Standout Papers
Citation Impact
Citing Papers
NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1
2005
High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses
2011
TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events
2008
Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release
2012
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
2011 StandoutNobel
Video-Rate Far-Field Optical Nanoscopy Dissects Synaptic Vesicle Movement
2008 StandoutScienceNobel
Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma
2012
Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE
2008
Extracellular HMGB1 as a Proinflammatory Cytokine
2004
ISO-1 Binding to the Tautomerase Active Site of MIF Inhibits Its Pro-inflammatory Activity and Increases Survival in Severe Sepsis
2005
Hallmarks of Cancer: The Next Generation
2011 Standout
High- and Low-Mobility Stages in the Synaptic Vesicle Cycle
2010 StandoutNobel
Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
2003
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
2000 StandoutNature
HMGB1 in the Immunology of Sepsis (Not Septic Shock) and Arthritis
2004
The mystery of nonclassical protein secretion
2003
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
2020 Standout
Mobility of Synaptic Vesicles in Different Pools in Resting and Stimulated Frog Motor Nerve Terminals
2006
HMGB1 is a potent trigger of arthritis
2004
The biology of the receptor for advanced glycation end products and its ligands
2000
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
2004 Standout
Temporal and spatial coordination of exocytosis and endocytosis
2003
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Alarmins: awaiting a clinical response
2012
Molecular determinants of immunogenic cell death elicited by anticancer chemotherapy
2011
The Significance of Changes in High Mobility Group-1 Protein mRNA Expression in Rats After Thermal Injury
2002
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
2002 StandoutNature
Synaptic vesicle pools
2004
Cell death, BAX activation, and HMGB1 release during infection with Chlamydia
2004
Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome
2001
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
2002 StandoutNature
Monocytes promote natural killer cell interferon gamma production in response to the endogenous danger signal HMGB1
2004
Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein
2004
Host–pathogen interactions in sepsis
2007
UNC-13 and UNC-10/Rim Localize Synaptic Vesicles to Specific Membrane Domains
2006
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
HMGB1 contributes to the development of acute lung injury after hemorrhage
2005
Cancer immunotherapy via dendritic cells
2012 Standout
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
Endocytosis at the synaptic terminal
2003
Novel strategies for the treatment of sepsis
2003
Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice
2017 Standout
Regulation of monocyte migration by amphoterin (HMGB1)
2004
The extracellular release of HMGB1 during apoptotic cell death
2006
Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells
2014 Standout
Extracellular role of HMGB1 in inflammation and sepsis
2004
High‐mobility group box 1 protein promotes development of microvascular thrombosis in rats
2006
High mobility group box 1 protein interacts with multiple Toll-like receptors
2005
Single proteins might have dual but related functions in intracellular and extracellular microenvironments
2009
HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice
2002
The enigma of sepsis
2003
Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas
2010 StandoutNobel
Functional roles for C5a receptors in sepsis
2008
The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy
2007
TREM-1 amplifies inflammation and is a crucial mediator of septic shock
2001 StandoutNature
Regulated expression and subcellular localization of HMGB1, a chromatin protein with a cytokine function
2004
Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
2013 Nature
RAGE (receptor for advanced glycation end products): a central player in the inflammatory response
2004
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
2005 StandoutNatureNobel
E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis
2010
Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response
2004
Intracellular high mobility group B1 protein (HMGB1) represses HIV-1 LTR-directed transcription in a promoter- and cell-specific manner
2003
High mobility group box chromosomal protein 1: A novel proinflammatory mediator in synovitis
2002
RAGE is the Major Receptor for the Proinflammatory Activity of HMGB1 in Rodent Macrophages
2005
Sepsis: Current Dogma and New Perspectives
2014
Differential effects between amphoterin and advanced glycation end products on colon cancer cells
2003
Host innate immune responses to sepsis
2013
Mechanisms and Consequences of Dendritic Cell Migration
2008
Receptor for age (RAGE) is a gene within the major histocompatibility class III region: implications for host response mechanisms in homeostasis and chronic disease
2001
Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock*
2005
High mobility group box 1 protein, a cue for stem cell recruitment
2004
Dendritic Cells In Vivo: A Key Target for a New Vaccine Science
2008 StandoutNobel
Cancer immunotherapy comes of age
2011 StandoutNature
