Standout Papers
Citation Impact
Citing Papers
Structural Basis of Transcription Initiation: RNA Polymerase Holoenzyme at 4 Å Resolution
2002 Science
Schizosacharomyces pombe RNA polymerase II at 3.6-Å resolution
2009 Nobel
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
Structural insight into the TFIIE–TFIIH interaction: TFIIE and p53 share the binding region on TFIIH
2008
Structural Basis of Transcription
2004 StandoutNobel
The role of TFIIB-RNA polymerase II interaction in start site selection in yeast cells
2002
Architecture of the RNA Polymerase II-TFIIS Complex and Implications for mRNA Cleavage
2003
Deletion of the RNA Polymerase Subunit RPB4 Acts as a Global, Not Stress-specific, Shut-off Switch for RNA Polymerase II Transcription at High Temperatures
2001
Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis
2006 StandoutNobel
Eukaryotic activators function during multiple steps of preinitiation complex assembly
1993 Nature
Evidence That Transcription Factor IIB Is Required for a Post-assembly Step in Transcription Initiation
1999
A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast
1993
RPB7, one of two dissociable subunits of yeast RNA polymerase II, is essential for cell viability
1993
Structures of Complete RNA Polymerase II and Its Subcomplex, Rpb4/7
2005
Functional Interplay between the Jaw Domain of Bacterial RNA Polymerase and Allele-specific Residues in the Product RNA-binding Pocket
2005
Phosphorylation of C-terminal domain of RNA polymerase II is not required in basal transcription
1993 Nature
A Yeast Transcriptional Stimulatory Protein Similar to Human PC4
1996 StandoutNobel
Yeast RNA Polymerase II Subunit RPB9
2000
A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID
1992
Repeated tertiary fold of RNA polymerase II and implications for DNA binding
1998 StandoutNobel
RNA Polymerase II Subunit Rpb9 Regulates Transcription Elongation in Vivo
2000
Three-dimensional structure of E. coil core RNA polymerase: Promoter binding and elongation conformations of the enzyme
1995
Protein Crystallization on Lipid Layers and Structure Determination of the RNA Polymerase II Transcription Initiation Complex
1999 StandoutNobel
Downstream DNA Selectively Affects a Paused Conformation of Human RNA Polymerase II
2004
CTD kinase associated with yeast RNA polymerase II initiation factor b
1991
Recruitment of P-TEFb for Stimulation of Transcriptional Elongation by the Bromodomain Protein Brd4
2005
The RNA Polymerase II Machinery
2002
Initiation of Transcription by RNA Polymerase II: A Multi-step Process
1993
Transcription factor b (TFIIH) is required during nucleotide-excision repair in yeast
1994 StandoutNatureNobel
A mediator required for activation of RNA polymerase II transcription in vitro
1991 StandoutNatureNobel
Bacterial RNA polymerase
2001
Formation and Crystallization of Yeast RNA Polymerase II Elongation Complexes
1997 StandoutNobel
The 8-Nucleotide-long RNA:DNA Hybrid Is a Primary Stability Determinant of the RNA Polymerase II Elongation Complex
2000
The C-terminal Domain Revealed in the Structure of RNA Polymerase II
1996 StandoutNobel
Promoting elongation with transcript cleavage stimulatory factors
2002
Three-dimensional structure of Escherichia coli RNA polymerase holoenzyme determined by electron crystallography
1989 StandoutNatureNobel
Two-dimensional and epitaxial crystallization of a mutant form of yeast RNA polymerase II
1991 StandoutNobel
Electron Crystal Structure of the Transcription Factor and DNA Repair Complex, Core TFIIH
2000 StandoutNobel
Structure of Yeast RNA Polymerase II in Solution
2002
Tails of RNA polymerase II
1990
Structural Organization of the RNA Polymerase-Promoter Open Complex
2000
Complete RNA Polymerase II Elongation Complex Structure and Its Interactions with NTP and TFIIS
2004
RNA polymerase II C-terminal repeat influences response to transcriptional enhancer signals
1990 Nature
Structure of wild-type yeast RNA polymerase II and location of Rpb4 and Rpb7
1998
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Zinc Stoichiometry of Yeast RNA Polymerase II and Characterization of Mutations in the Zinc-binding Domain of the Largest Subunit
2000
Emergence of vancomycin tolerance in Streptococcus pneumoniae
1999 StandoutNatureNobel
A mammalian SRB protein associated with an RNA polymerase II holoenzyme
1996 Nature
Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II
1994 StandoutNatureNobel
Purification and Characterization of RNA Polymerase II Holoenzyme from Schizosaccharomyces pombe
2000
A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II
1994 StandoutNobel
Control of RNA Polymerase II Elongation Potential by a Novel Carboxyl-terminal Domain Kinase
1996
Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription
2000
Effects of activation-defective TBP mutations on transcription initiation in yeast
1994 StandoutNatureNobel
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II
1992 Nature
Elongation by RNA polymerase II: the short and long of it
2004
Structure of an Archaeal Homolog of the Eukaryotic RNA Polymerase II RPB4/RPB7 Complex
2001
Dissociable Rpb4-Rpb7 Subassembly of RNA Polymerase II Binds to Single-strand Nucleic Acid and Mediates a Post-recruitment Step in Transcription Initiation
2001
Two-Dimensional Crystallography of TFIIB– and IIE–RNA Polymerase II Complexes: Implications for Start Site Selection and Initiation Complex Formation
1996 StandoutNobel
2D crystallization: from art to science
1992
The orientation of DNA in an archaeal transcription initiation complex.
