Standout Papers
Citation Impact
Citing Papers
A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo
2005
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process
2004
Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling
2009
The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling
2009
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Differential range and activity of various forms of the Hedgehog protein
2005
The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin
1990
Mammalian Suppressor-of-Fused modulates nuclear–cytoplasmic shuttling of GLI-1
1999
Shifting paradigms in Hedgehog signaling
2007
Posttranscriptional Regulation of Smoothened Is Part of a Self-Correcting Mechanism in the Hedgehog Signaling System
2000
Hedgehog regulates smoothened activity by inducing a conformational switch
2007 Nature
Hedgehog: functions and mechanisms
2008 Standout
Interactions with Costal2 and Suppressor of fused regulate nuclear translocation and activity of Cubitus interruptus
2000
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
1999 Standout
The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors
2001
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Hedgehog signalling: how to get from Smo to Ci and Gli
2006
Hedgehog and Patched in Neural Development and Disease
1998
Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification
2002
Molecular mechanisms of epithelial–mesenchymal transition
2014 Standout
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene
1994 StandoutNature
Hedgehog–GLI signaling and the growth of the brain
2002
Cloning and expression of a cDNA encoding an endothelin receptor
1990 StandoutNature
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Dynamic imine chemistry
2012 StandoutNobel
The regulation of sex determination and sexually dimorphic differentiation in Drosophila
1993
Incredible journey: how do developmental signals travel through tissue?
2004
Catching a Gli-mpse of Hedgehog
1997
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
1995 StandoutNature
Hedgehog Controls Limb Development by Regulating the Activities of Distinct Transcriptional Activator and Repressor Forms of Cubitus interruptus
1999
An Acylatable Residue of Hedgehog Is Differentially Required in Drosophila and Mouse Limb Development
2001
Oncoprotein Networks
1997
The hedgehog signaling network
2003
Modulation of Hedgehog target gene expression by the Fused serine–threonine kinase in wing imaginal discs
1998
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
1996 StandoutNature
Wnt proteins are lipid-modified and can act as stem cell growth factors
2003 StandoutNature
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
2003
The Hedgehog and Wnt signalling pathways in cancer
2001 StandoutNature
Genes Expressed in Neurons of Adult Male Drosophila
1997 StandoutNobel
wingless signaling acts through zeste-white 3, the drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate
1992
The Hallmarks of Cancer
2000 Standout
Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis
2009 Nature
Intraflagellar transport, cilia, and mammalian Hedgehog signaling: Analysis in mouse embryonic fibroblasts
2008
Identification of a Tetrameric Hedgehog Signaling Complex
2000
Segment polarity genes and cell patterning within the Drosophila body segment
1991
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli
2005
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
2011 StandoutNature
Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened
2000
Signalling by hedgehog family proteins in Drosophila and vertebrate development
1995
The Directional Preference of Kinesin Motors Is Specified by an Element outside of the Motor Catalytic Domain
1997
Hedgehog Signal Transduction in the Posterior Compartment of the Drosophila Wing Imaginal Disc
2000
A freely diffusible form of Sonic hedgehog mediates long-range signalling
2001 Nature
Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2
2003
Vertebrate Homologs of Drosophila Suppressor of Fused Interact with the Gli Family of Transcriptional Regulators
1999
Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor
1997
The single-cell transcriptional landscape of mammalian organogenesis
2019 StandoutNature
Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator
1998 Nature
Activin signalling and response to a morphogen gradient
1994 StandoutNatureNobel
Genetic Dissection of the Drosophila Cubitus interruptus Signaling Complex
2001
Hedgehog Signaling in Germ Cell Migration
2001
The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3
1998
Hedgehog Signal Transduction via Smoothened Association with a Cytoplasmic Complex Scaffolded by the Atypical Kinesin, Costal-2
2003
Hhat Is a Palmitoylacyltransferase with Specificity for N-Palmitoylation of Sonic Hedgehog
2008
The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal
1996
The Sonic Hedgehog–Patched–Gli Pathway in Human Development and Disease
2000
Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 Secretion
2006
Metastasis suppressors in breast cancers: mechanistic insights and clinical potential
2013
A role for Wnt signalling in self-renewal of haematopoietic stem cells
2003 StandoutNature
Beyond homeosis—HOX function in morphogenesis and organogenesis
2003
Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus
1999
New players and puzzles in the Hedgehog signaling pathway
1998
Nuclear Trafficking of Cubitus interruptus in the Transcriptional Regulation of Hedgehog Target Gene Expression
1999
Gli regulation by the opposing activities of Fused and Suppressor of Fused
2000
Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation
2001
Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
2004
Transducing Hedgehog: the story so far
1998
Hedgehog signaling in animal development: paradigms and principles
2001 Standout
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
2003
The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing
1999
A Role for the Segment Polarity Gene shaggy/GSK-3 in the Drosophila Circadian Clock
2001 StandoutNobel
Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1
1997
Hedgehog beyond medulloblastoma and basal cell carcinoma
2010
Polycomb complexes repress developmental regulators in murine embryonic stem cells
2006 StandoutNature
Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless Gene
1996 StandoutNobel
Mouse Suppressor of fused is a negative regulator of Sonic hedgehog signaling and alters the subcellular distribution of Gli1
1999
Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
1992
Cyclopamine Inhibition of Sonic Hedgehog Signal Transduction Is Not Mediated through Effects on Cholesterol Transport
2000
Costal2 Functions as a Kinesin-like Protein in the Hedgehog Signal Transduction Pathway
2008
A Hedgehog-Induced BTB Protein Modulates Hedgehog Signaling by Degrading Ci/Gli Transcription Factor
2006
Systematic Study of Drosophila MicroRNA Functions Using a Collection of Targeted Knockout Mutations
2014
A Gain-of-Function Mutant of patched Dissects Different Responses to the Hedgehog Gradient
2000
Divergence of Hedgehog Signal Transduction Mechanism between Drosophila and Mammals
2006
The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously
1995 StandoutNobel
G protein-coupled receptors: novel targets for drug discovery in cancer
2010
fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development
1994 StandoutNobel
Suppressor of fused links Fused and Cubitus interruptus on the Hedgehog signalling pathway
1998
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
2009
Wnt signalling in stem cells and cancer
2005 StandoutNature
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Genetic Elimination of Suppressor of Fused Reveals an Essential Repressor Function in the Mammalian Hedgehog Signaling Pathway
2006
Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3
1999
The Effect of Pertussis Toxin on Zebrafish Development: A Possible Role for Inhibitory G-Proteins in Hedgehog Signaling
1998
Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog
1998 Standout
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster.
1992
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
1998 StandoutNature
The patched gene in development and cancer
1998
Drosophila hedgehog acts as a morphogen in cellular patterning
1994
The primary cilium: a signalling centre during vertebrate development
2010 Standout
A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway
2005
The Zn Finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis
2009
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
2008 Standout
The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways
1995
Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway
1997
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
Gli1can rescue the in vivo function ofGli2
2001
Mice Deficient in the Fused Homolog Do Not Exhibit Phenotypes Indicative of Perturbed Hedgehog Signaling during Embryonic Development
2005
Drosophila in cancer research: the first fifty tumor suppressor genes
1994
Extensive phosphorylation of Smoothened in Hedgehog pathway activation
2004
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
2005
Gli proteins and the control of spinal‐cord patterning
2003
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
2000 Standout
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Hedgehog Signaling Pathway is a New Therapeutic Target for Patients with Breast Cancer
2004
Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities
2000
Characterization of two patched receptors for the vertebrate hedgehog protein family
1998
The segment polarity gene armadillo interacts with the wingless signaling pathway in both embryonic and adult pattern formation
1991 StandoutNobel
Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila
1992
Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein
1997
Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog inDrosophilaepithelia
2006
Recent advances in bone-targeting nanoparticles for biomedical applications
2021
Novel Lipid Modifications of Secreted Protein Signals
2004
Suppressor of Fused opposes Hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus
2000
Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus
1998
Genetic analysis of hedgehog signalling in the Drosophila embryo
1993
Smoothened Signal Transduction Is Promoted by G Protein-Coupled Receptor Kinase 2
2006 StandoutNobel
mir-276a strengthens Drosophila circadian rhythms by regulating timeless expression
2016 StandoutNobel
Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia
2007
Nuclear import of Cubitus interruptus is regulated by Hedgehog via a mechanism distinct from Ci stabilization and Ci activation
2000
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Mediation of Sonic Hedgehog-Induced Expression of COUP-TFII by a Protein Phosphatase
1997 Science
The Hedgehog Response Network: Sensors, Switches, and Routers
2004 Science
The subcellular localization and activity of Drosophila Cubitus interruptus are regulated at multiple levels
1999
Kinome siRNA Screen Identifies Regulators of Ciliogenesis and Hedgehog Signal Transduction
2008
Are There Close Encounters Between Signaling Pathways?
