Citation Impact
Citing Papers
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Crystallographic Structure of a Phosphonate Derivative of the Enterobacter cloacae P99 Cephalosporinase: Mechanistic Interpretation of a .beta.-Lactamase Transition-State Analog
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Molecular structure of the acyl-enzyme intermediate in β-lactam hydrolysis at 1.7 Å resolution
1992 Nature
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A Genomic and Functional Inventory of Deubiquitinating Enzymes
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Crystal structure of Thermus aquaticus DNA polymerase
1995 StandoutNatureNobel
Analysis of the Importance of the Metallo-β-Lactamase Active Site Loop in Substrate Binding and Catalysis
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β‐lactamase TEM1 of E. coli Crystal structure determination at 2.5 Å resolution
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Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
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1995
Molecular Evolution of a Class C β-Lactamase Extending Its Substrate Specificity
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2001
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1999
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1991
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2007
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2004
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1999 StandoutNatureNobel
Site-saturation Mutagenesis of Tyr-105 Reveals Its Importance in Substrate Stabilization and Discrimination in TEM-1 β-Lactamase
2004
Crystallographic structure analysis of lamprey hemoglobin from anomalous dispersion of synchrotron radiation
1988
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2001 StandoutNobel
Crystal structures of the class D β-lactamase OXA-13 in the native form and in complex with meropenem
2001
The Role of Tyrosine 150 in Catalysis of .beta.-Lactam Hydrolysis by AmpC .beta.-Lactamase from Escherichia coli Investigated by Site-Directed Mutagenesis
1994
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1993
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2002
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2002 StandoutNobel
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2011
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2011
Crystal Structures of the Ribosome in Complex with Release Factors RF1 and RF2 Bound to a Cognate Stop Codon
2005 StandoutNobel
Refined crystal structure of β-lactamase from Citrobacter freundiiindicates a mechanism for β-lactam hydrolysis
1990 Nature
The Importance of a Critical Protonation State and the Fate of the Catalytic Steps in Class A β-Lactamases and Penicillin-binding Proteins
2004
Structure of the imipenem-hydrolyzing class A β-lactamase SME-1 fromSerratia marcescens
2002
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2005
A theoretical study on the activation of Ser70 in the acylation mechanism of cephalosporin antibiotics
2004
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2000
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2002
Crystal Structures of the Apo and Penicillin-acylated Forms of the BlaR1 β-Lactam Sensor of Staphylococcus aureus
2004
pKa calculations for class A beta-lactamases: methodological and mechanistic implications
1997
Site-directed Mutagenesis of Glutamate 166 in Two β-Lactamases
1997
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2004
β-Lactamase inhibitors: evolving compounds for evolving resistance targets
2004
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2003
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2001
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2003
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2005
Recruitment of penicillin‐binding protein PBP2 to the division site of Staphylococcus aureus is dependent on its transpeptidation substrates
2004
Ovarian Tumor Domain-Containing Viral Proteases Evade Ubiquitin- and ISG15-Dependent Innate Immune Responses
2007
pKa Calculations for class A β‐lactamases: Influence of substrate binding
1999
The Extracytoplasmic Domain of the Mycobacterium tuberculosis Ser/Thr Kinase PknB Binds Specific Muropeptides and Is Required for PknB Localization
2011
Allosteric Receptors after 30 Years
1998
Evaluation of penicillin-based inhibitors of the class A and B β-lactamases from Bacillus anthracis
2003
Energetics-based Protein Profiling on a Proteomic Scale: Identification of Proteins Resistant to Proteolysis
2007
Penicillins and cephalosporins are active site-directed acylating agents: evidence in support of the substrate analogue hypothesis
1980
The crystal structure of SdsA1, an alkylsulfatase from Pseudomonas aeruginosa , defines a third class of sulfatases
2006
Crystal Structure of the 47-kDa Lipoprotein of Treponema pallidum Reveals a Novel Penicillin-binding Protein
2002
New Delhi Metallo-β-Lactamase: Structural Insights into β-Lactam Recognition and Inhibition
2012
Unusual septum formation in Streptococcus pneumoniae mutants with an alteration in the D,D-carboxypeptidase penicillin-binding protein 3
1990
Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains
2013 StandoutNobel
Evolutionary families of peptidases
1993
Structure, function, and fate of the BlaR signal transducer involved in induction of beta-lactamase in Bacillus licheniformis
1992
Near-native structure refinement using in vacuo energy minimization
2007 StandoutNobel
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Crystal Structures of the Bacillus licheniformis BS3 Class A β-Lactamase and of the Acyl−Enzyme Adduct Formed with Cefoxitin,
2002
Catalytic Mechanism of the Streptomyces K15 dd -Transpeptidase/Penicillin-Binding Protein Probed by Site-Directed Mutagenesis and Structural Analysis,
2003
Penicillin Target Enzyme and the Antibiotic Binding Site
1982 Science
TheybxIGene ofBacillus subtilis168 Encodes a Class D β-Lactamase of Low Activity
2004
The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme.
