Citation Impact
Citing Papers
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues
2009
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
2010 StandoutNobel
HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels
1997
Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype
2016 StandoutNobel
MCM Proteins Are Negative Regulators of Hypoxia-Inducible Factor 1
2011 StandoutNobel
Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation
2015
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
2005 StandoutNobel
Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression
2010
Hallmarks of Cancer: The Next Generation
2011 Standout
The Mouse Gene for Hypoxia‐Inducible Factor‐1α
1997
c- erb B-2 Related Aggressiveness in Breast Cancer Is Hypoxia Inducible Factor-1α Dependent
2004
PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia
2016 StandoutNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.
1998
ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis
2018
Early Expression of Angiogenesis Factors in Acute Myocardial Ischemia and Infarction
2000
Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1
2001 StandoutNobel
Induction of HIF‐1α expression by intermittent hypoxia: Involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR
2008 StandoutNobel
Natural antisense transcripts of hypoxia-inducible factor 1alpha are detected in different normal and tumour human tissues
2002
The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis
2007
Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2
1996 StandoutNatureNobel
Forces in Tissue Morphogenesis and Patterning
2013 Standout
Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors
2013 StandoutNobel
Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis
1998 StandoutNobel
The Role of Mitochondria in the Regulation of Hypoxia-inducible Factor 1 Expression during Hypoxia
2000
Hypoxia Regulates Expression of the Endothelin-1 Gene through a Proximal Hypoxia-Inducible Factor-1 Binding Site on the Antisense Strand
1998
Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α
1997 StandoutNobel
Effects of hypoxia on tumor metabolism
2007
Spermidine/Spermine-N1-Acetyltransferase 2 Is an Essential Component of the Ubiquitin Ligase Complex That Regulates Hypoxia-inducible Factor 1α
2007 StandoutNobel
Transcriptional Up-regulation of Inhibitory PAS Domain Protein Gene Expression by Hypoxia-inducible Factor 1 (HIF-1)
2007
Oxygen-regulated Transferrin Expression Is Mediated by Hypoxia-inducible Factor-1
1997
Regulation of tumor pH and the role of carbonic anhydrase 9
2007
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1
1998 StandoutNobel
Calcineurin Promotes Hypoxia-inducible Factor 1α Expression by Dephosphorylating RACK1 and Blocking RACK1 Dimerization
2007 StandoutNobel
Mersalyl Is a Novel Inducer of Vascular Endothelial Growth Factor Gene Expression and Hypoxia-Inducible Factor 1 Activity
1998 StandoutNobel
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis
2012 StandoutNobel
HIF-1α in Epidermis: Oxygen Sensing, Cutaneous Angiogenesis, Cancer, and Non-Cancer Disorders
2011
Ca2+/Calmodulin Kinase-dependent Activation of Hypoxia Inducible Factor 1 Transcriptional Activity in Cells Subjected to Intermittent Hypoxia
2004 StandoutNobel
Induction of hypoxia‐inducible factor‐1 (HIF‐1) and its target genes following focal ischaemia in rat brain
1999 StandoutNobel
Expression of Vascular Endothelial Growth Factor Receptor 1 in Bone Marrow-derived Mesenchymal Cells Is Dependent on Hypoxia-inducible Factor 1
2006 StandoutNobel
HIF-1 Inhibits Mitochondrial Biogenesis and Cellular Respiration in VHL-Deficient Renal Cell Carcinoma by Repression of C-MYC Activity
2007 StandoutNobel
Enhancement of Memory-Related Long-Term Facilitation by ApAF, a Novel Transcription Factor that Acts Downstream from Both CREB1 and CREB2
2000 StandoutNobel
Age-dependent Defect in Vascular Endothelial Growth Factor Expression Is Associated with Reduced Hypoxia-inducible Factor 1 Activity
2000 StandoutNobel
Super-Enhancers in the Control of Cell Identity and Disease
2013 Standout
Hypoxia and the extracellular matrix: drivers of tumour metastasis
2014 StandoutNobel
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia
2002 StandoutNobel
Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis
2012 StandoutNobel
Hypoxic Induction of Prolyl 4-Hydroxylase α(I) in Cultured Cells
2000
Age‐dependent impairment of HIF‐1α expression in diabetic mice: Correction with electroporation‐facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells
2008 StandoutNobel
Four-and-a-Half LIM Domain Proteins Inhibit Transactivation by Hypoxia-inducible Factor 1
2012 StandoutNobel
OS-9 Interacts with Hypoxia-Inducible Factor 1α and Prolyl Hydroxylases to Promote Oxygen-Dependent Degradation of HIF-1α
2005 StandoutNobel
HIF hydroxylation and the mammalian oxygen-sensing pathway
2003 StandoutNobel
The Human Hypoxia-Inducible Factor 1α Gene:HIF1AStructure and Evolutionary Conservation
1998 StandoutNobel
Lactate dehydrogenase 5 expression in non-Hodgkin B-cell lymphomas is associated with hypoxia regulated proteins
2008
The Lysyl Oxidases LOX and LOXL2 Are Necessary and Sufficient to Repress E-cadherin in Hypoxia
2009
Histone Deacetylase 7 Associates with Hypoxia-inducible Factor 1α and Increases Transcriptional Activity
2004
Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions
1997 Standout
RACK1 Competes with HSP90 for Binding to HIF-1α and Is Required for O2-Independent and HSP90 Inhibitor-Induced Degradation of HIF-1α
2007 StandoutNobel
Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology
2001 StandoutNobel
Hypoxia‐inducible factor 1 mediates increased expression of NADPH oxidase‐2 in response to intermittent hypoxia
2011 StandoutNobel
Hypoxic gene expression and metastasis
2004
Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling
2010 StandoutNobel
Induction of T-type Calcium Channel Gene Expression by Chronic Hypoxia
2003
Transcriptional Regulation of Urokinase-type Plasminogen Activator Receptor by Hypoxia-Inducible Factor 1 Is Crucial for Invasion of Pancreatic and Liver Cancer
2009
Role of Hypoxia-inducible Factor-1 in Transcriptional Activation of Ceruloplasmin by Iron Deficiency
2000
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
1999 StandoutNobel
Hypoxia-induced genetic instability—a calculated mechanism underlying tumor progression
2006
An altered repertoire of (AP-1) at the onset of replicative senescence
1992
Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α
2009 StandoutNobel
aHIF: a Natural Antisense Transcript Overexpressed in Human Renal Cancer and During Hypoxia
1999
Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha /ARNT
1998
Hypoxic induction ofCtgfis directly mediated by Hif-1
2004
Oncogenic alterations of metabolism
1999 StandoutNobel
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α
1998 StandoutNobel
Gene expression and hypoxia in breast cancer
2011
Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: Prolyl hydroxylases tune the biological normoxic set point
2006
Effect of Extracellular AMP on Cell Proliferation and Metabolism of Breast Cancer Cell Lines with High and Low Glycolytic Rates
1997
The function of hypoxia‐inducible factor 1 (HIF‐1) is impaired in senescent mice
1999
Regulation of Metabolism by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Development of novel therapeutic strategies that target HIF-1
2006 StandoutNobel
FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
2001 StandoutNobel
Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer
1998 StandoutNobel
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Oxygen homeostasis
2009 StandoutNobel
Spermidine/Spermine N1-Acetyltransferase-1 Binds to Hypoxia-inducible Factor-1α (HIF-1α) and RACK1 and Promotes Ubiquitination and Degradation of HIF-1α
2007 StandoutNobel
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
2001 Standout
Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation
2013 StandoutNobel
Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype
2014 StandoutNobel
Mammalian Oxygen Sensing, Signalling and Gene Regulation
2000
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Regulation of Transcription by Hypoxia Requires a Multiprotein Complex That Includes Hypoxia-Inducible Factor 1, an Adjacent Transcription Factor, and p300/CREB Binding Protein
1998
A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication
2013 StandoutNobel
Transcriptional repression by a novel member of the bZIP family of transcription factors.
