Citation Impact
Citing Papers
Crystal structure of a replication fork single-stranded DNA binding protein (T4 gp32) complexed to DNA
1995 StandoutNatureNobel
Induction of human neuronal cells by defined transcription factors
2011 StandoutNatureNobel
Structural Elements in RNA
1991
U1-snRNP-A protein selects a ten nucleotide consensus sequence from a degenerate RNA pool presented in various structural contexts
1991
A family of muscle gene promoter element (CArG) binding activities in Xenopus embryos: CArG/SRE discrimination and distribution during myogenesis
1991
A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos
1992 Nature
A community effect in animal development
1988 StandoutNatureNobel
Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily
1996
Concerted activities of the RNA recognition and the glycine‐rich C‐terminal domains of nucleolin are required for efficient complex formation with pre‐ribosomal RNA
1992
The ‘CC.Ar.GG’ box
1988
The yeast eIF3 subunits TIF32/a, NIP1/c, and eIF5 make critical connections with the 40S ribosome in vivo
2003
Oncogenic kinase signalling
2001 StandoutNature
Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo
1994
Eomesodermin, a Key Early Gene in Xenopus Mesoderm Differentiation
1996 StandoutNobel
A conserved secondary structure for telomerase RNA
1991 StandoutNobel
Primary structure of the human splicing factor asf reveals similarities with drosophila regulators
1991
A Novel Receptor-Mediated Nuclear Protein Import Pathway
1996
Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures
1990
A Xenopus mRNA related to Drosophila twist is expressed in response to induction in the mesoderm and the neural crest
1989 StandoutNobel
Two conserved domains of yeast U2 snRNA are separated by 945 nonessential nucleotides
1988
Mesoderm induction in Xenopus caused by activation of MAP kinase
1995 Nature
Ectopic mesoderm formation in Xenopus embryos caused by widespread expression of a Brachyury homologue
1992 Nature
A Distinct Nuclear Import Pathway Used by Ribosomal Proteins
1997 StandoutNobel
Cloning and domain structure of the mammalian splicing factor U2AF
1992 Nature
Signal Transduction by the Receptor Tyrosine Kinase Ret
1998
The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factors
1992 StandoutNobel
Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors
1993
The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA
2011 StandoutNobel
Activation of muscle genes without myogenesis by ectopic expression of MyoD in frog embryo cells
1990 StandoutNatureNobel
Proton, carbon-13, and nitrogen-15 NMR assignments and global folding pattern of the RNA-binding domain of the human hnRNP C proteins
1992
Recognition and specificity in protein tyrosine kinase-mediated signalling
1995
Mix.1, a homeobox mRNA inducible by mesoderm inducers, is expressed mostly in the presumptive endodermal cells of Xenopus embryos
1989
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
1993 StandoutNobel
Activin signalling and response to a morphogen gradient
1994 StandoutNatureNobel
Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing
1991
Antisense probing of the human U4U6 snRNP with biotinylated 2′-OMe RNA oligonucleotides
1989
Nuclear protein import
1997
Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo
1987
The mRNA encoding elongation factor 1-α (EF-1α) is a major transcript at the midblastula transition in Xenopus
1989
Genetic evidence for base pairing between U2 and U6 snRNA in mammalian mRNA splicing
1991 Nature
Caenorhabditis elegans has scores of homoeobox-containing genes
1989 StandoutNatureNobel
Crystal structure at 1.92 Å resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin
1994 Nature
Determinants of interferon-stimulated gene induction by RNAi vectors
2004
In vivo selection of RNAs that localize in the nucleus
1997
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
The KH domain occurs in a diverse set of RNA‐binding proteins that include the antiterminator NusA and is probably involved in binding to nucleic acid
1993
C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B
2000
The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus
1997
The RET proto-oncogene in human cancers
2000
Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A
1990 Nature
The trimethylguanosine cap structure of U1 snRNA is a component of a bipartite nuclear targeting signal
1990
C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons
1992 StandoutNatureNobel
Alteration of the RNA polymerase specificity of U3 snRNA genes during evolution and in vitro
1991
GDNF signalling through the Ret receptor tyrosine kinase
1996 StandoutNature