1996
Eukaryote-Like Serine/Threonine Kinases and Phosphatases in Bacteria
2011
Structure of the First-Shell Active Site in Metallolactamase: Effect of Water Ligands
2001
IMP-12, a New Plasmid-Encoded Metallo-β-Lactamase from a Pseudomonas putida Clinical Isolate
2003
β -Lactamases: which ones are clinically important?
2000
Determination of Macromolecular Structures from Anomalous Diffraction of Synchrotron Radiation
1991 Science
Impact of Specific pbp5 Mutations on Expression of β-Lactam Resistance in Enterococcus faecium
2004
Functional information and the emergence of biocomplexity
2007 StandoutNobel
Mixed Quantum Mechanical/Molecular Mechanical (QM/MM) Study of the Deacylation Reaction in a Penicillin Binding Protein (PBP) versus in a Class C β-Lactamase
2004
Staphylococcal methicillin resistance: fine focus on folds and functions
2004
Site-directed mutagenesis at the active site of Escherichia coli TEM-1 beta-lactamase. Suicide inhibitor-resistant mutants reveal the role of arginine 244 and methionine 69 in catalysis.
1992
Mutational Analysis of Metallo-β-lactamase CcrA from Bacteroides fragilis
2000
Chiroptical Molecular Switches
2000 StandoutNobel
Crystal Structure of the Zinc-Dependent β-Lactamase from Bacillus cereus at 1.9 Å Resolution: Binuclear Active Site with Features of a Mononuclear Enzyme,
1998
Diversity and Proliferation of Metallo-β-Lactamases: a Clarion Call for Clinically Effective Metallo-β-Lactamase Inhibitors
2018
Cytokinesis in Bacteria
2003
Bacterial Resistance to β-Lactam Antibiotics: Compelling Opportunism, Compelling Opportunity
2005 Standout
Bacterial Cell Wall Synthesis: New Insights from Localization Studies
2005
Functional evolution of the serine β-lactamase active site
2002
Crystal Structure of the Sensor Domain of the BlaR Penicillin Receptor from Bacillus licheniformis,
2003
Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines.
1996 StandoutNobel
Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase
2013 StandoutNobel
Crystal structure of core streptavidin determined from multiwavelength anomalous diffraction of synchrotron radiation.
