Standout Papers
Citation Impact
Citing Papers
Ambrisentan for the Treatment of Pulmonary Arterial Hypertension
2008 Standout
Increased Mortality, Postoperative Morbidity, and Cost After Red Blood Cell Transfusion in Patients Having Cardiac Surgery
2007 Standout
GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice
2010
Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack
2014 Standout
The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia
2011 Standout
The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS)
2009
Copper-free click chemistry in living animals
2010 StandoutNobel
Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine.
2004
Hospital utilization patterns and costs for adult sickle cell patients in Illinois.
1997
Indications and Results of HLA-Identical Sibling Hematopoietic Cell Transplantation for Sickle Cell Disease
2015
Long-Term Outcome and Evaluation of Organ Function in Pediatric Patients Undergoing Haploidentical and Matched Related Hematopoietic Cell Transplantation for Sickle Cell Disease
2013
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34 + Hematopoietic Stem and Progenitor Cells
2017
Tadalafil Therapy for Pulmonary Arterial Hypertension
2009 Standout
Survival among children and adults with sickle cell disease in Belgium: Benefit from hydroxyurea treatment
2015
Silent Cerebral Infarcts in Sickle Cell Anemia: A Risk Factor Analysis
1999
Dendritic cells in cancer immunology and immunotherapy
2019 Standout
Duration of Red-Cell Storage and Complications after Cardiac Surgery
2008 Standout
Ischemia and reperfusion—from mechanism to translation
2011 Standout
Pulmonary hypertension associated with sickle cell disease: Clinical and laboratory endpoints and disease outcomes
2007
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
A Multinational Trial of Prasugrel for Sickle Cell Vaso-Occlusive Events
2015
Eicosanoids in sickle cell disease: Potential relevance of neutrophil leukotriene B4 to disease pathophysiology
2002
The Clinical Sequelae of Intravascular Hemolysis and Extracellular Plasma Hemoglobin
2005 Standout
The cost of health care for children and adults with sickle cell disease
2009
Erythroid adhesion molecules in sickle cell disease: Effect of hydroxyurea
2008
Pain in Sickle Cell Disease
1991
von Willebrand Factor–Cleaving Protease in Thrombotic Thrombocytopenic Purpura and the Hemolytic–Uremic Syndrome
1998 Standout
Validation of a novel point of care testing device for sickle cell disease
2015
Acute chest syndrome of sickle cell disease: new light on an old problem
2001
SYSTEMIC FAT EMBOLISM AND PULMONARY HYPERTENSION IN SICKLE CELL DISEASE
1996
Pulmonary Hypertension as a Risk Factor for Death in Patients with Sickle Cell Disease
2004
The β-Thalassemias
1999 Standout
Cardiovascular complications and risk of death in sickle-cell disease
2016
Evidence review of hydroxyurea for the prevention of sickle cell complications in low-income countries
2013
Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia
1995 Standout
Renal Function in Infants with Sickle Cell Anemia: Baseline Data from the BABY HUG Trial
2009
CRISPR-Cas9 interrogation of a putative fetal globin repressor in human erythroid cells
2019
Sickle Cell Anaemia
2002
A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care
1999 Standout
Prediction of Adverse Outcomes in Children with Sickle Cell Disease
2000
Macrophages in the Pathogenesis of Atherosclerosis
2011 Standout
Cellular effects of hydroxyurea in Hb SC disease
1997
Influence of sickle cell disease and treatment with hydroxyurea on sperm parameters and fertility of human males
2008
Fetal Hemoglobin in Sickle Cell Anemia: Determinants of Response to Hydroxyurea
1997
Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease
2016
Outpatient Therapy with Ceftriaxone and Oral Cefixime for Selected Febrile Children with Sickle Cell Disease
1996
Haematopoietic cell transplantation in the treatment of sickle cell disease
2003
The Natural History of Sickle Cell Disease
2013
Infection in sickle cell disease: A review
2009
Aspirin plus Clopidogrel as Secondary Prevention after Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis
2014 Standout
Neonatal screening and clinical care programmes for sickle cell disorders in sub-Saharan Africa: Lessons from pilot studies
2008
Enalapril and hydroxyurea therapy for children with sickle nephropathy
2005
Long-term management of splenic sequestration in children with sickle cell disease
1990
The paradox of the neutrophilˈs role in tissue injury
2010
Evidence for a metabolic shift of arginine metabolism in sickle cell disease
2004
Phase 1 Study of the E-Selectin Inhibitor GMI 1070 in Patients with Sickle Cell Anemia
2014
Genetic modifiers of sickle cell disease
2012
Pulmonary Hypertension and Cor Pulmonale during Severe Acute Chest Syndrome in Sickle Cell Disease
2008
Clinical management of adult sickle-cell disease
2012
Gender and haplotype effects upon hematological manifestations of adult sickle cell anemia
1995
Sickle Cell Lung Disease and Sudden Death
2007
Sickle-cell disease
1997
Causes of death in sickle cell disease: an autopsy study
2003
NOVEL TREATMENT OPTIONS IN THE SEVERE β‐GLOBIN DISORDERS
1995
Cardiopulmonary complications leading to premature deaths in adult patients with sickle cell disease
2009
Asthma is associated with Increased mortality in individuals with sickle cell anemia
2007
Global Burden of Sickle Cell Anaemia in Children under Five, 2010–2050: Modelling Based on Demographics, Excess Mortality, and Interventions
2013
Treatment of plasma refractory thrombotic thrombocytopenic purpura with protein A immunoabsorption
