Standout Papers
Citation Impact
Citing Papers
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
2006 StandoutNobel
Fast molecular tracking maps nanoscale dynamics of plasma membrane lipids
2010 StandoutNobel
Myofibroblasts and mechano-regulation of connective tissue remodelling
2002 Standout
Hallmarks of Cancer: The Next Generation
2011 Standout
Two Distinct Urokinase-Serpin Interactions Regulate the Initiation of Cell Surface-associated Plasminogen Activation
1999
The N-terminal Domain of a Glycolipid-anchored Prion Protein Is Essential for Its Endocytosis via Clathrin-coated Pits
1995
Analysis of a Structural Determinant in Thrombin-Protease Nexin 1 Complexes That Mediates Clearance by the Low Density Lipoprotein Receptor-related Protein
1999
Structural aspects of serpin inhibition
1994 Nobel
Characterization of the Binding of Different Conformational Forms of Plasminogen Activator Inhibitor-1 to Vitronectin
1997
Inflammation and cancer
2002 StandoutNature
Sorting GPI-anchored proteins
2004
Structural and Functional Analysis of the Plasminogen Activator Inhibitor-1 Binding Motif in the Somatomedin B Domain of Vitronectin
1996
Plasminogen‐activator inhibitor type 2 (PAI‐2) is a spontaneously polymerising SERPIN
1993
Structural requirements for glycosyl‐phosphatidylinositol‐anchor attachment in the cellular receptor for urokinase plasminogen activator
1992
Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization
1998
The 39-kDa Receptor-associated Protein Modulates Lipoprotein Catabolism by Binding to LDL Receptors
1995
Plasminogen activator inhibitor-1 as a measure of vascular remodelling in breast cancer
2001
Instability and decay of the primary structure of DNA
1993 StandoutNatureNobel
Cytokeratin 18 Is Expressed on the Hepatocyte Plasma Membrane Surface and Interacts with Thrombin-Antithrombin Complexes
1997
LRP: a multifunctional scavenger and signaling receptor
2001
Additivity in Effects of Vitronectin and Monoclonal Antibodies against α-Helix F of Plasminogen Activator Inhibitor-1 on Its Reactions with Target Proteinases
2004
Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function
2000
Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1
1995
Cellular Internalization and Degradation of Antithrombin III-Thrombin, Heparin Cofactor II-Thrombin, and α1-Antitrypsin-Trypsin Complexes Is Mediated by the Low Density Lipoprotein Receptor-related Protein
1996
Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation
2000
Differential Recognition of α1-Antitrypsin-Elastase and α1-Antichymotrypsin-Cathepsin G Complexes by the Low Density Lipoprotein Receptor-related Protein
1995
The Low Density Lipoprotein Receptor-related Protein/α2-Macroglobulin Receptor Regulates Cell Surface Plasminogen Activator Activity on Human Trophoblast Cells
1998
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation
1995
Endothelial cell regulation by transforming growth factor‐beta
1991
The Chicken Oocyte Receptor for Yolk Precursors as a Model for Studying the Action of Receptor-associated Protein and Lactoferrin
1995
Angiogenesis in cancer and other diseases
2000 StandoutNature
Plasminogen Activator Inhibitor-1 and Vitronectin Promote the Cellular Clearance of Thrombin by Low Density Lipoprotein Receptor-related Proteins 1 and 2
1996
Mammalian GPI proteins: sorting, membrane residence and functions
1997
Engineering Plasminogen Activator Inhibitor 1 Mutants with Increased Functional Stability
1994
A role for the Drosophila neurogenic genes in mesoderm differentiation
1991 StandoutNobel
The Efficient Catabolism of Thrombin-Protease Nexin 1 Complexes Is a Synergistic Mechanism That Requires Both the LDL Receptor-related Protein and Cell Surface Heparins
1997
Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila
2005 StandoutNobel
Mechanisms of Cellular Uptake of Thrombin-Antithrombin II Complexes Role of the Low-Density Lipoprotein Receptor-Related Protein as a Serpin-Enzyme Complex Receptor
1997
The Fibrinolytic System of the Vessel Wall and Its Role in the Control of Thrombosis
1990
Membrane protein sequestering by ionic protein–lipid interactions
2011 StandoutNatureNobel
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
Familial bone marrow monosomy 7. Evidence that the predisposing locus is not on the long arm of chromosome 7.
