Standout Papers
- The nucleotide sequence of the mouse immunoglobulin epsilon gene: comparison with the human epsilon gene sequence. (1982)
- Rearrangements of Immunoglobulin Genes during Differentiation and Evolution (1981)
- Rat lymphoid cell lines producing human T cell leukemia virus. II. Constitutive expression of rat interleukin 2 receptor. (1985)
- Molecular cloning and structure of the human interleukin 2 receptor gene (1985)
- The human IL-2 receptor gene contains a positive regulatory element that functions in cultured cells and cell-free extracts. (1987)
- Nucleotide sequence of mouse IL-2 receptor cDNA and its comparison with the human IL-2 receptor sequence (1985)
- Structure and Function of the Interleukin 2 Receptor: Affinity Conversion Model (1986)
- Molecular cloning of cDNA encoding human interleukin-2 receptor (1984)
Citation Impact
Citing Papers
Mania-like behavior induced by disruption of CLOCK
2007
Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila
2006 StandoutNobel
Mammalian Clock Gene Cryptochrome Regulates Arthritis via Proinflammatory Cytokine TNF-α
2009
Regulation of CLOCK and MOP4 by Nuclear Hormone Receptors in the Vasculature
2001
The Circadian Regulatory Proteins BMAL1 and Cryptochromes Are Substrates of Casein Kinase Iε
2002
Zebrafish CRY represses transcription mediated by CLOCK‐BMAL heterodimer without inhibiting its binding to DNA
2002
A Clock Shock: Mouse CLOCK Is Not Required for Circadian Oscillator Function
2006
Interacting Molecular Loops in the Mammalian Circadian Clock
2000 Science
Nuclear Receptor Rev-erbα Is a Critical Lithium-Sensitive Component of the Circadian Clock
2006 Science
mCRY1 and mCRY2 Are Essential Components of the Negative Limb of the Circadian Clock Feedback Loop
1999
Interactivating Feedback Loops within the Mammalian Clock: BMAL1 Is Negatively Autoregulated and Upregulated by CRY1, CRY2, and PER2
2002
A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins
2002
Expression ofPeriodGenes: Rhythmic and Nonrhythmic Compartments of the Suprachiasmatic Nucleus Pacemaker
2001
Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK
2008
Cryptochrome, Circadian Cycle, Cell Cycle Checkpoints, and Cancer
2005 StandoutNobel
Molecular Analysis of Mammalian Circadian Rhythms
2001
Cryptochromes impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression
2007
A protein binding to the Jk recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif
1989 Nature
Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
2000 Standout
MicroRNAs
2004 Standout
Molecular Bases for Circadian Clocks
1999 Standout
Endothelin-1 mRNA is widely expressed in porcine and human tissues.
1990
Class Switch Recombination and Somatic Hypermutation in Early Mouse B Cells Are Mediated by B Cell and Toll-like Receptors
2007 StandoutNobel
Restricted feeding entrains liver clock without participation of the suprachiasmatic nucleus
2001
Altered behavioral rhythms and clock gene expression in mice with a targeted mutation in the Period1 gene
2001
Are Cycling Gene Products as Internal Zeitgebers No Longer the Zeitgeist of Chronobiology?
1996 StandoutNobel
Regulation of Copulation Duration by period and timeless in Drosophila melanogaster
2004
Regional distribution of immunoreactive endothelin in rats
1989
Synthesis and disulfide structure determination of porcine endothelin: an endothelium‐derived vasoconstricting peptide
1988
Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide
1988
The high affinity interleukin 2 receptor: Fvidence for three distinct polypeptide chains comprising the high affinity interleukin 2 receptor
1988
Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies
2002
cDNA cloning and chromosomal assignment of the endothelin 2 gene: Vasoactive intestinal contractor peptide is rat endothelin 2
1991
Expression of functional interleukin-2 receptors in human light chain/Tac ransgenic mice
1988 Nature
A role for microRNAs in the Drosophila circadian clock
2009 StandoutNobel
Circadian rhythms in olfactory responses of Drosophila melanogaster
1999 Nature
Temporal Mating Isolation Driven by a Behavioral Gene in Drosophila
2003
The Interleukin 2 Receptor
1988
A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization
1989
Major Depressive Disorder
2008 Standout
Biochemical Analysis of the Canonical Model for the Mammalian Circadian Clock
2011 StandoutNobel
Organ distribution of the three rat endothelin messenger RNAs and the effects of ischemia on renal gene expression.
