Citation Impact
Citing Papers
Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)
2001 StandoutScience
Evidence of a Role for Insulin-Like Growth Factor Binding Protein (IGFBP)-3 in Metabolic Regulation
2010
Targeting of Cyclic AMP Degradation to β 2 -Adrenergic Receptors by β-Arrestins
2002 StandoutScienceNobel
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
2005 StandoutScience
PDE4 cAMP-specific phosphodiesterases
2001
Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators
2006 Standout
Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
2022 StandoutNobel
Human conditions of insulin-like growth factor-I (IGF-I) deficiency
2012
Thiazolidinediones
2004 Standout
Non-Insulin-Dependent Diabetes Mellitus — A Genetically Programmed Failure of the Beta Cell to Compensate for Insulin Resistance
1996
Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes
1999
β-Arrestin Is Crucial for Ubiquitination and Down-regulation of the Insulin-like Growth Factor-1 Receptor by Acting as Adaptor for the MDM2 E3 Ligase
2005 StandoutNobel
Endothelin-1 Is a Potent Regulator of Human Bone Cell Metabolism In Vitro
1997
Recent applications of protein crystallography and structure-guided drug design
2005
Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.
1995
Effects of Torcetrapib in Patients at High Risk for Coronary Events
2007 Standout
Alterations of insulin signaling in type 2 diabetes: A review of the current evidence from humans
2008
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
1997 StandoutNature
Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles
1997
MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels
2016
The Insulin Receptor - A Critical Link in Glucose Homeostasis and Insulin Action
1998
The antisense homology box: A new motif within proteins that encodes biologically active peptides
1995 StandoutNobel
The metabolic syndrome
2010 Standout
Bariatric Surgery
2004 Standout
Nonalcoholic Fatty Liver Disease
2002 Standout
Metabolic, anabolic, and mitogenic insulin responses: A tissue-specific perspective for insulin receptor activators
2015
Cloning and functional expression of human cDNA for the ETB endothelin receptor
1991
Insulin Resistance — Mechanisms, Syndromes, and Implications
1991
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
1990 StandoutNature
Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 5-Year Outcomes
2017 Standout
Pathogenesis of Selective Insulin Resistance in Isolated Hepatocytes
2015
PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3
2004
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
2002 StandoutNature
Modulation of murine melanocyte function invitro by agouti signal protein
1997
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
1999
Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant
2000 StandoutNatureNobel
An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects.
1988
Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
1996
Diabetic Retinopathy
2012 Standout
Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia.
1995
Insulin receptor internalization: molecular mechanisms and physiopathological implications
1994
The metabolic syndrome
2005 Standout
Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice
2005
Polycystic Ovary Syndrome
1995 Standout
Central nervous system control of food intake
2000 StandoutNature
Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice
2004
Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 3-Year Outcomes
2014 Standout
Tumor necrosis factor-alpha- and hyperglycemia-induced insulin resistance. Evidence for different mechanisms and different effects on insulin signaling.
1996
Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance
2017
Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes
2012 Standout
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
Altered function of insulin receptor substrate-1–deficient mouse islets and cultured β-cell lines
1999
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss.
1988
Polycystic Ovary Syndrome
2005 Standout
A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance
1998
Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor
1991 StandoutNature
Phosphorylation and Desensitization of Human Endothelin A and B Receptors
1997 StandoutNobel
Who Would Have Thought It? An Operation Proves to Be the Most Effective Therapy for Adult-Onset Diabetes Mellitus
1995 Standout
Features and development of Coot
2010 Standout
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
Decreased tyrosine kinase activity in partially purified insulin receptors from muscle of young, non-obese first degree relatives of patients with Type 2 (non-insulin-dependent) diabetes mellitus
1993
Protein kinase C: Mediator or inhibitor of insulin action?
