Standout Papers
Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
2008 StandoutScienceNobel
Hypothalamic mTOR Signaling Regulates Food Intake
2006 Science
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
2007 Standout
Crystal Structures of the Adenylate Sensor from Fission Yeast AMP-Activated Protein Kinase
2007 Science
Adiponectin Cardioprotection After Myocardial Ischemia/Reperfusion Involves the Reduction of Oxidative/Nitrative Stress
2007
Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids
2005
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
2005 StandoutScience
Regulation of phosphoinositide 3-kinase expression in health and disease
2009
XBP1s Is an Anti-lipogenic Protein
2016
AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation
2009 Science
Sixteen hours of fasting differentially affects hepatic and muscle insulin sensitivity in mice
2004
Rosiglitazone (BRL49653), a PPARγ-selective agonist, causes peroxisome proliferator-like liver effects in obese mice
1999
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease
2007
Hypothalamic KATP channels control hepatic glucose production
2005 Nature
Insulin modifies the properties of glucose transporters in rat brown adipose tissue
1987
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
2003
Ceramides as modulators of cellular and whole-body metabolism
2011
Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle
2010
Obesity, adiponectin and vascular inflammatory disease
2003
Expression of adiponectin receptors in pancreatic β cells
2003
Regional differences in adipose tissue metabolism in obese men
2007
Molecular mediators of hepatic steatosis and liver injury
2004 Standout
Ceramides in insulin resistance and lipotoxicity
2005
Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas
2010
AMPK, the metabolic syndrome and cancer
2005
Cannabinoids and Ghrelin Have Both Central and Peripheral Metabolic and Cardiac Effects via AMP-activated Protein Kinase
2005
FoxO1 Regulates Multiple Metabolic Pathways in the Liver
2006
Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-α
2004
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
2006
Fatty acid metabolism as a target for obesity treatment
2005
Impaired Regulation of Hepatic Glucose Production in Mice Lacking the Forkhead Transcription Factor Foxo1 in Liver
2007
Norepinephrine Increases Glucose Transport in Brown Adipocytes via β3-Adrenoceptors through a cAMP, PKA, and PI3-Kinase-Dependent Pathway Stimulating Conventional and Novel PKCs
2003
KIN‐29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC
2006
Adipose tissue as a buffer for daily lipid flux
2002
Role of malonyl-CoA in heart disease and the hypothalamic control of obesity
2006
Pioglitazone Ameliorates Insulin Resistance and Diabetes by Both Adiponectin-dependent and -independent Pathways
2006
Thiazolidinediones Increase Plasma-Adipose Tissue FFA Exchange Capacity and Enhance Insulin-Mediated Control of Systemic FFA Availability
2001
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
2005 Nature
PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP
2005
Mice with AS160/TBC1D4-Thr649Ala Knockin Mutation Are Glucose Intolerant with Reduced Insulin Sensitivity and Altered GLUT4 Trafficking
2011
Adiponectin modulates carnitine palmitoyltransferase-1 through AMPK signaling cascade in rat cardiomyocytes
2006
Role of AMP-activated protein kinase in mechanism of metformin action
2001 Standout
Biochemical Regulation of Mammalian AMP-activated Protein Kinase Activity by NAD and NADH
2004
Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase
1999
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
2002 StandoutNature
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
2005 Standout
Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene
2000
Asymmetrical dimethylarginine triggers lipolysis and inflammatory response via induction of endoplasmic reticulum stress in cultured adipocytes
2009
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Effect of cold acclimation on the expression of glucose transporter Glut 4
1992
Lipolysis and lipid mobilization in human adipose tissue
2009
Increased oxidative stress in obesity and its impact on metabolic syndrome
2004 Standout
Estrogen Regulation of Adiposity and Fuel Partitioning
2005
Central nervous system control of food intake and body weight
2006 StandoutNature
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
2007 Standout
Chronic Intake of High-Fat and High-Sucrose Diets Differentially Affects Glucose Intolerance in Mice
2006
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B–null mice
2006
Molecular Physiology of Mammalian Glucokinase
2008
GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization
2004
Adiponectin Stimulates Angiogenesis in Response to Tissue Ischemia through Stimulation of AMP-activated Protein Kinase Signaling
2004
High Local Concentrations and Effects on Differentiation Implicate Interleukin‐6 as a Paracrine Regulator
2004
Adiponectin Stimulates Production of Nitric Oxide in Vascular Endothelial Cells
2003
The Akt–SREBP nexus: cell signaling meets lipid metabolism
2010
The lipid phosphatase SHIP2 controls insulin sensitivity
2001 Nature
