Citation Impact
Citing Papers
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
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Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
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eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
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Developmental Decline in Neuronal Regeneration by the Progressive Change of Two Intrinsic Timers
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Genetic variability of the AIDS virus: Nucleotide sequence analysis of two isolates from African patients
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Translation factors as effectors of cell growth and tumorigenesis
1993
Crystal Structure of a Human Alkylbase-DNA Repair Enzyme Complexed to DNA
1998
TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function
2003
Cation–π interactions in ligand recognition and catalysis
2002
Recognition of eIF4G by Rotavirus NSP3 Reveals a Basis for mRNA Circularization
2002
Solution Structure of the E. coli 70S Ribosome at 11.5 Å Resolution
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Activated eIF4E-binding Protein Slows G1 Progression and Blocks Transformation by c-myc without Inhibiting Cell Growth
2004
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway
1998
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
1999
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
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Unravelling hepatitis C virus replication from genome to function
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Uncoupling of Initiation Factor eIF5B/IF2 GTPase and Translational Activities by Mutations that Lower Ribosome Affinity
2002
Regulation of translation initiation by FRAP/mTOR
2001
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
2002 Standout
Translation initiation: structures, mechanisms and evolution
2004
The Cryo-EM Structure of a Translation Initiation Complex from Escherichia coli
2005 StandoutNobel
4E-BP3, a New Member of the Eukaryotic Initiation Factor 4E-binding Protein Family
1998
The proto‐oncogene/translation factor eIF4E: A survey of its expression in breast carcinomas
1995
The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNA
1997 StandoutNobel
HIV-1 TAT “activates” presynthesized RNA in the nucleus
1989
A Distinct Nuclear Import Pathway Used by Ribosomal Proteins
1997 StandoutNobel
Oncoprotein Networks
1997
Requirements for U2 snRNP addition to yeast pre-mRNA
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The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
2004
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
2000 StandoutNatureNobel
Quality control of mRNA 3′-end processing is linked to the nuclear exosome
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MicroRNAs: Target Recognition and Regulatory Functions
2009 Standout
Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation
2010 StandoutNobel
The Hallmarks of Cancer
2000 Standout
Cap-Dependent Translation Initiation in Eukaryotes Is Regulated by a Molecular Mimic of eIF4G
1999
Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI
2000
Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation
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Target of Rapamycin (TOR)-signaling and RAIP Motifs Play Distinct Roles in the Mammalian TOR-dependent Phosphorylation of Initiation Factor 4E-binding Protein 1
2003
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
1993 StandoutNobel
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function
1994 Nature
‘Ribozoomin’ – Translation Initiation from the Perspective of the Ribosome-bound Eukaryotic Initiation Factors (eIFs)
2012
Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway
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Internal ribosome entry sites in eukaryotic mRNA molecules
2001
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
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Upstream and downstream of mTOR
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Does the ribosome translate cancer?