1992 StandoutNobel
A clockwork web: circadian timing in brain and periphery, in health and disease
2003
Endothelin: A new inhibitor of renin release
1988
Trippings along the trail to the molecular mechanisms of biological clocks
1995 StandoutNobel
Circadian Cycling of the Mouse Liver Transcriptome, as Revealed by cDNA Microarray, Is Driven by the Suprachiasmatic Nucleus
2002
Site-directed mutagenesis study on DNA binding regions of the mouse homologue of Suppressor of Hairless, RBP-Jx
1994 StandoutNobel
USP2a Protein Deubiquitinates and Stabilizes the Circadian Protein CRY1 in Response to Inflammatory Signals
2012
Coordination of circadian timing in mammals
2002 StandoutNature
Endophenotypes in bipolar disorder†
2002
Structure-activity relationships of endothelin: Importance of the C-terminal moiety
1988
Molecular Neurobiology and Genetics of Circadian Rhythms in Mammals
1995
Rhythmic PER Abundance Defines a Critical Nodal Point for Negative Feedback within the Circadian Clock Mechanism
2009
Genetics and molecular biology of rhythms in Drosophila and other insects
2003 StandoutNobel
CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila
2012 StandoutNobel
Increased expression of the interleukin 2 (IL-2) receptor beta chain (p70) on CD56+ natural killer cells after in vivo IL-2 therapy: p70 expression does not alone predict the level of intermediate affinity IL-2 binding.
1990
Endothelin: visualization of mRNAs by in situ hybridization provides evidence for local action.
1989
Structure of human immunoglobulin gamma genes: implications for evolution of a gene family
1982 StandoutNobel
The Drosophila RBP-J kappa gene encodes the binding protein for the immunoglobulin J kappa recombination signal sequence.
1991 StandoutNobel
Circadian Organization of Behavior and Physiology in Drosophila
2010
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
1985 StandoutNature
Human Immunoglobulin Heavy Chain Genes Map to a Region of Translocations in Malignant B Lymphocytes
1982 Science
Interaction of the IL-2 Receptor with the src -Family Kinase p56 lck : Identification of Novel Intermolecular Association
1991 Science
Cryptochrome: The Second Photoactive Pigment in the Eye and Its Role in Circadian Photoreception
2000 StandoutNobel
Partial agonist/antagonist mouse interleukin-2 proteins indicate that a third component of the receptor complex functions in signal transduction.
1990
SCN Efferents to Peripheral Tissues: Implications for Biological Rhythms
2001
Expression of IgD may use both DNA rearrangement and RNA splicing mechanisms
1981
Conversion of low-affinity interleukin 2 receptors to a high-affinity state following fusion of cell membranes.
1986
cDNA cloning and chromosomal assignment of the gene encoding endothelin 3
1989
Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison.
1982 StandoutNobel
Evidence for additional subunits associated to the mouse interleukin 2 receptor p55/p75 complex.
1990
Japanese wild mouse, Mus musculus molossinus, has duplicated immunoglobulin γ2a genes
1982 StandoutNatureNobel
The nucleotide sequences of rearranged and germline immunoglobulin VH genes of a mouse myeloma MC101 and evolution of VH genes in mouse.
1982 StandoutNobel
Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies.
1989
Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism.
1981 StandoutNobel
Interleukin-2 Receptor β Chain Gene: Generation of Three Receptor Forms by Cloned Human α and β Chain cDNA's
1989 Science
HTLV-1 p27rex stabilizes human interleukin-2 receptor alpha chain mRNA.
