Citation Impact
Citing Papers
Oxidative Stress
2017 Standout
RNAi -Mediated Silencing of Nuclear Factor Erythroid-2–Related Factor 2 Gene Expression in Non–Small Cell Lung Cancer Inhibits Tumor Growth and Increases Efficacy of Chemotherapy
2008
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Redox Regulation of Cell Survival
2008
Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators
2006 Standout
The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress
2009 Standout
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
2013 StandoutNobel
Inference and analysis of cell-cell communication using CellChat
2021 Standout
A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy
2022 StandoutNobel
scAI: an unsupervised approach for the integrative analysis of parallel single-cell transcriptomic and epigenomic profiles
2020
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
2014
Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes
2011
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
2008
NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
2009 Standout
Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression
2017 Standout
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
2015
Antibody-cytokine fusion proteins: Biopharmaceuticals with immunomodulatory properties for cancer therapy
2018
Transcriptional Regulation of Renal Cytoprotective Genes by Nrf2 and Its Potential Use as a Therapeutic Target to Mitigate Cisplatin-Induced Nephrotoxicity
2010
The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease
2013
Targeting hypoxia in cancer therapy
2011 Standout
Inflammation and metabolic disorders
2006 StandoutNature
Cancer chemoprevention with dietary phytochemicals
2003 Standout
Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR‐dependent motor neuron apoptosis
2006
Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation
2013
Unique cistrome defined as CsMBE is strictly required for Nrf2-sMaf heterodimer function in cytoprotection
2015
Role of impaired Nrf2 activation in the pathogenesis of oxidative stress and inflammation in chronic tubulo-interstitial nephropathy
2013
Nrf2–Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
2006 Standout
Vascularized and functional human liver from an iPSC-derived organ bud transplant
2013 StandoutNature
PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria
2008
Novel n-3 Fatty Acid Oxidation Products Activate Nrf2 by Destabilizing the Association between Keap1 and Cullin3
2006
Repression of the Antioxidant NRF2 Pathway in Premature Aging
2016
Systemic inflammation and oxidative stress in hemodialysis patients are associated with down-regulation of Nrf2
2015
Macrophages in the Pathogenesis of Atherosclerosis
2011 Standout
Toward clinical application of the Keap1–Nrf2 pathway
2013
Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease
2013
NRF2 and the Hallmarks of Cancer
2018
Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression
2016
The Keap1–Nrf2 system and diabetes mellitus
2014
The Human Transcription Factors
2018 Standout
Multiorgan Autoimmune Inflammation, Enhanced Lymphoproliferation, and Impaired Homeostasis of Reactive Oxygen Species in Mice Lacking the Antioxidant-Activated Transcription Factor Nrf2
2006
Direct lineage conversions: unnatural but useful?
2011
Identification of polymorphisms in the promoter region of the human NRF2 gene
2004
The Epigenomics of Cancer
2007 Standout
Analyzing real-time PCR data by the comparative CT method
2008 Standout
Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
2014 Standout
Nuclear Factor Erythroid 2-related Factor 2 Deficiency Exacerbates Lupus Nephritis in B6/lpr mice by Regulating Th17 Cell Function
2016
Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway
2005
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
2011 StandoutNature
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
The emerging role of the Nrf2–Keap1 signaling pathway in cancer
2013
ROS Function in Redox Signaling and Oxidative Stress
2014 Standout
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
2007 Standout
Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response
2013
Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity
2015 Standout
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
Total insulin and IGF-I resistance in pancreatic β cells causes overt diabetes
2006
Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer
2006 Standout
Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
2006 Standout
Nrf2 Controls Constitutive and Inducible Expression of ARE-driven Genes through a Dynamic Pathway Involving Nucleocytoplasmic Shuttling by Keap1
2005
Keap1 inhibition attenuates glomerulosclerosis
2014
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Translation Attenuation through eIF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells
2009
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
2007 Standout
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
The Absence of the Pro-antioxidant Transcription Factor Nrf2 Exacerbates Experimental Autoimmune Encephalomyelitis
2009
The synthetic triterpenoid, RTA 405, increases the glomerular filtration rate and reduces angiotensin II–induced contraction of glomerular mesangial cells
2012
Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach
2018 Standout
Bardoxolone Methyl Decreases Megalin and Activates Nrf2 in the Kidney
2012
Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
2010 Standout
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
2010 Standout
