Citation Impact
Citing Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
2009 StandoutNobel
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility
2021 StandoutNobel
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
A small-molecule switch for Golgi sulfotransferases
2004 StandoutNobel
Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein
2005 StandoutNobel
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Ubiquitin-independent Mechanisms of Mouse Ornithine Decarboxylase Degradation Are Conserved between Mammalian and Fungal Cells
2003
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
DANGLE: A Bayesian inferential method for predicting protein backbone dihedral angles and secondary structure
2009
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
2003 StandoutNobel
Chemical genetics: tailoring tools for cell biology
2003
Clinical translation of angiogenesis inhibitors
2002 Standout
Proteasome inhibitors: from research tools to drug candidates
2001
Modular and tunable biological feedback control using a de novo protein switch
2019 StandoutNatureNobel
Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi
2001 StandoutNature
A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
2008 NatureNobel
Imaging in the era of molecular oncology
2008 StandoutNature
Proteasome-Mediated Processing of Nrf1 Is Essential for Coordinate Induction of All Proteasome Subunits and p97
2014
Drug development from marine natural products
2008 Standout
Proteasome Inhibitors: Complex Tools for a Complex Enzyme
2002
Chemical Genetics
2003
Phase II Clinical Trial of Didemnin B in Patients with Recurrent or Refractory Anaplastic Astrocytoma or Glioblastoma Multiforme (NSC 325319)
1999
Lack of Proteasome Active Site Allostery as Revealed by Subunit-Specific Inhibitors
2001
The Hallmarks of Cancer
2000 Standout
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
2006 StandoutNature
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
2002
Protein‐Reactive Natural Products
2005
New Approaches and Therapeutics Targeting Apoptosis in Disease
2005
Regulation of Ferroptotic Cancer Cell Death by GPX4
2014 Standout
Protein degradation and protection against misfolded or damaged proteins
2003 StandoutNature
Integrated genomic characterization of endometrial carcinoma
2013 StandoutNature
Mitochondrial cytochrome c release is caspase-dependent and does not involve mitochondrial permeability transition in didemnin B-induced apoptosis
2001
Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases
2015
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
Sequence and Analysis of Chromosome I of the Amitochondriate Intracellular Parasite Encephalitozoon cuniculi (Microspora)
2001
Inhibition of Angiogenesis by the Antifungal Drug Itraconazole
2007
Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease
2004
Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes
2007
Inflammation in atherosclerosis
2002 StandoutNature
The Proteasome
2001
Inhibition of protein synthesis by didemnin B is not sufficient to induce apoptosis in human mammary carcinoma (MCF7) cells
1999
Display cloning: functional identification of natural product receptors using cDNA-phage display
1999
Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools
2000
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14
2001
TMC-86A, B and TMC-96, New Proteasome Inhibitors from Streptomyces sp. TC 1084 and Saccharothrix sp. TC 1094. I. Taxonomy, Fermentation, Isolation, and Biological Activities.
1999
Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic β-subunits
2001
Sulfonyl Fluoride Analogues as Activity‐Based Probes for Serine Proteases
2012
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry
2014 StandoutNobel
Proteasome Inhibitors: An Expanding Army Attacking a Unique Target
2012
Natural products as probes of cell biology: 20 years of didemnin research
2002
Chapter 11 Proteinase families and their inhibitors
2001
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Angiogenesis as a therapeutic target
2005 StandoutNature
Proteasome inhibitors: fromin vitro uses to clinical trials
2000
Towards subunit-specific proteasome inhibitors: synthesis and evaluation of peptide α', β'-epoxyketones
1999
Mechanism-Based Profiling of Enzyme Families
2006
Structure of Human Methionine Aminopeptidase-2 Complexed with Fumagillin
1998 Science
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials
2004
Angiogenesis Inhibitors Endostatin or TNP-470 Reduce Intimal Neovascularization and Plaque Growth in Apolipoprotein E–Deficient Mice
1999
The antiangiogenic agent TNP-470 requires p53 and p21 CIP/WAF for endothelial cell growth arrest
2000
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
2009 StandoutScience
De Novo-Designed Enzymes as Small-Molecule-Regulated Fluorescence Imaging Tags and Fluorescent Reporters
2014 StandoutNobel
Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival
2001
Target Identification by Diazirine Photo‐Cross‐Linking and Click Chemistry
2009
Increased Antigen Presentation Efficiency by Coupling Antigens to MHC Class I Trafficking Signals
2008
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Asymmetric Catalysis by Architectural and Functional Molecular Engineering: Practical Chemo- and Stereoselective Hydrogenation of Ketones
2001 StandoutNobel
Mass spectrometry-based proteomics
2003 StandoutNature
An Essential Role of N-Terminal Arginylation in Cardiovascular Development
2002 Science
Copper-Catalyzed Synthesis of Mixed Alkyl Aryl Phosphonates
2014 StandoutNobel
Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1
2016 StandoutNobel
Sox17 and Sox4 Differentially Regulate β-Catenin/T-Cell Factor Activity and Proliferation of Colon Carcinoma Cells
2007
Current Developments in Activity-Based Protein Profiling
2014
The Ubiquitin-Proteasome System Plays an Important Role during Various Stages of the Coronavirus Infection Cycle
2010
Ribosomal Synthesis of Dehydroalanine-Containing Peptides
2006 StandoutNobel
Proteasome Inhibition Alleviates SNARE-Dependent Neurodegeneration
2012 StandoutNobel
Reduction of vascular and permeable regions in solid tumors detected by macromolecular contrast magnetic resonance imaging after treatment with antiangiogenic agent TNP-470.
2003
Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice
1999 Science
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
2002 StandoutScience
Printing Proteins as Microarrays for High-Throughput Function Determination
2000 StandoutScience
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
2005 StandoutScience
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
2004 StandoutScience
Emerging Targets in Photopharmacology
2016 StandoutNobel
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
1,2-Amino Alcohols and Their Heterocyclic Derivatives as Chiral Auxiliaries in Asymmetric Synthesis
1996
Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95- and mitochondrial-mediated mechanism.
2003
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation
2001 Standout
RGS4 and RGS5 are in vivo substrates of the N-end rule pathway
2005
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Changes in the proteolytic activities of proteasomes and lysosomes in human fibroblasts produced by serum withdrawal, amino-acid deprivation and confluent conditions
2003
Structural Basis for the Binding of Didemnins to Human Elongation Factor eEF1A and Rationale for the Potent Antitumor Activity of These Marine Natural Products
2004
Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity
2000
Crystal Structure of Epoxomicin:20S Proteasome Reveals a Molecular Basis for Selectivity of α‘,β‘-Epoxyketone Proteasome Inhibitors
2000 Nobel
Autophagy in Health and Disease: A Double-Edged Sword
2004 StandoutScience
Works of Ny Sin being referenced
Total synthesis of the-potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology
1999
Eponemycin analogues: syntheses and use as probes of angiogenesis
1998
Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: Insights into specificity and potency
1999
Diastereoselective [2,3] Wittig rearrangement of carbohydrate-derived tertiary allylic ethers. 2. Synthesis of an advanced rapamycin intermediate from D-glucose.
1993
The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2
1997
Eponemycin exerts its antitumor effect through the inhibition of proteasome function.
1999
Deuterium Isotope Effects on13C NMR Chemical Shifts of Amides
1997
Epoxomicin, a potent and selective proteasome inhibitor, exhibitsin vivoantiinflammatory activity
1999
The Antiproliferative Agent Didemnin B Uncompetitively Inhibits Palmitoyl Protein Thioesterase
1998