1993
β-Arrestins Regulate Mitogenic Signaling and Clathrin-mediated Endocytosis of the Insulin-like Growth Factor I Receptor
1998 StandoutNobel
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
Regulation of insulin receptor function
2007
Obesity and the Regulation of Energy Balance
2001 Standout
β-Arrestin and Mdm2 Mediate IGF-1 Receptor-stimulated ERK Activation and Cell Cycle Progression
2007 StandoutNobel
Endothelin receptor subtypes and their role in transmembrane signaling mechanisms
1995
Long-term effects of fluoxetine on glycemic control in obese patients with non-insulin-dependent diabetes mellitus or glucose intolerance: Influence on muscle glycogen synthase and insulin receptor kinase activity
1995
Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss. Effect on muscle glucose transport and glucose transporter GLUT4.
1992
Mechanisms of Bone Metastasis
2004 Standout
Mechanism of insulin receptor kinase inhibition in non-insulin-dependent diabetes mellitus patients. Phosphorylation of serine 1327 or threonine 1348 is unaltered.
1995
Biology of regional body fat distribution: Relationship to non‐insulin‐dependent diabetes mellitus
1989
Endothelins and sarafotoxins: Receptor heterogeneity
1994
Leptin and the regulation of body weight in mammals
1998 StandoutNature
HDL as a target in the treatment of atherosclerotic cardiovascular disease
2005
Cellular alterations in liver, skeletal muscle, and adipose tissue responsible for insulin resistance in obesity and type II diabetes
1989
Insulin Action and the Insulin Signaling Network*
1995
Molecular and Cellular Aspects of the Insulin-Like Growth Factor I Receptor
1995
Identification of endothelin–1 in the pathophysiology of metastatic adenocarcinoma of the prostate
1995
Leptin Inhibits Bone Formation through a Hypothalamic Relay
2000 Standout
Evidence Against Altered Expression of GLUT1 or GLUT4 in Skeletal Muscle of Patients With Obesity or NIDDM
1990
CrossTalk opposing view: Intramyocellular ceramide accumulation does not modulate insulin resistance
2016
Rosiglitazone in the Treatment of Haart-Associated Lipodystrophy – a Randomized Double-Blind Placebo-Controlled Study
2003
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System
2000 StandoutScienceNobel
A Transgenic Model of Visceral Obesity and the Metabolic Syndrome
2001 StandoutScience
Decreased expression of glucose transporter in muscle from insulin-resistant patients
1991
Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ
2001 StandoutScience
Pleiotropic Actions of Peroxisome Proliferator–Activated Receptors in Lipid Metabolism and Atherosclerosis
2002
Diabetes Reduces Basal Retinal Insulin Receptor Signaling
2006
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
1993 StandoutScience
Effects of Recombinant Agouti-Signaling Protein on Melanocortin Action
1997
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein
1997 StandoutScience
Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity.
2000
Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats.
1990
Rad: a Member of the Ras Family Overexpressed in Muscle of Type II Diabetic Humans
1993 Science
The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
1998 Standout
Pathophysiology and Pharmacological Treatment of Insulin Resistance*
2000
IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance
1996 StandoutScience
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
2000 StandoutScience
Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance
2016
Works of Olivia Ittoop being referenced
Identification of a subtype selective human PPARα agonist through parallel-array synthesis
2001
Detailed Characterization of a Purified Type 4 Phosphodiesterase, HSPDE4B2B: Differentiation of High- and Low-Affinity (R)-Rolipram Binding
1997
Bovine Cerebellum Endothelin Receptor: Solubilization and Indentification
1990
HIV protease inhibitors block adipogenesis and increase lipolysis in vitro
2000
Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver.
1988
Identification of a Single Binding Protein for Endothelin-1 and Endothelin-3 in Bovine Cerebellum Membranes
1991
Endothelin rapidly stimulates tyrosine phosphorylation in osteoblast-like cells
1992
Agouti Antagonism of Melanocortin Binding and Action in the B16F10 Murine Melanoma Cell Line
1995
Direct evidence for multiple endothelin receptors
1991
Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity.
1986
Mutations in the Carboxyl Terminus of the Agouti Protein Decrease Agouti Inhibition of Ligand Binding to the Melanocortin Receptors
1997
Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes.
1987
Structure-Based Design of Potent Retinoid X Receptor α Agonists
2004