Activation of Nuclear Factor (Erythroid-2 Like) Factor 2 by Toxic Bile Acids Provokes Adaptive Defense Responses to Enhance Cell Survival at the Emergence of Oxidative Stress
2007
Transcriptional control of granulocyte and monocyte development
2007
Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway
2006
Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2
2012
Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity
2008
Resurrection of endogenous retroviruses in antibody-deficient mice
2012 Nature
NADPH Oxidase and ERK Signaling Regulates Hyperoxia-induced Nrf2-ARE Transcriptional Response in Pulmonary Epithelial Cells
2004
Nrf2–Keap1 defines a physiologically important stress response mechanism
2004 Standout
Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents
2015
Ferroptosis: mechanisms, biology and role in disease
2021 Standout
Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus
2017
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Re(de)fining the dendritic cell lineage
2012
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
2009 Standout
Dose-dependent deleterious and salutary actions of the Nrf2 inducer dh404 in chronic kidney disease
2015
Integration-Free iPS Cells Engineered Using Human Artificial Chromosome Vectors
2011 StandoutNobel
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
2016
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
2011
Imaging Reactive Oxygen Species-Induced Modifications in Living Systems
2016
Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities
2018
Nrf2-Mediated Transcriptional Induction of Antioxidant Response in Mouse Embryos Exposed to Ethanol in vivo : Implications for the Prevention of Fetal Alcohol Spectrum Disorders
2008
Role of Nrf2 in Oxidative Stress and Toxicity
2013 Standout
Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress
2003
Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1–Nrf2 regulatory pathway
2004
Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo
2011
Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
2003
Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice
2004
Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway
2006 Standout
Signal transduction by reactive oxygen species
2011 Standout
Inflammation, a Key Event in Cancer Development
2006
The NRF2 gene variant, -653G/A, is associated with nephritis in childhood-onset systemic lupus erythematosus
2010
Nrf2 Protects Pancreatic β-Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice
2013
Disease Tolerance as a Defense Strategy
2012 StandoutScience
Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets
2010
Plenary Perspective: The complexity of constitutive and inducible gene expression in mononuclear phagocytes
2012
Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases
2014 Standout
The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy
2010
Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy
2011
Mechanisms of Diabetic Complications
2013 Standout
Emerging Role of Nrf2 in Protecting Against Hepatic and Gastrointestinal Disease
2007
Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-Δ12,14-Prostaglandin J2
2003
Th2 Skewing by Activation of Nrf2 in CD4+ T Cells
2012
Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease
2010
Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex
2004
Transcription Factor Nrf2 Plays a Pivotal Role in Protection against Elastase-Induced Pulmonary Inflammation and Emphysema
2005
Protection from mitochondrial complex II inhibitionin vitroandin vivoby Nrf2-mediated transcription
2004
Nrf2, a multi‐organ protector?
2005
The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus
2013
Derivative of Bardoxolone Methyl, dh404, in an Inverse Dose-Dependent Manner Lessens Diabetes-Associated Atherosclerosis and Improves Diabetic Kidney Disease
2014
KRAB zinc finger proteins
2017
Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2
2010
Deletion of Pten in Pancreatic β-Cells Protects Against Deficient β-Cell Mass and Function in Mouse Models of Type 2 Diabetes
2010 StandoutNobel
Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2
2003
Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia
2004
Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice
2017 StandoutNobel
Hydrogen Sulfide Mediates Cardioprotection Through Nrf2 Signaling
2009 Standout
Accelerated Ovarian Failure Induced by 4-Vinyl Cyclohexene Diepoxide in Nrf2 Null Mice
2006
Nrf2 and Redox Status in Prediabetic and Diabetic Patients
2014
Works of Naoki Morito being referenced
Nrf2-deficient female mice develop lupus-like autoimmune nephritis11See Editorial by Byrd and Thomas, p. 1606.
2001
Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels
2003
Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation
2012
Role of endogenous retroviruses in murine SLE
2010
EPR imaging of reducing activity in Nrf2 transcriptional factor-deficient mice
2003
Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2‐deficient mice
2008
Nrf2 deficiency improves autoimmune nephritis caused by the fas mutation lpr
2004
Selective Up-Regulation of Intact, but Not Defective env RNAs of Endogenous Modified Polytropic Retrovirus by the Sgp3 Locus of Lupus-Prone Mice
2009
GATA2 Regulates Body Water Homeostasis through Maintaining Aquaporin 2 Expression in Renal Collecting Ducts
2014
MafB Is Essential for Renal Development and F4/80 Expression in Macrophages
2006
MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion
2005
FP048MAFB MAY PLAY AN IMPORTANT ROLE IN PROXIMAL TUBULES DEVELOPMENT
2019