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HIV-1 Genome Nuclear Import Is Mediated by a Central DNA Flap
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An Efficient System for Cap- and Poly(A)-Dependent Translation In Vitro
2004
Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing
2001 StandoutNobel
Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system
2007
Ribosome Loading onto the mRNA Cap Is Driven by Conformational Coupling between eIF4G and eIF4E
2003
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
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RNA regulons in Hox 5′ UTRs confer ribosome specificity to gene regulation
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Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes
2003
The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection
2002
Individual Overexpression of Five Subunits of Human Translation Initiation Factor eIF3 Promotes Malignant Transformation of Immortal Fibroblast Cells
2006
Cap recap: The involvement of eIF-4F in regulating gene expression
1992
Cholesterol Depletion Disrupts Caveolae and Insulin Receptor Signaling for Metabolic Control via Insulin Receptor Substrate-1, but Not for Mitogen-activated Protein Kinase Control
2001
A Mammalian Pre-mRNA 5′ End Capping Quality Control Mechanism and an Unexpected Link of Capping to Pre-mRNA Processing
2013
The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila
2001
The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans
2002 StandoutNobel
Regulation and function of non-AUG-initiated proto-oncogenes
1994
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
Cross-Intron Bridging Interactions in the Yeast Commitment Complex Are Conserved in Mammals
1997 StandoutNobel
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
1993 StandoutNobel
Cryo-EM Visualization of a Viral Internal Ribosome Entry Site Bound to Human Ribosomes
2004 StandoutNobel
A Fresh Look at iPS Cells
2009 StandoutNobel
A Quantitative Molecular Model for Modulation of Mammalian Translation by the eIF4E-binding Protein 1
2001
Biophysical Studies of eIF4E Cap-binding Protein: Recognition of mRNA 5′ Cap Structure and Synthetic Fragments of eIF4G and 4E-BP1 Proteins
2002
The Exosome: A Conserved Eukaryotic RNA Processing Complex Containing Multiple 3′→5′ Exoribonucleases
1997
Growth Control of Translation in Mammalian Cells
1995
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
2004 Nature
Rrp6p, the Yeast Homologue of the Human PM-Scl 100-kDa Autoantigen, Is Essential for Efficient 5.8 S rRNA 3′ End Formation
1998
Human Interferon-γ mRNA Autoregulates Its Translation through a Pseudoknot that Activates the Interferon-Inducible Protein Kinase PKR
2002
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
2000 StandoutNatureNobel
Elevated levels of eukaryotic translation initiation factor eIF-4E, mRNA in a broad spectrum of transformed cell lines
1995
Translational regulation: versatile mechanisms for metabolic and developmental control
1995
Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E
2000
The role of the 5′ untranslated region of an mRNA in translation regulation during development
1999
Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms
2005
eIF4E expression in tumors: its possible role in progression of malignancies
1999
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Plasmid cDNA-directed protein synthesis in a coupled eukaryoticin vitrotranscription-translation system
1992 StandoutNobel
Phosphorylation Screening Identifies Translational Initiation Factor 4GII as an Intracellular Target of Ca2+/Calmodulin-dependent Protein Kinase I
2003
Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells
2004
microRNAs
2001 StandoutNobel
The functions of animal microRNAs
2004 StandoutNatureNobel
Brain-derived Neurotrophic Factor Enhances Neuronal Translation by Activating Multiple Initiation Processes
2001
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
Identification and functional analysis of the nuclear localization signals of ribosomal protein L25 from Saccharomyces cerevisiae
1991
A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis
1999 StandoutNobel
Cap-dependent eukaryotic initiation factor-mRNA interactions probed by cross-linking
2008
RNA sensors: novel regulators of gene expression
2003
A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding
2006
Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro.
1989
Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology.
1990
The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins
1995
Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase
1992 Science
eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation
1999 Standout
4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.
1996
Malignant transformation by overproduction of translation initiation factor eIF4G.
1997
Insulin induction of ornithine decarboxylase. Importance of mRNA secondary structure and phosphorylation of eucaryotic initiation factors eIF-4B and eIF-4E
1991
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Mechanism and regulation of eukaryotic protein synthesis
1992
A Nuclear 3′-5′ Exonuclease Involved in mRNA Degradation Interacts with Poly(A) Polymerase and the hnRNA Protein Npl3p
2000
Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.
1996
Multiple mRNAs encode the murine translation initiation factor eIF-4E
1991
Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.
1995
Tumor-suppressor genes: news about the interferon connection.
1993
Quality Control by DNA Repair
1999 StandoutScienceNobel
mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E
2003
Control of Rous sarcoma virus RNA translation and packaging by the 5′ and 3′ untranslated sequences
1986
Extract-specific heterogeneity in high-order complexes containing apolipoprotein B mRNA editing activity and RNA-binding proteins.
1993
DAP-5, a Novel Homolog of Eukaryotic Translation Initiation Factor 4G Isolated as a Putative Modulator of Gamma Interferon-Induced Programmed Cell Death
1997
The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3)
1996
Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection
1998
Specific binding of a HeLa cell nuclear protein to RNA sequences in the human immunodeficiency virus transactivating region.
