Standout Papers
- Synthesis of [11C-methyl]-(−)-OSU6162, its regional brain distribution and some pharmacological effects of (−)-OSU6162 on the dopaminergic system studied in the rhesus monkey by positron emission tomography (1997)
- Rodent data and general hypothesis: antipsychotic action exerted through 5-HT2A receptor antagonism is dependent on increased serotonergic tone (1998)
- The putatively antipsychotic agent amperozide produces behavioural stimulation in the rat (1989)
- Effects of the substituted (S)-3-phenylpiperidine (?)-OSU6162 on PET measurements in subhuman primates: Evidence for tone-dependent normalization of striatal dopaminergic activity (1998)
- Synthesis and biological activity of C-5 modified derivatives of (+)-AJ76 and (+)-UH232: Increased dopamine D3 receptor preference and improved pharmacokinetic properties (1994)
- MK-801-induced hyperlocomotion: Differential effects of M100907, SDZ PSD 958 and raclopride (1997)
- Behavioral and neurochemical data suggest functional differences between dopamine D2 and D3 receptors (1994)
- Intracerebral infusion of (+)-AJ76 and (+)-UH232: effects on dopamine release and metabolism in vivo (1994)
- Neurotransmitter interactions in schizophrenia-therapeutic implications (1999)
- Effects of the substituted (S)-3-phenylpiperidine (−)-OSU6162 on PET measurements of [11C]SCH23390 and [11C]raclopride binding in primate brains (1999)
- Neurotransmitter interactions in schizophrenia—therapeutic implications (1999)
- The dopamine D3 receptor and autoreceptor preferring antagonists (+)-AJ76 and (+)-UH232; a microdialysis study (1993)
- Locomotor inhibition by the D3 ligand R-(+)-7-OH-DPAT is independent of changes in dopamine release (1994)
- The dopamine D3-receptor: A postsynaptic receptor inhibitory on rat locomotor activity (1993)
- Neurotransmitter aberrations in schizophrenia: New perspectives and therapeutic implications (1997)
- A glutamatergic deficiency model of schizophrenia (1999)
- Differential effects of dopamine D2 and D3 receptor antagonists in regard to dopamine release, in vivo receptor displacement and behaviour (1994)
- Evidence for biochemical heterogeneity in schizophrenia: a multivariate study of monoaminergic indices in human post-mortal brain tissue (1994)
- Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity. (1997)
Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Pharmacology of AMPA/Kainate Receptor Ligands and Their Therapeutic Potential in Neurological and Psychiatric Disorders
2000
Dopamine Receptors and Dopamine Transporter in Brain Function and Addictive Behaviors: Insights from Targeted Mouse Mutants
1998
RIM1α and Interacting Proteins Involved in Presynaptic Plasticity Mediate Prepulse Inhibition and Additional Behaviors Linked to Schizophrenia
2010 StandoutNobel
Topographical Assessment of Ethological and Dopamine Receptor Agonist-Induced Behavioral Phenotype in Mutants with Congenic DARPP-32 ‘Knockout’
2003
In vivo evidence for preferential role of dopamine D3 receptor in the presynaptic regulation of dopamine release but not synthesis
1996
Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia
1999
Mechanisms and Functional Implications of Adult Neurogenesis
2008 Standout
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
2006 StandoutNature
Correlates of physical activity: why are some people physically active and others not?
2012 Standout
Adverse Health Effects of Marijuana Use
2014 Standout
Anatomical and physiological evidence for D1 and D2 dopamine receptor colocalization in neostriatal neurons
2000 StandoutNobel
Opposing Roles for Dopamine D2 and D3 Receptors on Neurotensin mRNA Expression in Nucleus Accumbens
1994
Dopamine-Independent Locomotor Actions of Amphetamines in a Novel Acute Mouse Model of Parkinson Disease
2005
Glutamate uptake
2001 Standout
Schizophrenia
2009 Standout
Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?
