Standout Papers

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabin... 1995 2026 2005 2015 2.3k
  1. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors (1995)
    Raphael Mechoulam, Shimon Ben‐Shabat et al. Biochemical Pharmacology

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Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
2003
The Cannabinoid System and Cytokine Network
2000
Endogenous cannabinoids and appetite.
2001
The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance
2005
Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease
2000
CB1 cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction
2003
Therapeutic potential of cannabinoid receptor agonists as analgesic agents
2005
Distinct Effects of TGF-β1 on CD4+ and CD8+ T Cell Survival, Division, and IL-2 Production: A Role for T Cell Intrinsic Smad3
2005
The neurobiology and evolution of cannabinoid signalling
2001
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB 1 Receptor Knockout Mice
1999 StandoutScience
In Vitro and in Vivo Pharmacological Characterization of JTE-907, a Novel Selective Ligand for Cannabinoid CB2 Receptor
2001
Dendritic cells with TGF-β1 differentiate naïve CD4+CD25T cells into islet-protective Foxp3+regulatory T cells
2007 StandoutNobel
Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide
1998
Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide.
1995
SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
1994 Standout
Cannabinoid Suppression of Noxious Heat-Evoked Activity in Wide Dynamic Range Neurons in the Lumbar Dorsal Horn of the Rat
1999
Δ-9-Tetrahydrocannabinol Enhances Breast Cancer Growth and Metastasis by Suppression of the Antitumor Immune Response
2005
Presynaptic Cannabinoid Sensitivity Is a Major Determinant of Depolarization-Induced Retrograde Suppression at Hippocampal Synapses
2002
The CB1 Cannabinoid Receptor of Astrocytes Is Coupled to Sphingomyelin Hydrolysis through the Adaptor Protein Fan
2001
Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172
2004
N-acyl-dopamines: novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo
2000
Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease
2005 StandoutNobel
Δ9 Tetrahydrocannabinol and cannabidiol alter cytokine production by human immune cells
1998
The Central Cannabinoid Receptor (CB1) Mediates Inhibition of Nitric Oxide Production by Rat Microglial Cells
1999
Role of Endogenous Cannabinoids in Synaptic Signaling
2003
The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling.
1995
Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit
2011 StandoutScience
Mesenteric Vasodilation Mediated by Endothelial Anandamide Receptors
1999
Cannabinoid Analgesia as a Potential New Therapeutic Option in the Treatment of Chronic Pain
2006
Central and Peripheral Signaling Mechanisms Involved in Endocannabinoid Regulation of Feeding: A Perspective on the Munchies
2005
Suppression of Nerve Growth Factor Trk Receptors and Prolactin Receptors by Endocannabinoids Leads to Inhibition of Human Breast and Prostate Cancer Cell Proliferation1
2000
Transforming Growth Factor-β and the Immune Response: Implications for Anticancer Therapy
2007
2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB 1 receptor
2001
Increased Seizure Susceptibility and Proconvulsant Activity of Anandamide in Mice Lacking Fatty Acid Amide Hydrolase
2003
Localization of cannabinoid CB1 receptors in the human anterior eye and retina.
1999
Modulation and Functional Involvement of CB2 Peripheral Cannabinoid Receptors During B-Cell Differentiation
1998
Molecular and Immune Mechanisms in the Pathogenesis of Cardiomyopathy
1997
Cloning and Pharmacological Characterization of the Rat CB2 Cannabinoid Receptor
2000
Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction.
1993
Platelet‐ and macrophage‐derived endogenous cannabinoids are involved in endotoxin‐induced hypotension
1998
Substrate Specificity and Stereoselectivity of Rat Brain Microsomal Anandamide Amidohydrolase
1999
Inhibitory effects of cannabinoid CB 1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis
2003
Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis
2003
CB1 cannabinoid receptors are involved in neuroprotection via NF-κB inhibition
2005
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
1998
Endocannabinoid 2-Arachidonyl Glycerol Is a Full Agonist through Human Type 2 Cannabinoid Receptor: Antagonism by Anandamide
2000
Inhibition of tumor angiogenesis by cannabinoids
2003
Functional CB1 cannabinoid receptors in human vascular endothelial cells
2000
Cannabinoid receptor agonists and antagonists
1998
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
Functional Interaction between Opioid and Cannabinoid Receptors in Drug Self-Administration
2001
Cannabinol Derivatives:  Binding to Cannabinoid Receptors and Inhibition of Adenylylcyclase
1997
Cannabinoid ligand-receptor signaling in the mouse uterus.
1995
Brain Regional Distribution of Endocannabinoids: Implications for Their Biosynthesis and Biological Function
1999
Cannabinoid CB1 receptor knockout mice exhibit markedly reduced voluntary alcohol consumption and lack alcohol‐induced dopamine release in the nucleus accumbens
2003
HU-308: A specific agonist for CB 2 , a peripheral cannabinoid receptor
1999
Cannabinoid‐receptor expression in human leukocytes
1993
Cannabinoids and the gastrointestinal tract
2001
Endocannabinoids and Neuroprotection
2002
Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning
2011 StandoutNobel
The Cannabinoid 1 Receptor Antagonist, AM251, Prolongs the Survival of Rats with Severe Acute Pancreatitis
2005
Δ9-Tetrahydrocannabinol Treatment Suppresses Immunity and Early IFN-γ, IL-12, and IL-12 Receptor β2 Responses toLegionella pneumophilaInfection
2000
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
2020 StandoutNobel
Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor.
