Standout Papers
Citation Impact
Citing Papers
Adjuvant Whole-Brain Radiotherapy Versus Observation After Radiosurgery or Surgical Resection of One to Three Cerebral Metastases: Results of the EORTC 22952-26001 Study
2010 Standout
A European Organisation for Research and Treatment of Cancer Phase III Trial of Adjuvant Whole-Brain Radiotherapy Versus Observation in Patients With One to Three Brain Metastases From Solid Tumors After Surgical Resection or Radiosurgery: Quality-of-Life Results
2012
The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains
1988 StandoutScience
In search of cellular mechanisms of memory
1989
Linoleic acid is a potent activator of protein kinase C type III- α isoform in pancreatic acinar cells; its role in amylase secretion
1988
Postsynaptic then presynaptic protein kinase C activity may be necessary for long-term potentiation
1992
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
1988 StandoutNature
The biology and management of non-small cell lung cancer
2018 StandoutNature
Neurocognitive Function of Patients with Brain Metastasis Who Received Either Whole Brain Radiotherapy Plus Stereotactic Radiosurgery or Radiosurgery Alone
2007
Molecular Events Mediating T Cell Activation
1990
Cardiac α1-Adrenoceptors that regulate contractile function: Subtypes and subcellular signal transduction mechanismsthat regulate contractile function: Subtypes and subcellular signal transduction mechanisms
1996
The origin of pattern and polarity in the Drosophila embryo
1992 StandoutNobel
Whole brain irradiation following surgery or radiosurgery for solitary brain metastases: Mature results of a prematurely closed randomized Trans-Tasman Radiation Oncology Group trial (TROG 98.05)
2006
A synaptic model of memory: long-term potentiation in the hippocampus
1993 StandoutNature
Modulation of the vasodepressor actions of acetylcholine, bradykinin, substance P and endothelin in the rat by a specific inhibitor of nitric oxide formation
1989
Protein kinase C inhibitors eliminate hippocampal long-term potentiation
1987
Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase
1989 StandoutNobel
Brain metastases: current management and new developments
2008
HIV infection does not require endocytosis of its receptor, CD4
1988 StandoutNobel
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors
1991 StandoutNatureNobel
Polymyxin B, an inhibitor of protein kinase C, prevents the maintenance of synaptic long-term potentiation in hippocampal CA1 neurons
1988
FMRFamide reverses protein phosphorylation produced by 5-HT and cAMP in Aplysia sensory neurons
1989 StandoutNatureNobel
Phospholipids in the nucleus—metabolism and possible functions
1992
Inositol trisphosphate and calcium signalling
1993 StandoutNature
The value of 4-month neurocognitive function as an endpoint in brain metastases trials
2014
Stereotactic Radiosurgery of the Postoperative Resection Cavity for Brain Metastases
2007
Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial
2009 Standout
Comparison of particle beam therapy and stereotactic body radiotherapy for early stage non-small cell lung cancer: A systematic review and hypothesis-generating meta-analysis
2017
Cardiac excitation–contraction coupling
2002 StandoutNature
Local and Systemic Effects of Intradermal Recombinant Interferon-γ in Patients with Lepromatous Leprosy
1986 StandoutNobel
Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.
1986 StandoutNobel
Protein kinase C phosphorylates pp60src at a novel site
1985
Distinct cellular and regional localization of immunoreactive protein kinase C in rat brain.
1987
Heterogeneous localization of protein kinase C in rat brain: autoradiographic analysis of phorbol ester receptor binding
1986
Translocation of phospholipid/Ca2+-dependent protein kinase in B-lymphocytes activated by phorbol ester or cross-linking of membrane immunoglobulin
1986
Isozymic forms of rat brain Ca2+-activated and phospholipid-dependent protein kinase.
1986
Immunochemical evidence that three protein kinase C isozymes increase in abundance during HL-60 differentiation induced by dimethyl sulfoxide and retinoic acid.
1988
Postsynaptic protein kinase C essential to induction and maintenance of long-term potentiation in the hippocampal CA1 region.
1992
Single-cell transplantation determines the time when Xenopus muscle precursor cells acquire a capacity for autonomous differentiation.
1993 StandoutNobel
Membrane Phospholipid Turnover, Receptor Function and Protein Phosphorylation
1982
Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase by protein kinase C.
1985
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.
