a requirement for Drosophila Notch function
2002
neuralized Encodes a Peripheral Membrane Protein Involved in Delta Signaling and Endocytosis
2001
Mind Bomb Is a Ubiquitin Ligase that Is Essential for Efficient Activation of Notch Signaling by Delta
2003
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
2002
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
Bare rudiments of notch signaling: how receptor levels are regulated
2007
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
2003
Spatial Representation of the Glomerular Map in the Drosophila Protocerebrum
2002 StandoutNobel
Implication of APP Secretases in Notch Signaling
2001
Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells
2011
Ectodomain Shedding and Intramembrane Cleavage of Mammalian Notch Proteins Are Not Regulated through Oligomerization
2004
kuzbanian-mediated cleavage of Drosophila Notch
2002
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts
2002
Notch Signaling: From the Outside In
2000
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
Localization of the Delta-like-1-binding Site in Human Notch-1 and Its Modulation by Calcium Affinity
2008
Signalization and cytoskeleton activity through myosin IB during the early steps of phagocytosis in Entamoeba histolytica: a proteomic approach
2005
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1
2002
Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement
2007
Mutational and Energetic Studies of Notch1 Transcription Complexes
2007
Quantitative Dissection of the Notch:CSL Interaction: Insights into the Notch-mediated Transcriptional Switch
2006
Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling
2008
The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity
2001
Notch and Presenilin: a proteolytic mechanism emerges
2001
Modular design of synthetic receptors for programmed gene regulation in cell therapies
2022
Presenilin clinical mutations can affect γ‐secretase activity by different mechanisms
2006
Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures
2013 Standout
Interaction of the MAGUK Family Member Acvrinp1 and the Cytoplasmic Domain of the Notch Ligand Delta1
2003
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Notch receptor cleavage depends on but is not directly executed by presenilins
2002 StandoutNobel
SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans
2000
NIH Image to ImageJ: 25 years of image analysis
2012 Standout
Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold
2011 StandoutScienceNobel
Oh no, Notch again!
2000
Myosin IIA is involved in the endocytosis of CXCR4 induced by SDF-1α
2007
TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity
2002 Standout
Fringe Glycosyltransferases Differentially Modulate Notch1 Proteolysis Induced by Delta1 and Jagged1
2004
Glycoprotein 130 Signaling RegulatesNotch1Expression and Activation in the Self-Renewal of Mammalian Forebrain Neural Stem Cells
2003
Growth Suppression of Pre-T Acute Lymphoblastic Leukemia Cells by Inhibition of Notch Signaling
2003
Phagocytosis of Microbes: Complexity in Action
2002
Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro
2012 StandoutNobel
The adhesion force of Notch with Delta and the rate of Notch signaling
2004
Identification of a Conserved Negative Regulatory Sequence That Influences the Leukemogenic Activity of NOTCH1
2006
Characterization of (+) Strand Initiation and Termination Sequences Located at the Center of the Equine Infectious Anemia Virus Genome
1999
Membrane proteomics of phagosomes suggests a connection to autophagy
2008 StandoutNobel
Leukemia-Associated Mutations within the NOTCH1 Heterodimerization Domain Fall into at Least Two Distinct Mechanistic Classes
2006
The molecular logic of Notch signaling – a structural and biochemical perspective
2008
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Kinase requirements in human cells: III. Altered kinase requirements inVHL−/− cancer cells detected in a pilot synthetic lethal screen
2008 StandoutNobel
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1
2000
HIV-1–cellular interactions analyzed by single virus tracing
2008
Understanding Nanomaterial–Liver Interactions to Facilitate the Development of Safer Nanoapplications
2022
Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila
2000
A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell ofDrosophila
2003
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase
2003
DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur
2007
The effects of conformational heterogeneity on the binding of the Notch intracellular domain to effector proteins: a case of biologically tuned disorder
2008
Intramembrane Proteolysis: Theme and Variations
2004 Science
Genetic Analysis of Caenorhabditis elegans glp-1 Mutants Suggests Receptor Interaction or Competition
2003
p300 and PCAF Act Cooperatively To Mediate Transcriptional Activation from Chromatin Templates by Notch Intracellular Domains In Vitro
2002
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling
2007 StandoutNobel
Anatomy and Dynamics of a Supramolecular Membrane Protein Cluster
2007 StandoutScienceNobel
HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway
1997
Syntaxins 3 and 4 Are Concentrated in Separate Clusters on the Plasma Membrane before the Establishment of Cell Polarity
2005
NOTCH AND PRESENILIN : Regulated Intramembrane Proteolysis Links Development and Degeneration
2003
Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation.
1996 StandoutNobel
Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain
2008 StandoutNobel
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors
2004 StandoutNobel
RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase
2013 StandoutNobel
The nuclear pore component Nup358 promotes transportin-dependent nuclear import
2009
Design of a hyperstable 60-subunit protein icosahedron
2016 StandoutNatureNobel
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Induction of Antiviral Cytidine Deaminases Does Not Explain the Inhibition of Hepatitis B Virus Replication by Interferons
2007
In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
1996 StandoutScience
The discrepancy between presenilin subcellular localization and γ-secretase processing of amyloid precursor protein
2001
The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation
2010
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL
2008
Immobilization of Notch ligand, Delta-1, is required for induction of Notch signaling
2000
A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP
2002
Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via T 1 -weighted MRI
2023 StandoutNobel
Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners
2012 StandoutNobel
Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor
2004
Recombination signal sequence-binding protein Jκ alters mesodermal cell fate decisions by suppressing cardiomyogenesis
2003 StandoutNobel
Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides
2020 StandoutNobel
Regulation of Notch Signaling Activity
2004
Works of Pascal Roux being referenced
Hepatic stellate cell hypertrophy is associated with metabolic liver fibrosis
2020
Optimisation of secretion of recombinant HBsAg virus-like particles: Impact on the development of HIV-1/HBV bivalent vaccines
2006
Newly visualized fibrillar collagen scaffolds dictate Entamoeba histolytica invasion route in the human colon
2012
A Novel Proteolytic Cleavage Involved in Notch Signaling
2000 Standout
Activity-Dependent Adjustments of the Inhibitory Network in the Olfactory Bulb following Early Postnatal Deprivation
2005
Activation-Induced Polarized Recycling Targets T Cell Antigen Receptors to the Immunological Synapse
2004
HIV-1 Reverse Transcription A Termination Step at the Center of the Genome
1994
Virulent Shigella flexneri Affects Secretion, Expression, and Glycosylation of Gel-Forming Mucins in Mucus-Producing Cells
2013
A role for cofilin and LIM kinase inListeria-induced phagocytosis
2001
The Secreted Form of Dengue Virus Nonstructural Protein NS1 Is Endocytosed by Hepatocytes and Accumulates in Late Endosomes: Implications for Viral Infectivity
2005