1989
Solvent dramatically affects protein structure refinement
2008 StandoutNobel
Fluorescence bleaching reveals asymmetric compartment formation prior to cell division in Caulobacter
2003 StandoutNobel
Organoselenium Chemistry: Role of Intramolecular Interactions
2010 Standout
Molecular Dynamics Study on Class A β-Lactamase: Hydrogen Bond Network among the Functional Groups of Penicillin G and Side Chains of the Conserved Residues in the Active Site
2003
Granular Layer in the Periplasmic Space of Gram-Positive Bacteria and Fine Structures ofEnterococcus gallinarumandStreptococcus gordoniiSepta Revealed by Cryo-Electron Microscopy of Vitreous Sections
2006 StandoutNobel
X-ray Structure of the Asn276Asp Variant of the Escherichia coli TEM-1 β-Lactamase: Direct Observation of Electrostatic Modulation in Resistance to Inactivation by Clavulanic Acid,
1999
Structural basis and specificity of human otubain 1-mediated deubiquitination
2008
Mechanisms of Antibiotic Resistance: QM/MM Modeling of the Acylation Reaction of a Class A β-Lactamase with Benzylpenicillin
2005
The mammalian central nervous synaptic cleft contains a high density of periodically organized complexes
2005 StandoutNobel
[28] Phase determination from multiwavelength anomalous diffraction measurements
1997
Molecular Dynamics Simulations of the Mononuclear Zinc-β-lactamase fromBacilluscereusComplexed with Benzylpenicillin and a Quantum Chemical Study of the Reaction Mechanism
2001
Modeling Domino Effects in Enzymes: Molecular Basis of the Substrate Specificity of the Bacterial Metallo-β-lactamases IMP-1 and IMP-6
2003
Protonation State of Asp120 in the Binuclear Active Site of the Metallo-β-Lactamase from Bacteroides fragilis
2003
Three Decades of β-Lactamase Inhibitors
2010 Standout
[20] Processing of X-ray diffraction data collected in oscillation mode
1997 Standout
Computationally designed peptide macrocycle inhibitors of New Delhi metallo-β-lactamase 1
2021 StandoutNobel
Exploring the Role and the Binding Affinity of a Second Zinc Equivalent in B. cereus Metallo-β-lactamase
2002
Structure-Based Approach for Binding Site Identification on AmpC β-Lactamase
2002
A New Route to Spiropyrrolidinyl-oxindole Alkaloids via Iodide Ion Induced Rearrangement of [(N-Aziridinomethylthio)methylene]-2-oxindoles
2001
Zn2+catalysed hydrolysis of β-lactams: experimental and theoretical studies on the influence of the β-lactam structure
2004
Progress in Modeling of Protein Structures and Interactions
2005 StandoutScienceNobel
[30] Multiwavelength anomalous diffraction phasing of macromolecular structures: Analysis of MAD data as single isomorphous replacement with anomalous scattering data using the MADMRG program
1997
Crystal Structure of Extended-Spectrum β-Lactamase Toho-1: Insights into the Molecular Mechanism for Catalytic Reaction and Substrate Specificity Expansion,
2003
Natural and Synthetic Small Boron-Containing Molecules as Potential Inhibitors of Bacterial and Fungal Quorum Sensing
2010
Determination of three-dimensional structure by multiwavelength anomalous diffraction
1991
Enzyme Redesign
2001
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Staphylococcal methicillin resistance: fine focus on folds and functions
2004
Kinship and Diversification of Bacterial Penicillin-Binding Proteins and β-Lactamases
1998
Discovering protein secondary structures: Classification and description of isolated α-turns
1996
Control over overall shape and size in de novo designed proteins
2015 StandoutNobel
A 1.2-Å snapshot of the final step of bacterial cell wall biosynthesis
2001
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
FemABX Peptidyl Transferases: a Link between Branched-Chain Cell Wall Peptide Formation and β-Lactam Resistance in Gram-Positive Cocci
2003
How β-Lactamases Have Driven Pharmaceutical Drug Discovery
1998
The mechanism of catalysis and the inhibition of the Bacillus cereus zinc-dependent β-lactamase
1998
Bifunctional homopolymeric hydrogen‐bonded tapes
1996 StandoutNobel
Crystal Structure of the IMP-1 Metallo β-Lactamase from Pseudomonas aeruginosa and Its Complex with a Mercaptocarboxylate Inhibitor: Binding Determinants of a Potent, Broad-Spectrum Inhibitor,
2000
Eine neuartige Methode zur Synthese von Spiro[pyrrolidin-3,3′-oxindolen]: katalysierte Ringerweiterung von Cyclopropanen mit Aldiminen
1999
Dynamic Control of Chiral Space in a Catalytic Asymmetric Reaction Using a Molecular Motor
2011 StandoutScienceNobel
Identification of Glu166 as the General Base in the Acylation Reaction of Class A β-Lactamases through QM/MM Modeling
2003
Structure of the Calcium-Dependent Lectin Domain from a Rat Mannose-Binding Protein Determined by MAD Phasing
1991 Science
[31] Treatment of multiwavelength anomalous diffraction data as a special case of multiple isomorphous replacement
1997 StandoutNobel
Evolution of an enzyme activity: crystallographic structure at 2-A resolution of cephalosporinase from the ampC gene of Enterobacter cloacae P99 and comparison with a class A penicillinase.