2010 Standout
Delirium in elderly people
2013 Standout
Identification of PSD-95 as a Regulator of Dopamine-Mediated Synaptic and Behavioral Plasticity
2004
Dopamine D3 Receptor Mutant Mice Exhibit Increased Behavioral Sensitivity to Concurrent Stimulation of D1 and D2 Receptors
1997 Nobel
Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice
1995 StandoutNatureNobel
Neurobiology of Dopamine in Schizophrenia
2007
Neuroprotection by pramipexole against dopamine- and levodopa-induced cytotoxicity
1999
User-guided 3D active contour segmentation of anatomical structures: Significantly improved efficiency and reliability
2006 Standout
Dopamine receptor-interacting proteins: the Ca2+ connection in dopamine signaling
2003
Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia
2000 StandoutNobel
Network interactions in schizophrenia — therapeutic implications
2000 StandoutNobel
C. elegans Locomotory Rate Is Modulated by the Environment through a Dopaminergic Pathway and by Experience through a Serotonergic Pathway
2000 StandoutNobel
Novel dopamine receptors half a decade later
1995
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
2005 StandoutNature
Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice
1994 Nobel
Glutamate neurotoxicity and diseases of the nervous system
1988 Standout
Neuroligins Determine Synapse Maturation and Function
2006 StandoutNobel
In vivo imaging of synaptic function in the central nervous system: II. Mental and affective disorders
2009
Psychosis as a State of Aberrant Salience: A Framework Linking Biology, Phenomenology, and Pharmacology in Schizophrenia
2002 Standout
The Physiology, Signaling, and Pharmacology of Dopamine Receptors
2011 Standout
Psychotogenic drugs and delirium pathogenesis: the central role of the thalamus
2004
Neocortical excitation/inhibition balance in information processing and social dysfunction
2011 StandoutNature
Moderation of the Effect of Adolescent-Onset Cannabis Use on Adult Psychosis by a Functional Polymorphism in the Catechol-O-Methyltransferase Gene: Longitudinal Evidence of a Gene X Environment Interaction
2005
Toward a developmental neurobiology of autism
2004
Does Fast Dissociation From the Dopamine D2Receptor Explain the Action of Atypical Antipsychotics?: A New Hypothesis
2001
Regulation of Dopamine D1 Receptor Function by Physical Interaction with the NMDA Receptors
2004
Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease
2008
Activation of Glycogen Synthase Kinase-3β Is Required for Hyperdopamine and D2Receptor-Mediated Inhibition of Synaptic NMDA Receptor Function in the Rat Prefrontal Cortex
2009
Crucial role of the accumbens nucleus in the neurotransmitter interactions regulating motor control in mice
1995 StandoutNobel
Teaching old receptors new tricks: biasing seven-transmembrane receptors
2010 StandoutNobel
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
Functional organization of the hippocampal longitudinal axis
2014 StandoutNobel
Candidate gene studies of ADHD: a meta-analytic review
2009
Analysis of the actions of the novel dopamine receptor‐directed compounds (S)‐OSU6162 and ACR16 at the D2dopamine receptor
2010
Major Depressive Disorder
2008 Standout
Modulation of mesolimbic dopamine release by the selective dopamine D3 receptor antagonist, (+)-S 14297
1994
Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review
2007 Standout
Uncoupling the D1-N-Methyl-D-Aspartate (NMDA) Receptor Complex Promotes NMDA-Dependent Long-Term Potentiation and Working Memory
2009
Induction of neurogenesis in the adult rat subventricular zone and neostriatum following dopamine D3 receptor stimulation
2004
MRI Study of Caudate Nucleus Volume and Its Cognitive Correlates in Neuroleptic-Naive Patients With Schizotypal Personality Disorder
2002
Dopaminergic Supersensitivity in G Protein-Coupled Receptor Kinase 6-Deficient Mice
2003 StandoutNobel
Structure and function of dopamine receptors
2000
Monoamine transporter pharmacology and mutant mice
2002
The human GLUD2 glutamate dehydrogenase and its regulation in health and disease
2011
Locomotor activity and accumbens Fos expression driven by ventral hippocampal stimulation require D1 and D2 receptors
1999
Withdrawal from Chronic Phencyclidine Treatment Induces Long-Lasting Depression in Brain Reward Function
2002
DAD1- and DAD2-like agonist effects on motor activity of C57 mice: Differences compared to rats
1997
Dorsal hippocampus NMDA receptors differentially mediate trace and contextual fear conditioning
2005
Dopamine receptors: Molecular biology, biochemistry and behavioural aspects
1994
Effects of the putative dopamine autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 on the discriminative stimulus properties of cocaine
1992
Antagonism of cocaine's pharmacological effects by the stimulant dopaminergic antagonists, (+)-AJ76 and (+)-UH232
1992 StandoutNobel
Differential Regulation of Dopamine D1A Receptor Responsiveness by Various G Protein-coupled Receptor Kinases
1996 StandoutNobel
Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway
1999 StandoutNobel
A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice.
