Standout Papers
- A mouse model for beta 0-thalassemia. (1995)
- Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system. (1985)
- Clones from the human gene complex coding for salivary proline-rich proteins. (1984)
- Targeted mutation of the Hprt gene in mouse embryonic stem cells. (1988)
- A dominant positive and negative selectable gene for use in mammalian cells. (1991)
- Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. (1998)
- Polymorphisms in the human haptoglobin gene cluster: chromosomes with multiple haptoglobin-related (Hpr) genes. (1986)
- Genetic control of blood pressure and the angiotensinogen locus. (1995)
- Recombination and balanced chromosome polymorphism suggested by DNA sequences 5' to the human delta-globin gene. (1983)
Citation Impact
Citing Papers
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
2006 StandoutNobel
The Molecular Genetics of Human Hemoglobin
1984
Human apolipoprotein A-I prevents atherosclerosis associated with apolipoprotein[a] in transgenic mice.
1994
The cultural mouse
2001 StandoutNobel
The Influence of Chromosomal Location on the Expression of Two Transgenes in Mice
1999 StandoutNobel
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
1999 StandoutNature
A family of candidate taste receptors in human and mouse
2000 StandoutNatureNobel
Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.
1998
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
1999 StandoutNature
Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells
1989
Germ-line transmission of a disrupted β2microglobulin gene produced by homologous recombination in embryonic stem cells
1989 Nature
Understanding hypertension through genetic manipulation in mice
2000
Angiotensinogen gene null-mutant mice lack homeostatic regulation of glomerular filtration and tubular reabsorption
1998
Complete nucleotide sequence of the rabbit β-like globin gene cluster
1989
Exploring type I angiotensin (AT1) receptor functions through gene targeting
2004
Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway
1999 StandoutNobel
Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes.
1997 StandoutNobel
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
1992 Standout
The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice.
1997 StandoutNobel
Forty years with homologous recombination
2001 StandoutNobel
Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation.
1995
Phosphorylation of the Type 1A Angiotensin II Receptor by G Protein-coupled Receptor Kinases and Protein Kinase C
1996 StandoutNobel
Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system
2005 StandoutNobel
Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1
2000
Haplotypes of Angiotensinogen in Essential Hypertension
1997
Genetic deficiency of angiotensinogen produces an impaired urine concentrating ability in mice
1998
Cardiac-specific overexpression of AT1 receptor mutant lacking G q/G i coupling causes hypertrophy and bradycardia in transgenic mice
2005
Transgenic and knockout mice to study the renin-angiotensin system and other interacting vasoactive pathways
2000
A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro.
1997
Divergent functions of angiotensin II receptor isoforms in the brain
2000
Renin-1 Is Essential for Normal Renal Juxtaglomerular Cell Granulation and Macula Densa Morphology
1997
Renal Vascular Reactivity in Mice
1999
Basic local alignment search tool
1990 Standout
Homeostasis in Mice with Genetically Decreased Angiotensinogen Is Primarily by an Increased Number of Renin-producing Cells
1999 StandoutNobel
Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes.
1996
Transgenic Mice as a Tool to Study the Renin-Angiotensin System
2001
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
2010 StandoutNature
Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice
1999 StandoutNobel
Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice
2002 StandoutNobel
Receptor Activity-modifying Proteins 2 and 3 Have Distinct Physiological Functions from Embryogenesis to Old Age
2007 StandoutNobel
Enhanced atherosclerosis and kidney dysfunction in eNOS–/–Apoe–/– mice are ameliorated by enalapril treatment
2000 StandoutNobel
Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion.
1997
Renin-dependent Cardiovascular Functions and Renin-independent Blood-Brain Barrier Functions Revealed by Renin-deficient Mice
2000
Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene. Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells.
1996
Angiotensin II Type 1a Receptor-deficient Mice with Hypotension and Hyperreninemia
1995
Role for Thromboxane Receptors in Angiotensin-II–Induced Hypertension
2004
Molecular Genetics of Human Blood Pressure Variation
1996 Science
Long-term telemetric measurement of cardiovascular parameters in awake mice: a physiological genomics tool
2001
Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo
2006 StandoutNobel
Gene targeting in physiological investigations: studies of the renin-angiotensin system
1998
Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E
1992 StandoutScience
Genetic Models of Human Vascular Disease
1995 StandoutNobel
Transgenic mouse models of lipoprotein metabolism and atherosclerosis.
1993
Isolating gene-corrected stem cells without drug selection
2005 StandoutNobel
Duplication within the haptoglobin Hp2 gene
1984 StandoutNatureNobel
Aberrant Renal Vascular Morphology and Renin Expression in Mutant Mice Lacking Angiotensin-Converting Enzyme
1997 StandoutNobel
Cotransformation and Gene Targeting in Mouse Embryonic Stem Cells
1991 StandoutNobel
Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice
2002 StandoutNobel
Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene
2001 StandoutNobel
Detection of a novel DNA polymorphism in the beta-globin gene cluster.