1992
Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
2000 StandoutNobel
DNA-Binding Specificity of the PAR Basic Leucine Zipper Protein VBP Partially Overlaps Those of the C/EBP and CREB/ATF Families and Is Influenced by Domains That Flank the Core Basic Region
1995
DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein.
1994
HIF hydroxylation and the mammalian oxygen-sensing pathway
2003 StandoutNobel
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
2011 StandoutNobel
Embryonal Carcinoma P19 Cells Produce Erythropoietin Constitutively But Express Lactate Dehydrogenase in an Oxygen-Dependent Manner
1998 StandoutNobel
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Hypoxia-Inducible Factor 1 and Cardiovascular Disease
2013 StandoutNobel
CRP2 (C/EBP beta) contains a bipartite regulatory domain that controls transcriptional activation, DNA binding and cell specificity.
1995
Cellular adaptation to hypoxia: O 2 ‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O 2 ‐regulated gene expression
2002
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene
2005
Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology
2013 StandoutNobel
Hypoxia Regulates β-Enolase and Pyruvate Kinase-M Promoters by Modulating Sp1/Sp3 Binding to a Conserved GC Element
1998
DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF.
1994
E2A-HLF-Mediated Cell Transformation Requires both the trans-Activation Domains of E2A and the Leucine Zipper Dimerization Domain of HLF
1995
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.
2000 StandoutNobel
TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins.
1991
Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.
1990
Molecular Cloning and Characterization of NF-IL3A, a Transcriptional Activator of the Human Interleukin-3 Promoter
1995
Chicken vitellogenin gene-binding protein, a leucine zipper transcription factor that binds to an important control element in the chicken vitellogenin II promoter, is related to rat DBP.
1991
Cell cycle kinase inhibitor expression and hypoxia-induced cell cycle arrest in human cancer cell lines
2004
Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia.
1992
HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells
2015 StandoutNobel
Regulation of Mammalian O2Homeostasis by Hypoxia-Inducible Factor 1
1999 StandoutNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Protection from Oxidative Stress–Induced Apoptosis in Cortical Neuronal Cultures by Iron Chelators Is Associated with Enhanced DNA Binding of Hypoxia-Inducible Factor-1 and ATF-1/CREB and Increased Expression of Glycolytic Enzymes, p21waf1/cip1, and Erythropoietin
1999 StandoutNobel
Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration
2018 StandoutNobel
Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1
2009 StandoutNobel
The RNA Component of Human Telomerase
1995 StandoutScienceNobel
Fusion of the Leucine Zipper Gene HLF to the E2A Gene in Human Acute B-Lineage Leukemia
1992 Science
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
2000
Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1
1998 StandoutNobel
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
Repression of alpha-fetoprotein gene expression under hypoxic conditions in human hepatoma cells: characterization of a negative hypoxia response element that mediates opposite effects of hypoxia inducible factor-1 and c-Myc.
2002
Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1
2007 StandoutNobel
Expression of hypoxia-inducible factor 1? in brain tumors
2000 StandoutNobel
Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart
2013 StandoutNobel
Hypoxia Induces High-Mobility-Group Protein I(Y) and Transcription of the Cyclooxygenase-2 Gene in Human Vascular Endothelium
1998
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.
1994 Standout
Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung
1998 StandoutNobel
Works of Pascal Maire being referenced
Six1 is required for the early organogenesis of mammalian kidney
2003
Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1
1996 StandoutNobel
Characterization of three optional promoters in the 5′ region of the human aldolase A gene
1987
Muscle Contraction Is Necessary to Maintain Joint Progenitor Cell Fate
2009
Transcription of the dystrophin gene in human muscle and non-muscle tissues
1988 Nature
A ubiquitous enhancer shared by two promoters in the human aldolase A gene
1991
DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally
1990
Altered myogenesis inSix1-deficient mice
2003
Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo
2005
The Role of Cis-Acting Promoter Elements in Tissue-Specific Albumin Gene Expression
1989 Science
Six1 and Eya1 Expression Can Reprogram Adult Muscle from the Slow-Twitch Phenotype into the Fast-Twitch Phenotype
2004
Molecular cloning and expression of rat aldolase C messenger RNA during development and hepatocarcinogenesis
1987