1996
An efficient synthesis of the novel dopamine autoreceptor antagonist S-(−)-OSU6162, via palladium catalyzed cross-coupling reaction
1994
Hydroamination: Direct Addition of Amines to Alkenes and Alkynes
2008 Standout
Potentiation of NMDA receptor currents by dopamine D 1 receptors in prefrontal cortex
2004
Synthesis of Pyridine and Dihydropyridine Derivatives by Regio- and Stereoselective Addition toN-Activated Pyridines
2012 Standout
Pramipexole vs Levodopa as Initial Treatment for Parkinson Disease
2000 Standout
Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene,PPP3CC, encoding the calcineurin gamma subunit
2003 Nobel
The Computational Anatomy of Psychosis
2013
Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter
2001
Dopamine D3 Receptors
1999
G Protein Activation by Human Dopamine D3 Receptors in High-Expressing Chinese Hamster Ovary Cells: A Guanosine-5′-O-(3-[35S]thio)-Triphosphate Binding and Antibody Study
1999
Mice carrying a human GLUD2 gene recapitulate aspects of human transcriptome and metabolome development
2016 StandoutNobel
G Protein-Coupled Receptors: Functional and Mechanistic Insights Through Altered Gene Expression
1998 StandoutNobel
Selected Patented Cross-Coupling Reaction Technologies
2006 Standout
The Synthesis of OSU 6162: Efficient, Large-Scale Implementation of a Suzuki Coupling
2003
Computational Elucidation of the Structural Basis of Ligand Binding to the Dopamine 3 Receptor through Docking and Homology Modeling
2006
Palladium-catalyzed reactions of 1-phenylphospholene-1-oxides with aryl iodides and aryldiazonium salts
1998
Enhanced Rewarding Properties of Morphine, but not Cocaine, in βarrestin-2 Knock-Out Mice
2003 StandoutNobel
Pavlovian conditioning–induced hallucinations result from overweighting of perceptual priors
2017 StandoutScience
Highly Flexible Synthesis of Chiral Azacycles via Iridium-Catalyzed Hydrogenation
2010
Prolactin: Structure, Function, and Regulation of Secretion
2000 Standout
Diverse Psychotomimetics Act Through a Common Signaling Pathway
2003 Science
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Akt/GSK3 Signaling in the Action of Psychotropic Drugs
2008
Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals
2011 Standout
NEW INSIGHTS INTO DOPAMINERGIC RECEPTOR FUNCTION USING ANTISENSE AND GENETICALLY ALTERED ANIMALS
1999
DESENSITIZATION OF G PROTEIN–COUPLED RECEPTORS AND NEURONAL FUNCTIONS
2004 StandoutNobel
A Paradigm Shift in Brain Research
2001 ScienceNobel
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
2001 Standout
Monoamine Transporters: From Genes to Behavior
2003
Altered excitatory-inhibitory balance in the NMDA-hypofunction model of schizophrenia
2008
The Heck Reaction as a Sharpening Stone of Palladium Catalysis
2000 Standout
Aryl−Aryl Bond Formation One Century after the Discovery of the Ullmann Reaction
2002 Standout
Dopamine Receptors: From Structure to Function
1998 Standout
Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia
2003 Nobel
Locomotor Activity in D2 Dopamine Receptor-Deficient Mice Is Determined by Gene Dosage, Genetic Background, and Developmental Adaptations
1998
Prescribed drugs containing nitrogen heterocycles: an overview
2020 Standout
Physiology of Microglia
2011 Standout
Rhodium-Catalyzed Intramolecular, Anti-Markovnikov Hydroamination. Synthesis of 3-Arylpiperidines
2006
Works of Nicholas Waters being referenced
Locomotor inhibition by the D3 ligand R-(+)-7-OH-DPAT is independent of changes in dopamine release