1984 StandoutNobel
Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene
2004 StandoutNobel
Hydrops Fetalis, Cardiovascular Defects, and Embryonic Lethality in Mice Lacking the Calcitonin Receptor-Like Receptor Gene
2006 StandoutNobel
Mice deficient for prion protein exhibit normal neuronal excitability and synaptic transmission in the hippocampus.
1996 StandoutNobel
β-Arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes
2006 StandoutNobel
Infectious Agents Are Not Necessary for Murine Atherogenesis
2000
Germ-Line Transmission of a c- abl Mutation Produced by Targeted Gene Disruption in ES Cells
1989 Science
Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A
1997 StandoutNobel
A genetically clamped renin transgene for the induction of hypertension
2002 StandoutNobel
The internally located telomeric sequences in the germ-line chromosomes of tetrahymena are at the ends of transposon-like elements
1985 StandoutNobel
Gene correction in hematopoietic progenitor cells by homologous recombination
2000 StandoutNobel
Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner
1998 StandoutNobel
Normal Development of Mice Deficient in β 2 M, MCClass I Proteins, and CD8 + T Cells
1990 StandoutScienceNobel
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.
1995 StandoutNobel
Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination.
1989
Angiotensin-converting enzyme and male fertility
1998 StandoutNobel
Gene Targeting Approaches to Analyzing Hypertension
1999 StandoutNobel
The role of angiotensin II in the feedback control of renin gene expression
1997
Gene targeting at the human CD4 locus by epitope addition.
1990 Nobel
High incidence of XXY and XYY males among the offspring of female chimeras from embryonic stem cells.
1995 StandoutNobel
Correction of a human beta S-globin gene by gene targeting.
1991 StandoutNobel
Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I.
1992
Cotransformation and gene targeting in mouse embryonic stem cells.
1991 StandoutNobel
The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system
1999 StandoutNobel
Regulation of Sodium Balance and Blood Pressure by the AT1AReceptor for Angiotensin II
2000 StandoutNobel
Angiotensin-Converting Enzyme Gene Mutations, Blood Pressures, and Cardiovascular Homeostasis
1997 StandoutNobel
The silent carrier allele: β thalassemia without a mutation in the β-globin gene or its immediate flanking regions
1984 StandoutNobel
Targeted Inactivation of the Ren-2 Gene in Mice
1996
Uncompensated polyuria in a mouse model of Bartter's syndrome
2000 StandoutNobel
Renal growth and development in mice lacking AT1Areceptors for angiotensin II
1998 StandoutNobel
High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors.
1992 StandoutNobel
A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation
2006 StandoutNobel
Reconstitution of lipoprotein(a) by infusion of human low density lipoprotein into transgenic mice expressing human apolipoprotein(a).
1992
Gene targeting approaches to complex genetic diseases: atherosclerosis and essential hypertension.
1995 StandoutNobel
Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system
2005 StandoutNobel
Elevated blood pressures in mice lacking endothelial nitric oxide synthase
1996 StandoutNobel
Reduced growth, abnormal kidney structure, and type 2 (AT 2 ) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT 1A and AT 1B receptors for angiotensin II
1998 StandoutNobel
Lifelong genetic minipumps
2004 StandoutNobel
Molecular phenotyping for analyzing subtle genetic effects in mice: Application to an angiotensinogen gene titration
2002 StandoutNobel
Works of Nobuo Maeda being referenced
Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption.
1994
Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling.
1998 StandoutNobel
Sequence of the putative low-density lipoprotein receptor-binding regions of apolipoprotein B in mouse and hamster
1990
Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice.
1994
Molecular evolution of intergenic DNA in higher primates: pattern of DNA changes, molecular clock, and evolution of repetitive sequences.
1988
Single-copy transgenic mice with chosen-site integration.
1996
Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element.
1985
Lack of apoA-I is not associated with increased susceptibility to atherosclerosis in mice.
1993
Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.
1992
Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression.
1994
Regulation of blood pressure by the type 1A angiotensin II receptor gene.
1995
Clones from the human gene complex coding for salivary proline-rich proteins.
1984 StandoutNobel
Genetic control of blood pressure and the angiotensinogen locus.
1995 StandoutNobel
DNA polymorphisms in the controlling region of the human haptoglobin genes: a molecular explanation for the haptoglobin 2-1 modified phenotype.
2020
Targeted mutation of the Hprt gene in mouse embryonic stem cells.
1988 StandoutNobel
Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells.
1989
Recombination and balanced chromosome polymorphism suggested by DNA sequences 5' to the human delta-globin gene.
1983 StandoutNobel