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
Targeted snRNP depletion reveals an additional role for mammalian U1 snRNP in spliceosome assembly
1990
Enhanced Phosphatidylinositol 3-Kinase Activity and High Phosphorylation State of Its Downstream Signalling Molecules Mediated by Ret with the MEN 2B Mutation
1999
Revealing the world of RNA interference
2004 StandoutNatureNobel
Identification and characterization of a yeast homolog of U1 snRNP-specific protein C
1997 StandoutNobel
Structure of the nuclear transport complex karyopherin-β2–Ran˙GppNHp
1999 StandoutNatureNobel
Monomethylated cap structures facilitate RNA export from the nucleus
1990
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
1989 StandoutNatureNobel
A common octamer motif binding protein is involved in the transcription of U6 snRNA by RNA polymerase III and U2 snRNA by RNA polymerase II
1987
The human U1 snRNP-Specific U1A protein inhibits polyadenylation of its own pre-mRNA
1993
Crystal structure of a hepatitis delta virus ribozyme
1998 StandoutNatureNobel
A 7 bp mutation converts a human RNA polymerase II snRNA promoter into an RNA polymerase III promoter
1989
A single amino acid substitution in a WW-like domain of diverse members of the PDGF receptor subfamily of tyrosine kinases causes constitutive receptor activation
1998
Injected Wnt RNA induces a complete body axis in Xenopus embryos
1991
U6 snRNA genes ofArabidopsisare transcribed by RNA polymerase III but contain the same two upstream promoter elements as RNA polymerase ll-transcribed U-snRNA genes
1990
RNA recognition: towards identifying determinants of specificity
1991
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Eomesodermin is required for mouse trophoblast development and mesoderm formation
2000 StandoutNatureNobel
Microinjection of synthetic Xhox-1A homeobox mRNA disrupts somite formation in developing Xenopus embryos
1988
A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1
1994 StandoutNatureNobel
Muscle gene activation in Xenopus requires intercellular communication during gastrula as well as blastula stages
1992 StandoutNobel
TheRb97Dgene encodes a potential RNA-binding protein required for spermatogenesis inDrosophila
1993
Retinoic acid perturbs the expression of Xhox.lab genes and alters mesodermal determination in Xenopus laevis.
1991
Kap104p: A Karyopherin Involved in the Nuclear Transport of Messenger RNA Binding Proteins
1996 StandoutScienceNobel
The Xenopus laevis poly(A) binding protein is composed of multiple functionally independent RNA binding domains.
1990
Activation of muscle-specific actin genes in xenopus development by an induction between animal and vegetal cells of a blastula
1985 StandoutNobel
The hnRNP proteins
1993
Two distinct Xenopus genes with homology to MyoD1 are expressed before somite formation in early embryogenesis.
1990
Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA.
1991
Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionarily conserved repeated motif.
1986
Multiple roles for U6 snRNA in the splicing pathway.
1990
Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation
2003
Mesoderm Induction in Amphibians: the Role of TGF-β2-Like Factors
1988 Science
The CArG promoter sequence is necessary for muscle-specific transcription of the cardiac actin gene in Xenopus embryos.
1989 StandoutNobel
Conserved amino acid residues within and outside of the N-terminal ribonucleoprotein motif of U1A small nuclear ribonucleoprotein involved in U1 RNA binding
1991
Nucleocytoplasmic Transport
1996 Science
A conserved double-stranded RNA-binding domain.
1992
Bix1, a direct target of Xenopus T-box genes, causes formation of ventral mesoderm and endoderm
1998
Two-level regulation of cardiac actin gene transcription: muscle-specific modulating factors can accumulate before gene activation.
1986
A homeobox-containing marker of posterior neural differentiation shows the importance of predetermination in neural induction
1987 StandoutNobel
Tissue-specific expression of actin genes injected into Xenopus embryos
1986
Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]
1993
A mutant nuclear protein with similarity to RNA binding proteins interferes with nuclear import in yeast.
1992
The DNA-binding protein E12 co-operates with XMyoD in the activation of muscle-specific gene expression in Xenopus embryos.
1992 StandoutNobel
Expression of a novel FGF in theXenopusembryo. A new candidate inducing factor for mesoderm formation and anteroposterior specification
1992
An enhancer screen identifies a gene that encodes the yeast U1 snRNP A protein: implications for snRNP protein function in pre-mRNA splicing.