2000 Science
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways fromDrosophilato vertebrates
2005
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Smoothened translates Hedgehog levels into distinct responses
2003
patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets
1995
Distinct and collaborative roles ofDrosophilaEXT family proteins in morphogen signalling and gradient formation
2004
Sex Determination and Dosage Compensation: Lessons from Flies and Worms
1994 Science
Hedgehog signaling
2006
Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog
1998
Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
1998
Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix
2006
Fission yeast orb 6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle
1998 StandoutNobel
Loss of the Serine/Threonine Kinase Fused Results in Postnatal Growth Defects and Lethality Due to Progressive Hydrocephalus
2005
Signals transmitted along retinal axons in Drosophila: Hedgehog signal reception and the cell circuitry of lamina cartridge assembly
1998
Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.
1996
The Mating of a Fly
1994 StandoutScienceNobel
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Sonic hedgehog Promotes G1Cyclin Expression and Sustained Cell Cycle Progression in Mammalian Neuronal Precursors
2000
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Mechanisms and functions of extracellular vesicle releasein vivo—What we can learn from flies and worms
2016
Planarian Hh Signaling Regulates Regeneration Polarity and Links Hh Pathway Evolution to Cilia
2009 Science
Sex-lethal, master and slave: a hierarchy of germ-line sex determination in Drosophila
1993
The Hedgehog Signaling Pathway in Cancer
2006
Proteolysis of Cubitus interruptus in Drosophila requires phosphorylation by Protein Kinase A
1999
Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein
1996 StandoutScience
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
An absolute requirement for Cubitus interruptus in Hedgehog signaling
2001
Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling
1999
Works of Pascal P. Thérond being referenced
The mechanisms of Hedgehog signalling and its roles in development and disease
2013 Standout
Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2
1997 Nobel
The Suppressor of fused gene encodes a novel PEST protein involved in Drosophila segment polarity establishment.
1995
Functional Domains of Fused, a Serine-Threonine Kinase Required for Signaling in Drosophila
1996
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog
2003
Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling
2010
The ESCRT machinery regulates the secretion and long-range activity of Hedgehog
2014 Nature
A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila
1990 Nature
Human receptor Smoothened, a mediator of Hedgehog signalling, expressed in its native conformation in yeast
2005
Cholesterol Modification of Hedgehog Is Required for Trafficking and Movement, Revealing an Asymmetric Cellular Response to Hedgehog
2003
Hedgehog Signaling: From the Drosophila Cuticle to Anti-Cancer Drugs
2005
Temporal modulation of the Hedgehog morphogen gradient by a patched-dependent targeting to lysosomal compartment
2004
Segmental polarity in Drosophila melanogaster: genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2.
1993
Human Receptors Patched and Smoothened Partially Transduce Hedgehog Signal When Expressed in Drosophila Cells
2006
Molecular organisation and expression pattern of the segment polarity gene fused of Drosophila melanogaster
1993
The role of kinases in the Hedgehog signalling pathway
2008
Cubitus interruptus-independent transduction of the Hedgehog signal in Drosophila
2000
Heart tube patterning inDrosophilarequires integration of axial and segmental information provided by theBithorax Complexgenes andhedgehogsignaling
2002
Differential requirements of the Fused kinase for Hedgehog signalling in the Drosophila embryo
1999
Control of Antagonistic Components of the Hedgehog Signaling Pathway by microRNAs in Drosophila
2008
Phosphorylation of the fused protein kinase in response to signaling from hedgehog.
1996 Nobel