gAd-globular Head Domain of Adiponectin Increases Fatty Acid Oxidation in Newborn Rabbit Hearts
2004
The role of pathway-selective insulin resistance and responsiveness in diabetic dyslipoproteinemia
2012
Glucose Transporter in Insulin Sensitive Tissues of Lean and Obese Mice. Effect of the Thermogenic Agent BRL 26830A*
1990
The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response
2009
Adiponectin-mediated modulation of hypertrophic signals in the heart
2004
Lipolysis Response to Endoplasmic Reticulum Stress in Adipose Cells
2012
The metabolic syndrome
2010 Standout
Thiazolidinediones: metabolic actions in vitro
2002
Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet
2006
Selective versus Total Insulin Resistance: A Pathogenic Paradox
2008 Nobel
Central mechanisms involved in the orexigenic actions of ghrelin
2011
New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes
2001
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
2004 Standout
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
2004 Standout
Fat cell enlargement is an independent marker of insulin resistance and ‘hyperleptinaemia’
2007
Rat PPARs: Quantitative Analysis in Adult Rat Tissues and Regulation in Fasting and Refeeding
2001
Ceramide Generation Is Sufficient to Account for the Inhibition of the Insulin-stimulated PKB Pathway in C2C12 Skeletal Muscle Cells Pretreated with Palmitate
1999
Relationship between fat cell size and number and fatty acid composition in adipose tissue from different fat depots in overweight/obese humans
2006
Relationship among Adiponectin, Adiponectin Gene Expression and Fatty Acids Composition in Morbidly Obese Patients
2007
Dissociating fatty liver and diabetes
2012
Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects
2005
Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk
2016
AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome
2009
Structural basis for AMP binding to mammalian AMP-activated protein kinase
2007 Nature
Pathogenesis of Selective Insulin Resistance in Isolated Hepatocytes
2015
Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
2017 Standout
Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells
2005
Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis
2009
The Fasting-induced Adipose Factor/Angiopoietin-like Protein 4 Is Physically Associated with Lipoproteins and Governs Plasma Lipid Levels and Adiposity
2005
Insulin and noradrenaline independently stimulate the translocation of glucose transporters from intracellular stores to the plasma membrane in mouse brown adipocytes
1992
Upper intestinal lipids trigger a gut–brain–liver axis to regulate glucose production
2008 Nature
Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism
2002
Absence of Sterol Regulatory Element-binding Protein-1 (SREBP-1) Ameliorates Fatty Livers but Not Obesity or Insulin Resistance in Lep/Lep Mice
2002
Regulation of ketogenesis and the renaissance of carnitine palmitoyltransferase
1989
Diabetic dyslipidaemia: from basic research to clinical practice*
2003
Hepatic monitoring of essential amino acid availability may regulate IGF-I activity, thermogenesis, and fatty acid oxidation/synthesis
2001
Molecular disruption of hypothalamic nutrient sensing induces obesity
2006
Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2
2007 Nature
α-Lipoic acid increases cardiac glucose oxidation independent of AMP-activated protein kinase in isolated working rat hearts
2007
Hormonal Regulation of Hepatic Glucose Production in Health and Disease
2011
AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation
2015
Insulin regulation of glucokinase gene expression: Evidence against a role for sterol regulatory element binding protein 1 in primary hepatocytes
2005
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice
2011
Opposite actions of testosterone and progesterone on UCP1 mRNA expression in cultured brown adipocytes
2002
Transcriptional Regulation of Metabolism
2006
Control of pyruvate dehydrogenase kinase gene expression
2001
Adiponectin: A Novel Adipokine Linking Adipocytes and Vascular Function
2004
Visceral fat thickness in overweight men correlates with alterations in serum fatty acid composition
2008
Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt
2000
The AMP‐Activated Protein Kinase
1997
Abnormal hepatic apolipoprotein B metabolism in type 2 diabetes
2010
Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males
2005
Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice
2004
Functional Analysis of Mutations in the γ2 Subunit of AMP-activated Protein Kinase Associated with Cardiac Hypertrophy and Wolff-Parkinson-White Syndrome
2002
PPARs and the complex journey to obesity
2004
AMP-activated protein kinase: the guardian of cardiac energy status
2004
The Antihyperglycaemic Effect of Metformin
1999
Adipokines in inflammation and metabolic disease
2011 Standout
Regulation of gene expression by SREBP and SCAP
2000
The Role of SREBP-1c in Nutritional Regulation of Lipogenic Enzyme Gene Expression
2002
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
2007
Adipose tissue distribution and risk of metabolic disease: does thiazolidinedione-induced adipose tissue redistribution provide a clue to the answer?