1990 StandoutNobel
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.
1989 Standout
The Human Preproendothelin-1 Gene
1989
Similarity of endothelin to snake venom toxin
1988 Nature
Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes.
1987 StandoutNobel
Expression of lymphocyte surface IgE does not require switch recombination
1982 StandoutNatureNobel
Molecular basis for two different affinity states of the interleukin 2 receptor: affinity conversion model.
1986 StandoutNobel
Transmembrane signaling of interleukin 2 receptor. Conformation and function of human interleukin 2 receptor (p55)/insulin receptor chimeric molecules.
1987
MAMMALIAN CIRCADIAN BIOLOGY: Elucidating Genome-Wide Levels of Temporal Organization
2004
Frequency of expressed immunoglobulin light chain genes in lipopolysaccharide-stimulated BALB/c spleen cells.
1984 StandoutNobel
Molecular cloning and nucleotide sequencing of human immunoglobulin € chain cDNA
1983 StandoutNobel
Recombination of exogenous interleukin 2 receptor gene flanked by immunoglobulin recombination signal sequences in a pre-B cell line and transgenic mice.
1991 StandoutNobel
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Concerted evolution of the mouse immunoglobulin gamma chain genes.
1984 StandoutNobel
Adrenergic regulation of clock gene expression in mouse liver
2003
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA
1985 StandoutNobel
Immunoglobulin switch region-like sequences inDrosophila melanogaster
1982 StandoutNobel
Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins
1993 StandoutScienceNobel
A larger number of L chains (Tac) enhance the association rate of interleukin 2 to the high affinity site of the interleukin 2 receptor.
1988 StandoutNobel
Organization of the constant-region gene family of the mouse immunoglobulin heavy chain
1982 StandoutNobel
Characterization and molecular cloning of the mRNA for the heavy (epsilon) chain of rat immunoglobulin E.
1982
Multiple DNA fragment polymorphisms associated with immunoglobulin mu chain switch-like regions in man.
1983 StandoutNobel
Structure-Activity Studies of Interleukin-2
1986 Science
Interleukin 2 high-affinity receptor expression requires two distinct binding proteins.
1987
Expression of functional human interleukin-2 receptor in mouse T cells by cDNA transfection
1986 StandoutNatureNobel
Immunoglobulin Genes
1983 StandoutNobel
Biochemical evidence for a third chain of the interleukin-2 receptor.
1991 StandoutNobel
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
2004 Standout
Origin of human T-lymphotrophic virus I-positive T cell lines in adult T cell leukemia. Analysis of T cell receptor gene rearrangement.
1985 StandoutNobel
Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes.
1982
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns.
1982 StandoutNobel
Dispersed localization of D segments in the human immunoglobulin heavy-chain locus.
1988 StandoutNobel
Expression of human immunoglobulin E ε chain cDNA inE.coli
1983 StandoutNobel
Nucleotide sequence of a rabbit genomic DNA encoding mature endothelin-3
1990
A short sequence in the COOH-terminus makes an adenovirus membrane glycoprotein a resident of the endoplasmic reticulum
1987 StandoutNobel
Targeted Disruption of the mPer3 Gene: Subtle Effects on Circadian Clock Function
2000
Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cells.
1985
Reconstitution of functional receptor for human interleukin-2 in mouse cells
1985 Nature
Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein
2002
Cloning of human immunoglobulin epsilon chain genes: evidence for multiple C epsilon genes.
1982
Duplication and deletion in the human immunoglobulin ϵ genes
1982
Distinct Reactivities of Four Monoclonal Antibodies with Human Interleukin 2 Receptor
1985
Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5
2006 StandoutNobel
Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins.
1987 StandoutNobel
The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes.
1982
Phenotypic Rescue of a Peripheral Clock Genetic Defect via SCN Hierarchical Dominance
2002
Interleukin 2 regulates its own receptors.
1985
Structure and evolution of the heavy chain from rat immunoglobulin E
1982
Somatic generation of antibody diversity
1983 StandoutNatureNobel
Structural Organization and Chromosomal Assignment of the Gene Encoding Endothelin
1989
Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide.
