Citation Impact
Citing Papers
Oxidative Stress
2017 Standout
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
2012 StandoutScience
Pathophysiology of Migraine: A Disorder of Sensory Processing
2017 Standout
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
2005 StandoutScience
Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Study of the Cortical Spreading Depression Inhibiting Agent Tonabersat in Migraine Prophylaxis
2009
Phenotypic and Biochemical Analyses of BACE1- and BACE2-deficient Mice
2005
Tiagabine
1998
Behavioral phenotypes of amyloid‐based genetically modified mouse models of Alzheimer's disease
2005
The Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks
2002
Synthesis of pyrido[2,3-b]indoles and pyrimidoindoles via Pd-catalyzed amidation and cyclization
2012
The Neural Cell Adhesion Molecules L1 and CHL1 Are Cleaved by BACE1 Protease in Vivo
2012
The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes
2003 Standout
Antinociception in the rat induced by a cold environment
1990
A view on drug resistance in cancer
2019 StandoutNature
The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache
2008
Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1
2015
Modulation of learning and memory by natural polyamines
2016
Molecular, pharmacological and functional diversity of 5-HT receptors
2002 Standout
Brown and beige fat: development, function and therapeutic potential
2013 Standout
Treatment Strategies Targeting Amyloid -Protein
2012
PDF Cells Are a GABA-Responsive Wake-Promoting Component of the Drosophila Sleep Circuit
2008 StandoutNobel
Promotion of sleep by targeting the orexin system in rats, dogs and humans
2007
Occipital activation in glyceryl trinitrate induced migraine with visual aura
2005
The delta opioid receptor: an evolving target for the treatment of brain disorders
2011
5-HT7 Receptor Inhibition and Inactivation Induce Antidepressantlike Behavior and Sleep Pattern
2005
Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane
2009 StandoutNobel
Zebrafish TRPA1 Channels Are Required for Chemosensation But Not for Thermosensation or Mechanosensory Hair Cell Function
2008 StandoutNobel
A meta-analysis of 25 years of mood-creativity research: Hedonic tone, activation, or regulatory focus?
2008 Standout
Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A−/−, 5-HT1B−/−, 5-HT2A−/−, 5-HT3A−/− and 5-HTT−/− knock-out male mice
2007 StandoutNobel
The hypocretins: Setting the arousal threshold
2002
The memory function of sleep
2010 Standout
A reproducible evaluation of ANTs similarity metric performance in brain image registration
2010 Standout
Trafficking and Proteolytic Processing of APP
2012
Cortical Spreading Depression Triggers Migraine Attack: Pro
2010
Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors
2001
[3H]‐SB‐269970 – A selective antagonist radioligand for 5‐HT7 receptors
2000
Hypocretin/Orexin Overexpression Induces An Insomnia-Like Phenotype in Zebrafish
2006
Effects of tonabersat on migraine with aura: a randomised, double-blind, placebo-controlled crossover study
2009
Sleep Homeostasis Modulates Hypocretin-Mediated Sleep-to-Wake Transitions
2009
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
Circadian regulation of sleep in mammals: Role of the suprachiasmatic nucleus
2005
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Transgenic models of Alzheimer’s disease: Learning from animals
2005
Role of delivery and trafficking of δ-opioid peptide receptors in opioid analgesia and tolerance
2006
Cortical spreading depression: Its role in migraine pathogenesis and possible therapeutic intervention strategies
2004
Functional characterisation of the human cloned 5‐HT7 receptor (long form); antagonist profile of SB‐258719
1998
Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer’s Disease
2017
Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal culture
2003
Interaction between the Corticotropin-Releasing Factor System and Hypocretins (Orexins): A Novel Circuit Mediating Stress Response
2004
Stress and the brain: from adaptation to disease
2005 Standout
Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors
1999
Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134)
2001
The effect of SB‐269970, a 5‐HT7 receptor antagonist, on 5‐HT release from serotonergic terminals and cell bodies
2001
Emerging Biological Principles of Metastasis
2017 Standout
Alzheimer's disease
2016 Standout
5-HT6 receptor antagonists: lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides
2001
Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
2006 Standout
Orexin receptors as therapeutic drug targets
2012
Neurotoxic in vivo models of Parkinson’s disease
2010
elastix: A Toolbox for Intensity-Based Medical Image Registration
2009 Standout
A review of central 5-HT receptors and their function
1999 Standout
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
2012
Major Depressive Disorder
2008 Standout
The Therapeutic Potential of Modifying Inflammasomes and NOD-Like Receptors
2013
Characterization of [125I]‐SB‐258585 binding to human recombinant and native 5‐HT6 receptors in rat, pig and human brain tissue
2000
Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
2016 Nature
The Amyloid State of Proteins in Human Diseases
2012 Standout
Circadian-dependent and circadian-independent behavioral actions of hypocretin/orexin
2002
Is there more to gaba than synaptic inhibition?
