Citation Impact
Citing Papers
Origins of coevolution between residues distant in protein 3D structures
2017 StandoutNobel
Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
2009 StandoutScienceNobel
Targeted cell killing by reconstituted caspases
2007 StandoutNobel
Tumor imaging by means of proteolytic activation of cell-penetrating peptides
2004 StandoutNobel
Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase
1999
Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease
2000
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Functional Characterization of the Prodomain of Interleukin1β-converting Enzyme
1996
Nitrotyrosine generation via inducible nitric oxide synthase in vascular wall in focal ischemia-reperfusion
2000
Nitric Oxide Synthase and Postischemic Liver Injury
2000
Control of type-D GABAergic neuron differentiation by C. elegans UNC-30 homeodomain protein
1994 StandoutNatureNobel
Physiological and pathophysiological roles of nitric oxide in the central nervous system
1996
The structure of the cofactor-binding fragment of the LysR family member, CysB: a familiar fold with a surprising subunit arrangement
1997
Expression and Regulation of Endothelial Nitric Oxide Synthase
1997
GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injury
2003
Signal integration by JNK and p38 MAPK pathways in cancer development
2009 Standout
Innate and adaptive immune responses to Listeria monocytogenes: a short overview
2007
Regulation of Inducible Nitric Oxide Synthase Expression by Macrophage Purinoreceptors and Calcium
1996
A guide to immunometabolism for immunologists
2016 Standout
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
1993 Standout
Inducible Nitric Oxide Synthase Requires Both the Canonical Calmodulin-binding Domain and Additional Sequences in Order to Bind Calmodulin and Produce Nitric Oxide in the Absence of Free Ca2+
1996
p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway
2007
Cloning and Expression of Four Novel Isoforms of Human Interleukin-1β Converting Enzyme with Different Apoptotic Activities
1995
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
2011 Standout
Essential Roles of S-Nitrosothiols in Vascular Homeostasis and Endotoxic Shock
2004
The kinase p38α serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
2008
Intrinsic Pituitary Interleukin-1β Is Induced by Bacterial Lipopolysaccharide**
1990
Regulation of skeletal muscle gene expression by p38 MAP kinases
2005
Phenotype of Mice and Macrophages Deficient in Both Phagocyte Oxidase and Inducible Nitric Oxide Synthase
1999
The Inflammasome
2002 Standout
Development and Disease in Proteinase-Deficient Mice
1998
Natural resistance and nitric oxide
1995
Activation of p38 Has Opposing Effects on the Proliferation and Migration of Endothelial Cells
2005
Angiogenesis in cancer and other diseases
2000 StandoutNature
Structural Diversity in the 5’-Untranslated Region of Cytokine-stimulated Human Inducible Nitric Oxide Synthase mRNA
1995
Structure and mechanism of interleukin-lβ converting enzyme
1994 Nature
An Alternatively Spliced C. elegans ced-4 RNA Encodes a Novel Cell Death Inhibitor
1996 StandoutNobel
Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis
2009
Paracrine and autocrine effects of nitric oxide on myocardial function
2000
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
The biochemistry of apoptosis
2000 StandoutNature
Molecular Cloning and Expression of an Avian Macrophage Nitric-oxide Synthase cDNA and the Analysis of the Genomic 5′-Flanking Region
1996
Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock
2003
Cytokine Pathways and Joint Inflammation in Rheumatoid Arthritis
2001 Standout
Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival
2009
Resistance to endotoxic shock as a consequence of defective NF-kappa B activation in poly (ADP-ribose) polymerase-1 deficient mice
1999
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
Matrix metalloproteinase inhibitors in rheumatic diseases
2001
p38 MAP-Kinases pathway regulation, function and role in human diseases
2007
MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover
1999
l-N6-(1-Iminoethyl)-lysine potently inhibits inducible nitric oxide synthase and is superior to NG-monomethyl-arginine in vitro and in vivo
1995
Nitric oxide inhibits viral replication in murine myocarditis.