1989
The Molecular Mechanics of Eukaryotic Translation
2004
Ribosomal Protein L3 Mutants Alter Translational Fidelity and Promote Rapid Loss of the Yeast Killer Virus
1999
A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme.
1997 StandoutNobel
The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts.
1992
Dual Interactions of the Translational Repressor Paip2 with Poly(A) Binding Protein
2001
TNF-α impairs insulin signaling and insulin stimulation of glucose uptake in C2C12muscle cells
1999
Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin
1997 Science
Disruption of an RNA helicase/RNAse III gene in Arabidopsis causes unregulated cell division in floral meristems
1999
Translational Control of Programmed Cell Death: Eukaryotic Translation Initiation Factor 4E Blocks Apoptosis in Growth-Factor-Restricted Fibroblasts with Physiologically Expressed or Deregulated Myc
1996
Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.
1990
Xid -Like Immunodeficiency in Mice with Disruption of the p85α Subunit of Phosphoinositide 3-Kinase
1999 Science
Identification and characterization of a HeLa nuclear protein that specifically binds to the trans-activation-response (TAR) element of human immunodeficiency virus.
1990
Overproduction of ornithine decarboxylase caused by relief of translational repression is associated with neoplastic transformation.
1994
Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells
2006
Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.
1996
Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.
1993
Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action
2006
Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.
1995
Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice
2000 Nobel
Control of the Interferon-Induced 68-Kilodalton Protein Kinase by the HIV-1 tat Gene Product
1990 Science
A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes.
1994
Alternative Translation of Human Fibroblast Growth Factor 2 mRNA Occurs by Internal Entry of Ribosomes
1995
mRNAs containing extensive secondary structure in their 5′ non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E.
1992
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function.
1993
Stimulation of Protein Synthesis, Eukaryotic Translation Initiation Factor 4E Phosphorylation, and PHAS-I Phosphorylation by Insulin Requires Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase
1996
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E
1999
Fragments of the HIV-1 Tat Protein Specifically Biand TAR RNA
1990 StandoutScienceNobel
Cap-Independent Translation Is Required for Starvation-Induced Differentiation in Yeast
2007 StandoutScienceNobel
Works of Nahum Sonenberg being referenced
Internal ribosome initiation of translation and the control of cell death
2000
Interaction of eIF4G with poly(A)-binding protein stimulates translation and is critical for Xenopus oocyte maturation
2000
Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap
1990 Nature
Assays for Eukaryotic Translation Factors That Bind mRNA
1997
The involvement of mRNA secondary structure in protein synthesis
1987
Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: A novel translational control mechanism
1989
Structure of translation factor elF4E bound to m7GDP and interaction with 4E-binding protein
1997
Cap-Independent Translation of Poliovirus mRNA is Conferred by Sequence Elements within the 5′ Noncoding Region
1988
Insulin Signalling and Insulin Actions in the Muscles and Livers of Insulin-Resistant, Insulin Receptor Substrate 1-Deficient Mice
1996
Photochemical Cross-Linking of Cap Binding Proteins to Eucaryotic mRNAs: Effect of mRNA 5′ Secondary Structure
1985
Decoying the Cap2 mRNA Degradation System by a Double-Stranded RNA Virus and Poly(A)2 mRNA Surveillance by a Yeast Antiviral System
1995
Bidirectional RNA Helicase Activity of Eucaryotic Translation Initiation Factors 4A and 4F
1990
eIF4E, the mRNA cap-binding protein: from basic discovery to translational researchThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process.
2008
A Lysine Substitution in the ATP-Binding Site of Eucaryotic Initiation Factor 4A Abrogates Nucleotide-Binding Activity
1989
RNA Unwinding in Translation: Assembly of Helicase Complex Intermediates Comprising Eukaryotic Initiation Factors eIF-4F and eIF-4B
1991