Citation Impact
Citing Papers
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
2003 StandoutScienceNobel
Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine
2011 StandoutScience
Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity
2013 StandoutScience
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
2009 StandoutScience
Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance
2015 Science
Spontaneous autoimmunity prevented by thymic expression of a single self-antigen
2006
Selective delivery of β cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8 + T cells in NOD mice
2008 StandoutNobel
Dnmt3L and the Establishment of Maternal Genomic Imprints
2001 Science
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
2013 StandoutScienceNobel
Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein
2002 StandoutScience
Genome-scale DNA methylation maps of pluripotent and differentiated cells
2008 StandoutNature
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
2009 StandoutNature
JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome
2000
Gout-associated uric acid crystals activate the NALP3 inflammasome
2006 StandoutNature
Back to Central Tolerance
2004 Standout
Epigenetic events in mammalian germ-cell development: reprogramming and beyond
2008
The genetic background of autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy and its autoimmune disease components
2002
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
2008 Nature
The Autoimmune Regulator (AIRE) Is a DNA-binding Protein
2001
Cryopyrin activates the inflammasome in response to toxins and ATP
2006 StandoutNature
A decade of AIRE
2007
Central tolerance: learning self-control in the thymus
2005
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning
2008 StandoutNature
Animal models of autoimmunity and their relevance to human diseases
2000 StandoutNobel
Tolerance and Autoimmunity
2001
Commitment to the Regulatory T Cell Lineage Requires CARMA1 in the Thymus but Not in the Periphery
2009 StandoutNobel
Transposon Silencing and Imprint Establishment in Mammalian Germ Cells
2004
Thymic selection revisited: how essential is it?
2003
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation
2007 Nature
Immunogenicity of induced pluripotent stem cells
2011 StandoutNature
Mechanisms regulating imprinted genes in clusters
2007
Manifestations and linkage analysis in X-linked autoimmunity-immunodeficiency syndrome
2000
Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi
2006 StandoutNobel
AIRE Mutations and Human Leukocyte Antigen Genotypes as Determinants of the Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Phenotype
2002
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
Aire deficient mice develop multiple features of APECED phenotype and show altered immune response
2002
Lack of involvement of known DNA methyltransferases in familial hydatidiform mole implies the involvement of other factors in establishment of imprinting in the human female germline
2003
Mutations in the AIRE Gene: Effects on Subcellular Location and Transactivation Function of the Autoimmune Polyendocrinopathy-Candidiasis–Ectodermal Dystrophy Protein
2000
TRP channels as cellular sensors
2003 StandoutNature
β-Cell Autoantibodies, Human Leukocyte Antigen II Alleles, and Type 1 Diabetes in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy*
2000
Thymic Commitment of Regulatory T Cells Is a Pathway of TCR-Dependent Selection That Isolates Repertoires Undergoing Positive or Negative Selection
2005
Initial sequence of the chimpanzee genome and comparison with the human genome
2005 StandoutNature
Heterogeneity of thymic dendritic cells
2005
CTLA4 gene polymorphism and autoimmunity
2005
Mechanisms of immunological tolerance
2015
TET enzymes, TDG and the dynamics of DNA demethylation
2013 StandoutNature
Search-and-replace genome editing without double-strand breaks or donor DNA
2019 StandoutNature
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
2001 StandoutNobel
Immunity by ubiquitylation: a reversible process of modification
2005
A TRP Channel that Senses Cold Stimuli and Menthol
2002 StandoutNobel
limma powers differential expression analyses for RNA-sequencing and microarray studies
2015 Standout
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA
2007 Nature
A germline-specific class of small RNAs binds mammalian Piwi proteins
2006 Nature
Gene defect behind APECED: a new clue to autoimmunity
1998
Good riddance: thymocyte clonal deletion prevents autoimmunity
2004
The Polycomb group protein EZH2 directly controls DNA methylation
2005 StandoutNature
The role of regulatory T cells in controlling immunologic self-tolerance
2003 StandoutNobel
WHSC1, a 90 kb SET Domain-Containing Gene, Expressed in Early Development and Homologous to a Drosophila Dysmorphy Gene Maps in the Wolf-Hirschhorn Syndrome Critical Region and is Fused to IgH in t(1;14) Multiple Myeloma
1998
p63 is a p53 homologue required for limb and epidermal morphogenesis
1999 StandoutNature
Negative selection and autoimmunity
2003
Human thymic stromal lymphopoietin promotes dendritic cell–mediated CD4+ T cell homeostatic expansion
2004
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
2001
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
2010 StandoutNature
Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription
2001
Human DNA methylomes at base resolution show widespread epigenomic differences
2009 StandoutNature
lincRNAs act in the circuitry controlling pluripotency and differentiation
2011 StandoutNature
Molecular Cloning of a Novel Putative Ca2+Channel Protein (TRPC7) Highly Expressed in Brain
1998
10 Years ofGenomics,Chromosome 21, and Down Syndrome
1998
Autoimmune disease: why and where it occurs
2001
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
Autophagy in immunity and inflammation
2011 StandoutNature
Aire regulates negative selection of organ-specific T cells
2003
Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L
2004 Nature
The DNA methyltransferases of mammals
2000 Standout
TNFRSF1A mutations and autoinflammatory syndromes
2000
Genetic clues to understanding periodic fevers, and possible therapies
2002
A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3