1993
Familial Mutations and Zinc Stoichiometry Determine the Rate-Limiting Step of Nitrocefin Hydrolysis by Metallo-β-lactamase from Bacteroides fragilis
2001
Identification of BlaR, the signal transducer for beta-lactamase production in Bacillus licheniformis, as a penicillin-binding protein with strong homology to the OXA-2 beta-lactamase (class D) of Salmonella typhimurium
1990
Structure of Ribonuclease H Phased at 2 Å Resolution by MAD Analysis of the Selenomethionyl Protein
1990 Science
A Detailed View of a Ribosomal Active Site
1999 StandoutNobel
Thiols as Classical and Slow-Binding Inhibitors of IMP-1 and Other Binuclear Metallo-β-lactamases
2003
An Ultrahigh Resolution Structure of TEM-1 β-Lactamase Suggests a Role for Glu166 as the General Base in Acylation
2002
Structure of the Extended-Spectrum Class C β-Lactamase of Enterobacter cloacae GC1, a Natural Mutant with a Tandem Tripeptide Insertion,
1999
Structural Insights into Group II Intron Catalysis and Branch-Site Selection
2002 StandoutScienceNobel
Structure of the A20 OTU domain and mechanistic insights into deubiquitination
2007
Works of O. Dideberg being referenced
The Structures and Catalytic Mechanisms of Active-Site Serine β-Lactamases
1994
Crystal Structure of a Peptidoglycan Synthesis Regulatory Factor (PBP3) from Streptococcus pneumoniae
2005
Comparison of the Structures of Wild-type and a N313T Mutant ofEscherichia coliGlyceraldehyde 3-Phosphate Dehydrogenases: Implication for NAD Binding and Cooperativity
1996
The Structural Modifications Induced by the M339F Substitution in PBP2x from Streptococcus pneumoniae Further Decreases the Susceptibility to β-Lactams of Resistant Strains
2003
X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme
1996
Crystal Structure of PBP2x from a Highly Penicillin-resistant Streptococcus pneumoniae Clinical Isolate
2001
Crystal Structure of UDP-N-acetylmuramoyl-l-alanyl-d-glutamate:meso-Diaminopimelate Ligase from Escherichia Coli
2001
Crystal Structure ofProteus mirabilisPR Catalase With and Without Bound NADPH
1995
“Open” structures of MurD: domain movements and structural similarities with folylpolyglutamate synthetase
2000
Properties and crystallization of a genetically engineered, water‐soluble derivative of penicillin‐binding protein 5 of Escherichia coli K12
1988
X-ray Structure of the ZnII β-Lactamase from Bacteroides fragilis in an Orthorhombic Crystal Form
1998
Structural studies of the transpeptidase domain of PBP1a fromStreptococcus pneumoniae
2003
Purification, crystallization and preliminary X-ray analysis ofBacteroides fragilisZn2+β-lactamase
1997
A Metallo-β-lactamase Enzyme in Action: Crystal Structures of the Monozinc Carbapenemase CphA and its Complex with Biapenem
2004
Arginine 220 is a critical residue for the catalytic mechanism of the Streptomyces albus G β-lactamase
1991
Crystal Structure of Phosphorylcholine Esterase Domain of the Virulence Factor Choline-binding Protein E from Streptococcus pneumoniae
2005
The d ,d ‐carboxypeptidase PBP3 organizes the division process of Streptococcus pneumoniae
2004
1.85 Å Resolution Structure of the ZincII β-Lactamase from Bacillus cereus
1998
The 1.5-Å Structure of Chryseobacterium meningosepticum Zinc β-Lactamase in Complex with the Inhibitor, D-Captopril
2003
Engineering a novel β-Iactamase by a single point mutation
1990
A PBP2x from a Clinical Isolate of Streptococcus pneumoniae Exhibits an Alternative Mechanism for Reduction of Susceptibility to β-Lactam Antibiotics
2004
Structural effects of the active site mutation cysteine to serine in Bacillus cereus zinc–β–lactamase
2000
The Three-Dimensional Structure of VIM-2, a Zn-β-Lactamase from Pseudomonas aeruginosa in Its Reduced and Oxidised Form
2007
Mutations in the Active Site of Penicillin-binding Protein PBP2x from Streptococcus pneumoniae