2007
The metabolic syndrome
2005 Standout
Interleukin-15 stimulates adiponectin secretion by 3T3-L1 adipocytes: Evidence for a skeletal muscle-to-fat signaling pathway
2005
AMP-activated protein kinase signaling in metabolic regulation
2006
Enhanced Leptin-Stimulated Pi3k Activation in the CNS Promotes White Adipose Tissue Transdifferentiation
2007 StandoutNobel
Brown adipose tissue thermogenesis and obesity
1989
Mechanism for Fatty Acid “Sparing” Effect on Glucose-induced Transcription
2002
Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.
1998
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Candidate Genes for Type 2 Diabetes
2004
Alterations in energy metabolism in cardiomyopathies
2007
Insulin Receptor Signaling in Normal and Insulin-Resistant States
2014
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
2005 StandoutNature
Biochemical and cellular properties of insulin receptor signalling
2017
Myocardial Substrate Metabolism in the Normal and Failing Heart
2005 Standout
Effects of Intravenously Infused Leptin on Insulin Sensitivity and on the Expression of Uncoupling Proteins in Brown Adipose Tissue1
1999
Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop
2011
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms
2005
Impaired Multimerization of Human Adiponectin Mutants Associated with Diabetes
2003
Thermogenic effects of sibutramine and its metabolites
1999
Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c
2003
Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway
2000
Increased Levels of Nuclear SREBP-1c Associated with Fatty Livers in Two Mouse Models of Diabetes Mellitus
1999
Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis
2008
AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise
2004
Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo
2004
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
2002 StandoutNobel
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
2013
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
2006
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Glucose and Insulin Function through Two Distinct Transcription Factors to Stimulate Expression of Lipogenic Enzyme Genes in Liver
2001
Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity
2016
Polyunsaturated Fatty Acids Suppress Hepatic Sterol Regulatory Element-binding Protein-1 Expression by Accelerating Transcript Decay
2001
Adiponectin: mechanistic insights and clinical implications
2012
An obesity-associated gut microbiome with increased capacity for energy harvest
2006 StandoutNature
Adiponectin Stimulates Angiogenesis by Promoting Cross-talk between AMP-activated Protein Kinase and Akt Signaling in Endothelial Cells
2004
Insulin and insulin resistance:
2004 Standout
The Mitochondrial Carnitine Palmitoyltransferase System — From Concept to Molecular Analysis
1997
Metformin
1996
Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists
2005
A proposed model of fat packaging by exchangeable lipid droplet proteins
2006
APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function
2006
SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
2008
Conserved α-Helix Acts as Autoinhibitory Sequence in AMP-activated Protein Kinase α Subunits
2006
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations
2004
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
2010
Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance
2009
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation
2001 Nobel
The delicate balance between fat and muscle: adipokines in metabolic disease and musculoskeletal inflammation
2004
gp130 receptor ligands as potential therapeutic targets for obesity
2007
Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
2000
AMP-activated Protein Kinase Is Required for the Lipid-lowering Effect of Metformin in Insulin-resistant Human HepG2 Cells
2004
Effects of TNF-α neutralization on adipocytokines and skeletal muscle adiposity in the metabolic syndrome
2007
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Does brown adipose tissue have a role to play in glucose homeostasis?