2000
Three-dimensional structure of yeast RNA polymerase II at 16 Å resolution
1991 StandoutNobel
Electron Crystal Structure of an RNA Polymerase II Transcription Elongation Complex
1999 StandoutNobel
Structure and Function of the Transcription Elongation Factor GreB Bound to Bacterial RNA Polymerase
2003
A novel mediator between activator proteins and the RNA polymerase II transcription apparatus
1990 StandoutNobel
Selenomethionine Incorporation in Saccharomyces cerevisiae RNA Polymerase II
2001 StandoutNobel
Biochemical analysis of TREX complex recruitment to intronless and intron‐containing yeast genes
2004 StandoutNobel
A Minimal Set of RNA Polymerase II Transcription Protein Interactions
1996 StandoutNobel
Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II
1989 Nature
A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3
2001 StandoutNobel
Involvement of multiple genetic determinants in high-level methicillin resistance in Staphylococcus aureus
1989
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
Phosphorylation of RNA polymerase IIA occurs subsequent to interaction with the promoter and before the initiation of transcription.
1990
Diffusion of nucleoside triphosphates and role of the entry site to the RNA polymerase II active center
2004 StandoutNobel
Purification and characterization of yeast RNA polymerase II transcription factor b.
1991 StandoutNobel
Structural basis of transcription: α-Amanitin–RNA polymerase II cocrystal at 2.8 Å resolution
2002 StandoutNobel
RNA polymerase II subunit RPB9 is required for accurate start site selection.
1995
Potential RNA polymerase II-induced interactions of transcription factor TFIIB.
1993
Two-dimensional crystals of proteins on lipid layers
1991 StandoutNobel
Engines of gene expression
2000
RNA Polymerase II Initiation Factor Interactions and Transcription Start Site Selection
1994 StandoutScienceNobel
Transcription from a TATA-less promoter requires a multisubunit TFIID complex.
1991
Mechanism of ATP-Dependent Promoter Melting by Transcription Factor IIH
2000 Science
Yeast TFIIE. Cloning, expression, and homology to vertebrate proteins.
1994 StandoutNobel
Resolution of factors required for the initiation of transcription by yeast RNA polymerase II.
1990 StandoutNobel
Photo-Cross-Linking of a Purified Preinitiation Complex Reveals Central Roles for the RNA Polymerase II Mobile Clamp and TFIIE in Initiation Mechanisms
2004
Structural Basis of Transcription: An RNA Polymerase II Elongation Complex at 3.3 Å Resolution
2001 StandoutScienceNobel
Interactions of Escherichia coli σ 70 within the transcription elongation complex
1999
Purification and properties of Saccharomyces cerevisiae RNA polymerase II general initiation factor a
1992 StandoutNobel
Three-dimensional model of yeast RNA polymerase I determined by electron microscopy of two-dimensional crystals.
1993
Promoter-dependent phosphorylation of RNA polymerase II by a template-bound kinase. Association with transcriptional initiation
1991
A Complex Containing RNA Polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p Plays a Role in Protein Kinase C Signaling
1999
Formation of a Carboxy-Terminal Domain Phosphatase (Fcp1)/TFIIF/RNA Polymerase II (pol II) Complex in Schizosaccharomyces pombe Involves Direct Interaction between Fcp1 and the Rpb4 Subunit of pol II
2002
Two dissociable subunits of yeast RNA polymerase II stimulate the initiation of transcription at a promoter in vitro.
1991 StandoutNobel
CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae.
