Citation Impact
Citing Papers
Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes
2010
Hypoxia and loss of PHD 2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis
2015
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: Assessment of an oral agent that stimulates erythropoietin production
2005 StandoutNobel
IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma
2018
Polycomb Group Protein Enhancer of Zeste 2 Is an Oncogene That Promotes the Neoplastic Transformation of a Benign Prostatic Epithelial Cell Line
2009
Metabolic Alterations in Lung Cancer–Associated Fibroblasts Correlated with Increased Glycolytic Metabolism of the Tumor
2013
Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts
2014
Immunogenomic analysis of human brain metastases reveals diverse immune landscapes across genetically distinct tumors
2023
Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment
2015
HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O2 levels
2003 StandoutNobel
Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling
2013 StandoutNobel
Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR
2014
Microenvironmental regulation of tumour angiogenesis
2017
Concepts of extracellular matrix remodelling in tumour progression and metastasis
2020
Hallmarks of Cancer: The Next Generation
2011 Standout
Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts
2015
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
p53‐repressed miRNAs are involved with E2F in a feed‐forward loop promoting proliferation
2008
Carcinoma‐associated fibroblasts: Non‐neoplastic tumour‐promoting mesenchymal cells
2013
Role of Carcinoma-Associated Fibroblasts and Hypoxia in Tumor Progression
2010
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
2007
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
2015
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
p53: traffic cop at the crossroads of DNA repair and recombination
2005
Inflammation and Cancer: Triggers, Mechanisms, and Consequences
2019 Standout
Regulation of cell death and autophagy by IKK and NF‐κB: critical mechanisms in immune function and cancer
2012
Inflammation meets cancer, with NF-κB as the matchmaker
2011
The Multifaceted Role of Perivascular Macrophages in Tumors
2016
Host tissue determinants of tumour immunity
2019
High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis
2013 StandoutNobel
Cell-cycle checkpoints and cancer
2004 StandoutNature
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
2012 Standout
Tie2-expressing monocytes (TEMs): Novel targets and vehicles of anticancer therapy?
2009
P53 and radiation responses
2003
Pro-resolving lipid mediators are leads for resolution physiology
2014 StandoutNature
Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: Contrasting, overlapping and compensatory functions
2009
Microenvironmental regulation of therapeutic response in cancer
2014
A microRNA component of the p53 tumour suppressor network
2007 StandoutNature
The evolution of diverse biological responses to DNA damage: insights from yeast and p53
2001
Epithelial-Mesenchymal Transition Induced by Senescent Fibroblasts
2011
Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth
2011
Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment
2014
The role of myeloid cells in the promotion of tumour angiogenesis
2008
Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling
2013
Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state
2014
The biology and function of fibroblasts in cancer
2016 Standout
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
Clinical and therapeutic relevance of cancer-associated fibroblasts
2021
Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice
2011
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
2014 StandoutNature
Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice
2011
Oxygen sensing by HIF hydroxylases
2004 StandoutNobel
The Role of Stromal Myofibroblast and Extracellular Matrix in Tumor Angiogenesis
2011
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Hallmarks of cancer: Interactions with the tumor stroma
2010
Macrophage Diversity Enhances Tumor Progression and Metastasis
2010 Standout
Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor
2003
Blinded by the Light: The Growing Complexity of p53
2009 Standout
Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy
2017
Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer
2018
Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor
2004 StandoutNobel
Corrupt policemen: inflammatory cells promote tumor angiogenesis
2008
p21 in cancer: intricate networks and multiple activities
2009 Standout
Immune-mediated mechanisms influencing the efficacy of anticancer therapies
2015
Multiplexed and Programmable Regulation of Gene Networks with an Integrated RNA and CRISPR/Cas Toolkit in Human Cells
2014
Immunity, Inflammation, and Cancer
2010 Standout
Mesenchymal Cells in Colon Cancer
2017
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
Fibroblasts as architects of cancer pathogenesis
2012
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
2010 Standout
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
2023 Standout
CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness
2018
Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma
2011
Elusive Identities and Overlapping Phenotypes of Proangiogenic Myeloid Cells in Tumors
2010
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts
2013
Metabolic Reprogramming of Stromal Fibroblasts through p62-mTORC1 Signaling Promotes Inflammation and Tumorigenesis
2014
Modeling and predicting clinical efficacy for drugs targeting the tumor milieu
2012
Macrophage plasticity and polarization: in vivo veritas
2012 Standout
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
2014
The fibrotic tumor stroma
2018
Modulated expression of WFDC1 during carcinogenesis and cellular senescence
2008
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Basic and Therapeutic Aspects of Angiogenesis
2011 Standout