1996
Nitric Oxide as a Regulator of Embryonic Development
1998
Ligation of CD40 Activates Interleukin 1β-converting Enzyme (Caspase-1) Activity in Vascular Smooth Muscle and Endothelial Cells and Promotes Elaboration of Active Interleukin 1β
1997
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
1997 StandoutNatureNobel
Beneficial effects of GW274150, a novel, potent and selective inhibitor of iNOS activity, in a rodent model of collagen-induced arthritis
2002
Suppression of Interleukin-1β-induced Nitric-oxide Synthase Promoter/Enhancer Activity by Transforming Growth Factor-β1 in Vascular Smooth Muscle Cells
1996
Atherosclerosis — An Inflammatory Disease
1999 Standout
p38α: A Suppressor of Cell Proliferation and Tumorigenesis
2007
Expression, Refolding, and Autocatalytic Proteolytic Processing of the Interleukin-1β-converting Enzyme Precursor
1995
Activation of the Native 45-kDa Precursor Form of Interleukin-1-converting Enzyme
1996
Evolutionary conservation of a genetic pathway of programmed cell death
1996
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003 StandoutNatureNobel
Interspecies homology of nodulation genes in Rhizobium
1987
Long-Term Potentiation Is Reduced in Mice That Are Doubly Mutant in Endothelial and Neuronal Nitric Oxide Synthase
1996 StandoutNobel
p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
2007
Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death
2002
Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock
1995
Rhizobium–plant signal exchange
1992 Nature
Effect of hypoxia on proximal tubules isolated from nitric oxide synthase knockout mice
1998
Cancer-related inflammation
2008 StandoutNature
Is nitric oxide overproduction the target of choice for the management of septic shock?
2001
Selective pharmacological inhibition of distinct nitric oxide synthase isoforms
1996
Enhanced atherosclerosis and kidney dysfunction in eNOS–/–Apoe–/– mice are ameliorated by enalapril treatment
2000 StandoutNobel
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
1994 StandoutNobel
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Radical causes of cancer
2003
Identification and Characterization of ICH-2, a Novel Member of the Interleukin-1β-converting Enzyme Family of Cysteine Proteases
1995
Hydrogen sulfide as a gasotransmitter
2010
Matrix Elasticity Directs Stem Cell Lineage Specification
2006 Standout
Enhanced Post-Ischemic Liver Injury in iNOS-Deficient Mice: A Cautionary Note
2001
Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme
1992 Standout
Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ
1996 StandoutNobel
Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases
1995
Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
1995 StandoutNatureNobel
C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
1998 StandoutNatureNobel
Interleukin‐1βconverting enzyme: A novel cysteine protease required for IL‐1β production and implicated in programmed cell death
1995
p38α MAPK inhibits JNK activation and collaborates with IκB kinase 2 to prevent endotoxin‐induced liver failure
2008
Gene knockout of the KCNJ8‐encoded Kir6.1 K ATP channel imparts fatal susceptibility to endotoxemia
2006
Cell biology and molecular basis of denitrification
1997 Standout
β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα
2004 StandoutNobel
Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha.
1990
17β-Estradiol reduces vasoconstriction in endothelium-denuded rat aortas through inducible NOS
1998
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Macrophage apoptosis in the absence of active interleukin-1β-converting enzyme
1995
Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β
2002 StandoutScienceNobel
Canonical ordered cosmid library of the symbiotic plasmid of Rhizobium species NGR234.
1991 StandoutNobel
Substrate specificity of the protease that processes human interleukin-1 beta.
1990
Effects of oxidant stress on inflammation and survival of iNOS knockout mice after marrow transplantation
2001
Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway.
