Standout Papers
Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Antidepressant Drug Effects and Depression Severity
2010 Standout
Methyltetrahydrofolate is a potent and selective agonist for kainic acid receptors
1980 Nature
The neural basis of drug craving: An incentive-sensitization theory of addiction
1993 Standout
Interaction of caffeine with the GABAA receptor complex: alterations in receptor function but not ligand binding
1989
Modulation of anxiety through blockade of anandamide hydrolysis
2002 Standout
Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice
1999 StandoutNobel
Purinergic mechanisms in epilepsy
1988
Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor
1995 StandoutNatureNobel
PHARMACOLOGICAL ASPECTS OF HUMAN AND CANINE NARCOLEPSY
1997
Release of dopamine is reduced by diazepam more in the nucleus accumbens than in the caudate nucleus of conscious rats
1991
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
2005 Standout
Why Does Social Exclusion Hurt? The Relationship Between Social and Physical Pain.
2005 Standout
Mechanisms of Actions of Inhaled Anesthetics
2003 Standout
High doses of oxytocin cause sedation and low doses cause an anxiolytic-like effect in male rats
1994
Theta Oscillations in the Hippocampus
2002 Standout
Synergism by caffeine and by cocaine of the motor control deficit produced by midazolam
1991
The putatively antipsychotic agent amperozide produces behavioural stimulation in the rat
1989 StandoutNobel
Caffeine: Implications of recent research for clinical practice.
1984
Canine cataplexy is preferentially controlled by adrenergic mechanisms: evidence using monoamine selective uptake inhibitors and release enhancers
1993
Neurobiological Similarities in Depression and Drug Dependence: A Self-Medication Hypothesis
1998
The biological, social and clinical bases of drug addiction: commentary and debate
1996
Independence of benzodiazepine and opiate action in the suppression of isolation distress in rat pups.
1990
Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+
1990 StandoutNobel
Caffeine-diazepam interaction and local cerebral glucose utilization in the conscious rat
1987
Synthesis and Release of Dopamine in Rat Brain: Comparison Between Substantia Nigra Pars Compacta, Pars Reticulata, and Striatum
1989 StandoutNobel
GABA A -receptors: Structural requirements and sites of gene expression in mammalian brain
1990
Specific modulation of social memory in rats by cholinomimetic and nootropic drugs, by benzodiazepine inverse agonists, but not by psychostimulants
1989
Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors
2005 Standout
Benzodiazepine-induced decreases in extracellular concentrations of dopamine in the nucleus accumbens after acute and repeated administration
1992
Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila
2008 StandoutNobel
Stress signalling pathways that impair prefrontal cortex structure and function
2009 Standout
Anticonvulsant activity of carbamazepine and N6-L-phrnylisopropyladenosine in rabbits. Relationship to adenosine receptors in central nervous system
1988
Response of Obstructive Sleep Apnea to Fluoxetine and Protriptyline
1991
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
Narcolepsy in orexin Knockout Mice
1999 Standout
Blockade of the picrotoxin-induced in vivo release of dopamine in the cat caudate nucleus by diazepam
1977
Physiology and Pathophysiology of Purinergic Neurotransmission
2007 Standout
The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene
1999 Standout
Caffeine-induced anxiety and increase of Kynurenine concentration in plasma of healthy subjects: A pilot study
1991
Evidence for a role for dopamine in the diazepam locomotor stimulating effect
1991
Functional properties of recombinant rat GABAA receptors depend upon subunit composition
1990 StandoutNobel
Increased dopamine and norepinephrine release in medial prefrontal cortex induced by acute and chronic stress: Effects of diazepam
1995
Major Depressive Disorder
2008 Standout
Socially mediated reduction of isolation distress in rat pups is blocked by naltrexone but not by Ro 15-1788.