1989
Effects of glycogen stores and non-esterified fatty acid availability on insulin-stimulated glucose metabolism and tissue pyruvate dehydrogenase activity in the rat
1991
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
2008 Nature
Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance
2008
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype
2011
Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus
1996
AMP-activated Protein Kinase Plays a Role in the Control of Food Intake
2004
A Ceramide-Centric View of Insulin Resistance
2012
UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators
2008
Regulation of Hepatic De Novo Lipogenesis in Humans
1996
Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling
2011
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
2013 Nature
Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
2003 Nature
Management of cellular energy by the AMP‐activated protein kinase system
2003
The role of autophagy during the early neonatal starvation period
2004 StandoutNatureNobel
Nonalcoholic fatty liver disease
2005 Standout
Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling
2017
Lipid overload and overflow: metabolic trauma and the metabolic syndrome
2003
The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling
2012
Cardiac expression of adiponectin and its receptors in streptozotocin-induced diabetic rats
2007
TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue
2018
Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c
2002 Nobel
S14 protein in breast cancer cells: Direct evidence of regulation by SREBP-1c, superinduction with progestin, and effects on cell growth
2005
Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression
2012 Standout
In vitro induction of UCP1 mRNA in preadipocytes from rabbit considered as a model of large mammals brown adipose tissue development: importance of PPARγ agonists for cells isolated in the postnatal period
1998
Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice
2011
AMP‐activated protein kinase: the energy charge hypothesis revisited
2001
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ
2000
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
2010
Transgenic rescue of insulin receptor–deficient mice
2004
Ghrelin: Structure and Function
2005 Standout
AMPK β Subunit Targets Metabolic Stress Sensing to Glycogen
2003
Accumulation of metformin by tissues of the normal and diabetic mouse
1994
Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
2011
Obesity is associated with macrophage accumulation in adipose tissue
2003 Standout
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Adiponectin, driver or passenger on the road to insulin sensitivity?
2013
The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways
2002
AMPK: a nutrient and energy sensor that maintains energy homeostasis
2012 Standout
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
2008 Standout
Effects of adenosine on myocardial glucose and palmitate metabolism after transient ischemia: role of 5′-AMP-activated protein kinase
2006
The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together
2007 StandoutNobel
Obesity Wars
2004
The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans
2012
The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor
2007
AMPK and PPARδ Agonists Are Exercise Mimetics
2008
Structure of mammalian AMPK and its regulation by ADP
2011 Nature
Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia
2000
Intramyocellular lipids and insulin resistance
2004
Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism
2005
Circulating Resistin Levels Are Not Associated with Obesity or Insulin Resistance in Humans and Are Not Regulated by Fasting or Leptin Administration: Cross-Sectional and Interventional Studies in Normal, Insulin-Resistant, and Diabetic Subjects
2003
Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes
2004
Roles of PPARs in health and disease
2000 StandoutNature
BRCA1 Affects Lipid Synthesis through Its Interaction with Acetyl-CoA Carboxylase
2005
The Human Obesity Gene Map: The 2004 Update
2005
Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity
2004
Obesity and insulin resistance
2000 Standout
AMP-activated protein kinase kinase: detection with recombinant AMPK α1 subunit
2002
Insulin signaling to hepatic lipid metabolism in health and disease
2011
Adenosine Monophosphate-Activated Protein Kinase: A Central Regulator of Metabolism with Roles in Diabetes, Cancer, and Viral Infection
2011
Function of Mammalian LKB1 and Ca2+/Calmodulin-dependent Protein Kinase Kinase α as Snf1-activating Kinases in Yeast
2005
AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling
2007
Pathophysiology of Human Visceral Obesity: An Update
2013 Standout
5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.
2000
NUTRITIONAL AND HORMONAL REGULATION OF ENZYMES IN FAT SYNTHESIS: Studies of Fatty Acid Synthase and Mitochondrial Glycerol-3-Phosphate Acyltransferase Gene Transcription
1998
Clues from cell metabolism
2010 StandoutNatureNobel
Relative importance of malonyl CoA and carnitine in maturation of fatty acid oxidation in newborn rabbit heart
2003
Metformin Prevents the Development of Acute Lipid-Induced Insulin Resistance in the Rat Through Altered Hepatic Signaling Mechanisms
2004
Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status
2003
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
2006 Standout
Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
2012 Nobel
Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver
2005
Adiponectin Replenishment Ameliorates Obesity-Related Hypertension
2006
Peroxisome-proliferator-activated receptor-α (PPARα) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin
2002
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
2002 StandoutNobel
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Mechanisms of Leptin Action and Leptin Resistance
2007
Molecular Mechanisms Regulating Hormone-Sensitive Lipase and Lipolysis
2000
Omental Adipose Tissue Type 1 11β-Hydroxysteroid Dehydrogenase Oxoreductase Activity, Body Fat Distribution, and Metabolic Alterations in Women
2009
Mechanisms of the free fatty acid-induced increase in hepatic glucose production
2003
Adipose Tissue, Inflammation, and Cardiovascular Disease
2005 Standout
AMP-activated protein kinase — the fat controller of the energy railroadThis paper is one of a selection of papers published in this Special issue, entitled Second Messengers and Phosphoproteins—12th International Conference.