2001
Norepinephrine and beta 2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo.
2001
CB 2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids
2005
Pharmacology of cannabinoids.
2004
The cannabinoid system and immune modulation
2003
Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
2004
Activation of CB 2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS
2003
TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES
2005 Standout
Host-Gut Microbiota Metabolic Interactions
2012 StandoutScience
CANNABINOID RECEPTORS AS THERAPEUTIC TARGETS
2005
SR 144528, an Antagonist for the Peripheral Cannabinoid Receptor that Behaves as an Inverse Agonist
1999
Cannabinoids Promote Oligodendrocyte Progenitor Survival: Involvement of Cannabinoid Receptors and Phosphatidylinositol-3 Kinase/Akt Signaling
2002
Cannabinoids Protect Cells from Oxidative Cell Death: A Receptor-Independent Mechanism
2000
Differential Expression of Cannabinoid Receptors in the Human Colon: Cannabinoids Promote Epithelial Wound Healing
2005
ENDOCANNABINOID-MEDIATED SYNAPTIC PLASTICITY IN THE CNS
2006
Dysregulated Cannabinoid Signaling Disrupts Uterine Receptivity for Embryo Implantation
2001
Plant, Synthetic, and Endogenous Cannabinoids in Medicine
2005
Tetrahydrocannabinol and endocannabinoids in feeding and appetite
2002
Nonpsychotropic Cannabinoid Receptors Regulate Microglial Cell Migration
2003
Evidence for a New G Protein-Coupled Cannabinoid Receptor in Mouse Brain
2001
A beneficial aspect of a CB1 cannabinoid receptor antagonist: SR141716A is a potent inhibitor of macrophage infection by the intracellular pathogen Brucella suis
2000
N-arachidonoyll-serine, an endocannabinoid-like brain constituent with vasodilatory properties
2006
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
2003
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice
2001 StandoutScienceNobel
Endogenous cannabinoids and appetite
2001
Anandamide, a Natural Ligand for the Peripheral Cannabinoid Receptor Is a Novel Synergistic Growth Factor for Hematopoietic Cells
1997
The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1receptor coupling to Gq/11G proteins
2005
Endocannabinoids Acting at Cannabinoid-1 Receptors Regulate Cardiovascular Function in Hypertension
2004
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
2001
2-Arachidonoylglycerol
2004
Mechanism of action of cannabinoids: how it may lead to treatment of cachexia, emesis, and pain.
2006
Up‐regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation
2006
Δ-9-Tetrahydrocannabinol Inhibits Antitumor Immunity by a CB2 Receptor-Mediated, Cytokine-Dependent Pathway
2000
Involvement of Cannabinoid Receptors in the Intraocular Pressure-Lowering Effects of WIN55212-2
2000
A biosynthetic pathway for anandamide
2006
Structural determinants for recognition and translocation by the anandamide transporter
1999
A new strategy to block tumor growth by inhibiting endocannabinoid inactivation
2004
Mutation of a Highly Conserved Aspartate Residue in the Second Transmembrane Domain of the Cannabinoid Receptors, CB1 and CB2, Disrupts G-Protein Coupling
1998

Works of Norbert E. Kaminski being referenced

Effects of putative cannabinoid receptor ligands, anandamide and 2-arachidonyl-glycerol, on immune function in B6C3F1 mouse splenocytes.