1982 Standout
Regulation of transmembrane signaling by receptor phosphorylation
1987 StandoutNobel
Rapid phosphorylation and modulation of the T4 antigen on cloned helper T cells induced by phorbol myristate acetate or antigen.
1986
Inositol trisphosphate, a novel second messenger in cellular signal transduction
1984 StandoutNature
A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release
1995 StandoutScienceNobel
Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.
1985 StandoutNobel
Domain structure and phosphorylation of protein kinase C.
1987
Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant Transformation
1989 StandoutScienceNobel
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
1992 StandoutScience
Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases
2016 Standout
Experimental Approaches to Understanding the Role of Protein Phosphorylation in the Regulation of Neuronal Function
1983
β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family
1989 StandoutScienceNobel
Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species
2001 StandoutScience
Association of calmodulin with peptide analogs of the inhibitory region of the heat-stable protein inhibitor of adenosine cyclic 3',5'-phosphate dependent protein kinase
1986 StandoutNobel
In Vitro Activation and Nuclear Translocation of NF-κB Catalyzed by Cyclic AMP-Dependent Protein Kinase and Protein Kinase C
1989
Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP
1994 StandoutScienceNobel
Regulation of protein kinase C by lysophospholipids. Potential role in signal transduction.
1988
Activation of calcium and phospholipid-dependent protein kinase by epidermal growth factor (EGF) in A431 cells: Attenuation by 12-0-tetradecanoylphorbol-13-acetate (TPA)
1982
Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane
1984 Nature
Activation and differentiation requirements of primary T cells in vitro.
1993 StandoutNobel
Identification of high-affinity phorbol ester receptor in cytosol of EL4 thymoma cells: requirement for calcium, magnesium, and phospholipids.
1983
Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene
1997 StandoutNobel
Protein kinase C translocates from cytosol to membrane upon hormone activation: Effects of thyrotropin-releasing hormone in GH3 cells
1985
The role of protein kinase C in cell surface signal transduction and tumour promotion
1984 StandoutNature
Phorbol ester induces intracellular translocation of phospholipid/Ca2+ ‐dependent protein kinase and stimulates amylase secretion in isolated pancreatic acini
1984
Pleiotropic loss of activation pathways in a T-cell receptor α-chain deletion variant of a cytolytic T-cell clone
1987 StandoutNatureNobel
Phosphorylation of B‐50 Protein by Calcium‐Activated, Phospholipid‐Dependent Protein Kinase and B‐50 Protein Kinase
1983
Activation of the beta 2-adrenergic receptor promotes growth and differentiation in thyroid cells.
1989 StandoutNobel
Down regulation of protein kinase C in neuronal cells: effects on neurotransmitter release
1987
Calmodulin pharmacology
1981
Binding of protein kinase C to neutrophil membranes in the presence of Ca2+ and its activation by a Ca2+-requiring proteinase.
1985
Free cytoplasmic Ca2+ and neurotransmitter release: studies on PC12 cells and synaptosomes exposed to alpha-latrotoxin.
1984 StandoutNobel
A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans.
1991 StandoutNobel
Phosphorylation of Ion channels
1985
Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase
1986 Standout
Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro.
1982
Induction of DNA Synthesis in Cultured Rat Hepatocytes Through Stimulation of α 1 Adrenoreceptor by Norepinephrine
1985 Science
Protein kinase C activity appears to be required for the synthesis of platelet-activating factor and leukotriene B4 by human neutrophils.
1987
Studies and Perspectives of Protein Kinase C
1986 StandoutScience
Differential distribution of protein kinase C isozymes in the various regions of brain.
1987
Inositol trisphosphate and diacylglycerol as second messengers
1984 Standout
Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells.
1982
A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca 2+ -Dependent Protein Kinase
1984 Science
Regulation of microtubule cold stability by calmodulin-dependent and -independent phosphorylation.
1983 StandoutNobel
Neuronal inhibition by the peptide FMRFamide involves opening of S K+ channels
1987 StandoutNatureNobel
Bepridil and cetiedil. Vasodilators which inhibit Ca2+-dependent calmodulin interactions with erythrocyte membranes.
1984 StandoutNobel
Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface
1992 StandoutScienceNobel
Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3‘:5‘-monophosphate-dependent protein kinase.
1985
Cyclic AMP-dependent protein kinase closes the serotonin-sensitive K+channels of Aplysia sensory neurones in cell-free membrane patches
1985 StandoutNatureNobel
Identification of serine 24 as the unique site on the transferrin receptor phosphorylated by protein kinase C.