2001 StandoutNobel
The Inherited Basis of Diabetes Mellitus: Implications for the Genetic Analysis of Complex Traits
2003
Development of Monocytes, Macrophages, and Dendritic Cells
2010 StandoutScience
CD4+CD25−LAG3+regulatory T cells controlled by the transcription factor Egr-2
2009 StandoutNobel
Aire
2009
Three Yeast Proteins Related to the Human Candidate Tumor Suppressor p33ING1 Are Associated with Histone Acetyltransferase Activities
2000
Dependence of Self-Tolerance on TRAF6-Directed Development of Thymic Stroma
2005 Science
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
Cloning of a Mammalian Transcriptional Activator That Binds Unmethylated CpG Motifs and Shares a CXXC Domain with DNA Methyltransferase, Human Trithorax, and Methyl-CpG Binding Domain Protein 1
2000
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
2008 StandoutNature
Epigenetic Reprogramming in Mammalian Development
2001 StandoutScience
EUKARYOTIC CYTOSINE METHYLTRANSFERASES
2005 Standout
Colony Inhibition of Fibroblasts from Chimeric Dogs Mediated by the Dogs' Own Lymphocytes and Specifically Abrogated by Their Serum
1970 StandoutNobel
Functional mapping of disease susceptibility loci using cell biology
2006 StandoutNobel
Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters
2004
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
Normal Thymic Architecture and Negative Selection Are Associated with Aire Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)
2000
NF-κB-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner
2004 StandoutNobel
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
AIRE Functions As an E3 Ubiquitin Ligase
2004
Subcellular Location and Expression Pattern of Autoimmune Regulator (Aire), the Mouse Orthologue for Human Gene Defective in Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)
2001
PD-1 deficiency reveals various tissue-specific autoimmunity by H-2band dose-dependent requirement of H-2g7for diabetes in NOD mice
2008 StandoutNobel
Subcellular Partitioning and Intramacrophage Selectivity of Antimicrobial Compounds against Mycobacterium tuberculosis
2017 StandoutNobel
The Role of DNA Methylation in Mammalian Epigenetics
2001 StandoutScience
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
2014 StandoutScienceNobel
Delineation of the Molecular Defects in the AIRE Gene in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients from Southern Italy
2002
THE NOD MOUSE: A Model of Immune Dysregulation
2004
Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes
2002
Immunotherapy: Bewitched, Bothered, and Bewildered No More
2004 StandoutScienceNobel
An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
1997
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
2011
How defects in central tolerance impinge on a deficiency in regulatory T cells
2005
Works of Pärt Peterson being referenced
Anti-Interferon Autoantibodies in Autoimmune Polyendocrinopathy Syndrome Type 1
2006
Autoimmune Regulator Deficiency Results in Decreased Expression of CCR4 and CCR7 Ligands and in Delayed Migration of CD4+ Thymocytes
2009
Aire-Deficient C57BL/6 Mice Mimicking the Common Human 13-Base Pair Deletion Mutation Present with Only a Mild Autoimmune Phenotype
2009
DNA-PK contributes to the phosphorylation of AIRE: Importance in transcriptional activity
2007
Autoantibodies to cytochrome P450 enzymes P450scc, P450c17, and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease.
1994
AIRE's CARD Revealed, a New Structure for Central Tolerance Provokes Transcriptional Plasticity
2007
Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage
2004
Subcellular Localization of the Autoimmune Regulator Protein
2001
A common mutation in Sardinian autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients
1998
The Autoimmune Regulator Protein Has Transcriptional Transactivating Properties and Interacts with the Common Coactivator CREB-binding Protein
2000
Cooperative activation of transcription by autoimmune regulator AIRE and CBP
2005
Isolation and Characterization of the MouseAireGene
1999
A novel mutation in the third extracellular domain of the tumor necrosis factor receptor 1 in a Finnish family with autosomal‐dominant recurrent fever
2002
Subcellular Expression of Autoimmune Regulator Is Organized in a Spatiotemporal Manner
2004
Steroid 21‐hydroxylase gene polymorphism in Addison's disease patients
1995
RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse
2000
Autoimmune regulator: from loss of function to autoimmunity
2003
Novel AIRE mutations and P450 cytochrome autoantibodies in Central and Eastern European patients with APECED
2001
APECED: a monogenic autoimmune disease providing new clues to self-tolerance
1998
Modulation of Aire regulates the expression of tissue-restricted antigens
2007
Major histocompatibility complex class II and III in Addison's disease MHC alleles do not predict autoantibody specificity and 21-hydroxylase gene polymorphism has no independent role in disease susceptibility
1994
Lymphotoxin pathway directs thymic Aire expression
2003
Positional cloning of the APECED gene
1997
Isolation and Initial Characterization of a Novel Zinc Finger Gene, DNMT3L, on 21q22.3, Related to the Cytosine-5- Methyltransferase 3 Gene Family
2000
Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17α-hydroxylase
1992
Autoimmune Regulator Is Expressed in the Cells Regulating Immune Tolerance in Thymus Medulla
1999
Mutation analyses of North American APS-1 patients
1999
APECED mutations in the autoimmune regulator (AIRE) gene
2001
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy: known and novel aspects of the syndrome
2011
The autoimmune regulator PHD finger binds to non‐methylated histone H3K4 to activate gene expression
2008
A cytotoxic T lymphocyte antigen‐4 (CTLA‐4) gene polymorphism is associated with autoimmune Addison's disease in English patients
1998
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): a model disease to study molecular aspects of endocrine autoimmunity
2004
Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis
2005
Uptake and activity of rifapentine in human peritoneal macrophages and polymorphonuclear leukocytes
1987
Detection of candidal antigens in autoimmune polyglandular syndrome type I
1996