2006
Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression
2000
Type 2 diabetes: principles of pathogenesis and therapy
2005 Standout
A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver
2001
Spot 14: A Marker of Aggressive Breast Cancer and a Potential Therapeutic Target
2006
Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation
2002
Myocardial Fatty Acid Metabolism in Health and Disease
2010 Standout
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
2003
Regulation of Fasted Blood Glucose by Resistin
2004 Science
Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue.
1993
Adiponectin Multimeric Complexes and the Metabolic Syndrome Trait Cluster
2006
Effect of Pioglitazone on Abdominal Fat Distribution and Insulin Sensitivity in Type 2 Diabetic Patients
2002
The AMP-activated protein kinase cascade – a unifying system for energy control
2003
Adiponectin and Adiponectin Receptors
2005 Standout
Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytes.
1999
Coordinate Regulation of Malonyl-CoA Decarboxylase,sn-Glycerol-3-phosphate Acyltransferase, and Acetyl-CoA Carboxylase by AMP-activated Protein Kinase in Rat Tissues in Response to Exercise
2002
Increased Fatty Acid Re-esterification by PEPCK Overexpression in Adipose Tissue Leads to Obesity Without Insulin Resistance
2002
Fat and Beyond: The Diverse Biology of PPARγ
2008 Standout
Maturation of fatty acid and carbohydrate metabolism in the newborn heart
1998
Noradrenaline stimulates glucose transport in rat brown adipocytes by activating thermogenesis. Evidence that fatty acid activation of mitochondrial respiration enhances glucose transport
1991
Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction
2000
Endocrine Functions of Adipose Tissue
2006
Effect of fatty acids on glucose production and utilization in man.
1983
Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1α
2006 StandoutNobel
Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR
2001 Nobel
Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet–Fed Mice
2012
Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis
2003
Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets
2000
Determinants of leptin gene expression in fat depots of lean mice
2002
A Transgenic Mouse with a Deletion in the Collagenous Domain of Adiponectin Displays Elevated Circulating Adiponectin and Improved Insulin Sensitivity
2003
Brown Adipose Tissue: Function and Physiological Significance
2004 Standout
Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK)
2002
Reversal of Nonalcoholic Hepatic Steatosis, Hepatic Insulin Resistance, and Hyperglycemia by Moderate Weight Reduction in Patients With Type 2 Diabetes
2005
Visceral Adipocyte Hypertrophy is Associated With Dyslipidemia Independent of Body Composition and Fat Distribution in Women
2011
Malonyl‐CoA decarboxylase (MCD) is differentially regulated in subcellular compartments by 5′AMP‐activated protein kinase (AMPK)
2004
Involvement of AMP-Activated Protein Kinase in Glucose Uptake Stimulated by the Globular Domain of Adiponectin in Primary Rat Adipocytes
2003
Understanding the pathogenesis and treatment of insulin resistance and type 2 diabetes mellitus: what can we learn from transgenic and knockout mice?
2000
Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver
2004
Mimicry of a Cellular Low Energy Status Blocks Tumor Cell Anabolism and Suppresses the Malignant Phenotype
2005
Hypoadiponectinemia Is an Independent Risk Factor for Hypertension
2004
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
2022 StandoutScienceNobel
Transgenic rescue of insulin receptor–deficient mice
2004
Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands
2001 Nobel
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
2010 Nobel
Targeting Fatty Acid Synthase in Breast and Endometrial Cancer: An Alternative to Selective Estrogen Receptor Modulators?
2006
Disordered Fat Storage and Mobilization in the Pathogenesis of Insulin Resistance and Type 2 Diabetes
2002
Cardiac Energy Metabolism in Obesity
2007
Adiponectin: a key adipocytokine in metabolic syndrome
2006
Pharmacologic Therapy for Type 2 Diabetes Mellitus
1999
Androgens Stimulate Lipogenic Gene Expression in Prostate Cancer Cells by Activation of the Sterol Regulatory Element-Binding Protein Cleavage Activating Protein/Sterol Regulatory Element-Binding Protein Pathway
2001
Pioglitazone Reduces Hepatic Fat Content and Augments Splanchnic Glucose Uptake in Patients With Type 2 Diabetes
2003
ChREBP, a Transcriptional Regulator of Glucose and Lipid Metabolism
2007
Stimulatory effect of cold adaptation on glucose utilization by brown adipose tissue. Relationship with changes in the glucose transporter system.
