Orla Howe

Infrared molecular fingerprinting of blood-based liquid biopsies for the detection of cancer

Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging

Quantitative analysis of human blood serum using vibrational spectroscopy

Stability of person-specific blood-based infrared molecular fingerprints opens up prospects for health monitoring

The DNA-damage response in human biology and disease

In vitro cytotoxicity, DNA cleavage and SOD-mimic activity of copper(II) mixed-ligand quinolinonato complexes

Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu2(μ-terephthalate)(1,10-phen)4]2+

Synthesis, structural characterization and in vitro biological screening of some homoleptic copper(II) complexes with substituted guanidines

Efficient DNA cleavage mediated by mononuclear mixed ligand copper(II) phenolate complexes: The role of co-ligand planarity on DNA binding and cleavage and anticancer activity

Epidemiology of Prostate Cancer

Redox-cycling and intercalating properties of novel mixed copper(II) complexes with non-steroidal anti-inflammatory drugs tolfenamic, mefenamic and flufenamic acids and phenanthroline functionality: Structure, SOD-mimetic activity, interaction with albumin, DNA damage study and anticancer activity

Improved protocols for vibrational spectroscopic analysis of body fluids

Using Raman spectroscopy to characterize biological materials

Bystander autophagy mediated by radiation-induced exosomal miR-7-5p in non-targeted human bronchial epithelial cells

The DNA Damage Response: Making It Safe to Play with Knives

Raman spectroscopic analysis of human skin tissue sectionsex-vivo: evaluation of the effects of tissue processing and dewaxing

The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes

Defective DNA Repair and Neurodegenerative Disease

Cisplatin: The first metal based anticancer drug

A Tri‐copper(II) Complex Displaying DNA‐Cleaving Properties and Antiproliferative Activity against Cancer Cells

Systemic delivery of a targeted synthetic immunostimulant transforms the immune landscape for effective tumor regression

ROS signalling in the biology of cancer

Diagnostic radiation procedures and risk of prostate cancer

Redox-Modulated Phenomena and Radiation Therapy: The Central Role of Superoxide Dismutases

Evaluation of Flavonoid Derivative and Doxorubicin Effects in Lung Cancer Cells (A549) Using Differential Pulse Voltammetry Method

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

Monitoring Radiotherapeutic Response in Prostate Cancer Patients Using High Throughput FTIR Spectroscopy of Liquid Biopsies

Targeted Delivery to Tumors: Multidirectional Strategies to Improve Treatment Efficiency

Vibrational spectroscopic analysis of body fluids: avoiding molecular contamination using centrifugal filtration

Spectropathology for the next generation: Quo vadis?

Vibrational spectroscopy of liquid biopsies for prostate cancer diagnosis

Electron Transfer from Graphene Quantum Dots to the Copper Complex Enhances Its Nuclease Activity

Investigating optimum sample preparation for infrared spectroscopic serum diagnostics

Vibrational Spectroscopy Fingerprinting in Medicine: from Molecular to Clinical Practice

The biology , function , and biomedical applications of exosomes

Nuclease Activity via Self-Activation and Anticancer Activity of a Mononuclear Copper(II) Complex: Novel Role of the Tertiary Butyl Group in the Ligand Frame

An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

Advances in Copper Complexes as Anticancer Agents

Glowing Graphene Quantum Dots and Carbon Dots: Properties, Syntheses, and Biological Applications

Synthesis, characterization, and biomedical assessment of novel bisimidazole–coumarin conjugates

Molecular Origin of Blood‐Based Infrared Spectroscopic Fingerprints**

Important Flavonoids and Their Role as a Therapeutic Agent

Targeting the Folate Receptor: Improving Efficacy in Inorganic Medicinal Chemistry

Radical-induced DNA damage by cytotoxic square-planar copper(II) complexes incorporating o-phthalate and 1,10-phenanthroline or 2,2′-dipyridyl

Quantitative reagent-free detection of fibrinogen levels in human blood plasma using Raman spectroscopy

Apoptosis is signalled early by low doses of ionising radiation in a radiation-induced bystander effect

Cell Death Mechanisms Associated with G₂Radiosensitivity in Patients with Prostate Cancer and Benign Prostatic Hyperplasia

Analyses of Ionizing Radiation EffectsIn Vitroin Peripheral Blood Lymphocytes with Raman Spectroscopy

Reactive oxygen species-induced release of signalling factors in irradiated cells triggers membrane signalling and calcium influx in bystander cells

Bis-phenanthroline copper(ii) phthalate complexes are potent in vitro antitumour agents with ‘self-activating’ metallo-nuclease and DNA binding properties

A novel form of ataxia oculomotor apraxia characterized by oxidative stress and apoptosis resistance

Copper(II) complexes of coumarin-derived Schiff base ligands: Pro- or antioxidant activity in MCF-7 cells?

Evaluation of the potential of Raman microspectroscopy for prediction of chemotherapeutic response to cisplatin in lung adenocarcinoma

Radiation and chemotherapy bystander effects induce early genomic instability events: Telomere shortening and bridge formation coupled with mitochondrial dysfunction

Regulating Bioactivity of Cu²⁺ Bis-1,10-phenanthroline Artificial Metallonucleases with Sterically Functionalized Pendant Carboxylates

Prediction of DNA damage and G2 chromosomal radio-sensitivity ex vivo in peripheral blood mononuclear cells with label-free Raman micro-spectroscopy

Doxorubicin kinetics and effects on lung cancer cell lines using in vitro Raman micro‐spectroscopy: binding signatures, drug resistance and DNA repair

Vibrational spectroscopy in sensing radiobiological effects: analyses of targeted and non-targeted effects in human keratinocytes

Copper(II) Complexes of Salicylic Acid Combining Superoxide Dismutase Mimetic Properties with DNA Binding and Cleaving Capabilities Display Promising Chemotherapeutic Potential with Fast Acting in Vitro Cytotoxicity against Cisplatin Sensitive and Resistant Cancer Cell Lines

Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development