1989
Importance of the Hinge Region between α-Helix F and the Main Part of Serpins, Based upon Identification of the Epitope of Plasminogen Activator Inhibitor Type 1 Neutralizing Antibodies
2000
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
2023 StandoutNobel
Determination of intermediates, products and cleavage site in the reaction between plasminogen activator inhibitor type‐2 and urokinases
1988
Urokinase and macrophages in tumour angiogenesis
1995
An Antibody Fragment from a Phage Display Library Competes for Ligand Binding to the Low Density Lipoprotein Receptor Family and Inhibits Rhinovirus Infection
1995 StandoutNobel
A serpin‐induced extensive proteolytic susceptibility of urokinase‐type plasminogen activator implicates distortion of the proteinase substrate‐binding pocket and oxyanion hole in the serpin inhibitory mechanism
2001
Tumour-educated macrophages promote tumour progression and metastasis
2004 Standout
Direct observation of the nanoscale dynamics of membrane lipids in a living cell
2008 StandoutNatureNobel
The Chicken LDL Receptor—Related Protein/α2‐Macroglobulin Receptor Familya
1994
Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta.
1991
C1 Inhibitor-C 1 ¯ s
1997
Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator
1990
Roles of the Heparin and Low Density Lipid Receptor-related Protein-binding Sites of Protease Nexin 1 (PN1) in Urokinase-PN1 Complex Catabolism
2000
Ligand Binding Properties of the Very Low Density Lipoprotein Receptor
1999
Inactivation of Plasminogen Activator Inhibitor-1 by Specific Proteolysis with Stromelysin-1 (MMP-3)
2000
Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
1991 Standout
Identification of Residues in α-Macroglobulins Important for Binding to the α2-Macroglobulin Receptor/Low Density Lipoprotein Receptor-related Protein
1996
Kinetics of inhibition of tissue‐type and urokinase‐type plasminogen activator by plasminogen‐activator inhibitor type 1 and type 2
1988
Plasminogen Activator Inhibitor-1 Contains a Cryptic High Affinity Binding Site for the Low Density Lipoprotein Receptor-related Protein
1998
Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity
1990
TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence
1990
The Very Low Density Lipoprotein Receptor Regulates Urokinase Receptor Catabolism and Breast Cancer Cell Motility in Vitro
1999
The Macrophage Growth Factor CSF-1 in Mammary Gland Development and Tumor Progression
2002
Specificity of Serine Proteinase/Serpin Complex Binding to Very‐Low‐Density Lipoprotein Receptor and α2‐Macroglobulin Receptor/Low‐Density‐Lipoprotein‐Receptor‐Related Protein
1997
The pathogenesis of atherosclerosis: a perspective for the 1990s
1993 StandoutNature
The Chicken Oocyte Receptor for Lipoprotein Deposition Recognizes α2-Macroglobulin
1995
Sites within the 39-kDa protein important for regulating ligand binding to the low-density lipoprotein receptor-related protein
1995
Matrix Elasticity Directs Stem Cell Lineage Specification
2006 Standout
Distribution of the ?2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues
1992
Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme
1992 Standout
Transforming growth factor ? regulation of cell proliferation
1987
Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
1995 StandoutNatureNobel
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Facultative polypeptide translocation allows a single mRNA to encode the secreted and cytosolic forms of plasminogen activators inhibitor 2.
1989
Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes
1997
Conformation of one- and two-chain high molecular weight urokinase analyzed by small-angle neutron scattering and vacuum ultraviolet circular dichroism
1991 StandoutNobel
Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein
1994
Activation of pro-urokinase and plasminogen on human sarcoma cells: a proteolytic system with surface-bound reactants.
1989
Prourokinase activation on the surface of human rhabdomyosarcoma cells: localization and inactivation of newly formed urokinase-type plasminogen activator by recombinant class 2 plasminogen activator inhibitor.
1990
Bicyclic Peptide Inhibitor Reveals Large Contact Interface with a Protease Target
2012 StandoutNobel
TGF-β SIGNAL TRANSDUCTION
1998 Standout
Production of large amounts of hydrogen peroxide by human tumor cells.
1991 Standout
Serpin Structure, Mechanism, and Function
2002 Standout
Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor.
1986
Concomitant loss of transforming growth factor (TGF)-beta receptor types I and II in TGF-beta-resistant cell mutants implicates both receptor types in signal transduction.
1990
Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor.
1992
Regulation of the endothelial cell urokinase-type plasminogen activator receptor. Evidence for cyclic AMP-dependent and protein kinase C-dependent pathways.
1993 StandoutNobel
Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol
1991
Functional rafts in cell membranes
1997 StandoutNature
Impaired wound healing in mice with a disrupted plasminogen gene
1996
Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function
2000
A major estrogen-regulated protein secreted from the liver of Xenopus laevis is a member of the serpin superfamily. Nucleotide sequence of cDNA and hormonal induction of mRNA.