1987
Regional Differences in Adipose Tissue Metabolism in Women
2006
Leptin Stimulates Fatty Acid Oxidation and Peroxisome Proliferator-Activated Receptor α Gene Expression in Mouse C2C12 Myoblasts by Changing the Subcellular Localization of the α2 Form of AMP-Activated Protein Kinase
2007
Expression of Adiponectin Receptor mRNA in Human Skeletal Muscle Cells Is Related to In Vivo Parameters of Glucose and Lipid Metabolism
2004
Glucose or Insulin, but not Zinc Ions, Inhibit Glucagon Secretion From Mouse Pancreatic α-Cells
2005
Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity
2002
Dual Mechanisms Regulating AMPK Kinase Action in the Ischemic Heart
2005
Stimulation of glucose transport by insulin and norepinephrine in isolated rat brown adipocytes
1989
Comparison of Circulating Adiponectin and Proinflammatory Markers Regarding Their Association With Metabolic Syndrome in Japanese Men
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GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization
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Mechanisms of nutritional and hormonal regulation of lipogenesis
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Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice
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Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI
2008 Standout
Adaptation and Maladaptation of the Heart in Diabetes: Part II
2002
The gut microbiota as an environmental factor that regulates fat storage
2004 Standout
T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin
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Adiponectin: More Than Just Another Fat Cell Hormone?
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Opposing Effects of Adiponectin Receptors 1 and 2 on Energy Metabolism
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Resveratrol stimulates AMP kinase activity in neurons
2007
Obesity is associated with macrophage accumulation in adipose tissue
2003 Standout
Microarray Analyses during Adipogenesis: Understanding the Effects of Wnt Signaling on Adipogenesis and the Roles of Liver X Receptor α in Adipocyte Metabolism
2002
Dietaryn-3 fatty acids affect mRNA level of brown adipose tissue uncoupling protein 1, and white adipose tissue leptin and glucose transporter 4 in the rat
2000
PPAR-α–Null Mice Are Protected From High-Fat Diet–Induced Insulin Resistance
2001
Induction of Adiponectin, a Fat-Derived Antidiabetic and Antiatherogenic Factor, by Nuclear Receptors
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Adiponectinemia in Visceral Obesity: Impact on Glucose Tolerance and Plasma Lipoprotein and Lipid Levels in Men
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Upregulation of 5′-AMP–Activated Protein Kinase Is Responsible for the Increase in Myocardial Fatty Acid Oxidation Rates Following Birth in the Newborn Rabbit
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Malonyl-CoA and the regulation of fatty acid oxidation in soleus muscle
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A Mutant Allele Encoding DNA Binding–Deficient FoxO1 Differentially Regulates Hepatic Glucose and Lipid Metabolism
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Nutritional regulation of the fatty acid synthase promoter in vivo : Sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element
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AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes
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Altered Hepatic and Muscle Substrate Utilization Provoked by GLUT4 Ablation
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Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1
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Insulin Receptor Knockout Mice
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Glucose transporter expression and glucose utilization in skeletal muscle and brown adipose tissue during starvation and re-feeding
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Glucokinase and molecular aspects of liver glycogen metabolism
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Intramyocellular Ceramides: Subcellular Concentrations and Fractional De Novo Synthesis in Postabsorptive Humans
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Insulin-like growth factor I and insulin induce adipogenic-related gene expression in fetal brown adipocyte primary cultures
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NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness
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AMP-activated protein kinase: the guardian of cardiac energy status
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Molecular mediators of hepatic steatosis and liver injury
2004 Standout
Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis
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Physiological modulation of the uptake and fate of glucose in brown adipose tissue
1993
Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver
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Adiponectin, an Adipocyte-Derived Protein, Predicts Future Insulin Resistance: Two-Year Follow-Up Study in Japanese Population
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The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents
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Key Role for AMP-Activated Protein Kinase in the Ventromedial Hypothalamus in Regulating Counterregulatory Hormone Responses to Acute Hypoglycemia
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Regulation of Pyruvate Dehydrogenase Kinase Expression by Peroxisome Proliferator–Activated Receptor-α Ligands, Glucocorticoids, and Insulin
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Time courses of the responses of pyruvate dehydrogenase activities to short-term starvation in diaphragm and selected skeletal muscles of the rat
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Ghrelin Gene Expression Is Markedly Higher in Fetal Pancreas Compared with Fetal Stomach: Effect of Maternal Fasting
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Glucose and cAMP: Adversaries in the regulation of hepatic gene expression
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Acetyl-CoA carboxylase involvement in the rapid maturation of fatty acid oxidation in the newborn rabbit heart.