Elusive roles for reactive astrocytes in neurodegenerative diseases
2015
Addicted to Death
2004
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
2005 Standout
Three-Dimensional Architecture of Presynaptic Terminal Cytomatrix
2007
The Pathophysiology and Treatment of Sepsis
2003 Standout
Membrane curvature and mechanisms of dynamic cell membrane remodelling
2005 StandoutNature
A readily retrievable pool of synaptic vesicles
2011 StandoutNobel
Reactive Astrocytes: Production, Function, and Therapeutic Potential
2017 Standout
Harmful molecular mechanisms in sepsis
2008
Successful treatment of collagen‐induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity
2003
Mechanisms maintaining peripheral tolerance
2009
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
NEW EMBO MEMBERS' REVIEW: The double life of HMGB1 chromatin protein: architectural factor and extracellular signal
2001
Cancer-related inflammation
2008 StandoutNature
Hepatoma-derived Growth Factor Is a Neurotrophic Factor Harbored in the Nucleus
2004
The inflammatory reflex
2002 StandoutNature
Giant reticulospinal synapse in lamprey: molecular links between active and periactive zones
2006
Temporal characteristics of the protective effect of aminoguanidine on cerebral ischemic damage
1998
High mobility group 1 B‐box mediates activation of human endothelium
2003
Selective pharmacological inhibition of distinct nitric oxide synthase isoforms
1996
Protection from septic shock by neutralization of macrophage migration inhibitory factor
2000
Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein
2008
Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects
2003
The dark side of C5a in sepsis
2004
Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice
2011
Extracellular histones are major mediators of death in sepsis
2009 Standout
The immunopathogenesis of sepsis
2002 StandoutNature
Immunogenic cell death and DAMPs in cancer therapy
2012 Standout
STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis
2006 StandoutNatureNobel
HMGB1, an architectural chromatin protein and extracellular signalling factor, has a spatially and temporally restricted expression pattern in mouse brain
2003
Contributions of High Mobility Group Box Protein in Experimental and Clinical Acute Lung Injury
2004
HMGB1 is an endogenous immune adjuvant released by necrotic cells
2004
Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: Insights from vesicle recycling in nerve terminals
2004
Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells
2010 StandoutNobel
Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?
2006
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
2016 Standout
High Mobility Group Box Protein 1: An Endogenous Signal for Dendritic Cell Maturation and Th1 Polarization
2004
Ultrastructural organization of presynaptic terminals
2011
HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines
2008
Increased Expression of the DNA-Binding Cytokine HMGB1 in Human Atherosclerotic Lesions
2004
HMGB-1, A DNA-BINDING PROTEIN WITH CYTOKINE ACTIVITY, INDUCES BRAIN TNF AND IL-6 PRODUCTION, AND MEDIATES ANOREXIA AND TASTE AVERSION
2002
RAGE limits regeneration after massive liver injury by coordinated suppression of TNF-α and NF-κB
2005
The Structural Organization of the Readily Releasable Pool of Synaptic Vesicles
2004 Science
Unconventional Mechanisms of Protein Transport to the Cell Surface of Eukaryotic Cells
2008
Transcriptional mechanisms of acute lung injury
2001
Cutting Edge: HMG-1 as a Mediator of Acute Lung Inflammation
2000
The nuclear protein HMGB1 is secreted by monocytes via a non‐classical, vesicle‐mediated secretory pathway
2002
The High Mobility Group (Hmg) Boxes of the Nuclear Protein Hmg1 Induce Chemotaxis and Cytoskeleton Reorganization in Rat Smooth Muscle Cells
2001
Human Tumor Cells Killed by Anthracyclines Induce a Tumor-Specific Immune Response
2011
Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis
2000
A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses
2007
RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release
2011 StandoutScienceNobel
Activation of gene expression in human neutrophils by high mobility group box 1 protein
2003
Borna Disease Virus Phosphoprotein Binds a Neurite Outgrowth Factor, Amphoterin/HMG-1
2001
Structural Basis for the Proinflammatory Cytokine Activity of High Mobility Group Box 1
2003
Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
2001
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation
2002
Endogenous HMGB1 regulates autophagy
2010
The Critical Role of p38 MAP Kinase in T Cell HIV-1 Replication
1997
HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection
2011
Ethyl Pyruvate Protects against Lethal Systemic Inflammation by Preventing HMGB1 Release
2003
Mitochondrial Transcription Factor A Serves as a Danger Signal by Augmenting Plasmacytoid Dendritic Cell Responses to DNA
2012
The Roles of Therapy-Induced Autophagy and Necrosis in Cancer Treatment
2007
HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4
2012
Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils
1997 StandoutNobel
Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells
2003
Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron
2012 StandoutNobel
HMGB1 and RAGE in Inflammation and Cancer
2010
Overexpression of high mobility group box 1 in gastrointestinal stromal tumors with KIT mutation.