1990
Cerebral Activity and Behavior: Control by Central Cholinergic and Serotonergic Systems
1988
Changes in Emotional Responses to Aversive Pictures Across Periods Rich in Slow-Wave Sleep Versus Rapid Eye Movement Sleep
2002
GABAergic dysfunction in mood disorders
2003
Molecular Basis of Buspirone's Anxiolytic Action
1991
[3H]Ro 15-1788 binding to benzodiazepine receptors in mouse brain in vivo: marked enhancement by GABA agonists and other CNS drugs
1987
Caffeine-induced anxiogenesis: The role of adenosine, benzodiazepine and noradrenergic receptors
1989
A Controlled Trial of Riluzole in Amyotrophic Lateral Sclerosis
1994 Standout
Controlled Microwave Heating in Modern Organic Synthesis
2004 Standout
Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects
1992 Standout
The diversity of GABAA receptors
1998
Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory
1998 StandoutNobel
Iron Catalysis in Organic Synthesis
2015 Standout
Binding Characteristics and Interactions of Depressant Drugs with [35S]t‐Butylbicyclophosphorothionate, a Ligand that Binds to the Picrotoxinin Site
1984
Iron(III)-catalyzed synthesis of multi-substituted imidazoles via [3+2] cycloaddition reaction of nitroolefins and N-aryl benzamidines
2013
Rat pup ultrasonic isolation calls: Possible mediation by the benzodiazepine receptor complex
1986
Caffeine induced changes in cerebral circulation.
1985
Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines
1980
Anxiety and caffeine consumption in people with anxiety disorders
1985
BENZODIAZEPINES AND CENTRAL GLYCINE RECEPTORS
1976
The Physiological Role of Adenosine In The Central Nervous System
1985
Are benzodiazepines GABA antagonists?
1977 Nature
Structural and functional characterization of the gamma 1 subunit of GABAA/benzodiazepine receptors.
1990
International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.
1998
‘Inverse agonists’, cooperativity and drug action at benzodiazepine receptors
1986
Quinolinic Acid: An Endogenous Metabolite That Produces Axon-Sparing Lesions in Rat Brain
1983 StandoutScience
A Double-blind Comparative Trial of Moclobemide v. Imipramine and Placebo in Major Depressive Episodes
1989
Modulation of the GABA receptor complex by a steroid anaesthetic
1984
Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology
1989 StandoutNature
The effects of caffeine on plasma MHPG, subjective anxiety, autonomic symptoms and blood pressure in healthy humans
1984
New concepts on the mechanism of action of benzodiazepines
1975
Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors.
1980 Standout
Specificity of GABA as a stimulator of dopamine release in rat substantia nigra
1980
GABA and its receptors in the spinal cord
1996
Effect of Nitrous Oxide on Excitatory and Inhibitory Synaptic Transmission in Hippocampal Cultures
1998
Biochemical and Electrophysiological Characteristics of Mammalian Gaba Receptors
1983
Early Exposure to Common Anesthetic Agents Causes Widespread Neurodegeneration in the Developing Rat Brain and Persistent Learning Deficits
2003 Standout
Dopamine autoreceptors and the effects of drugs on locomotion and dopamine synthesis
1985 StandoutNobel
Interaction of Convulsive Ligands with Benzodiazepine Receptors
1982 StandoutScience
Drug Discovery: A Historical Perspective
2000 StandoutScience
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
1988 Standout
The neuropsychology and neuropharmacology of the dorsal ascending noradrenergic bundle—a review
1980
Cellular and Molecular Mechanisms of Drug Dependence
1988 StandoutScience
The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle
1972
Synthesis of imidazole-4-carboxylic acids via solid-phase bound 3-N,N-(dimethylamino)-2-isocyanoacrylate
2004
Quantitative receptor autoradiography using [3H]Ultrofilm: application to multiple benzodiazepine receptors
1982
About Sleep's Role in Memory
2013 Standout
Chronic caffeine consumption increases the number of brain adenosine receptors
1983
Prolactin: Structure, Function, and Regulation of Secretion
2000 Standout
Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor
1986 StandoutScience
Putative endogenous ligands for the benzodiazepine receptor
1979
Receptors for the Age of Anxiety: Pharmacology of the Benzodiazepines