2002
Learning to Modulate Transmitter Release: Themes and Variations in Synaptic Plasticity
1993 StandoutNobel
Structure of the δ-opioid receptor bound to naltrindole
2012 StandoutNatureNobel
Orexins and appetite regulation
2002
Hypoglycemia activates arousal-related neurons and increases wake time in adult rats
2007
Spatial learning and memory impairment and increased locomotion in a transgenic amyloid precursor protein mouse model of Alzheimer's disease
2011
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease
2014
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
2012 Standout
Ghrelin: Structure and Function
2005 Standout
Excitatory actions of gaba during development: the nature of the nurture
2002 Standout
Optogenetics in Neural Systems
2011 Standout
The amyloid state and its association with protein misfolding diseases
2014 Standout
The Monomer State of Beta-Amyloid: Where the Alzheimer's Disease Protein Meets Physiology
2010
Involvement of 5-HT1A Receptors in Homeostatic and Stress-Induced Adaptive Regulations of Paradoxical Sleep: Studies in 5-HT1A Knock-Out Mice
2002
Novel 5-HT7Receptor Inverse Agonists. Synthesis and Molecular Modeling of Arylpiperazine- and 1,2,3,4-Tetrahydroisoquinoline-Based Arylsulfonamides
2004
Dynorphin A decreases voltage‐dependent calcium conductance of mouse dorsal root ganglion neurones.
1986
Immunohistochemical characterization of calcitonin gene-related peptide in the trigeminal system of the familial hemiplegic migraine 1 knock-in mouse
2011
Innovative Synthesis of 4-Carbaldehydepyrrolin-2-ones by Zwitterionic Rhodium Catalyzed Chemo- and Regioselective Tandem Cyclohydrocarbonylation/CO Insertion of α-Imino Alkynes
2001
Magnesium in Man: Implications for Health and Disease
2014 Standout
Effect of Idalopirdine as Adjunct to Cholinesterase Inhibitors on Change in Cognition in Patients With Alzheimer Disease
2018
Differential contribution of the three Aph1 genes to γ-secretase activity in vivo
2005
Marine Indole Alkaloids: Potential New Drug Leads for the Control of Depression and Anxiety
2010 Standout
Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids
2012 Standout
Control of Sleep and Wakefulness
2012
Rapid access to diverse α-carbolines through sequential transition metal catalyzed amination and direct C–H arylation
2014
Spermidine in health and disease
2018 StandoutScience
Interferon-Stimulated Genes: A Complex Web of Host Defenses
2014 StandoutNobel
The Thermal Grill Illusion: Unmasking the Burn of Cold Pain
1994 StandoutScience
Biomedical Application of Orexin/Hypocretin Receptor Ligands in Neuroscience
2009
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
2011
A new approach to the synthesis of functionalized pyrido[2,3-b]indoles by way of a palladium-catalyzed ring closing reaction between the N-1 and C-9a positions
1998
First Suzuki–Miyaura type cross-coupling of ortho-azidobromobenzene with arylboronic acids and its application to the synthesis of fused aromatic indole-heterocycles
2007
A Novel, Potent, and Selective 5-HT7Antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)
2000
About Sleep's Role in Memory
2013 Standout
Generation of a Set of Simple, Interpretable ADMET Rules of Thumb
2008
Morphine can produce analgesia via spinal kappa opioid receptors in the absence of mu opioid receptors
2006
Catalytic Asymmetric Synthesis of Unprotected β2-Amino Acids
2021 StandoutNobel
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
SB‐334867‐A: the first selective orexin‐1 receptor antagonist
2001
Serotonin Receptors
2008
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Medicinal Chemistry Driven Approaches Toward Novel and Selective Serotonin 5-HT6Receptor Ligands
2004
ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties
2021 Standout
Transition-Metal-Catalyzed Reactions in Heterocyclic Synthesis
2004 Standout
The Role of Hypocretins (Orexins) in Sleep Regulation and Narcolepsy
2002
Familial Hemiplegic Migraine Type 1 Shows no Hypersensitivity to Nitric Oxide
2008
A one-pot, four-component synthesis of α-carboline derivatives
2009