2003
RIM genes differentially contribute to organizing presynaptic release sites
2012 StandoutNobel
Ischemic Cell Death in Brain Neurons
1999 Standout
Precision glycocalyx editing as a strategy for cancer immunotherapy
2016 StandoutNobel
Endosomal sorting of readily releasable synaptic vesicles
2010 StandoutNobel
Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis
2016 StandoutNobel
The precursor form of IL-1α is an intracrine proinflammatory activator of transcription
2004
The Inflammatory Response to Cell Death
2008
At the Crossroads of Necrosis and Apoptosis: Signaling to Multiple Cellular Targets by HMGB1
2002
IFN-γ Induces High Mobility Group Box 1 Protein Release Partly Through a TNF-Dependent Mechanism
2003
Reversing established sepsis with antagonists of endogenous high-mobility group box 1
2003
Delayed Reduction of Ischemic Brain Injury and Neurological Deficits in Mice Lacking the Inducible Nitric Oxide Synthase Gene
1997
Pharmacological Stimulation of the Cholinergic Antiinflammatory Pathway
2002
Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury
2000 Standout
High mobility group box chromosomal protein 1 as a nuclear protein, cytokine, and potential therapeutic target in arthritis
2003
Role of HMGB1 in apoptosis-mediated sepsis lethality
2006
Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response
2004 Standout
Nitric oxide prevents axonal degeneration by inducing HIF-1–dependent expression of erythropoietin
2011 StandoutNobel
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
2005
Expression of TNF and TNF Receptors (p55 and p75) in the Rat Brain after Focal Cerebral Ischemia
1997
Unconventional Secretion, Unconventional Solutions
2013 StandoutScienceNobel
The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis
2006 StandoutNobel
HMGB1: Endogenous Danger Signaling
2008
Adverse functions of IL‐17A in experimental sepsis
2008
Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms
2004
Antibody to Langerin/CD207 localizes large numbers of CD8α + dendritic cells to the marginal zone of mouse spleen
2009 StandoutNobel
High mobility group box 1 protein as a late-acting mediator of acute lung inflammation.
2004
DAMPs, PAMPs and alarmins: all we need to know about danger
2006 Standout
Immunogenic Cell Death in Cancer Therapy
2012 Standout
Delayed Treatment with Aminoguanidine Decreases Focal Cerebral Ischemic Damage and Enhances Neurologic Recovery in Rats
1998
Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation
2004
Works of Ona Bloom being referenced
Colocalization of synapsin and actin during synaptic vesicle recycling
2003
Tumor necrosis factor is a brain damaging cytokine in cerebral ischemia.
1997
A pre-embedding immunogold approach for detection of synaptic endocytic proteins in situ
2004
Non-mammalian model systems for studying neuro-immune interactions after spinal cord injury
2014
HYPOPHYSECTOMY, HIGH TUMOR NECROSIS FACTOR LEVELS, AND HEMOGLOBINEMIA IN LETHAL ENDOTOXEMIC SHOCK
1998
Disruption of E-Cadherin-Mediated Adhesion Induces a Functionally Distinct Pathway of Dendritic Cell Maturation
2007
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
1999 StandoutScience
Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes
1999
TUMOR NECROSIS FACTOR IS A BRAIN DAMAGING CYTOKINE IN CEREBRAL ISCHEMIA
1997
Impaired recycling of synaptic vesicles after acute perturbation of the presynaptic actin cytoskeleton
2002
Neurotoxicity of advanced glycation endproducts during focal stroke and neuroprotective effects of aminoguanidine.
1995
Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone.
1996
High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes
2000
DEVELOPMENT OF A SELECTIVE INHIBITOR OF CYTOKINE-INDUCIBLE L-ARGININE TRANSPORT (CNI-1493) THAT BLOCKS MACROPHAGE PRODUCTION OF NO, and TNFa, and PROTECTS AGAINST LPS LETHALITY
1995
Cerebroprotective Effects of Aminoguanidine in a Rodent Model of Stroke
1996
An Inhibitor of Macrophage Arginine Transport and Nitric Oxide Production (CNI-1493) Prevents Acute Inflammation and Endotoxin Lethality
1995
Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes
1999