Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo
2008
Binding of small molecules to an adaptive protein–protein interface
2003
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Navigating the protein fitness landscape with Gaussian processes
2012 StandoutNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Visualization of the movement of single histidine kinase molecules in live Caulobacter cells
2004 StandoutNobel
In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles
2009 StandoutNobel
The use of mRNA display to select high-affinity protein-binding peptides
2001 StandoutNobel
Fast molecular tracking maps nanoscale dynamics of plasma membrane lipids
2010 StandoutNobel
Structure of the Quaternary Complex of Interleukin-2 with Its α, ß, and γ c Receptors
2005 Science
Hot-spot mimicry of a cytokine receptor by a small molecule
2006
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis
2009
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
Interleukin‐6: Structure‐function relationships
1997
The atomic structure of protein-protein recognition sites 1 1Edited by A. R. Fersht
1999 Standout
Molecular dynamics study of unbinding of the avidin-biotin complex
1997
NMR characterization of interleukin‐2 in complexes with the IL‐2Rα receptor component, and with low molecular weight compounds that inhibit the IL‐2/IL‐Rα interaction
2003
[21] Phage display for selection of novel binding peptides
2000
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
Multifarious Determinants of Cytokine Receptor Signaling Specificity
2014
Crystal structure of a cytokine-binding region of gp130
1998
Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling
2003 StandoutNobel
Structural mechanisms of costimulation
2002
Genetically programmed chiral organoborane synthesis
2017 StandoutNatureNobel
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
The Motion of a Single Molecule, the λ-Receptor, in the Bacterial Outer Membrane
2002
In vitro selection of nucleic acids and proteins: what are we learning?
1999
Anatomy of hot spots in protein interfaces
1998 Standout
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Covalently functionalized nanotubes as nanometre- sized probes in chemistry and biology
1998 Nature
An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway
2008
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Signaling—2000 and Beyond
2000 Standout
The Erythropoietin Receptor Transmembrane Domain Mediates Complex Formation with Viral Anemic and Polycythemic gp55 Proteins
2003
Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands
2015
Antagonists of protein–protein interactions
2000
The immune response of Drosophila
2003 StandoutNatureNobel
β Phorbol Ester- and Diacylglycerol-Induced Augmentation of Transmitter Release Is Mediated by Munc13s and Not by PKCs
2002 StandoutNobel
Programmable synthetic receptors: the next-generation of cell and gene therapies
2024
Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement
2018 StandoutNobel
Streptavidin-binding and -dimerizing ligands discovered by phage display, topochemistry, and structure-based design
1999
Lineage-Specific Hematopoietic Growth Factors
2006
Interactions with Aromatic Rings in Chemical and Biological Recognition
2003 Standout
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Cytoskeletal Control of CD36 Diffusion Promotes Its Receptor and Signaling Function
2011
Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity
1998
Dynamic Partitioning of a Glycosyl‐Phosphatidylinositol‐Anchored Protein in Glycosphingolipid‐Rich Microdomains Imaged by Single‐Quantum Dot Tracking
2009
Structure and dynamics of the M3 muscarinic acetylcholine receptor
2012 StandoutNatureNobel
Convergent Mechanisms for Recognition of Divergent Cytokines by the Shared Signaling Receptor gp130
2003 StandoutNobel
Luxury accommodations: the expanding role of structural plasticity in protein–protein interactions
2000
Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
2000
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Erythropoietin Inhibits Calcium-Induced Neurotransmitter Release from Clonal Neuronal Cells
2000
Contribution of the Box 1 and Box 2 Motifs of Cytokine Receptors to Jak1 Association and Activation
2002
Selective Complexation of N-Alkylpyridinium Salts: Recognition of NAD+ in Water
2002
Efficiency of signalling through cytokine receptors depends critically on receptor orientation
1998 Nature
Copper is required for oncogenic BRAF signalling and tumorigenesis
2014 Nature
Cross-crystal averaging reveals that the structure of the peptidyl-transferase center is the same in the 70S ribosome and the 50S subunit
2008 StandoutNobel
Convergent Solutions to Binding at a Protein-Protein Interface