1988
Switch region of immunoglobulin Cμ gene is composed of simple tandem repetitive sequences
1981 StandoutNatureNobel
Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex.
1986
Interleukin-2: Inception, Impact, and Implications
1988 StandoutScience
Works of Norio Ishida being referenced
Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts
2004
Functional CLOCK is not involved in the entrainment of peripheral clocks to the restricted feeding: entrainable expression of mPer2 and BMAL1 mRNAs in the heart of Clock mutant mice on Jcl:ICR background
2002
Rhythmic Expression of BMAL1 mRNA Is Altered in Clock Mutant Mice: Differential Regulation in the Suprachiasmatic Nucleus and Peripheral Tissues
2000
The Expression of the Melatonin Synthesis Enzyme: ArylalkylamineN-Acetyltransferase in the Suprachiasmatic Nucleus of Rat Brain
1999
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium‐derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin
1988
Involvement of circadian clock gene Clock in diabetes‐induced circadian augmentation of plasminogen activator inhibitor‐1 (PAI‐1) expression in the mouse heart
2005
Sex difference in circadian period of body temperature in Clock mutant mice with Jcl/ICR background
2003
Multitissue Circadian Expression of Rat periodHomolog (rPer2) mRNA Is Governed by the Mammalian Circadian Clock, the Suprachiasmatic Nucleus in the Brain
1998
Transcriptional regulation alone does not explain the constitutive expression of the interleukin 2 receptor (Tac/L-chain) in HTLV-1 infected cells
1989 Nobel
Diurnal regulation of per repeat family in the suprachiasmatic nucleus of rat brain
1994
Genome-wide Expression Analysis Reveals 100 Adrenal Gland-dependent Circadian Genes in the Mouse Liver
2005
Molecular biological approach to the circadian clock mechanism
1995
A Role for Glycogen Synthase Kinase-3β in the Mammalian Circadian Clock
2005
Effect of feeding on peripheral circadian rhythms and behaviour in mammals
2004
A Role for the Drosophila Fragile X-Related Gene in Circadian Output
2002
Circadian regulation of per repeat mRNA in the suprachiasmatic nucleus of rat brain
1993
Rearrangements of Immunoglobulin Genes during Differentiation and Evolution
1981 StandoutNobel
Interleukin-2 Receptor: Structure, Function, and Expression
1986 Nobel
Nuclear Entry Mechanism of Rat PER2 (rPER2): Role of rPER2 in Nuclear Localization of CRY Protein
2001
Circadian rhythms of female mating activity governed by clock genes in Drosophila
2001
Biological clocks
1999
Molecular cloning and structure of the human interleukin 2 receptor gene
1985 StandoutNobel
Promoter Analysis for Daily Expression of Drosophila timeless Gene
2001
Rat lymphoid cell lines producing human T cell leukemia virus. II. Constitutive expression of rat interleukin 2 receptor.
1985 StandoutNobel
Nucleotide sequence of mouse IL-2 receptor cDNA and its comparison with the human IL-2 receptor sequence
1985 StandoutNobel
The Expression of the Melatonin Synthesis Enzyme: Arylalkylamine N-Acetyltransferase in the Suprachiasmatic Nucleus of Rat Brain
1999
Cloning of mouse immunoglobulin epsilon gene and its location within the heavy chain gene cluster.
1981
Humoral signals mediate the circadian expression of rat period homologue (rPer2) mRNA in peripheral tissues
1998
The nucleotide sequence of the mouse immunoglobulin epsilon gene: comparison with the human epsilon gene sequence.
1982 StandoutNobel
A Novel Peptide, Vasoactive Intestinal Contractor, of a New (Endothelin) Peptide Family
1989
The human IL-2 receptor gene contains a positive regulatory element that functions in cultured cells and cell-free extracts.
1987 StandoutNobel
Molecular cloning of cDNA encoding human interleukin-2 receptor
1984 StandoutNatureNobel