1995
Putative Link between Transcriptional Regulation of IgM Expression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin and the Aryl Hydrocarbon Receptor/Dioxin-Responsive Enhancer Signaling Pathway
2000
Cannabinol-Mediated Inhibition of Nuclear Factor-κB, cAMP Response Element-Binding Protein, and Interleukin-2 Secretion by Activated Thymocytes
1999
Cannabinoids inhibit the activation of ERK MAPK in PMA/Io-stimulated mouse splenocytes
2003
Cyclic AMP Is an Essential Factor in Immune Responses
1995
Identification of functional aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator in murine splenocytes
1996
Modulation of Airway Responses to Influenza A/PR/8/34 by Δ9-Tetrahydrocannabinol in C57BL/6 Mice
2007
Attenuation of the ovalbumin-induced allergic airway response by cannabinoid treatment in A/J mice ☆
2003
Δ9-tetrahydrocannabinol selectivity inhibits T-cell dependent humoral immune responses through direct inhibition of accessory T-cell function
1993
Inhibition of the Cyclic AMP Signaling Cascade and Nuclear Factor Binding to CRE and κB Elements by Cannabinol, a Minimally CNS-Active Cannabinoid
1998
Involvement of Blimp-1 and AP-1 Dysregulation in the 2,3,7,8-Tetrachlorodibenzo-p-dioxin–mediated Suppression of the IgM Response by B Cells
2009
Regulation of the cAMP cascade, gene expression and immune function by cannabinoid receptors
1998
Cannabinoid-Mediated Elevation of Intracellular Calcium: A Structure-Activity Relationship
2006
Cannabinoid Inhibition of Adenylate Cyclase-mediated Signal Transduction and Interleukin 2 (IL-2) Expression in the Murine T-cell Line, EL4.IL-2
1996
Molecular Mechanisms of Toxicant-Induced Immunosuppression: Role of Second Messengers
1996
Inhibition of protein kinase A and cyclic AMP response element (CRE)-specific transcription factor binding by Δ9-tetrahydrocannabinol (Δ9-THC)
1997
Inhibition of adenylate cyclase by Δ9-Tetrahydrocannabinol in mouse spleen cells: A potential mechanism for cannabinoid- mediated immunosuppression
1992
Endocannabinoid Regulates Blood Pressure via Activation of the Transient Receptor Potential Vanilloid Type 1 in Wistar Rats Fed a High-Salt Diet
2007
Transient CRE- and κB site-binding is cross-regulated by cAMP-dependent protein kinase and a protein phosphatase in mouse splenocytes
1997
Suppression of Interleukin-2 by the Putative Endogenous Cannabinoid 2-Arachidonyl-Glycerol Is Mediated through Down-regulation of the Nuclear Factor of Activated T Cells
1998
A Cyclooxygenase Metabolite of Anandamide Causes Inhibition of Interleukin-2 Secretion in Murine Splenocytes
2004
Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line
2003
Interactions at a dioxin responsive element (DRE) and an overlapping κB site within the hs4 domain of the 3′α immunoglobulin heavy chain enhancer
2004
Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism
1994
TGF-β1 differentially regulates IL-2 expression and [3H]-thymidine incorporation in CD3ε mAb- and CD28 mAb-activated splenocytes and thymocytes
2000
Examination of the immunosuppressive effect of Δ9-tetrahydrocannabinol in streptozotocin-induced autoimmune diabetes
2001
Aryl Hydrocarbon Receptor-Dependent Inhibition of AP-1 Activity by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Activated B Cells
2002
Evidence for a Cannabinoid Receptor in Immunomodulation by Cannabinoid Compounds
1993
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
1995 Standout
Cannabinol Enhancement of Interleukin-2 (IL-2) Expression by T Cells Is Associated with an Increase in IL-2 Distal Nuclear Factor of Activated T Cell Activity
2002
Cannabinoid Receptors CB1 and CB2: A Characterization of Expression and Adenylate Cyclase Modulation within the Immune System
1997
Inhibition of the cAMP signaling cascade via cannabinoid receptors: a putative mechanism of immune modulation by cannabinoid compounds
1998
Immune regulation by cannabinoid compounds through the inhibition of the cyclic AMP signaling cascade and altered gene expression
1996
Evidence for Cannabinoid Receptor-Dependent and -Independent Mechanisms of Action in Leukocytes
2003
Leukocyte Activation Induces Aryl Hydrocarbon Receptor Up-Regulation, DNA Binding, and Increased Cyp1a1Expression in the Absence of Exogenous Ligand
1997
Transforming Growth Factor-Beta 1 (TGF-β1) Promotes IL-2 mRNA Expression Through the Up-regulation of NF-κB, AP-1 and NF-AT in EL4 Cells
1998
Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation.
1992
Aryl Hydrocarbon Receptor-Dependent Suppression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin of IgM Secretion in Activated B Cells
1998
Role of mitogen-activated protein kinases in the differential regulation of interleukin-2 by cannabinol
2001
Attenuation of inducible nitric oxide synthase gene expression by delta 9-tetrahydrocannabinol is mediated through the inhibition of nuclear factor- kappa B/Rel activation.
1996
Cannabinol-mediated inhibition of nuclear factor-kappaB, cAMP response element-binding protein, and interleukin-2 secretion by activated thymocytes.
1999
Transforming growth factor-beta 1 (TGF-beta1) promotes IL-2 mRNA expression through the up-regulation of NF-kappaB, AP-1 and NF-AT in EL4 cells.
1998
VR1-Mediated Depressor Effects During High-Salt Intake
2005
AP-1 activity is negatively regulated by cannabinol through inhibition of its protein components, c-fos and c-jun
2000
Lipopolysaccharide Activation of Murine Splenocytes and Splenic B Cells Increased the Expression of Aryl Hydrocarbon Receptor and Aryl Hydrocarbon Receptor Nuclear Translocator
1998
Time-Dependent Airway Epithelial and Inflammatory Cell Responses Induced by Influenza Virus A/PR/8/34 in C57BL/6 Mice
2007
Smad3 Is Essential for TGF-β1 to Suppress IL-2 Production and TCR-Induced Proliferation, but Not IL-2-Induced Proliferation
2004
Anandamide-Induced Depressor Effect in Spontaneously Hypertensive Rats
2003
Rankless by CCL
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