1992
Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.
1992
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
1993 Standout
Regulation of Urokinase-Type Plasminogen Activator Gene Transcription by Macrophage Colony-Stimulating Factor
1995
Apoptosis in the Pathogenesis and Treatment of Disease
1995 StandoutScience
Serpin reactive center loop mobility is required for inhibitor function but not for enzyme recognition.
1994
Localization of vitronectin binding domain in plasminogen activator inhibitor-1.
1994
Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells.
1996
The rate of telomere sequence loss in human leukocytes varies with age
1998 StandoutNobel
Cloning and expression of a cDNA coding for a human monocyte-derived plasminogen activator inhibitor.
1988
Characterization of human endothelial cell urokinase-type plasminogen activator receptor protein and messenger RNA
1990
Inhibition of Hepatic Chylomicron Remnant Uptake by Gene Transfer of a Receptor Antagonist
1994 Science
The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor.
1994
The somatic cell-specific low density lipoprotein receptor-related protein of the chicken. Close kinship to mammalian low density lipoprotein receptor gene family members.
1994
The mechanism of the reaction between human plasminogen-activator inhibitor 1 and tissue plasminogen activator
1990 StandoutNobel
Surface receptors for urokinase plasminogen activator
1988
Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator.
1992
Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family.
1994
Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.
1992
The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants.
1990
CpG Mutations in the Reactive Site of Human C1 ¯
1989
Differential regulation of extracellular matrix proteoglycan (PG) gene expression. Transforming growth factor-beta 1 up-regulates biglycan (PGI), and versican (large fibroblast PG) but down-regulates decorin (PGII) mRNA levels in human fibroblasts in culture
1991
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures
2017 StandoutNobel
A unique interhelical insertion in plasminogen activator inhibitor-2 contains three glutamines, Gln83, Gln84, Gln86, essential for transglutaminase-mediated cross-linking.
1994
Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.
1994
Determinants of binding and internalization of tissue-type plasminogen activator by human vascular smooth muscle and endothelial cells
1993
Some recent advances in the chemistry and biology of transforming growth factor-beta.
1987
A genetically clamped renin transgene for the induction of hypertension
2002 StandoutNobel
The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases.
1987
Receptor-mediated endocytosis of urokinase-type plasminogen activator is regulated by cAMP-dependent protein kinase
1997
Chicken oocyte growth is mediated by an eight ligand binding repeat member of the LDL receptor family.
1994
One-chain urokinase-type plasminogen activator from human sarcoma cells is a proenzyme with little or no intrinsic activity.
1988
Interaction of single-chain urokinase-type plasminogen activator with human endothelial cells.
1990 StandoutNobel
A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits.
1994
The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds lipoprotein lipase and beta-migrating very low density lipoprotein associated with the lipase
1993
Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells
2000 StandoutScienceNobel
Thrombin neutralizes plasminogen activator inhibitor 1 (PAI-1) that is complexed with vitronectin in the endothelial cell matrix.
1991
Anatomy and Dynamics of a Supramolecular Membrane Protein Cluster
2007 StandoutScienceNobel
Endocytosis of urokinase-plasminogen activator inhibitor type 1 complexes bound to a chimeric transmembrane urokinase receptor.
1994 StandoutNobel
Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1.
1990
Structure-function studies of the SERPIN plasminogen activator inhibitor type 1. Analysis of chimeric strained loop mutants
1990
Ultrastructural localization of plasma membrane-associated urokinase-type plasminogen activator at focal contacts.
1988
Binding of urokinase-type plasminogen activator–plasminogen activator inhibitor-1 complex to the endocytosis receptors α2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-low-density lipoprotein receptor involves basic residues in the inhibitor
1998
Molecular dissection of ligand binding sites on the low density lipoprotein receptor-related protein.
1994
Better reception for urokinase
1990 Nature
A chemical approach to unraveling the biological function of the glycosylphosphatidylinositol anchor
2007 StandoutNobel
Saturation mutagenesis of the plasminogen activator inhibitor-1 reactive center.
1992
Endosomal sorting of readily releasable synaptic vesicles
2010 StandoutNobel
The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.
1990
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains
1996 StandoutNobel
Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein
1998
LRP: a multifunctional scavenger and signaling receptor
2001
Structures of Active and Latent PAI-1: A Possible Stabilizing Role for Chloride Ions
2000
Proteolysis and physiological regulation
1987
On the target specificity of plasminogen activator inhibitor 1: the role of heparin, vitronectin, and the reactive site
1991
C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells
2001
Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity.