1993 StandoutNobel
RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins.
1991
Efficient association of U2 snRNPs with pre-mRNA requires an essential U2 RNA structural element.
1991
The initiation of new gene transcription duringXenopusgastrulation requires immediately preceding protein synthesis
1987 StandoutNobel
Inductive effects of fibroblast growth factor and lithium ion on Xenopus blastula ectoderm
1988
Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA.
1990
Functional gap junctions are not required for muscle gene activation by induction in Xenopus embryos.
1987 StandoutNobel
Microinjected U snRNAs are imported to oocyte nuclei via the nuclear pore complex by three distinguishable targeting pathways.
1992
Nuclear export of different classes of RNA is mediated by specific factors
1994
A cap binding protein that may mediate nuclear export of RNA polymerase II-transcribed RNAs.
1992
Transcription of a yeast U6 snRNA gene requires a polymerase III promoter element in a novel position.
1990
Loss of competence in amphibian induction can take place in single nondividing cells.
1989 StandoutNobel
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
Cell interactions and the control of gene activity during early development of Xenopus laevis
1986
Structure of spliceosomal snRNPs and their role in pre-mRNA splicing
1990
Xenopus embryos contain a somite-specific, MyoD-like protein that binds to a promoter site required for muscle actin expression.
1991 StandoutNobel
Expression of the Tcp-1 locus of the mouse during early embryogenesis
1985
From Nuclear Transfer to Nuclear Reprogramming: The Reversal of Cell Differentiation
2006 StandoutNobel
Involvement of the MAP kinase cascade in Xenopus mesoderm induction.
1995
Upstream Regions of the Human Cardiac Actin Gene That Modulate Its Transcription in Muscle Cells: Presence of an Evolutionarily Conserved Repeated Motif
1986
Universally conserved and yeast-specific U1 snRNA sequences are important but not essential for U1 snRNP function.
1990 StandoutNobel
Mesodermal Patterning by a Gradient of the Vertebrate Homeobox Gene goosecoid
1994 Science
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
1993 StandoutNatureNobel
Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1
1996
Secretion and mesoderm-inducing activity of the TGF-beta-related domain of Xenopus Vg1.
1993
Localization of specific mRNAs in Xenopus embryos by whole-mount in situ hybridization
1990
Transcripts of α-cardiac and α-skeletal actins are early markers for myogenesis in the mouse embryo
1988
Muscle-specific (CArG) and serum-responsive (SRE) promoter elements are functionally interchangeable inXenopusembryos and mouse fibroblasts
1989
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
Bix4is activated directly by VegT and mediates endoderm formation inXenopusdevelopment
1999
Upstream sequences required for tissue-specific activation of the cardiac actin gene in Xenopus laevis embryos.
1986 StandoutNobel
Developmental expression of a neurofilament-M and two vimentin-like genes in Xenopus laevis
1988
The yeast branchpoint sequence is not required for the formation of a stable U1 snRNA-pre-mRNA complex and is recognized in the absence of U2 snRNA.
1991 StandoutNobel
The RNA Component of Human Telomerase
1995 StandoutScienceNobel
Functional domains of the human splicing factor ASF/SF2.
1993
Localization of specific mRNA sequences in Xenopus laevis embryos by in situ hybridization
1986
Renal agenesis and hypodysplasia in ret-k – mutant mice result from defects in ureteric bud development
1996
Developmental regulation of a gastrula-specific gene injected into fertilized Xenopus eggs.
1985
A role for cytoplasmic determinants in mesoderm patterning: cell-autonomous activation of the goosecoid and Xwnt-8 genes along the dorsoventral axis of early Xenopus embryos
1994 StandoutNobel
MyoD expression in the forming somites is an early response to mesoderm induction in Xenopus embryos.
1989 StandoutNobel
Embryonic induction - molecular prospects
1987 StandoutNobel
Multiple pathways in nuclear transport: the import of U2 snRNP occurs by a novel kinetic pathway.
1991
Two-Level Regulation of Cardiac Actin Gene Transcription: Muscle-Specific Modulating Factors Can Accumulate before Gene Activation
1986
A Nuclear Import Pathway for a Protein Involved in tRNA Maturation
1997 StandoutNobel
Direct interaction of the U1 snRNP-A protein with the upstream efficiency element of the SV40 late polyadenylation signal.