2000 Science
Structural basis for recognition by an in vitro evolved affibody
2003
The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction
2010 StandoutNobel
Bioorganometallic Chemistry of Ferrocene
2004 Standout
Search and Discovery Strategies for Biotechnology: the Paradigm Shift
2000
JAK2 activation by growth hormone and other cytokines
2015
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
The game of chess and searches in protein sequence space
1998
The Protein Kinase Complement of the Human Genome
2002 StandoutScience
Genetic Optimization of Metalloenzymes: Enhancing Enzymes for Non‐Natural Reactions
2016
Carbon Nanotubes--the Route Toward Applications
2002 StandoutScience
Investigation of Synthetic Hosts That Model Cation-π Sites Found at Protein Binding Domains
2002
Ligand-Binding Proteins: Their Potential for Application in Systems for Controlled Delivery and Uptake of Ligands
2000
Mapping epitopes and antigenicity by site-directed masking
2006 StandoutNobel
Recent Developments in Magnetic Diagnostic Systems
2015
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins
2011 StandoutNobel
The Cation−π Interaction
1997 Standout
Adhesion Forces Between Individual Ligand-Receptor Pairs
1994 StandoutScience
Insights into Cytokine–Receptor Interactions from Cytokine Engineering
2014
A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling
2012
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
2008 StandoutNobel
Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors
2003 StandoutScienceNobel
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Crystal structure of the TSP-1 type 1 repeats
2002
Mechanistic Diversity of Cytokine Receptor Signaling Across Cell Membranes
2004
Ligand Binding: Molecular Mechanics Calculation of the Streptavidin-Biotin Rupture Force
1996 Science
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Modular repeat protein sculpting using rigid helical junctions
2020 StandoutNobel
Dimerization of the Erythropoietin Receptor Transmembrane Domain in Micelles
2006
Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation
2018
What Can We Learn from Molecular Recognition in Protein–Ligand Complexes for the Design of New Drugs?
1996
STRUCTURAL AND MECHANISTIC DETERMINANTS OF AFFINITY AND SPECIFICITY OF LIGANDS DISCOVERED OR ENGINEERED BY PHAGE DISPLAY
1997
Structure and mechanism of the reversible photoswitch of a fluorescent protein
2005 StandoutNobel
THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions
1999
Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin
2011 StandoutScienceNobel
Dimerization: An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function
2002
Structural Plasticity in a Remodeled Protein-Protein Interface
1997 Science
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Computational design of a pH-sensitive IgG binding protein
2013 StandoutNobel
Exceedingly small iron oxide nanoparticles as positive MRI contrast agents
2017 StandoutNobel
Was läßt sich aus der molekularen Erkennung in Protein‐Ligand‐Komplexen für das Design neuer Wirkstoffe lernen?
1996
Nonnatural protein–protein interaction-pair design by key residues grafting
2007
A simple physical model for binding energy hot spots in protein–protein complexes
2002 StandoutNobel
Works of Oded Livnah being referenced
Rational Design of an Active Avidin Monomer
2003
An antagonist peptide–EPO receptor complex suggests that receptor dimerization is not sufficient for activation
1998
Isolation of Intrinsically Active (MEK-independent) Variants of the ERK Family of Mitogen-activated Protein (MAP) Kinases
2008
Ligand Exchange between Proteins
2002
Active Mutants of the Human p38α Mitogen-activated Protein Kinase
2004
Essentials of biorecognition: The (strept)avidin–biotin system as a model for protein–protein and protein–ligand interaction
2005
Shared and Unique Determinants of the Erythropoietin (EPO) Receptor Are Important for Binding EPO and EPO Mimetic Peptide
1999
Ruminant Placental Lactogens Act as Antagonists to Homologous Growth Hormone Receptors and as Agonists to Human or Rabbit Growth Hormone Receptors
1999
Identification of a 13 Amino Acid Peptide Mimetic of Erythropoietin and Description of Amino Acids Critical for the Mimetic Activity of EMP1
1998
Functional Mimicry of a Protein Hormone by a Peptide Agonist: The EPO Receptor Complex at 2.8 Å
1996 Science
Crystallographic Evidence for Preformed Dimers of Erythropoietin Receptor Before Ligand Activation
1999 Science
A Novel Substrate Mimetic Inhibitor of PKB/Akt Inhibits Prostate Cancer Tumor Growth in Mice by Blocking the PKB Pathway
2007
Three-dimensional structures of avidin and the avidin-biotin complex.
1993