1994
Hormonal regulation of glucose transport in a brown adipose cell preparation isolated from rats that shows a large response to insulin
1996
Cloning and expression of rat pancreatic β-cell malonyl-CoA decarboxylase
1999
Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report. National Institutes of Health.
1998 Standout
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
1999 Nobel
The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin
2015
Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin
2002 Standout
Association of Genetic Variation of the Adiponectin gene with Body Fat Distribution and Carotid Atherosclerosis in Japanese Obese Subjects
2007
Alternative Macrophage Activation and Metabolism
2011
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
2000 Standout
RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells.
2003
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Site-specific regulation of gene expression by n-3 polyunsaturated fatty acids in rat white adipose tissues
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Evidence for the presence of several phosphodiesterase isoforms in brown adipose tissue of Zucker rats: modulation of PDE2 by the fa gene expression
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Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver
2011
New insights into ER stress-induced insulin resistance
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Anti-lipolytic Action of AMP-activated Protein Kinase in Rodent Adipocytes
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AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
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1995
Glucose regulation of gene expression
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Differential Regulation of Sterol Regulatory Element-binding Protein 1c Transcriptional Activity by Insulin and Liver X Receptor during Liver Development
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Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP‐1c
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Cholesterol‐Induced Caveolin Targeting to Lipid Droplets in Adipocytes: A Role for Caveolar Endocytosis
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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
2002 Standout
Endoplasmic reticulum stress: a new actor in the development of hepatic steatosis
2010
Regulation of lipogenic enzyme expression by glucose in liver and adipose tissue: A review of the potential cellular and molecular mechanisms
1996
SREBP transcription factors: master regulators of lipid homeostasis
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Adipocyte functions are modulated by cell size change: potential involvement of an integrin/ERK signalling pathway
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Regulation of lipogenic enzyme and phosphoenolpyruvate carboxykinase gene expression in cultured white adipose tissue
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Discrete brain areas express the insulin-responsive glucose transporter GLUT4
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Long chain fatty acyl-CoA synthetase 5 expression is induced by insulin and glucose: involvement of sterol regulatory element-binding protein-1c
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Hepatic Glucokinase Is Required for the Synergistic Action of ChREBP and SREBP-1c on Glycolytic and Lipogenic Gene Expression
2004
Cholesterol, a Cell Size-dependent Signal That Regulates Glucose Metabolism and Gene Expression in Adipocytes
2001
AMP-activated Protein Kinase Inhibits the Glucose-activated Expression of Fatty Acid Synthase Gene in Rat Hepatocytes
1998
Progesterone Stimulates Adipocyte Determination and Differentiation 1/Sterol Regulatory Element-binding Protein 1c Gene Expression
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Effects of insulin and norepinephrine on glucose transport and metabolism in rat brown adipocytes
1987
GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice
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Obesity-related Overexpression of Fatty-acid Synthase Gene in Adipose Tissue Involves Sterol Regulatory Element-binding Protein Transcription Factors
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SREBP-1c Transcription Factor and Lipid Homeostasis: Clinical Perspective
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Pioglitazone-induced increase of insulin sensitivity in the muscles of the obese Zucker fa/fa rat cannot be explained by local adipocyte differentiation
1998
Functions of AMP‐activated protein kinase in adipose tissue
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Sterol Regulatory Element-binding Protein-1c Mimics the Negative Effect of Insulin on Phosphoenolpyruvate Carboxykinase (GTP) Gene Transcription
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Molecular and metabolic changes in white adipose tissue of the rat during development of ventromedial hypothalamic obesity
1992
Decreased Resistin Expression in Mice with Different Sensitivities to a High-Fat Diet
2001
Characterising the Inhibitory Actions of Ceramide upon Insulin Signaling in Different Skeletal Muscle Cell Models: A Mechanistic Insight
2014
Regulation of gene expression by glucose
1999
Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells: IMPLICATION OF THE DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE
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Sterol-regulatory-element-binding protein I c mediates insulin action on hepatic gene expression
2001
Initial glucose kinetics and hormonal response to a gastric glucose load in unrestrained post-absorptive and starved rats
1990
Adaptations of glucose and fatty acid metabolism during perinatal period and suckling-weaning transition
1992
Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes
2000
New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c
2002
Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)
2004
Metabolic fate of a gastric glucose load in unrestrained rats bearing a portal vein catheter
1988
Polyunsaturated fatty acids inhibit fatty acid synthase and spot-14-protein gene expression in cultured rat hepatocytes by a peroxidative mechanism
1999
Stimulation of Acetyl-CoA Carboxylase Gene Expression by Glucose Requires Insulin Release and Sterol Regulatory Element Binding Protein 1c in Pancreatic MIN6 β-Cells
2002
Pioglitazone Induces In Vivo Adipocyte Differentiation in the Obese Zucker fa/fa Rat
1997
Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat
1997
Nutritional regulation of glucose transporter in muscle and adipose tissue of weaned rats
1991
Influence of exogenous fat and gluconeogenic substrates on glucose homeostasis in the newborn rat.