1994 StandoutNobel
Rodent data and general hypothesis: antipsychotic action exerted through 5-HT2A receptor antagonism is dependent on increased serotonergic tone
1998 StandoutNobel
Neurotransmitter interactions in schizophrenia-therapeutic implications
1999 StandoutNobel
Intracerebral infusion of (+)-AJ76 and (+)-UH232: effects on dopamine release and metabolism in vivo
1994 StandoutNobel
Behavioral and neurochemical data suggest functional differences between dopamine D2 and D3 receptors
1994 StandoutNobel
Evidence for biochemical heterogeneity in schizophrenia: a multivariate study of monoaminergic indices in human post-mortal brain tissue
1994 StandoutNobel
Increased dopamine release by the autoreceptor antagonist (+)-AJ 76 is Ca2+-dependent
1990
Different corticostriatal patterns of L‐DOPA utilization in patients with untreated schizophrenia and patients treated with classical antipsychotics or clozapine
2003 Nobel
Effects of the substituted (S)-3-phenylpiperidine (−)-OSU6162 on PET measurements of [11C]SCH23390 and [11C]raclopride binding in primate brains
1999 StandoutNobel
The 5-HT2A receptor antagonist M100907 is more effective in counteracting NMDA antagonist- than dopamine agonist-induced hyperactivity in mice
1999
The dopamine D3-receptor: A postsynaptic receptor inhibitory on rat locomotor activity
1993 StandoutNobel
On the Quantitative Structure-Activity Relationships of Meta-Substituted (S)-Phenylpiperidines, a Class of Preferential Dopamine D2 Autoreceptor Ligands: Modeling of Dopamine Synthesis and Release in Vivo by Means of Partial Least Squares Regression
1995
The dopamine D3 receptor and autoreceptor preferring antagonists (+)-AJ76 and (+)-UH232; a microdialysis study
1993 StandoutNobel
Neurotransmitter interactions in schizophrenia—therapeutic implications
1999 StandoutNobel
Altered pattern of brain dopamine synthesis in male adolescents with attention deficit hyperactivity disorder.
2006
Effects of the substituted (S)-3-phenylpiperidine (?)-OSU6162 on PET measurements in subhuman primates: Evidence for tone-dependent normalization of striatal dopaminergic activity
1998 StandoutNobel
A behavioural pattern analysis of hypoglutamatergic mice - effects of four different antipsychotic agents
2001 Nobel
Neurotransmitter aberrations in schizophrenia: New perspectives and therapeutic implications
1997 StandoutNobel
Differential effects of dopamine D2 and D3 receptor antagonists in regard to dopamine release, in vivo receptor displacement and behaviour
1994 StandoutNobel
Interactions Between Monoamines, Glutamate, and GABA in Schizophrenia: New Evidence
2001 Nobel
Synthesis and Evaluation of a Set of 4-Phenylpiperidines and 4-Phenylpiperazines as D2Receptor Ligands and the Discovery of the Dopaminergic Stabilizer 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine (Huntexil, Pridopidine, ACR16)
2010
Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists
1993
substituted (S)-Phenylpiperidines and Rigid Congeners as Preferential Dopamine Autoreceptor Antagonists: Synthesis and Structure-Activity Relationships
1994
A glutamatergic deficiency model of schizophrenia
1999 StandoutNobel
Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity.
1997 StandoutNobel
Concurrent locomotor stimulation and decrease in dopamine release in rats and mice after treatment with the competitive NMDA receptor antagonists D-CPPene and CGS 19755
1996