1995
The potential role of nitric oxide in multiple sclerosis
1998
Macrophage Deletion of p38α Partially Impairs Lipopolysaccharide-Induced Cellular Activation
2008
Therapeutic Administration of a Selective Inhibitor of Nitric Oxide Synthase Does Not Ameliorate the Chronic Inflammation and Tissue Damage Associated with Adjuvant-Induced Arthritis in Rats
1998
Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis.
1996
Interleukin 1 is processed and released during apoptosis.
1991
Matrix Metalloproteinases
2002
The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen.
1995
Mitochondrial Reactive Oxygen Species Activation of p38 Mitogen-Activated Protein Kinase Is Required for Hypoxia Signaling
2005
The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy.
1995
Generation and Characterization of p38β (MAPK11) Gene-Targeted Mice
2005
The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types
2002 StandoutNobel
Isoforms of nitric oxide synthase
1995
Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils
1997 StandoutNobel
NITRIC OXIDE AND MACROPHAGE FUNCTION
1997 Standout
Regulation of biosynthesis of nitric oxide.
1994
Expression of inducible nitric oxide synthase in rat pulmonary Cryptococcus neoformans granulomas.
1996
Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death
2002
The Inflammasomes: Guardians of the Body
2009 Standout
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.
1995 StandoutNobel
Caspases: the executioners of apoptosis
1997 Standout
Complementary roles of gasotransmitters CO and H2S in sleep apnea
2017 StandoutNobel
Delayed K + clearance associated with aquaporin-4 mislocalization: Phenotypic defects in brains of α-syntrophin-null mice
2003 StandoutNobel
Molecular Cloning of the Interleukin-1β Converting Enzyme
1992 Science
Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.
1994
Arrest of endotoxin-induced hypotension by transforming growth factor beta1.
1996
Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.
1996
Delayed Reduction of Ischemic Brain Injury and Neurological Deficits in Mice Lacking the Inducible Nitric Oxide Synthase Gene
1997
Redox cycling and kinetic analysis of single molecules of solution-phase nitrite reductase
2011 StandoutNobel
Interleukin 1 beta (IL-1 beta) processing in murine macrophages requires a structurally conserved homologue of human IL-1 beta converting enzyme.
1993
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of theMycobacterium tuberculosisvirulence factor Sulfolipid-1
2007 StandoutNobel
Disruption of Inducible Nitric Oxide Synthase Improves β-Adrenergic Inotropic Responsiveness but Not the Survival of Mice With Cytokine-Induced Cardiomyopathy
2002
Purification and characterization of active human interleukin-1 beta-converting enzyme from THP.1 monocytic cells.
1993
Map kinase signaling pathways and hematologic malignancies
2003
Structural organization of the human neuronal nitric oxide synthase gene (NOS1)
1994
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
1996 Standout
Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death
2000 StandoutScienceNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase.
1996
Interleukin-1 and interleukin-1 antagonism
1991 Standout
Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter.
1996
Elevated blood pressures in mice lacking endothelial nitric oxide synthase
1996 StandoutNobel
Interleukin-1 beta converting enzyme requires oligomerization for activity of processed forms in vivo.
1995
Processing of precursor interleukin 1 beta and inflammatory disease.
1990
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Expression of Inducible Nitric Oxide Synthase in Human Heart Failure
1996
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Lack of Evidence for Linkage of the Endothelial Cell Nitric Oxide Synthase Gene to Essential Hypertension
1995
Works of Nicole Chartrain being referenced
Chemical Genetics Define the Roles of p38α and p38β in Acute and Chronic Inflammation
2007
Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
1995
Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction
1998
Expression of symbiotic genes of Rhizobium japonicum USDA 191 in other rhizobia
1985
Essential role for p38α mitogen-activated protein kinase in placental angiogenesis
2000
Identification of a monocyte specific pre-interleukin 1 beta convertase activity.
1989
Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts. Synergistic effects of interleukin-1 and tumor necrosis factor-alpha on stromelysin expression.
1990
Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene.
1994
Rhizobium japonicum USDA 191 has two nodD genes that differ in primary structure and function
1988