1997
The effect of storage time of human red cells on intestinal microcirculatory oxygenation in a rat isovolemic exchange model*
2005
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Sensitization of nociceptive spinal neurons contributes to pain in a transgenic model of sickle cell disease
2015
Outcome of Sickle Cell Anemia
2005
Sickle cell disease: renal manifestations and mechanisms
2015
Advances in clinical research in sickle cell disease
2008
Pulmonary hypertension in sickle cell hemoglobinopathy: A clinicopathologic study of 20 cases
2002
Causes and Outcomes of the Acute Chest Syndrome in Sickle Cell Disease
2000
Diastolic Dysfunction Is an Independent Risk Factor for Death in Patients With Sickle Cell Disease
2007
Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis
2011
The Association of Provider Communication with Trust among Adults with Sickle Cell Disease
2010
Reconstructing sickle cell disease: A data‐based analysis of the “hyperhemolysis paradigm” for pulmonary hypertension from the perspective of evidence‐based medicine
2010
Sickle cell acute chest syndrome associated with parvovirus B19 infection: Case series and review
1996
A cell stress signaling model of fetal hemoglobin induction: what doesn't kill red blood cells may make them stronger
2008
Sickle Cell Hemoglobin Polymerization
1990
Reductions of erythrocyte membrane viscoelastic coefficients reflect spectrin deficiencies in hereditary spherocytosis.
1988 StandoutNobel
Updated Clinical Classification of Pulmonary Hypertension
2013 Standout
Heterogeneity of terminology and clinical definitions in adult idiopathic thrombocytopenic purpura: a critical appraisal from a systematic review of the literature
2007
The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans
2021 StandoutNobel
Mutation of von Hippel–Lindau Tumour Suppressor and Human Cardiopulmonary Physiology
2006 StandoutNobel
Sickle cell disease: no longer a single gene disorder
2001
Effects of Iron Supplementation and Depletion on Hypoxic Pulmonary Hypertension
2009 StandoutNobel
Sickle-cell disease
2010 Standout
Incentive Spirometry to Prevent Acute Pulmonary Complications in Sickle Cell Diseases
1995
Airway hyperresponsiveness and acute chest syndrome in children with sickle cell anemia
2007
Promotion of airway anastomotic microvascular regeneration and alleviation of airway ischemia by deferoxamine nanoparticles
2013 StandoutNobel
Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease
2001
Neutrophils, from Marrow to Microbes
2010 Standout
Bone marrow transplantation in sickle cell anemia
2001
The risks and benefits of long‐term use of hydroxyurea in sickle cell anemia: A 17.5 year follow‐up
2010
A Comparison of Analgesic Management for Emergency Department Patients With Sickle Cell Disease and Renal Colic
2010
The many roles of histone deacetylases in development and physiology: implications for disease and therapy
2008 Standout
Painful Episodes in Children With Sickle Cell Disease and Asthma are Temporally Associated With Respiratory Symptoms
2006
Pulmonary Arterial Hypertension
2004
Therapeutic vaccines for cancer: an overview of clinical trials
2014
Neutrophil microdomains: linking heterocellular interactions with vascular injury
2009
Guidelines for the management of the acute painful crisis in sickle cell disease
2003
Global epidemiology of haemoglobin disorders and derived service indicators
2008 Standout
Stroke recurrence in children with sickle cell disease treated with hydroxyurea following first clinical stroke
2011
The pathophysiology and management of thrombotic thrombocytopenic purpura
1996
Early detection and the course of glomerular injury in patients with sickle cell anemia
1996
Sickle cell disease in Africa: burden and research priorities
2007
Pulmonary Complications of Sickle Cell Disease
2008
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
Pulmonary hypertension in patients with sickle cell disease: a longitudinal study
2006
Idiopathic thrombocytopenic purpura: Current concepts in pathophysiology and management
2007
A Comparison of Conservative and Aggressive Transfusion Regimens in the Perioperative Management of Sickle Cell Disease
1995
5‐hydroxymethyl‐2‐furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells†,‡
2005
Relationship between the clinical manifestations of sickle cell disease and the expression of adhesion molecules on white blood cells
2002
The increase in pulmonary arterial pressure caused by hypoxia depends on iron status
2008 StandoutNobel
Sickle cell disease and the kidney
2008
Immune thrombocytopenic purpura in adults
2007
The paradox of hemoglobin SC disease
2003
Incidence of Invasive Pneumococcal Disease among Individuals with Sickle Cell Disease before and after the Introduction of the Pneumococcal Conjugate Vaccine
2007
The mouse as a model for human biology: a resource guide for complex trait analysis
2006
Glycosylation in cancer: mechanisms and clinical implications
2015 Standout
Hydroxyurea (HU) for prevention of recurrent stroke in sickle cell anemia (SCA)
2002
Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis
2014 Standout
Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia
2005
Mapping the prevalence of sickle cell and beta thalassaemia in England: estimating and validating ethnic‐specific rates
1999
Pharmacologic Modulation of Fetal Hemoglobin
2001
Circumstances of death in adult sickle cell disease patients
2006
Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
1993 Standout
Day‐care management of sickle cell painful crisis in Jamaica: a model applicable elsewhere?