1986
Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.
1983
Distinct patterns of expression of different protein kinase C mRNAs in rat tissues
1987
Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane
1983 Nature
Rapid down‐regulation of protein kinase C and membrane association in phorbol ester‐treated leukemia cells
1985
Immunocytochemical localization of protein kinase C in identified neuronal compartments of rat brain
1986
A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans
1987 StandoutNatureNobel
The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.
1991 StandoutNobel
A MOLECULAR DESCRIPTION OF NERVE TERMINAL FUNCTION
1983
Generation of Calcium Oscillations in Fibroblasts by Positive Feedback Between Calcium and IP 3
1991 StandoutScienceNobel
A cDNA encoding protein kinase C identifies two species of mRNA in brain and GH3 cells.
1986
Phorbol diester receptor copurifies with protein kinase C.
1983
Rapid microassay for protein kinase C translocation in Swiss 3T3 cells
1986 StandoutNobel
1-(5-isoquinol inesulfonyl)-2-methylpiperazine (H-7) is a selective inhibitor of protein kinase c in rabbit platelets
1984
Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene.
1987
Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.
1982
In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C.
1989
Purification and characterization of rhodopsin kinase.
1988
Turnover of Inositol Phospholipids and Signal Transduction
1984 Science
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
Ca2+-independent activation of protease-activated kinase II by phospholipids/diolein and comparison with the Ca2+/phospholipid-dependent protein kinase.
1986
Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol 12-myristate 13-acetate.
1985
Calmodulin
1982
Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.
1988 StandoutNobel
Elevated blood pressures in mice lacking endothelial nitric oxide synthase
1996 StandoutNobel
Purified rat brain calcium- and phospholipid-dependent protein kinase phosphorylates ribosomal protein S6.
1983
Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase
1985 StandoutNobel
Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase.
1985 StandoutNobel
Works of Norio Katoh being referenced
Stereotactic body radiotherapy using gated radiotherapy with real-time tumor-tracking for stage I non-small cell lung cancer
2013
Stereotactic Radiosurgery Plus Whole-Brain Radiation Therapy vs Stereotactic Radiosurgery Alone for Treatment of Brain Metastases
2006 Standout
Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.
1980
Phosphorylation of high mobility group 1 protein by phospholipid-sensitive Ca2+-dependent protein kinase from pig testis
1985
Phosphorylation of cardiac troponin inhibitory subunit (troponin I) and tropomyosin-binding subunit (troponin T) by cardiac phospholipid-sensitive Ca2+-dependent protein kinase
1983
Phospholipid-Sensitive Ca2+-Dependent Protein Kinase System in Testis: Localization and Endogenous Substrates*
1984
Phospholipid-sensitive Ca2+-dependent protein kinase from heart. II. Substrate specificity and inhibition by various agents.
1982
Inhibition by phenothiazine antipsychotic drugs of calcium-dependent phosphorylation of cerebral cortex proteins regulated by phospholipid or calmodulin
1981
Subcellular distribution of phospholipid-sensitive calcium-dependent protein kinase in guinea pig heart, spleen and cerebral cortex, and inhibition of the enzyme by Triton X-100
1982
Inhibition by gossypol of phospholipid-sensitive Ca2+-dependent protein kinase from pig testis
1985
Inhibition by melittin of phospholipid-sensitive and calmodulin-sensitive Ca2+ -dependent protein kinases
1982
Substrate proteins for calmodulin-sensitive and phospholipid-sensitive Ca2+-dependent protein kinases in heart, and inhibition of their phosphorylation by palmitoylcarnitine.
1981
Inhibition by adriamycin of calmodulin-sensitive and phospholipid-sensitive calcium-dependent phosphorylation of endogenous proteins from heart
1981
Stimulation by phosphatidylserine and calmodulin of calcium-dependent phosphorylation of endogenous proteins from cerebral cortex.
1980
Stimulation by phspholipid of calcium-dependent phosphorylation of endogenous proteins from mammalian tissues
1981
Immunochemically detected structural difference in the heavy chains of chicken breast muscle myosin isozymes.
1981
Polymyxin B is a more selective inhibitor for phospholipid-sensitive Ca2+-dependent protein kinase than for calmodulin-sensitive Ca2+-dependent protein kinase
1982