1990
MATRIX PROTEOGLYCANS: From Molecular Design to Cellular Function
1998 Standout
PRIM: Proximity imaging of green fluorescent protein-tagged polypeptides
1998 StandoutNobel
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
Evidence for a second alpha 2-macroglobulin receptor.
1994
Tumors: Wounds That Do Not Heal
1986 Standout
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties.
1990
Stability of Plasminogen Activator Inhibitor 1 (PAI-1)
1989 StandoutNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
cDNA cloning and expression in Escherichia coli of a plasminogen activator inhibitor from human placenta.
1987
Urokinase-type plasminogen activator: proenzyme, receptor, and inhibitors
1987
COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform
1997 StandoutNobel
Caspases: Enemies Within
1998 StandoutScience
Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26
2000
THE CAVEOLAE MEMBRANE SYSTEM
1998 Standout
Protease nexin-1-urokinase complexes are internalized and degraded through a mechanism that requires both urokinase receptor and alpha 2-macroglobulin receptor.
1994
Identification of domains on the 39-kDa protein that inhibit the binding of ligands to the low density lipoprotein receptor-related protein.
1993
Type I Receptors Specify Growth-Inhibitory and Transcriptional Responses to Transforming Growth Factor β and Activin
1994
Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis.
1990
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
A type 1 serine/threonine kinase receptor that can dorsalize mesoderm in Xenopus.
1995 StandoutNobel
Works of P.A. Andreasen being referenced
The Multiligand α2‐Macroglobulin Receptor/Low Density Lipoprotein Receptor‐Related Protein (α2MR/LRP)
1994
Prognostic significance of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in primary breast cancer
1998
Plasminogen activator inhibitor-type 1 in Lewis lung carcinoma
1990
The plasminogen activation system in tumor growth, invasion, and metastasis
2000
Inactive proenzyme to tissue-type plasminogen activator from human melanoma cells, identified after affinity purification with a monoclonal antibody.
1984
Plasminogen activator inhibitor type‐1 : reactive center and amino‐terminal heterogeneity determined by protein and cDNA sequencing
1986
Interaction of Plasminogen Activator Inhibitor (PAI-1) with Vitronectin
1989
Plasminogen Activators, Tissue Degradation, and Cancer
1985 Standout
Urokinase receptor. An activation antigen in human T lymphocytes.
1994
Both Pro‐uPA and uPA: PAI‐1 Complex Bind to the α2‐Macroglobulin Receptor/LDL Receptor–Related Protein
1994
Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta.
1986
Plasminogen activator inhibitors from placenta and fibrosarcoma cells are antigenically different as evaluated with monoclonal and polyclonal antibodies
1987
cDNA cloning of human plasminogen activator-inhibitor from endothelial cells.
1986
Transforming growth factor beta 1-responsive element: closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor I in the type 1 plasminogen activator inhibitor gene.
1992
Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells
1987
Plasminogen activator inhibitor from human fibrosarcoma cells binds urokinase-type plasminogen activator, but not its proenzyme.
1986
Plasminogen activator inhibitor type 1 gene is located at region q21.3-q22 of chromosome 7 and genetically linked with cystic fibrosis.
1987
Proenzyme to urokinase‐type plasminogen activator in the mouse in vivo
1985
Transforming growth factor-beta is a strong and fast acting positive regulator of the level of type-1 plasminogen activator inhibitor mRNA in WI-38 human lung fibroblasts.
1987
Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes
1993
alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor.
1995
Vitronectin and Substitution of a β-Strand 5A Lysine Residue Potentiate Activity-neutralization of PA Inhibitor-1 by Monoclonal Antibodies against α-Helix F
2000
Lysosomal degradation of receptor-bound urokinase-type plasminogen activator is enhanced by its inhibitors in human trophoblastic choriocarcinoma cells.
1990
Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor.
1989
Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.
1992
Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that the urokinase receptor protects pro-urokinase against binding to the endocytic receptor.
1994
Monoclonal Antibodies to Human 54,000 Molecular Weight Plasminogen Activator Inhibitor from Fibrosarcoma Cells - Inhibitor Neutralization and One-Step Affinity Purification
1986
Alpha 2-macroglobulin-proteinase complexes, plasminogen activator inhibitor type-1-plasminogen activator complexes, and receptor-associated protein bind to a region of the alpha 2-macroglobulin receptor containing a cluster of eight complement-type repeats
1993