1999
Deacylation Kinetics Analysis of Streptococcus pneumoniae Penicillin-Binding Protein 2x Mutants Resistant to β-Lactam Antibiotics Using Electrospray Ionization– Mass Spectrometry
2000
β‐Lactamase of Bacillus licheniformis 749/C at 2 Å resolution
1990
Probing the Specificity of the Subclass B3 FEZ-1 Metallo-β-lactamase by Site-directed Mutagenesis
2004
Structural basis for the broad-spectrum inhibition of metallo-β-lactamases by thiols
2008
Structural Insights into the Design of Inhibitors for the L1 Metallo-β-lactamase from Stenotrophomonas maltophilia
2007
The crystal structure of the penicillin-binding protein 2x from Streptococcus pneumoniae and its acyl-enzyme form: implication in drug resistance 1 1Edited by R. Huber
2000
Mechanism of acyl transfer by the class A serine β-lactamase of Streptomyces albus G
1991
Three-dimensional Structure of FEZ-1, a Monomeric Subclass B3 Metallo-β-lactamase from Fluoribacter gormanii, in Native Form and in Complex with d-Captopril
2002
Triflocine: acide [m-(trifluorométhyl)phénylamino]-4 nicotinique
1979
Site-directed mutagenesis of proposed active-site residues of penicillin-binding protein 5 from Escherichia coli
1994
Active site restructuring regulates ligand recognition in class A penicillin-binding proteins
2005
Crystal Structure of Human Survivin Reveals a Bow Tie–Shaped Dimer with Two Unusual α-Helical Extensions
2000
The active-site-serine penicillin-recognizing enzymes as members of the Streptomyces R61 dd -peptidase family
1988
Crystallographic data for the β-lactamase from Enterobacter cloacae P99
1983
Competitive Inhibitors of the CphA Metallo-β-Lactamase from Aeromonas hydrophila
2007
Identification of a structural determinant for resistance to β-lactam antibiotics in Gram-positive bacteria
1998
Update of the Standard Numbering Scheme for Class B β-Lactamases
2004
Structure cristalline et moléculaire du bromure d'o-formyl phénylsélényle (C7H5OSeBr)
1975
Growth and division of Streptococcus pneumoniae: localization of the high molecular weight penicillin‐binding proteins during the cell cycle
2003
The 4.5 Å resolution structure analysis of the exocellular DD‐carboxypeptidase of Streptomyces albus G
1980
Comparison of the sequences of class A beta-lactamases and of the secondary structure elements of penicillin-recognizing proteins
1991
The crystal structure of the β-lactamase of Streptomyces albus G at 0.3 nm resolution
1987
Crystal structure of human otubain 2
2004
Crystal structure of Pseudomonas aeruginosa catabolic ornithine transcarbamoylase at 3.0-A resolution: a different oligomeric organization in the transcarbamoylase family.
1995
Primary and predicted secondary structures of the Actinomadura R39 extracellular dd -peptidase, a penicillin-binding protein (PBP) related to the Escherichia coli PBP4
1992
Structure cristalline et moléculaire d'un nouvel alcalöide bisindolique: complexe moléculaire 1:2 strychnofoline–ethanol (C30H34N4O2.2C2H6O)
1977
La structure cristalline et moléculaire d'un nouvel alcaloïde bisindolique: la strychnopentamine, C35H43N5O
1977
Preference of Cd(II) and Zn(II) for the Two Metal Sites in Bacillus cereus β-Lactamase II: A Perturbed Angular Correlation of γ-rays Spectroscopic Study
1999
Crystal structure study of Opsanus tau parvalbumin by multiwavelength anomalous diffraction
1985
Crystallographic data for the dd-carboxypeptidase-endopeptidase of low penicillin sensitivity excreted by Streptomyces albus G
1979
Standard Numbering Scheme for Class B β-Lactamases
2001
Crystallization and preliminary X-ray data for the exocellular β-lactamase of Bacillus licheniformis 749/C
1985
The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold.
1995
Biochemical Characterization of Streptococcus pneumoniae Penicillin-Binding Protein 2b and Its Implication in β-Lactam Resistance
2004