1991
Architecture of initiation-competent 12-subunit RNA polymerase II
2003
The RNA Polymerase II Elongation Complex
2003
Characterization of the RNA Binding Properties of Ku Protein
1998
Cloning of a Subunit of Yeast RNA Oolymerase II Transcription Factor b and CTD Kinase
1992 StandoutScienceNobel
The molecular basis of eukaryotic transcription
2007 Nobel
A Portion of RNA Polymerase II Molecules Has a Component Essential for Stress Responses and Stress Survival
1993
Interplay of positive and negative effectors in function of the C-terminal repeat domain of RNA polymerase II.
1994
Multiple Mechanisms of Suppression Circumvent Transcription Defects in an RNA Polymerase Mutant
2000
RNA polymerase transcription factor IIH holoenzyme from yeast.
1994 StandoutNobel
The requirement for the basal transcription factor IIE is determined by the helical stability of promoter DNA.
1995
Structure of Eukaryotic RNA Polymerases
2008
TRANSCRIPTION OF EUKARYOTIC PROTEIN-CODING GENES
2000
Mediator of Transcriptional Regulation
2000 StandoutNobel
Complete, 12-subunit RNA polymerase II at 4.1-Å resolution: Implications for the initiation of transcription
2003 StandoutNobel
Association of an activator with an RNA polymerase II holoenzyme.
1995
Yeast RNA polymerase II initiation factor e: isolation and identification as the functional counterpart of human transcription factor IIB.
1992 StandoutNobel
A carboxyl-terminal-domain kinase associated with RNA polymerase II transcription factor delta from rat liver.
1992
The A14–A43 heterodimer subunit in yeast RNA pol I and their relationship to Rpb4–Rpb7 pol II subunits
2002
Structural Basis for the Transition from Initiation to Elongation Transcription in T7 RNA Polymerase
2002 StandoutScienceNobel
Transposable elements
1980
Functional Evidence for an RNA Template in Telomerase
1990 StandoutScienceNobel
Structural Basis of Transcription: An RNA Polymerase II-TFIIB Cocrystal at 4.5 Angstroms
2004 StandoutScienceNobel
Rpb7 Can Interact with RNA Polymerase II and Support Transcription during Some Stresses Independently of Rpb4
1999
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
The yeast general transcription factor TFIIA is composed of two polypeptide subunits.
1991
Tn554—a site-specific represser-controlled transposon in Staphylococcus aureus
1979 Nature
Multiple sets of basal factors initiate transcription by RNA polymerase II
1994
Bacterial RNA polymerase subunit ω and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly
2001
RNA polymerase II carboxy-terminal domain contributes to the response to multiple acidic activators in vitro.
1991
Unique insertion site of Tn7 in the E. coli chromosome
1982 StandoutNatureNobel
Reconstitution of transcription with five purified initiation factors and RNA polymerase II from Saccharomyces cerevisiae
1992 StandoutNobel
Yeast and human TFIIDs are interchangeable for the response to acidic transcriptional activators in vitro.
1992 StandoutNobel
Initiation on chromatin templates in a yeast RNA polymerase II transcription system.
1992 StandoutNobel
Works of Nancy E. Thompson being referenced
Immunoaffinity purification of RNA polymerase II and transcription factors using polyol-responsive monoclonal antibodies
1996
Yeast RNA Polymerase II at 5 Å Resolution
1999 StandoutNobel
Structure and function of the .sigma.-70 subunit of Escherichia coli RNA polymerase. Monoclonal antibodies: localization of epitopes by peptide mapping and effects on transcription
1988
Isolation and characterization of a polyol-responsive monoclonal antibody useful for gentle purification of Escherichia coli RNA polymerase
1992
A Novel Collection of Accessory Factors Associated with Yeast RNA Polymerase II
1996
The HIP1 Initiator Element Plays a Role in Determining the In Vitro Requirement of the Dihydrofolate Reductase Gene Promoter for the C-Terminal Domain of RNA Polymerase II
1992
CDK9 Autophosphorylation Regulates High-Affinity Binding of the Human Immunodeficiency Virus Type 1 Tat–P-TEFb Complex to TAR RNA
2000
Inhibition of in Vivo and in Vitro Transcription by Monoclonal Antibodies Prepared against Wheat Germ RNA Polymerase II That React with the Heptapeptide Repeat of Eukaryotic RNA Polymerase II
1989
Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoter.
1990
Chromosomal map locations of integrated plasmids and related elements in Staphylococcus aureus
1977
Architecture of RNA Polymerase II and Implications for the Transcription Mechanism
2000 StandoutScienceNobel
Purification and lipid-layer crystallization of yeast RNA polymerase II.
1990 StandoutNobel
Purification of eukaryotic RNA polymerase II by immunoaffinity chromatography. Elution of active enzyme with protein stabilizing agents from a polyol-responsive monoclonal antibody.
1990
Transformation in Staphylococcus aureus: role of bacteriophage and incidence of competence among strains
1977