Functional Heterogeneity of Breast Fibroblasts Is Defined by a Prostaglandin Secretory Phenotype that Promotes Expansion of Cancer-Stem Like Cells
2011
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
2015 StandoutNature
Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment
2015
The angiogenic switch in carcinogenesis
2009
The role of senescent cells in ageing
2014 StandoutNature
Neutrophils in cancer: neutral no more
2016 Standout
p53 in recombination and repair
2006
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling
2015
LIF Mediates Proinvasive Activation of Stromal Fibroblasts in Cancer
2014
Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S
2014
The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy
2014
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Fibroblasts as immune regulators in infection, inflammation and cancer
2021
Microenvironmental regulation of tumor progression and metastasis
2013 Standout
A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion
2017
Cancer-related inflammation: Common themes and therapeutic opportunities
2011
Chemokines, cytokines and exosomes help tumors to shape inflammatory microenvironment
2016
Developmental and Pathological Angiogenesis
2011
The Polycomb complex PRC2 and its mark in life
2011 StandoutNature
NF-κB, inflammation, immunity and cancer: coming of age
2018 Standout
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
2011 StandoutNature
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth
2020
Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
2012
Tumor microenvironment and cancer therapy resistance
2015
Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy
2010
Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation
2006 StandoutNobel
System-Wide Analysis Reveals a Complex Network of Tumor-Fibroblast Interactions Involved in Tumorigenicity
2013
IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer
2015
The NF-κB Pathway and Cancer Stem Cells
2016
Diversity and Biology of Cancer-Associated Fibroblasts
2020
Leukocyte composition of human breast cancer
2011
Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma
2017
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
A Critical Role for Macrophages in Promotion of Urethane-Induced Lung Carcinogenesis
2011
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
2006 StandoutNobel
Tumor–Stroma Interaction: Revealing Fibroblast-Secreted Exosomes as Potent Regulators of Wnt-Planar Cell Polarity Signaling in Cancer Metastasis
2013
Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation
2020
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood “resident” monocytes, and embryonic macrophages suggests common functions and developmental relationships
2009
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis
2015
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy
2014 StandoutNobel
Cancer Genome Landscapes
2013 StandoutScience
Regulation of the anti-tumour immune response by cancer-associated fibroblasts
2014
Immunity, inflammation, and cancer: an eternal fight between good and evil
2015
Fibroblast heterogeneity in the cancer wound
2014
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer
2013
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
Promotion of direct reprogramming by transformation-deficient Myc
2010 StandoutNobel
The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis
2016
Osteopontin at the Crossroads of Inflammation and Tumor Progression
2017
Activation of fibroblasts in cancer stroma
2010
The Molecular Balancing Act of p16INK4a in Cancer and Aging
2013
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
2013
Works of Neta Erez being referenced
Tumor-Derived Osteopontin Reprograms Normal Mammary Fibroblasts to Promote Inflammation and Tumor Growth in Breast Cancer
2015
Transcriptional Programs following Genetic Alterations in p53 , INK4A , and H-Ras Genes along Defined Stages of Malignant Transformation
2005
Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity
2021
NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis
2019
p53-dependent Down-regulation of Telomerase Is Mediated by p21
2004
A glitch in the matrix: organ-specific matrisomes in metastatic niches
2021
Chemotherapy-induced complement signaling modulates immunosuppression and metastatic relapse in breast cancer
2022
Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators
2019
Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1
2017
The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment
2019
Structural and functional involvement of p53 in BER in vitro and in vivo
2001
Activated p53 suppresses the histone methyltransferase EZH2 gene
2004
Cancer-associated fibroblasts in the single-cell era
2022
Plasticity in Tumor-Promoting Inflammation: Impairment of Macrophage Recruitment Evokes a Compensatory Neutrophil Response
2008
Cancer Associated Fibroblasts express pro-inflammatory factors in human breast and ovarian tumors
2013
Falkor, a novel cell growth regulator isolated by a functional genetic screen
2002
Isolation of Normal and Cancer-associated Fibroblasts from Fresh Tissues by Fluorescence Activated Cell Sorting (FACS)
2013
Leukocytes as paracrine regulators of metastasis and determinants of organ‐specific colonization
2011
Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner
2010
Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype.
2003
Bone marrow–derived fibroblasts are a functionally distinct stromal cell population in breast cancer
2018
Expression of prolyl-hydroxylase-1 (PHD1/EGLN2) suppresses hypoxia inducible factor-1alpha activation and inhibits tumor growth.
2003
Astrocytes facilitate melanoma brain metastasis via secretion of IL ‐23
2015
A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis
2019
The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA
2002
From sentinel cells to inflammatory culprits: cancer‐associated fibroblasts in tumour‐related inflammation
2012
Isolation of Normal and Cancer-associated Fibroblasts from Fresh Tissues by Fluorescence Activated Cell Sorting (FACS)
2013