1978
Development of obesity in Zucker rats. Early insulin resistance in muscles but normal sensitivity in white adipose tissue
1987
Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
1999
Plasma Membrane Subdomain Compartmentalization Contributes to Distinct Mechanisms of Ceramide Action on Insulin Signaling
2009
DNase I hypersensitivity sites and nuclear protein binding on the fatty acid synthase gene: identification of an element with properties similar to known glucose-responsive elements
1995
The Biology of Peroxisome Proliferator-Activated Receptors
2004
Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory elementbinding protein-1c
2005
Glucose Utilization Rates and Insulin Sensitivity In Vivo in Tissues of Virgin and Pregnant Rats
1986
Glucose utilization in vivo and insulin-sensitivity of rat brown adipose tissue in various physiological and pathological conditions
1986
Insulin and tri-iodothyronine induce glucokinase mRNA in primary cultures of neonatal rat hepatocytes
1990
MECHANISMS BY WHICH CARBOHYDRATES REGULATE EXPRESSION OF GENES FOR GLYCOLYTIC AND LIPOGENIC ENZYMES
1997
Development of Obesity in Zucker Rats: Early Insulin Resistance in Muscles But Normal Sensitivity in White Adipose Tissue
1987
ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose
1999
Adenovirus-Mediated Overexpression of Sterol Regulatory Element Binding Protein-1c Mimics Insulin Effects on Hepatic Gene Expression and Glucose Homeostasis in Diabetic Mice
2001
Induction of fatty acid synthase and S14 gene expression by glucose, xylitol and dihydroxyacetone in cultured rat hepatocytes is closely correlated with glucose 6-phosphate concentrations
1997
Decreased hepatic fatty acid oxidation at weaning in the rat is not linked to a variation of malonyl-CoA concentration.
1988
Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes
2000
Effect of anesthesia on glucose production and utilization in rats
1987
SREBF-1 Gene Polymorphisms Are Associated With Obesity and Type 2 Diabetes in French Obese and Diabetic Cohorts
2004
Effects of fasting on tissue glucose utilization in conscious resting rats. Major glucose-sparing effect in working muscles
1987
Fetal metabolic response to maternal fasting in the rat.
1977
Sterol Regulatory Element Binding Protein-1c Expression and Action in Rat Muscles: Insulin-Like Effects on the Control of Glycolytic and Lipogenic Enzymes and UCP3 Gene Expression
2002
Glucose stimulation of lipogenic enzyme gene expression in cultured white adipose tissue. A role for glucose 6-phosphate.
1992
Pregnancy-induced insulin resistance in the rat: assessment by glucose clamp technique
1984
Characterization of the Role of AMP-Activated Protein Kinase in the Regulation of Glucose-Activated Gene Expression Using Constitutively Active and Dominant Negative Forms of the Kinase
2000
A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat
1985
Adipose tissue-specific increase in angiotensinogen expression and secretion in the obese (fa/fa) Zucker rat
2002
A New Transgenic Mouse Model of Chronic Hyperglycemia
1994
AMP-activated protein kinase and hepatic genes involved in glucose metabolism
2003
Regulation of lipogenic enzyme gene expression by nutrients and hormones
1994
Hypoglycaemic effect of metformin in genetically obese (fa/fa) rats results from an increased utilization of blood glucose by intestine
1989
A new transgenic mouse model of chronic hyperglycemia
1994
Glucose metabolism during lactation in the rat: quantitative and regulatory aspects
1983