1999
Principles and problems of transfusion in sickle cell disease
2001
Invasive pneumococcal infections in children with sickle cell disease in the era of penicillin prophylaxis, antibiotic resistance, and 23-valent pneumococcal polysaccharide vaccination
2003
Sickle cell vaso-occlusion: multistep and multicellular paradigm
2002
Increased F 2 Isoprostanes in the Acute Chest Syndrome of Sickle Cell Disease as a Marker of Oxidative Stress
2001
Pulmonary Complications of Sickle Cell Disease
2012
Low Exhaled Nitric Oxide and a Polymorphism in the NOS I Gene Is Associated with Acute Chest Syndrome
2001
Arginine Therapy
2003
Extracellular DNA traps promote thrombosis
2010 Standout
A simple, rapid, low-cost diagnostic test for sickle cell disease
2013
Guidelines for the Early Management of Patients With Acute Ischemic Stroke
2013 Standout
Transcranial Doppler ultrasonography in adults with sickle cell disease
2006
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
2006 Standout
Sickle cell anemia day hospital: an approach for the management of uncomplicated painful crises
2000
Predictors of fetal hemoglobin response in children with sickle cell anemia receiving hydroxyurea therapy
2002
High mortality among children with sickle cell anemia and overt stroke who discontinue blood transfusion after transition to an adult program
2015
Variants in the VCAM1 gene and risk for symptomatic stroke in sickle cell disease
2002
Vascular Endothelial Growth Factor: Basic Science and Clinical Progress
2004 Standout
Acute Chest Syndrome in Sickle Cell Disease: Clinical Presentation and Course
1997
Mortality Rates and Age at Death from Sickle Cell Disease: U.S., 1979–2005
2013
Current Options for the Treatment of Idiopathic Thrombocytopenic Purpura
2007
Genetic disruption of the KLF1 gene to overexpress the γ‐globin gene using the CRISPR/Cas9 system
2016
Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease
2004
Cerebrovascular accidents in sickle cell disease: rates and risk factors.
1998 Standout
A case for developing North-South partnerships for research in sickle cell disease
2004
Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice
2012
Leukocytosis and Ischemic Vascular Disease Morbidity and Mortality
2005
Mast cell activation contributes to sickle cell pathobiology and pain in mice
2013
Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults
2007
Foetal Haemoglobin, Erythrocytes Containing Foetal Haemoglobin, and Hematological Features in Congolese Patients with Sickle Cell Anaemia
2012
Malaria chemoprophylaxis in sickle cell disease
2006
Blood Polymorphonuclear Leukocytes From the Majority of Sickle Cell Patients in the Crisis Phase of the Disease Show Enhanced Adhesion to Vascular Endothelium and Increased Expression of CD64
1998
Pulmonary Arterial Hypertension
2006
Hydroxyurea as an Alternative to Blood Transfusions for the Prevention of Recurrent Stroke in Children With Sickle Cell Disease
1999
Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells
2016
Prothrombotic changes in children with sickle cell disease: relationships to cerebrovascular disease and transfusion
1998
Sickle Cell Disease: A Question of Equity and Quality
2006
Muc1 Immunotherapy
2010
Hemolysis-associated priapism in sickle cell disease
2005
Phospholipase A2 levels in acute chest syndrome of sickle cell disease
1996
Divergent Nitric Oxide Bioavailability in Men and Women With Sickle Cell Disease
2003
Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group
2008 Standout
Pain, quality of life, and coping in sickle cell disease.