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
2010
5-ht6 Receptors as Emerging Targets for Drug Discovery
2000
Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model
2007 StandoutScience
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
G Protein–Coupled Receptors, Cholinergic Dysfunction, and Aβ Toxicity in Alzheimer’s Disease
2009
Microwave-Assisted Synthesis of Novel (5-Nitropyridin-2-yl)alkyl and (5-Nitropyridin-3-yl)alkyl Carbamates
2009
Hypocretin-1 Modulates Rapid Eye Movement Sleep through Activation of Locus Coeruleus Neurons
2000
Circadian neuron feedback controls the Drosophila sleep–activity profile
2016 StandoutNatureNobel
Chemical Glycoproteomics
2016 StandoutNobel
Metal-Free Multicomponent Syntheses of Pyridines
2014 Standout
Works of Neil Upton being referenced
Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity
2001
5-HT6 Receptor Antagonists as Novel Cognitive Enhancing Agents for Alzheimer's Disease
2008
Identification of (−)-cis-6-acetyl-4S-(3-chloro-4-fluoro-benzoylamino)-3,4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3S-ol as a potential antimigraine agent
1999
BACE1 (β-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes
2003
Pharmacological profile of SB-357134: A potent, selective, brain penetrant, and orally active 5-HT6 receptor antagonist
2002
Characterization of SB‐269970‐A, a selective 5‐HT7 receptor antagonist
2000
Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX 1 ) receptors, with downstream 5-HT 2C receptor involvement
2001
Studies on the role of 5-HT2C and 5-HT2B receptors in regulating generalised seizure threshold in rodents
1998
Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings
1994
Analysis of serial magnetic resonance images of mouse brains using image registration
2008
Cortical spreading depression produces increased cGMP levels in cortex and brain stem that is inhibited by tonabersat (SB-220453) but not sumatriptan
2001
Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease
2007
Characterization of the binding of [3H]‐SB‐204269, a radiolabelled form of the new anticonvulsant SB‐204269, to a novel binding site in rat brain membranes
1997
Protection against Aβ-mediated rapid disruption of synaptic plasticity and memory by memantine
2009
Identification of a series of 1,2,3,4-tetrahydroisoquinolinyl- benzamides with potential anticonvulsant activity
1998
GABAB receptor isoforms GBR1a and GBR1b, appear to be associated with pre‐ and post‐synaptic elements respectively in rat and human cerebellum
1999
Tonabersat (SB‐220453) a novel benzopyran with anticonvulsant properties attenuates trigeminal nerve‐induced neurovascular reflexes
2001
Evidence for a Selective Role of the δ-Opioid Agonist [8 R-(4b S*,8aα,8aβ,12bβ)]7,10-Dimethyl-1-methoxy-11-(2-methylpropyl)oxycarbonyl 5,6,7,8,12,12b-hexahydro-(9 H)-4,8-methanobenzofuro[3,2-e]pyrrolo[2,3-g]isoquinoline Hydrochloride (SB-235863) in Blocking Hyperalgesia Associated with Inflammatory and Neuropathic Pain Responses
2003
The novel brain neuropeptide, orexin‐A, modulates the sleep–wake cycle of rats
2000
The design of 8,8-Dimethyl[1,6]naphthyridines as potential anticonvulsant agents
2003
Characterization of SB‐271046: A potent, selective and orally active 5‐HT6 receptor antagonist
2000
SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models
2006
A beam-walking apparatus to assess behavioural impairments in MPTP-treated mice: Pharmacological validation with R-(−)-deprenyl
2007
Differentiation of potent μ- and κ-opiate agonists using heat and pressure antinociceptive profiles and combined potency analysis
1982
The Neuroprotective Effect of a Specific P2X7 Receptor Antagonist Derives from its Ability to Inhibit Assembly of the NLRP3 Inflammasome in Glial Cells
2011
Stereochemical differentiation of anticonvulsant and antihypertensive effects in 4-(fluorobenzoylamino)-benzopyrans
1995
(R)-3,N-Dimethyl-N-[1-methyl-3-(4-methylpiperidin-1-yl)propyl]benzenesulfonamide: The First Selective 5-HT7Receptor Antagonist
1998
Synthesis and potential anxiolytic activity of 4-amino-pyrido[2,3-b]indoles
1993