1980 Science
Fatal Familial Insomnia and Dysautonomia with Selective Degeneration of Thalamic Nuclei
1986
Pathophysiology of Sleep Apnea
2010 Standout
Benzodiazepine receptors in rat brain
1977 StandoutNature
2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission—I
1985
Basic and clinical aspects of adenosinergic neuromodulation
1985
The effects of FG 7142 and RO 15-1788 on the release of punished responding produced by chlordiazepoxide and ethanol in the rat
1986
Benzodiazepines: GABA and glycine receptors on single neurons in the rat medulla
1976
Up-regulation of brain [3H]diazepam binding sites in chronic caffeine-treated rats
1984
Activity patterns of catecholamine‐containing pontine neurons in the dorso‐lateral tegmentum of unrestrained cats
1974
Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice
2011 StandoutNobel
The Oxytocin Receptor System: Structure, Function, and Regulation
2001 Standout
Benzodiazepine- and barbiturate-interactions with GABAA receptor responses on lactotrophes
1986
Interaction of benzodiazepines with neuroleptics at central dopamine neurons
1976
Nucleus locus ceruleus: new evidence of anatomical and physiological specificity
1983 Standout
Serotonin receptor knockouts: A moody subject
1998 StandoutNobel
Up-regulation of brain [3H]diazepam binding sites in chronic caffeine treated rats
1986
Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
2001 Standout
Increased Anxiogenic Effects of Caffeine in Panic Disorders
1985
An opioid benzodiazepine
1982 Nature
On the mode of action of diazepam on brain catecholamine metabolism
1978 StandoutNobel
Effect of chronic exposure to methylxanthines on diazepam cerebral binding in female rats and their offsprings
1986
Benzodiazepines attenuate single unit activity in the locus coeruleus
1980
Masseteric reflex response to reticular stimulation reverses during active sleep compared with wakefulness or quiet sleep
1973
Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle
1981 Standout
Localization and quantitation of tritiated compounds in tissue sections with a gaseous detector of beta particles: comparison with film autoradiography.
1991 StandoutNobel
Inherited prion diseases.
1994 StandoutNobel
Endogenous ligands for benzodiazepine recognition sites
1985
Diazepam and chlordiazepoxide: powerful GABA antagonists in explants of rat cerebellum
1976
Methylxanthine discrimination in the rat: Possible benzodiazepine and adenosine mechanisms
1985
Reversal of the anti-conflict action of valproate by various GABA and benzodiazepine antagonists
1984
Works of P. Polc being referenced
Effects of the selective benzodiazepine antagonist Ro 15-1788 on the cat spinal cord
1981
Pharmacological profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type A.
1989
Benzodiazepines and GABA
1976 Nature
Effects of intravenous kainic acid, N-methyl-d-aspartate, and (-)-nuciferine on the cat spinal cord
1977
Electrophysiological studies on the specific benzodiazepine antagonist Ro 15-1788
1981
Effects of several centrally active drugs on the sleep-wakefulness cycle of cats
1979
Pharmacology of midazolam.
1981
Possible involvement of GABA in the central actions of benzodiazepines.
1975
Selective suppression of rapid eye movement sleep (REMS) in cats by typical and atypical antidepressants.
1982
Low-dose benzodiazepine neuronal inhibition: enhanced Ca2+-mediated K+-conductance
1983
Nicotinamide is a brain constituent with benzodiazepine-like actions
1979 Nature
An activating mechanism in the ponto-bulbar raphe system of the rabbit
1970
Blutdruckreizeffekte aus dem Locus coeruleus, dem ponto-bulbären Raphe-System und der medullären Formatio reticularis beim Kaninchen
1970
The effect of diazepam on spinal cord activities: Possible sites and mechanisms of action
1974
Antagonism of benzodiazepine receptors by beta carbolines
1981
Effects of two benzodiazepines, phenobarbitone, and baclofen on synaptic transmission in the cat cuneate nucleus
1976
[Pharmacology and toxicology of the anticonvulsant agent clonazepam].
1973
Electrophysiology of benzodiazepine receptor ligands: Multiple mechanisms and sites of action
1988
Selective antagonists of benzodiazepines
1981 StandoutNature
Caffeine antagonizes several central effects of diazepam
1981