Citation Impact
Citing Papers
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms
2005 Standout
CD4+ Tregs and immune control
2004 StandoutNobel
T:T Antigen Presentation by Activated Murine CD8+ T Cells Induces Anergy and Apoptosis
1998
The role of CD28 and cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) in regulatory T‐cell biology
2006
Control of immune homeostasis by naturally arising regulatory CD4+ T cells
2003
Effector pathways regulating T cell activation
1998
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
1998 StandoutNature
CASK and Protein 4.1 Support F-actin Nucleation on Neurexins
2001 StandoutNobel
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
1997 Standout
Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer
2003 Standout
mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
2002 Standout
Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling
1994 Nature
Requirement of Phosphatidylinositol 3-Kinase Activity for Bradykinin Stimulation of NF-κB Activation in Cultured Human Epithelial Cells
1999
Inhibition of CD28‐mediated T cell costimulation by the phosphoinositide 3‐kinase inhibitor wortmannin
1995
Anti-inflammatory actions of steroids: molecular mechanisms
1993
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
2009 Standout
CD28-B7 interactions in T-cell activation
1994 StandoutNobel
PD‐1 signaling in primary T cells
2009
Phosphatidylinositol-3-OH kinase direct target of Ras
1994 StandoutNature
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
2005 StandoutNobel
Upstream-Downstream: CD28 Cosignaling Pathways and T Cell Function
1996
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
T cell antigen CD28 binds to the GRB‐2/SOS complex, regulators of p21ras
1995
β-Arrestin1 Mediates Insulin-like Growth Factor 1 (IGF-1) Activation of Phosphatidylinositol 3-Kinase (PI3K) and Anti-apoptosis
2003 StandoutNobel
Protein modules and signalling networks
1995 StandoutNature
CD28 signal transduction: tyrosine phosphorylation and receptor association of phosphoinositide‐3 kinase correlate with Ca2+‐independent costimulatory activity
1994
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
2017 Standout
The blockade of immune checkpoints in cancer immunotherapy
2012 Standout
Ligation of the T cell co‐stimulatory receptor CD28 activates the serine‐threonine protein kinase protein kinase B
1997
The Role of CTLA‐4 in the Regulation and Initiation of T‐Cell Responses
1996 StandoutNobel
Reciprocal expression of co‐stimulatory molecules, B7‐1 and B7‐2, on murine T cells following activation
1995
Phosphoinositides in cell regulation and membrane dynamics
2006 StandoutNature
Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25+ regulatory T cells
2002
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Cytotoxic T Lymphocyte-associated Molecule-4, a High Avidity Receptor for CD80 and CD86, Contains an Intracellular Localization Motif in Its Cytoplasmic Tail
1995
The B7 and CD28 receptor families
1994
CD40 ligand is a T cell growth factor
1993 StandoutNobel
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
PIKE
2000
In vivoblockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance
1999 StandoutNobel
Thymocyte development is normal in CTLA-4-deficient mice
1997 StandoutNobel
Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer
1997 StandoutNobel
The Cytoplasmic Domain of CD28 Is both Necessary and Sufficient for Costimulation of Interleukin-2 Secretion and Association with Phosphatidylinositol 3′-Kinase
1994
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4+T cell responses
1999 StandoutNobel
The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase.
1994
SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade
2008 StandoutNobel
CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.
1996 StandoutNobel
Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.
1994
CTLA-4 blockade synergizes with tumor-derived granulocyte– macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
1998 StandoutNobel
Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
2000 StandoutNobel
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
Integrated NY-ESO-1 antibody and CD8+T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab
2011 StandoutNobel
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
1997 StandoutNobel
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.
1995 StandoutNobel
CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.
1994
CD43 is a ligand for E-selectin on CLA+ human T cells
2005
Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses
2001 StandoutNobel
Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model
2012 StandoutNobel
CD4+ Tregs and immune control
2004 StandoutNobel
The Yin and Yang of T Cell Costimulation
1995 StandoutScienceNobel
The future of immune checkpoint therapy
2015 StandoutScienceNobel
Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer
2001
The CD28-B7 costimulatory pathway and its role in autoimmune disease
1997
Functional expression of B7/BB1 on activated T lymphocytes.
1993
Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells
2000 StandoutNobel
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4+T cells
2000 StandoutNobel
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
2010 StandoutNobel
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit
2008 StandoutNobel
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells.
1995
Enhancement of Antitumor Immunity by CTLA-4 Blockade
1996 StandoutScienceNobel
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human gamma 1.
1993
CD28 Costimulation Mediates Down-Regulation of p27kip1 and Cell Cycle Progression by Activation of the PI3K/PKB Signaling Pathway in Primary Human T Cells
2002
Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation
1999 StandoutNobel
Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy
1999 StandoutNobel
B7 Expression on T Cells Down-Regulates Immune Responses through CTLA-4 Ligation via R-T Interactions
2004 StandoutNobel
Works of Nicolas Hall being referenced
Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both phosphatidylinositol 3-kinase and acidic sphingomyelinase signals.
1996
Ligation of CD28 receptor by B7 induces formation of D‐3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation
1993
B7/BB1, the ligand for CD28, is expressed on repeatedly activated human T cells in vitro
1993
Expression of the cutaneous lymphocyte antigen and its counter-receptor E-selectin in the skin and joints of patients with psoriatic arthritis.
1997
Autoantibodies to recombinant lipocortin-1 in rheumatoid arthritis and systemic lupus erythematosus.
1989
B7/CD28 but not LFA-3/CD2 interactions can provide 'third-party' co-stimulation for human T-cell activation.
1993