1996
Adenosine A2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease
2010
DNA polymorphisms at the BCL11A , HBS1L-MYB , and β- globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease
2008
Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation
2015
Survival of children with sickle cell disease
2004
Improving Clinician Attitudes of Respect and Trust for Persons With Sickle Cell Disease
2015
Haemoglobinuria is associated with chronic kidney disease and its progression in patients with sickle cell anaemia
2013
The ethics of a proposed study of hematopoietic stem cell transplant for children with “less severe” sickle cell disease
2014
Patient satisfaction in specialized versus nonspecialized adult sickle cell care centers: the PiSCES study.
2007
Hydroxyurea as an Alternative to Blood Transfusions for the Prevention of Recurrent Stroke in Children With Sickle Cell Disease
1999
Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.
1999
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
2018 Standout
How I treat idiopathic thrombocytopenic purpura (ITP)
2005
Six Months of Hydroxyurea Reduces Albuminuria in Patients with Sickle Cell Disease
2015
Transgenic sickle mice have vascular inflammation
2003
Wound Healing: A Cellular Perspective
2018 Standout
Customizing the genome as therapy for the β-hemoglobinopathies
2016
Five years of experience with hydroxyurea in children and young adults with sickle cell disease
2001
Hydroxyurea for treatment of severe sickle cell anemia: a pediatric clinical trial
1996
Primary role for adherent leukocytes in sickle cell vascular occlusion: A new paradigm
2002
Mechanism of monocyte activation and expression of proinflammatory cytochemokines by placenta growth factor
2003
Asthma is associated with acute chest syndrome and pain in children with sickle cell anemia
2006
Factors associated with survival in a contemporary adult sickle cell disease cohort
2014
Splenectomy for adult patients with idiopathic thrombocytopenic purpura: a systematic review to assess long-term platelet count responses, prediction of response, and surgical complications
2004
Hydroxyurea corrects the dysregulated L-selectin expression and increased H2O2 production of polymorphonuclear neutrophils from patients with sickle cell anemia
2002
Sickle cell disease related mortality in the United States (1999-2009)
2013
Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease
2016
Static and dynamic rigidities of normal and sickle erythrocytes. Major influence of cell hemoglobin concentration.
1984
Reperfusion injury pathophysiology in sickle transgenic mice
2000
Thrombophilia in sickle cell disease: the red cell connection
2001
ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension
2009 Standout
Density-based separation in multiphase systems provides a simple method to identify sickle cell disease
2014
Newborn screening program for hemoglobinopathies in Rio de Janeiro, Brazil
2013
Sparing effect of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S at physiologic ligand saturations.
1993
Systematic Review: Hydroxyurea for the Treatment of Adults with Sickle Cell Disease
2008
Oral magnesium pidolate: effects of long‐term administration in patients with sickle cell disease
2000
Sustained long-term hematologic efficacy of hydroxyurea at maximum tolerated dose in children with sickle cell disease
2003
Protein C and Protein S Activity in Sickle Cell Disease and Stroke
1997
Prognostic significance of early vaso-occlusive complications in children with sickle cell anemia
2006
Secretory phospholipase A2 predicts impending acute chest syndrome in sickle cell disease
2000
A randomized, controlled clinical trial of ketoprofen for sickle-cell disease vaso-occlusive crises in adults
2009
How I treat renal complications in sickle cell disease
2014
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
2018 Science
Hydroxymethylfurfural, A Versatile Platform Chemical Made from Renewable Resources
2013 Standout
Multiagent induction and maintenance therapy for patients with refractory immune thrombocytopenic purpura (ITP)
2007
Disabling Cas9 by an anti-CRISPR DNA mimic
2017 StandoutNobel
Targeted Therapeutic Strategies for Fetal Hemoglobin Induction
2011
Works of Panpit Klug being referenced
Flow dynamics of human sickle erythrocytes in the mesenteric microcirculation of the exchange-transfused rat
1987
Tumor Burden Influences Cytotoxic T Cell Development in Metastatic Breast Cancer Patients—A Phase I/II Study
2009
Effectiveness of the cryosupernatant fraction of plasma in the treatment of refractory thrombotic thrombocytopenic purpura
1990
Initial management of immune thrombocytopenic purpura in adults: A randomized controlled trial comparing intermittent anti‐D with routine care
2003
Mortality In Sickle Cell Disease -- Life Expectancy and Risk Factors for Early Death
1994 Standout
Mortality in Children and Adolescents With Sickle Cell Disease
1989
Rheological Aspects of Sickle Cell Disease
1974