1994
Xenopus cytoskeletal actin and human c-fos gene promoters share a conserved protein-binding site.
1987
The multiple RNA-binding domains of the mRNA poly(A)-binding protein have different RNA-binding activities.
1991
Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development
1992
The Xenopus MyoD gene: an unlocalised maternal mRNA predates lineage- restricted expression in the early embryo
1990
Activin-mediated mesoderm induction requires FGF
1994
Xenopus Myf-5 marks early muscle cells and can activate muscle genes ectopically in early embryos
1991 StandoutNobel
Interaction of the RNA-binding domain of the hnRNP C proteins with RNA.
1992
Transcription of muscle-specific actin genes in early xenopus development: Nuclear transplantation and cell dissociation
1984 StandoutNobel
Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate
1990 Nature
Expression of genes encoding the transcription factor SRF during early development of Xenopus laevis: identification of a CArG box-binding activity as SRF.
1991
Intracellular distribution of the U1A protein depends on active transport and nuclear binding to U1 snRNA.
1992
All components required for the eventual activation of muscle-specific actin genes are localized in the subequatorial region of an uncleaved amphibian egg.
1985 StandoutNobel
Nucleo-cytoplasmic transport of U snRNPs: definition of a nuclear location signal in the Sm core domain that binds a transport receptor independently of the m3G cap.
1993
Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.
1992
Conserved Structures and Diversity of Functions of RNA-Binding Proteins
1994 StandoutScience
Epidermal keratin gene expressed in embryos of Xenopus laevis.
1985
Expression ofXenopusN-CAM RNA in ectoderm is an early response to neural induction
1987
Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1.
1992 StandoutNobel
Isolation and characterization of sarcomeric actin genes expressed in Xenopus laevis embryos
1986
Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains.
1993
Mutations in the Extracellular Domain Cause RET Loss of Function by a Dominant Negative Mechanism
1998
An Essential Signaling Role for the m 3 G Cap in the Transport of U1 snRNP to the Nucleus
1990 Science
Recognition of U1 and U2 small nuclear RNAs can be altered by a 5-amino-acid segment in the U2 small nuclear ribonucleoprotein particle (snRNP) B" protein and through interactions with U2 snRNP-A' protein.
1991
Morphogen gradient interpretation
2001 StandoutNatureNobel
Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein
1991 Science
Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?
2012 Standout
Works of Nina Dathan being referenced
Changing the RNA polymerase specificity of U snRNA gene promoters
1988
A weak interaction between the U2A′ protein and U2 snRNA helps to stabilize their complex with the U2B” protein
1991
Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide
2010
Major determinants of the specificity of interaction between small nuclear ribonucleoproteins U1A and U2B" and their cognate RNAs
1990 Nature
Delineation of human papillomavirus type 18 enhancer binding proteins: the intracellular distribution of a novel octamer binding protein p92 is cell cycle regulated
1991
The Arabidopsis SUPERMAN protein is able to specifically bind DNA through its single Cys2-His2 zinc finger motif
2002
Activation of RET as a Dominant Transforming Gene by Germline Mutations of MEN2A and MEN2B
1995 Science
Cell type-specific activation of actin genes in the early amphibian embryo
1984 StandoutNatureNobel
The U2B″ RNP motif as a site of protein-protein interaction.
1990
Diversity in the signals required for nuclear accumulation of U snRNPs and variety in the pathways of nuclear transport.
1991
Functional analysis of mutant Xenopus U2 snRNAs
1989
Activated RET/PTC oncogene elicits immediate early and delayed response genes in PC12 cells.
1995
Identification of the RNA binding segment of human U1 A protein and definition of its binding site on U1 snRNA.
1989
Formation of the 3′ end on U snRNAs requires at least three sequence elements.
1986
Developmental expression of the RET protooncogene.
1994
Xenopus myc proto-oncogene during development: expression as a stable maternal mRNA uncoupled from cell division.
1986
A mutation in the RET proto-oncogene in Hirschsprung's disease affects the tyrosine kinase activity associated with multiple endocrine neoplasia type 2A and 2B
1996
Multiple domains of U1 snRNA, including U1 specific protein binding sites, are required for splicing.
1990